Clinical trials: Vascular Risk
Coronary Artery Ectasia
Arrhythmogenic Risk Assessment in Coronary Artery Ectasia Patients
The investigators thought to explore arrhythmias outcome - hidden arrhythmias, ECG features: Tp-Te interval and Tp-Te/QTc ratio, fQRS among patients with coronary artery ectasia as compared to normal coronary artery patients.
- Trial name
- NCT05106530
- Testing
- Holter, ECG
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Stroke, Transient Ischemic Attack
Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II
The primary objective of this trial is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated…
- Trial name
- CHANCE-2 (NCT04078737)
- Testing
- Ticagrelor and Aspirin, Clopidogrel and Aspirin
- Where
- 214 sites in China
- Volunteers
- 6,412 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
The purpose of this study is to find risk factors for hemorrhagic stroke.
- Trial name
- GERFHS (NCT00682695)
- Where
- 7 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Hypercholesterolemia, Dyslipidemia
Follow-on Protocol of Pitavastatin Versus Simvastatin in Patients With Hypercholesterolemia or Dyslipidemia and Coronary Heart Disease Risk Factors
This is a sixteen-week follow-on and 28 week single-blind extension study for patients who participated in study NK-104-304.
- Conditions
- Hypercholesterolemia, Dyslipidemia, Coronary Heart Disease
- Trial name
- NCT00344175
- Testing
- pitavastatin, simvastatin
- Where
- 28 sites in Denmark, Netherlands and 2 more
- Volunteers
- 178 people
- Sponsor
- Kowa Research Europe
Hypertension, Cardiovascular Diseases
Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce CVD events, including incident HF. SGLT2 is a glucose transport protein in the kidneys. Inhibition of this protein results in glucosuria and lower serum blood sugar.
- Trial name
- NCT06507657
- Testing
- empagliflozin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota
Lacunar Stroke
The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke
The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke.
- Trial name
- LACUNAR_CA (NCT06354881)
- Testing
- Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Leicester
Stroke, Cardiovascular Diseases
Effectiveness of Stroke Riskometer Apps In Improving Awareness and Stroke Risk Probability
This intervention study using the Stroke Riskometer Apps as health promotion and disease prevention tools for the stroke prevention.
- Conditions
- Stroke, Cardiovascular Diseases, Risk Factor, Cardiovascular
- Trial name
- NCT04529681
- Testing
- Stroke Riskometer Application, Informational Leaflets
- Where
- Malaysia
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Malaysia
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
A Phase 1 Dose Escalation Study of TAK-901 in Subjects With Advanced Hematologic Malignancies
The purpose of this study is to determine the maximum tolerated dose (MTD) of TAK-901 in subjects with advanced hematological malignancies, and to further assess the safety and tolerability of TAK-901 at or below the MTD in an…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Chronic Lymphocytic Leukemia
- Trial name
- NCT00807677
- Testing
- TAK-901
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Coronary Artery Disease, Risk Factor
Asan Medical Center CCTA Registry
A total of 9269 adults who received CCTA scans for coronary disease evaluation during a general medical checkup at the Health Screening and Promotion Center in Asan Medical Center, Seoul, Korea between January 2007 and December…
- Conditions
- Coronary Artery Disease, Risk Factor, Computed Tomography
- Trial name
- NCT06036901
- Testing
- Coronary CT
- Volunteers
- 6,343 people, healthy volunteers welcome
- Sponsor
- CardioVascular Research Foundation, Korea
Pulmonary Embolism, Venous Thromboembolism
Residual Pulmonary Vascular Obstruction Index Computed With Ventilation/Perfusion SPECT/CT Imaging to Predict the Risk of Venous Thromboembolism Recurrence in Patients With Pulmonary Embolism (PRONOSPECT)
Major risk after pulmonary embolism (PE) is recurrence, fatal in 10% of patients. Patients with PE can be stratified in 3 groups according to the risk of recurrence : very low risk, high risk or Intermediate risk.
- Trial name
- PRONOSPECT (NCT06372730)
- Testing
- Ventilation/Perfusion Single Photon Emission Computed Tomography (V/Q SPECT/CT)
- Where
- 13 sites in France
- Volunteers
- 665 people
- Sponsor
- University Hospital, Brest
Ischemic Stroke, TIA
Personalized Antiplatelet Secondary Stroke PRevenTion
This is a descriptive study designed to evaluate the safety and feasibility of a precision medicine approach to antiplatelet selection for secondary stroke prevention.
- Trial name
- PASSPoRT (NCT03979781)
- Testing
- tailored antiplatelet selection, standard of care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- State University of New York - Upstate Medical University
Stroke, Cerebrovascular Disorders
Comprehensive Management of High-risk PopuLatIon for Stroke Based on Social Network
The purpose of this study is to evaluate the effectiveness of social network in improving drug compliance and risk factors control rate of stroke high-risk population after discharge.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- COMPLIANCE-MT (NCT05963828)
- Testing
- conventional care, Social network-based intervention
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Changhai Hospital
Overweight or Obesity, Obesity, Abdominal
Hypocaloric Mediterranean Diet or Physical Activity to Lower Cardiometabolic Risk
The purpose of this randomized controlled trial is to test the effects of a hypocaloric Mediterranean diet or of physical activity in participants who take at least 2 antihypertensive drugs but do not reach blood pressure…
- Conditions
- Overweight or Obesity, Obesity, Abdominal, Hypertension
- Trial name
- MeDiPA (NCT04155112)
- Testing
- Physical activity, Hypocaloric Mediterranean diet
- Where
- Norway
- Volunteers
- 90 people
- Sponsor
- Oslo University Hospital
Atherosclerosis
Long-term Impact Evaluation of a Worksite-based Lifestyle Intervention to Reduce Cardiovascular Risk in Office Workers
The main objective of TANSNIP-PESA is to determine in a population of asymptomatic bank employees with high and low imaging defined cardiovascular disease (CVD) risk the effectiveness of a comprehensive 3-year worksite-based…
- Trial name
- TANSNIP-PESA (NCT02561065)
- Testing
- Lifestyle intervention
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Stroke, Ischemic Attack, Transient
Post-Stroke Disease Management - Stroke Card
Patients after ischemic stroke are at high risk of recurrent cardiovascular events and of developing post-stroke complications. There is a substantial gap between risk factor management in real life and that recommended by…
- Conditions
- Stroke, Ischemic Attack, Transient, Secondary Prevention, Disease Management
- Trial name
- Stroke Card (NCT02156778)
- Testing
- Active Comparator: Extended Standard Care (Stroke Card), Active Comparator: Standard Care
- Where
- Austria
- Volunteers
- 2,149 people
- Sponsor
- Medical University Innsbruck
Coronary Heart Disease Risk
GENErating Behavior Change, An Integrative Health Coaching and Genetic Risk Testing Pilot
The purpose of this 4 group (2x2) pilot randomized controlled trial is to test the feasibility and logistics of incorporating genetic risk information (9p21)into standard Coronary Heart Disease (CHD) risk counseling or health…
- Trial name
- NCT01766271
- Testing
- Health Coaching, 9p21, Standard Risk Assessment
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Coronary Artery Disease, Menopause
The Effects of Resveratrol on Sirtuins and Apoptosis Biomarkers
Cardiovascular diseases (CVD) and neoplasms are the main causes of death in Brazilian women. Coronary artery disease (CAD) and stroke were responsible for approximately 54% of deaths from CVD in this population.
- Conditions
- Coronary Artery Disease, Menopause, Endothelial Dysfunction
- Trial name
- RE-AGES (NCT05808387)
- Testing
- Resveratrol
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- InCor Heart Institute
Myocardial Infarction
Safety And Feasibility of Early DischargE - a Prospective And Randomized Trial of Low-risk Primary Percutaneous Coronary Intervention (PCI) Patients
The purpose of this study is to determine if early hospital discharge (at 48-72 hours), is feasible, safe, cost-effective, and/or improves compliance with medications, positive lifestyle changes and quality-of-life, in low-risk…
- Trial name
- SAFE-DEPART (NCT00474214)
- Testing
- Early hospital discharge facilitated by close nurse practitioner follow-up
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Hamilton Health Sciences Corporation
Surgical Wound Infection, Vascular Surgery
Supplemental Oxygen in Vascular Surgery
The purpose of this study was to test the hypothesis that supplemental postoperative oxygen reduces the risk of surgical wound infection in patients following lower limb vascular surgery.
- Trial name
- NCT00873704
- Testing
- supplemental postoperative oxygen
- Where
- 6 sites in Finland
- Volunteers
- 274 people
- Sponsor
- North Karelia Central Hospital
Diabetes Mellitus, High Blood Pressure
Comparative Effectiveness of Family vs. Individually Focused Diabetes Education and Support
The objective of this study is to compare the effectiveness of a novel program-Family Support for Health Action (FAM-ACT) - to individual patient-focused diabetes self-management education and support (I-DSMES).
- Conditions
- Diabetes Mellitus, High Blood Pressure, High Blood Sugar, Hypertension
- Trial name
- NCT03812614
- Testing
- FAM ACT, I-DSMES
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- University of Pittsburgh
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