Clinical trials: Vascular Thrombosis
COVID-19, Thrombosis Embolism
The Effect of Dexamethasone 12 mg vs 6 mg on Thromboembolic Events in Patients With Critical COVID-19
Thromboembolisms (TEs) in patients with critical COVID-19 has been reported to be three times higher than for other critically ill patients. Immunothrombosis has been proposed as a plausible mechanism for COVID-19 coagulopathy.
- Conditions
- COVID-19, Thrombosis Embolism, Bleeding
- Trial name
- NCT05195242
- Testing
- Dexamethasone
- Where
- Sweden
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Heart Failure, Respiratory Failure
Reduced Anticoagulation Targets in ECLS (RATE)
The objective of the RATE-trial is to study if reduced anticoagulation targets during ECLS diminish bleeding complications without an increase in thromboembolic complications or a negative impact on outcome.
- Conditions
- Heart Failure, Respiratory Failure, Extracorporeal Membrane Oxygenation, Bleeding
- Trial name
- RATE (NCT04536272)
- Testing
- Heparin, LMWH
- Where
- 8 sites in Netherlands
- Volunteers
- 330 people
- Sponsor
- University Medical Center Groningen
Age Related Macular Degeneration, Diabetic Retinopathy
Effect of Video Viewing on Intravitreal Injection Experience
Study Objective The goal of this clinical trial is to evaluate whether viewing a procedural video can improve the patient experience and reduce the incidence and severity of subconjunctival hemorrhage in individuals undergoing…
- Conditions
- Age Related Macular Degeneration, Diabetic Retinopathy, Choroidal Neovascularization, Retinal Vein Occlusion
- Trial name
- NCT07002372
- Testing
- Procedure video viewing
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain and Central Nervous System Tumors, Thromboembolism
Risk Factors for Developing a Blood Clot in Patients Who Are Undergoing Cancer Treatment for Newly Diagnosed Gliomas
RATIONALE: Patients with gliomas may be at risk for developing blood clots. Learning about the risk factors for developing blood clots may help doctors plan better treatment for gliomas.
- Trial name
- NCT00253669
- Testing
- laboratory biomarker analysis, physiologic testing, management of therapy complications
- Where
- 9 sites in United States
- Volunteers
- 110 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cardiac Death, Congestive Heart Failure
Correlation Between Reticulated Platelets and Major Adverse Cardiac and Cerebrovascular Events After Noncardiac Surgery
This is an observational study designed to monitor the course of the fraction of reticulated platelets and the correlation thereof to major adverse cardiac and cerebrovascular events after noncardiac surgery.
- Conditions
- Cardiac Death, Congestive Heart Failure, Angina Pectoris, Stroke
- Trial name
- NCT02097602
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Kidney Failure
Clotting With Different Dialyzer Membranes
Primary Objective: The purpose of this study is to measure the amount of convection achieved with two different haemodiafilters designed for haemodiafiltration and clotting during haemodiafiltration treatment.
- Trial name
- TAGPSOLACEA (NCT02546037)
- Testing
- FX100 dialyzer, SOLACEA 21H
- Volunteers
- 10 people
- Sponsor
- University College, London
Stent Thrombosis, Clopidogrel
VerifyNow French Registry
The purpose of this study is to determine the effect of clopidogrel or aspirin reactivity as measured by a point-of-care platelet function assay on thrombotic or bleeding events after percutaneous coronary intervention (PCI) with…
- Conditions
- Stent Thrombosis, Clopidogrel, Aspirin, Bleeding
- Trial name
- VERIFRENCHY (NCT00753753)
- Where
- France
- Volunteers
- 1,001 people
- Sponsor
- Association Pour le Développement des Soins Cardiologiques de la ville de Chartres
Coronary Artery Bypass Grafting, Postoperative Atrial Fibrilation
Apixaban Versus Warfarin for the Management of Post-operative Atrial Fibrillation
In this open-label, prospective, randomized pilot study, patients who develop atrial fibrillation after isolated coronary artery bypass grafting surgery will be identified.
- Conditions
- Coronary Artery Bypass Grafting, Postoperative Atrial Fibrilation, Stroke, Systemic Embolism
- Trial name
- NCT02889562
- Testing
- Apixaban, Warfarin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sanford Health
Coronary Artery Disease, Aortic Aneurysm
Computed Tomography Dose Reduction Using Sequential or Fast Pitch Sprial Technique
This is a prospective, controlled observational trial of patients undergoing clinically indicated cardiothoracic computed tomography (CT), including pulmonary or aortic angiography and coronary CT angiography (CCTA).
- Conditions
- Coronary Artery Disease, Aortic Aneurysm, Pulmonary Embolism
- Trial name
- CTDOSE (NCT01272453)
- Where
- 9 sites in United States, Saudi Arabia
- Volunteers
- 2,640 people
- Sponsor
- Gilbert L. Raff, MD
Raynaud Disease, Systemic Sclerosis
Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort Study
This study evaluates the efficacy and safety of routine medical treatments of digital ulcers in patients with systemic sclerosis in a prospective cohort study.
- Conditions
- Raynaud Disease, Systemic Sclerosis, Digital Ulcer
- Trial name
- NCT02642146
- Testing
- Calcium Channel Blockers, Phosphodiesterase Inhibitors, Endothelin receptor blocker
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- Seoul National University Hospital
Deep Venous Thrombosis, Pulmonary Embolism
Comparing Enoxaparin to Fondaparinux to Prevent Venous Thromboembolism (VTE) in Bariatric Surgical Patients
This pilot study is designed to determine the feasibility of conducting a randomized clinical trial comparing fondaparinux sodium (Arixtra) once daily with enoxaparin (Lovenox®) twice daily with respect to preventing deep vein…
- Trial name
- NCT00894283
- Testing
- Enoxaparin, Fondaparinux
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Johns Hopkins University
Carcinoma, Hepatocellular
Proteomic Analysis of Human Hepatocellular Carcinoma
This is a pilot study to evaluate the difference between the protein expression between hepatocellular carcinoma and tumor with vessel invasion in Asian patients with hepatocellular carcinoma.
- Trial name
- NCT01177631
- Testing
- Operation
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- Far Eastern Memorial Hospital
Venous Thromboembolism, Deep Vein Thrombosis
Detecting the Impact of Statin Therapy On Lowering Risk of Venous Thrombo-Embolic Events (DISOLVE)
Patients with cancer have a high risk of developing venous blood clots or thromboembolism (VTE). In an effort to target patients at highest risk of VTE for thromboprophylaxis (protective treatment for blood clots), numerous…
- Conditions
- Venous Thromboembolism, Deep Vein Thrombosis, Neoplasms
- Trial name
- DISOLVE (NCT01524653)
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Vermont
ST Segment Elevation Myocardial Infarction, Left Ventricular Thrombus
Prevention of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant (EARLYmyo-LVT Ⅱ)
Left ventricular thrombus is a common complication subsequent to ST-segment elevation myocardial infarction (STEMI) that related to increased embolic events.
- Trial name
- NCT03786757
- Testing
- Rivaroxaban
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Thromboelastography, Coagulation; Fetus or Newborn
Thromboelastographic Profile in Healthy Newborns and Infants of Diabetic Mothers Using TEG6s
Thromboelastography (TEG) is a laboratory technique used to examine the process of clot formation and degradation by measuring and reporting the kinetic changes, the rate of clot formation, clot strength, and clot stability.
- Conditions
- Thromboelastography, Coagulation; Fetus or Newborn, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT04917965
- Testing
- Laboratory clotting studies
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Deep Vein Thrombosis
Reduction to Preventive Doses of Enoxaparin After 3 to 6 Months of Treatment With Blood Thinners for Cancer-associated Blood Clots
Background: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disorder after myocardial infarction and stroke.
- Trial name
- STEP-CAT (NCT02752607)
- Where
- 7 sites in Canada
- Volunteers
- 52 people
- Sponsor
- Dr. Vicky Tagalakis
Gynecologic Cancer, Venous Thromboembolism
Oral Apixaban (Eliquis) Versus Enoxaparin (Lovenox) for Thromboprophylaxis in Women With Suspected Pelvic Malignancy
The study will evaluate the incidence of major bleeding (including clinically relevant non-major (CRNM) bleeding) events in women undergoing surgery for gynecologic cancer with apixaban 2.5 mg twice a day (BID) compared to…
- Trial name
- NCT02366871
- Testing
- Oral apixaban, Subcutaneous enoxaparin
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Colorado, Denver
Cerebral Venous Sinus Thrombosis
Glymphatic Function and White Matter Integrity in Cerebral Venous Disorders
Cerebral venous disorders, including cerebral venous sinus stenosis (CVSS) and cerebral venous sinus thrombosis (CVST), can obstruct venous blood drainage, leading to intracranial hypertension.
- Trial name
- NCT07072663
- Testing
- Baseline and 3-month follow-up, Baseline
- Where
- China
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Traumatic Intracranial Haemorrhage
OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage (OPTTTICH Feasibility Study)
Victims of trauma with severe head injury who have bled into their brains are at high risk of developing blood clots in their legs. These blood clots can break off and travel through the bloodstream to the lungs causing death.
- Trial name
- OPTTTICH (NCT01589393)
- Testing
- Enoxaparin
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- McMaster University
Branch Retinal Vein Occlusion
Proof of Concept Study of Re-treatment in BRVO With Ranibizumab Guided by OCT
The aim of the trial is to evaluate the efficacy and safety of intravitreal injections of ranibizumab for the treatment of macular edema due to BRVO if the re-treatment regimen is guided by morphological macular changes detected…
- Trial name
- RabOCT (NCT01968239)
- Testing
- Ranibizumab
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Leipzig
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