Clinical trials: Vascular Risk
Myocardial Infarction
Reduced Antithrombotic Strategy for High Bleeding Risk Patients With Myocardial Infarction
Rationale: Heart attacks are a major cause of death and result from coronary blood clots that require acute coronary intervention and antithrombotic drugs to restore blood flow and prevent new heart attacks.
- Trial name
- Dan-DAPT (NCT05262803)
- Testing
- CYP2C19*2/*3, Shorter DAPT duration
- Where
- 6 sites in Denmark
- Volunteers
- 2,808 people
- Sponsor
- Rikke Sorensen
Venous Thromboembolism, Critical Illness
Predicting the Risk of Venous Thromboembolism in Critically Ill Patients
Introduction: Venous thrombosis (VTE), including both deep vein thrombosis (DVT) and pulmonary embolism (PE) remains a frequent complication in patients admitted to the Intensive Care Unit (ICU).
- Trial name
- NCT05498142
- Volunteers
- 7,600 people
- Sponsor
- University Medical Center Groningen
Type 2 Diabetes Mellitus, Cardiovascular Disease
Effects of Pioglitazone in Type 2 Diabetes Mellitus and Coronary Heart Disease
The goal of the study is to investigate the impact of a 4 week treatment with pioglitazone (in comparison to placebo) on biomarkers for atherosclerosis and cardiovascular risk, as well as the degree of activation of the immune…
- Trial name
- PIOcard (NCT00479986)
- Testing
- pioglitazone
- Where
- 2 sites in Germany
- Volunteers
- 92 people
- Sponsor
- IKFE Institute for Clinical Research and Development
Urinary Stones, Hypertension
The Links Between Water and Salt Intake, Body Weight, Hypertension and Kidney Stones: a Difficult Puzzle
Nephrolithiasis is a disease that strikes roughly 10% of the Italian population and its incidence in industrialized countries is on the increase.
- Conditions
- Urinary Stones, Hypertension, Overweight, Obesity
- Trial name
- NCT01100580
- Testing
- low salt diet, water therapy
- Where
- Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Parma
Spinal Anesthesia Induced Hypotension, Caeserian Section
AI Prediction of Post-Induction Hypotension in Cesarean Sections With Spinal Anesthesia
The cesarean section, medically necessary for both the mother and the baby in certain cases, is a life-saving operation.The most commonly used anesthesia method worldwide is spinal anesthesia.
- Trial name
- NCT06158542
- Testing
- Spinal Anesthesia, Blood Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 370 people
- Sponsor
- Hacettepe University
Atherosclerosis
Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)
Main Study (CACZ885M2301): The purpose of the pivotal phase of this trial was to test the hypothesis that canakinumab treatment of patients with myocardial infarction (MI) at least one month prior to study entry and elevated…
- Trial name
- CANTOS (NCT01327846)
- Testing
- Canakinumab, Standard of care
- Where
- 1,131 sites in United States, Argentina and 38 more
- Volunteers
- 10,066 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease, High Bleeding Risk Patients
PaneLux PTCA : Proposing an Alternative Treatment to patiEnts for Whom DES Implantation is Not Indicated, Thanks to Pantera LUX Drug Eluting Balloon
The propose of this study is to demonstrate, whenever using Drug Eluting Stent is not possible, the clinical security at 12 months, of the combinaison Bare Metal Stent plus Drug Eluting Balloon.
- Trial name
- PaneLux PTCA (NCT01930903)
- Testing
- Pantera Lux Drug Eluting Balloon
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Biotronik France
Diabetic Foot Ulcer (DFU)
Remote Temperature and Visual Monitoring To Help Manage Diabetic Foot Ulcers
This study is a prospective, observational investigation evaluating the effectiveness of Remote ThermoVisual Monitoring (RTVM) in the early detection of diabetic foot ulcers (DFUs) in high-risk populations.
- Trial name
- NCT06782386
- Testing
- OneStep Foot Scanner
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Bluedrop Medical Limited
Bariatric Surgery Candidate
Pre-operative Exercise and Nutrition Therapy on Cardio-metabolic Health in Patients Undergoing Bariatric Surgery
Obesity is a major health concern that has been associated with an estimated 2.8 million deaths worldwide each year. The number of individuals considered obese with a Body Mass Index (BMI) above 30 kg/m2 has grown to more than…
- Trial name
- NCT03854981
- Testing
- Exercise, Standard Care
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Deep Venous Thrombosis
D-Dimer Guided Oral Anticoagulant Treatment (OAT)
This clinical trial will investigate the hypothesis that D-Dimer testing can be successfully used to tailor the duration of OAT in patients after an unprovoked episode of deep venous thrombosis (DVT) using a prospective…
- Trial name
- DDOAT2006 (NCT00895505)
- Testing
- Phenprocoumon, Warfarin-Natrium
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bonn
Diabetes Mellitus, Type 2, Myocardial Infarction
Novel Strategies to Improve Cardiometabolic Status and Adherence to Exercise Regimens in Patients at High Risk for Cardiovascular Disease
This is a 2x2 study examining the impacts of a novel exercise regimen and daily text message reminders in patients at high risk for cardiovascular disease.
- Conditions
- Diabetes Mellitus, Type 2, Myocardial Infarction, Coronary Artery Disease, Atrial Fibrillation
- Trial name
- BURST (NCT03103854)
- Testing
- BURST physical activity, Text Message Reminders, Moderate Intensity Continuous Training
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Cambridge Cardiac Care Centre
ST Elevation Myocardial Infarction
The Relationship Between Myonectin Concentration and the Course of ST-segment Elevation Myocardial Infarction
The aim of this study is to test the potentially protective role of myonectin in patients with a first episode of ST elevation myocardial infarction (MI) treated with primary percutaneous coronary intervention (PCI).
- Trial name
- NCT05700773
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Michał Jaśkiewicz
Aneurysm Cerebral
Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy
This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm.
- Trial name
- ASPRIN (NCT07086183)
- Testing
- Observation
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease
Relationship Between Coronary CT Angiography Findings and Prognosis Of Patients Undergoing PCI
Researchers at Cerrahpaşa Medical School in Istanbul are studying how a heart imaging test called coronary CT angiography can help improve care for people with coronary artery disease.
- Trial name
- NCT07051473
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Cardiovascular Risk Factor
Short Term Choline and Cardiovascular Health
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular…
- Trial name
- NCT03327805
- Testing
- Choline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Multiple Myeloma
Busulfan, Melphalan, Fludarabine and T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Followed by Post Transplantation Donor Lymphocyte Infusions
The patients are being offered a stem cell transplant. Stem cells are very early blood cells. They have not yet matured to become red or white blood cells or platelets.
- Trial name
- NCT01131169
- Testing
- busulfan, melphalan and fludarabine
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Coronary Heart Disease, Heart Failure
Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 5 Years Follow-up
HIV-infection is associated not only with a reduced function of the immune system, but also linked with diseases of other organ systems, in particular with the heart.
- Conditions
- Coronary Heart Disease, Heart Failure, HIV, AIDS
- Trial name
- NCT01196273
- Testing
- Comprehensive non invasive cardiovascular examination
- Where
- 5 sites in Germany
- Volunteers
- 1,424 people
- Sponsor
- University Hospital, Essen
CAD - Coronary Artery Disease
REWRITE-CAD Protocol: Risk Evaluation With AI-CPA to Reduce Progression and Improve Lifetime Care for Patients With Known Coronary Artery Disease
REWRITE-CAD is a prospective, randomized, multi-center trial assessing the management of asymptomatic participants with a history of PCI or MI who will undergo a blinded CCTA and be randomly assigned to either the test arm in…
- Trial name
- REWRITE-CAD (NCT07834372)
- Testing
- Heartflow Analysis
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- HeartFlow, Inc.
Venous Thromboembolism (VTE), Cancer
Vortosiran for VTE Prevention
Blood clots remain a serious cause of illness and death. Long-term treatment and prevention of these clots with blood thinners is often limited by bleeding risk, drug interactions, and daily dosing, leading many patients to stop…
- Conditions
- Venous Thromboembolism (VTE), Cancer, Pulmonary Embolism (Diagnosis)
- Trial name
- NCT07850453
- Testing
- Vortosiran
- Where
- 30 sites in Bulgaria, France and 2 more
- Volunteers
- 150 people
- Sponsor
- Ribocure Pharmaceuticals AB
Venous Thromboembolism
Development and Validation of the Patient-completed Caprini Risk Score
The investigators aimed to test the reliability and validity of the Chinese version of patient-completed CRS in hospitalized patients and to evaluate whether this form can be widely used in clinical practice instead of only…
- Trial name
- NCT04663477
- Testing
- patient-completed Caprini Risk Score
- Where
- China
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- China-Japan Friendship Hospital
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