Clinical trials: Vascular Risk
Acute Leukemia, Deep Vein Thrombosis
Understanding the Risk of Blood Clots and Bleeding in Patients With Hematological Malignancies, HAT Study
This study evaluates the risks and experience of blood clots and bleeding in patients with blood cancers. While it is standard of care to use medications to reduce the risk of blood clots in hospitalized individuals, some…
- Conditions
- Acute Leukemia, Deep Vein Thrombosis, Hematopoietic and Lymphoid Cell Neoplasm, Hodgkin Lymphoma
- Trial name
- NCT05053100
- Testing
- Biospecimen Collection, Electronic Health Record Review
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Acute Coronary Syndrome, Premature Coronary Heart Disease
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment
The aim of study is to examine the relationship between lipid subfractions, inflammation and structural-functional properties of the arterial wall in patients with premature coronary heart disease, to study genetic polymorphisms…
- Conditions
- Acute Coronary Syndrome, Premature Coronary Heart Disease, Lipoproteinemia, Inflammation
- Trial name
- GEBI (NCT04613167)
- Testing
- Alirocumab, Evolocumab, Control group
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
Diabetes, Diabetic Foot
Foot Assessment in People With Diabetes: A Quantitative Diagnostic Approach
This observational cohort study aims to develop a novel risk stratification system implementing biomechanics to aid in the prevention of diabetic foot ulcers.
- Conditions
- Diabetes, Diabetic Foot, Diabetes Complications, Diabetes; Neuropathic (Manifestation)
- Trial name
- NCT03089463
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 153 people
- Sponsor
- Staffordshire University
Cardiovascular Diseases, Heart Diseases
Dietary Intervention to Improve Health of Cardiovascular Patients
Voed je Beter is a randomized, multicenter, controlled trial to examine whether personalized guidance to increase adherence to the Dutch dietary guidelines, compared to usual care, improves health of cardiovascular patients who…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Vascular Diseases
- Trial name
- NCT05071092
- Testing
- Dietary counselling
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Wageningen University
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Chronic Stable Angina
Multi-slice CT Coronary Angiography in Patients With Stable Angina
early identification of vulnerable plaques by remodeling index prior to rupture and development of acute event is of considerable importance especially by a reliable non-invasive method as CT coronary angiography.
- Trial name
- NCT03963609
- Testing
- multisclice CT
- Volunteers
- 150 people
- Sponsor
- Benha University
Atheroscleroses, Cerebral, Carotid Plaque
Carotid Plaque-Burden Scale and Outcomes. A Real Life Study
Carotid ultrasonography has been proposed as a tool for prediction of future cardiovascular disease (CVD). Nevertheless, its role in clinical practice remains controversial.
- Trial name
- NCT06187532
- Volunteers
- 1,004 people
- Sponsor
- Fundación para la Formación e Investigación de los Profesionales de la Salud de Extremadura
Pulmonary Embolism
Catheter-Directed Pulmonary Reperfusion in Treatment of Pulmonary Embolism Patients
Primary objective: to evaluate the success and mortality rates of catheter-directed reperfusion therapy in comparison to traditional use of systemic intravenous fibrinolytic therapy, will focus at safety of such management…
- Trial name
- NCT04911192
- Testing
- mechanical fragmentation, In Situ thrombolysis
- Volunteers
- 60 people
- Sponsor
- Assiut University
Atrial Fibrillation, Hypertension
Graz Study on the Risk of Atrial Fibrillation
Atrial fibrillation (AF) is the most common clinical arrhythmia. AF is associated with increased risk for stroke due to blood clots formed in the fibrillating atria.
- Conditions
- Atrial Fibrillation, Hypertension, Diabetes, Chronic Heart Failure
- Trial name
- GRAF (NCT01461434)
- Testing
- Medtronic Reveal XT implantable loop recorder
- Where
- Austria
- Volunteers
- 82 people
- Sponsor
- Medical University of Graz
Essential Hypertension, Metabolic Cardiovascular Syndrome
Technological Innovation in the Virtual Assistance of Patients With Uncontrolled Arterial Hypertension - Hyper 2
The purpose of this study is to evaluate the effectiveness of the use of artificial intelligence in home monitoring in patients with uncontrolled arterial hypertension.
- Conditions
- Essential Hypertension, Metabolic Cardiovascular Syndrome, Heart Disease Risk Factors
- Trial name
- Hyper2 (NCT05843682)
- Testing
- Using the Avatr App
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Dyslipidemia, Angina (Stable)
Validation of Remote Photoplethysmography (rPPG)-Derived Cardiovascular Parameters Against Standard Clinical Measurements and Risk Scores in a Community
The goal of this observational study is to evaluate whether a contactless camera-based technology, called remote photoplethysmography (rPPG), can accurately measure cardiovascular parameters and estimate cardiovascular risk in…
- Conditions
- Dyslipidemia, Angina (Stable), Coronary Artery Disease (CAD), Heart Disease
- Trial name
- NCT07502703
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Diagnosis of TIA, MRI
Small-vessel Disease Burden and Early Risk of Stroke After Transient Ischemic Attack
Predicting the risk of stroke remains a challenge in the management of transient ischemic attack (TIA). In addition to clinical variables, morphological features such as the presence of a diffusion weighted sequence (DWI) lesion…
- Trial name
- TIA (NCT04108754)
- Testing
- microangiopathic burden
- Where
- France
- Volunteers
- 376 people
- Sponsor
- Hospices Civils de Lyon
Hypertension, Coronary Arteriosclerosis
SAFE-CRP: Structural Alterations and Function of Endothelium in Cardiovascular Risk Patients
The aim of this trial is to evaluate the efficacy and safety of telmisartan 80 mg administered once daily in patients with documented coronary artery disease (CAD) and a probably cardiovascular risk profile concerning the…
- Trial name
- NCT00274105
- Testing
- telmisartan
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Boehringer Ingelheim
Fasting, Intermittent, Diet
Intermittent Fasting Versus Diet to Stop Hypertension on Metabolic Risk Profile in Nonalcoholic Fatty Liver Patients
This study was conducted to compare between the effect of intermittent fasting and diatery approach to stop hypertension on metabolic risk profile in nonalcoholic fatty liver patients.
- Conditions
- Fasting, Intermittent, Diet, Hypertension, Metabolic Syndrome
- Trial name
- NCT06666894
- Testing
- Intermittent fasting, Dietary approach to stop hypertension (DASH)
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Cardiovascular Risk Factors, Coronary Disease
CPR Training: Video Self-Instruction Kit or Video-Only
Prompt delivery of cardiopulmonary resuscitation (CPR) is a crucial determinant of survival for many victims of sudden cardiac arrest (SCA), yet bystander CPR is provided in less than one third of witnessed SCA events.
- Conditions
- Cardiovascular Risk Factors, Coronary Disease, Cardiac Arrest
- Trial name
- NCT01514656
- Testing
- CPR Training using the Family and Friends CPR Anytime Video Self Instruction, Implementation of a Hospital-based CPR Training Model, Follow-up prompting to encourage skill retention
- Where
- 3 sites in United States
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
High Risk Smoldering Multiple Myeloma (HR-SMM)
A Study to Compare Linvoseltamab and Daratumumab Treatment in High-Risk Smoldering Multiple Myeloma (HR-SMM)
This study is researching an experimental drug called linvoseltamab (also called "study drug") compared to another drug called daratumumab, in participants with Smoldering Multiple Myeloma (SMM), who are at a High Risk (HR) of…
- Trial name
- LINKER-SMM2 (NCT07393282)
- Testing
- Linvoseltamab, Daratumumab
- Where
- 33 sites in United States, France and 4 more
- Volunteers
- 270 people
- Sponsor
- Regeneron Pharmaceuticals
Hypertension, Cardiovascular Disease
Combination of OLMesartan and CCB or Low Dose Diuretics in High Risk Elderly Hypertensive Patients Study (COLM-Study)
The purpose of this study is to investigate which combination therapy is more effective in reducing the incidence of cardiovascular events in Japanese elderly high-risk hypertensive patients: AT1 subtype angiotensin II receptor…
- Conditions
- Hypertension, Cardiovascular Disease, Diabetes
- Trial name
- NCT00454662
- Testing
- olmesartan medoxomil / amlodipine or azelnidipine, olmesartan medoxomil / low dose thiazide type drug
- Where
- Japan
- Volunteers
- 5,141 people
- Sponsor
- COLM Study Research Organization
Acute Coronary Syndrome
Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
Ticagrelor, a more potent P2Y12 inhibitor, has been shown to reduce major adverse cardiac events (MACE) in acute coronary syndromes (ACS). It is increasingly used as a first line therapy in ACS.
- Trial name
- RAPID CABG (NCT02668562)
- Testing
- Early CABG (Day 2-3 after ticagrelor discontinuation), Delayed CABG (Day 5-7 after ticagrelor discontinuation)
- Where
- 2 sites in Canada
- Volunteers
- 143 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hypertension, Diabetes Mellitus Type 2
County Medical Community-based, Cardiovascular Risk Stratified Integrated Care Model: a Pragmatic Cluster Randomised Control Trial
The goal of this cluster randomized trial is to evaluate the effectiveness of the RISIMA model based on an integrated county healthcare consortium implemented by multi-level family health teams (FHTs)on patients with diabetes…
- Conditions
- Hypertension, Diabetes Mellitus Type 2, Cardiovascular Diseases
- Trial name
- C-RISIMA (NCT06302127)
- Testing
- Team-based care, Risk-stratified care pathway, Strengthened health education
- Where
- 3 sites in China
- Volunteers
- 2,560 people
- Sponsor
- Peking University
Multiple Myeloma
Post-Transplant Maintenance Therapy With Isatuximab Plus Lenalidomide for High-Risk Multiple Myeloma Patients
To learn if isatuximab can help to control highrisk MM when given in combination with lenalidomide after an autologous stem cell transplantation (ASCT).
- Trial name
- NCT05776979
- Testing
- Isatuximab, lenalidomide
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- M.D. Anderson Cancer Center
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