Clinical trials: Vascular Risk
Coronary Artery Disease, Genetic Predisposition to Disease
Genetic Risk Stratification for Primary Prevention of CAD in Men and Pre & Post-menopausal Women
The investigators propose to genotype males and females at age 40 years and older, who are asymptomatic and without known heart disease (N=2000).
- Trial name
- NCT05169840
- Testing
- Genetic Risk Score for Coronary Artery Disease
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Heart Failure, Coronary Artery Disease
The Usefulness of Growth Differentiation Factor 15 (GDF-15) for Risk Stratification in Cardiac Surgery
Growth determination factor 15 (GDF-15) and high sensitive troponin-t (hsTnT) are emerging humoral markers for risk stratification in clinically stable heart failure patients and in patients with stable coronary artery disease.
- Trial name
- NCT01166360
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Luebeck
Metabolic Disorders, Physical Inactivity
Interactive Roles of Cardiorespiratory Fitness and Adiposity on Glucose and Vascular Control After Physical Inactivity
The far-reaching negative health effects of the reduced physical activity (RPA) epidemic are often overlooked by the general population and health professionals.
- Conditions
- Metabolic Disorders, Physical Inactivity, Vascular Disease Risk
- Trial name
- NCT06842225
- Testing
- reduced physical activity
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Miami University
Myocardial Infarction, Surgery-Complications
Cardiology Consultation in Noncardiac Surgery
Recently, a predictive model has been developed to assess the risk of myocardial infarction or cardiac arrest (MICA) during and after surgery using the American Society of Surgeons' National Surgical Quality Improvement Program…
- Trial name
- NCT05532917
- Testing
- Gupta score
- Where
- Turkey (Türkiye)
- Volunteers
- 898 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Acute Pulmonary Embolism
HOME-PE2 : Home Treatment Versus Hospitalization in Patients With Acute Pulmonary Embolism, no Clinical Severity Criteria, and Either Right Ventricular Dysfunction or Elevated Troponin: a Randomized Controlled Trial
This study (HOME-PE2) is a multicenter, randomized controlled trial comparing home treatment versus hospitalization in patients with acute pulmonary embolism (PE) who have no clinical severity criteria according to the Hestia…
- Trial name
- HOME-PE2 (NCT07506291)
- Testing
- Home treatment, Hospitalization
- Where
- 18 sites in France
- Volunteers
- 568 people
- Sponsor
- University Hospital, Angers
Advanced Gastric Cancer
Venous Thromboembolism in Advanced Gastric Cancer Patients
Venous thromboembolism (VTE), which includes pulmonary embolism (PE) and deep vein thrombosis (DVT), is a common complication and leading cause of death in cancer patients.
- Trial name
- NCT01047618
- Where
- South Korea
- Volunteers
- 259 people
- Sponsor
- Asan Medical Center
Carotid Artery Diseases
Post-approval Study of Transcarotid Artery Revascularization in Standard Risk Patients With Significant Carotid Artery Disease
The study objective is to evaluate real world usage of the ENROUTE Transcarotid Stent when used with the ENROUTE Transcarotid Neuroprotection System in patients at standard risk for adverse events from carotid endarterectomy
- Trial name
- NCT05365490
- Testing
- Transcarotid Artery Revascularization (TCAR)
- Where
- 53 sites in United States
- Volunteers
- 344 people
- Sponsor
- Silk Road Medical
Ischemic Stroke, TIA
A Comparison of Hemorrhagic and Ischemic Strokes Among Blacks and Whites
Our primary goal is to study temporal trends in the incidence rate, causes, treatment, and outcome of stroke among a large biracial metropolitan population of 1,349,351, of whom 215,611 (15%) are black (2000 Census).
- Conditions
- Ischemic Stroke, TIA, Hemorrhage
- Trial name
- GCNKSS (NCT00642213)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Cincinnati
High-risk Smoldering Multiple Myeloma, Smoldering Multiple Myeloma
Immuno-PRISM (PRecision Intervention Smoldering Myeloma)
The purpose of this study is to test the anti-cancer activity of Teclistamab and to compare it with Lenalidomide + Dexamethasone combination in people with high risk smoldering multiple myeloma.
- Conditions
- High-risk Smoldering Multiple Myeloma, Smoldering Multiple Myeloma, Multiple Myeloma
- Trial name
- NCT05469893
- Testing
- Teclistamab, Lenalidomide, Dexamethasone
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Irene Ghobrial, MD
Central Line, Central Venous Catheter
Statseal® for Central Venous Catheter Insertion Sites in Critical Care
All participants in this clinical trial will be undergoing surgery and will have a central venous catheter (also known as a central line) placed in the large vein in the neck as part of their routine care.
- Conditions
- Central Line, Central Venous Catheter, Vascular Access, Critical Care
- Trial name
- SCENIC (NCT06451185)
- Testing
- A haemostatic mineral powder product.
- Where
- United Kingdom
- Volunteers
- 451 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Dialysis Patients, Hypertension
Carotid Intima-media Thickness in Dialysis Patients and Traditional Risk Factors
Cardiovascular disease (CVD) is the leading cause of mortality in hemodialysis (HD) patients. Carotid intima-media thickness (CIMT) is a validated surrogate marker for atherosclerosis.
- Conditions
- Dialysis Patients, Hypertension, Atherosclerosis
- Trial name
- NCT07558239
- Testing
- Ultrasound measurements of carotid intima- media thickness
- Volunteers
- 100 people
- Sponsor
- Minia University
Telemetry Usage, Chest Pain
A Randomized Trial of Telemetry Compared With Unmonitored Floor Admissions in ED Patients With Low-Risk Chest Pain
This study aims to determine, relative to telemetry admission, if admission to an unmonitored floor bed saves resources without an increased rate of adverse events in emergency department (ED) patients admitted with chest pain…
- Conditions
- Telemetry Usage, Chest Pain, Unstable Angina, Resource Utilization
- Trial name
- NCT03906812
- Testing
- Telemetry, Unmonitored
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Myocardial Infarction, Stroke
Psychosocial Risk Factors in Stroke and Myocardial Infarction
The aim of this study is to identify groups of subjects at risk of recurrence in secondary prevention based on Psychosocial Factors.
- Trial name
- INEV@L (NCT02824107)
- Testing
- blood sample, questionnaires for psychosocial factors
- Where
- France
- Volunteers
- 294 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Atherosclerosis
Longitudinal Study in Perimenopausal Women With Risk Factors for Atherosclerosis
The study hypothesis (or theory) is that monthly loss of iron before menopause may reduce women's risk of hardening of the arteries, or atherosclerosis.
- Trial name
- NCT00921011
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Ohio State University
Coronary Artery Disease
Rosuvastatin Pre-Treatment Influences the Risk of Coronary Intervention Study
The aim of this study is to determine whether a pre-treatment with high-dose statin (one day prior and just before intervention, rosuvastatin 20mg/day) has a positive impact on the occurrence of periprocedural myocardial…
- Trial name
- TIPS-3 (NCT01378715)
- Testing
- Rosuvastatin
- Where
- 4 sites in Czechia, Slovakia
- Volunteers
- 400 people
- Sponsor
- University Hospital, Motol
Stroke, Ischemic
Validation of TriAGE+ for Predicting Stroke Risk in ED Patients Presenting With Dizziness
Ischemic cerebrovascular diseases originating from the brain's posterior circulation account for 20-25% of cases. Among patients diagnosed with cerebellar infarction, 10% present with isolated dizziness as their sole symptom.
- Trial name
- NCT06641050
- Testing
- TRIAGE+ score assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 818 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Cognitive Impairment, Stroke
Effect of a fNIRS-based Personalized Multi-domain Intervention on Cognitive in Elderly Population With High Risk of Stroke
This functional near-infrared spectroscopy-based personalized multidomain intervention study aims to prevent cognitive impairment and reduce dementia and cerebrovascular events in 45-74 years old persons with high risk of stroke…
- Conditions
- Cognitive Impairment, Stroke, Dementia
- Trial name
- NCT05930249
- Testing
- Personalized multidomain intervention
- Where
- China
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Carotid Atherosclerosis, Cerebrovascular Accident
Potential Risk Factors for Stroke
Early studies have shown that the immune system may play a role in the development of strokes. Conditions such as high blood pressure, high cholesterol, diabetes, and old age can activate the immune system and increase the risk…
- Conditions
- Carotid Atherosclerosis, Cerebrovascular Accident, Diabetes Mellitus, Hypercholesterolemia
- Trial name
- NCT00001368
- Testing
- cytokine and leukocyte activation profile
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Acute Ischemic Stroke
Study to Evaluate The Safety and Efficacy of Balovaptan in Participants With Acute Ischemic Stroke at a High Risk of Developing Malignant Brain Edema
This study is designed to evaluate the safety, efficacy, and pharmacokinetics of balovaptan compared with placebo in participants with acute ischemic stroke (AIS) at risk of developing Malignant Cerebral Edema (MCE)
- Trial name
- NCT05399550
- Testing
- Balovaptan
- Where
- United States
- Sponsor
- Hoffmann-La Roche
Perioperative Myocardial Infarction, Perioperative Myocardial Injury
Monitoring of Vital Signs for Phenotyping of Perioperative Myocardial Infarction/Injury After Noncardiac Surgery
The goal of this observational prospective cohort study is to learn about the pathophysiology of perioperative myocardial infarction/injury in high-risk patients undergoing major non-cardiac surgery.
- Trial name
- PMI-VITAL (NCT05866874)
- Where
- Switzerland
- Volunteers
- 875 people
- Sponsor
- University Hospital, Basel, Switzerland
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