Clinical trials: Vasoconstriction
Obesity, Healthy
Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity
Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men.
- Conditions
- Obesity, Healthy, Vasoconstriction, Vasodilation
- Trial name
- NCT04436731
- Testing
- Cold Pressor Test
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Sleep Apnea, Healthy
Reflex Responses to Intermittent Hypoxia in Humans: Mechanisms and Consequences
The overall goal of this project is to better understand the effect of intermittent hypoxia (IH) on sympathetic neuronal discharge patterns in humans, as well as mechanisms that mediate persistent sympathoexcitation with IH.
- Conditions
- Sleep Apnea, Healthy, Vasoconstriction, Vasodilation
- Trial name
- NCT05146089
- Testing
- Hypoxic exposure, modified Oxford test, Oral Bosentan 62.5 mg
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hypoxic Pulmonary Vasoconstriction, Hypoxemia
Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2
Summary Currently, the COVID-19 pandemic has overtaken health systems worldwide, exceeding the capacity of intensive care units.
- Conditions
- Hypoxic Pulmonary Vasoconstriction, Hypoxemia, Acute Respiratory Distress Syndrome, SARS-CoV-2 Acute Respiratory Disease
- Trial name
- COVID-19 (NCT04998253)
- Testing
- Effects in oxygenation and hypoxic pulmonary vasoconstriction
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
Hypertension, Cancer
Bevacizumab and Vasoconstriction
Rationale: The introduction of angiogenesis inhibitors has remarkably improved treatment of patients with several types of cancer. One of the most common side effects of angiogenesis inhibitors is hypertension.
- Trial name
- BVZ1 (NCT00929058)
- Testing
- Bevacizumab
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus
Microcirculatory Vasomotor Changes in Type 2 Diabetes With Peripheral Neuropathy
Microcirculatory flow is subject to cyclic changes under the influence of heart rate, respiration, myogenic activity, neurogenic factors and endothelial factors.
- Conditions
- Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus, Vasodilation, Vasoconstriction
- Trial name
- NEUROMICRO (NCT03847779)
- Testing
- "Rest", "Exercise", "Foot lowering"
- Where
- France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Hypertension,Essential
Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension
Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed.
- Trial name
- IMPROVEH (NCT03778489)
- Testing
- Training
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
The Validity of Retinal Blood Flow Measurements During Hyperoxia in Humans Using Fourier Domain Color Doppler Optical Coherence Tomography (CDOCT)
Noninvasive monitoring of blood flow in retinal circulation may elucidate the progression and treatment of ocular disorders, including diabetic retinopathy, age-related macular degeneration and glaucoma.
- Trial name
- NCT00431600
- Testing
- 100% Oxygen
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hypoxic Pulmonary Vasoconstriction
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction and Exercise Capacity at High Altitude
The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxygenation at rest and during…
- Trial name
- NCT00708565
- Testing
- iloprost
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System
Pulmonary Arterial Hypertension, Vasodilation
Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3)
Endothelin-1 (ET-1) has been linked to a number of conditions including pulmonary arterial hypertension (PAH). ET-1 acts via 2 receptors, ETA and ETB.
- Conditions
- Pulmonary Arterial Hypertension, Vasodilation, Vasoconstriction
- Trial name
- NCT01100736
- Testing
- Bosentan, Sitaxsentan, Endothelin-3
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Healthy
The Dose-response "Pilot" Study of Topically Delivered Clobetasol Propionate Lotion in Healthy Adult Subjects
To determine the dose-response relationship for Clobex TM (clobetasol propionate) Lotion, 0.05%. This information will be used to estimate the ED50, D1, D2 parameters for use in a full bioequivalence study.
- Trial name
- NCT00864240
- Testing
- Clobex TM (Clobetasol) 0.05% Lotion, single exposure
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
High Altitude Pulmonary Edema
Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction
It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia.
- Trial name
- NCT00559442
- Testing
- Altitude Exposure:
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Autonomic Nervous System Imbalance, Blood Pressure
Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators
An intervention study to assess the short-term cardiovascular effects of reducing personal air pollution exposure by wearing particulate filtering respirators.
- Conditions
- Autonomic Nervous System Imbalance, Blood Pressure, Inflammation, Vasoconstriction
- Trial name
- NCT02238028
- Testing
- Wear respirator
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fudan University
Psoriasis Vulgaris
A Vasoconstriction Study With LEO 90100
The purpose of this study is to compare the pharmacodynamic activity of LEO 90100 with Dermovate® cream, Dovobet® ointment, betamethasone dipropionate in LEO90100 vehicle, Synalar® ointment and LEO 90100 vehicle using a human…
- Trial name
- NCT01946386
- Testing
- LEO 90100 Aerosol, foam, Betamethasone dipropionate in LEO 90100 Aerosol, foam, vehicle, LEO 90100 Aerosol, foam, vehicle
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Vasoconstriction, Vasodilation
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences
The main purpose of this interventional study is to examine differences in resting blood pressure control between healthy males and females. The main questions it aims to answer are: 1.
- Trial name
- STARS (NCT05997732)
- Testing
- Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Vasodilation, Vasoconstriction
Vascular Function Improvements After Chronic Passive Stretching
Acutely, during different bouts of passive stretching (PS), blood flow (Q ̇) and shear rate ( ) in the feeding artery of the stretched muscles increases during the first two elongations and then it reduces during the following…
- Conditions
- Vasodilation, Vasoconstriction, Stretch, Sympathetic; Imbalance
- Trial name
- NCT04271241
- Testing
- Passive stretching (PS) training
- Where
- Italy
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Milan
Vasoconstriction Disorder of Extremities
Response of the Autonomic Nervous System to Auricular Stimulation of the Vagus Nerve (x)
While invasive vagal stimulation has proven its therapeutic effectiveness over the past 20 years, particularly in the treatment of epilepsy or depression, its implementation is hampered by the high cost, high technicality and…
- Trial name
- AURIX (NCT04130893)
- Testing
- stimulation of G13 then G15, stimulation of G15 then G13
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Vasodilation, Vasoconstriction
The Impact of Carbon Monoxide and Altitude on Vascular Function
The CarMA (Carbon Monoxide and Altitude) Study aims to observe the vascular effects of carbon monoxide exposure at low and high altitudes.
- Trial name
- CarMA (NCT04928183)
- Testing
- Carbon monoxide rebreathe, Sodium Nitroprusside, Phenylephrine Hydrochloride
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cardiovascular Effects
Diesel Exhaust and Vascular Function
Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function.
- Trial name
- CVDTRAP4 (NCT01508637)
- Testing
- Diesel Exhaust, Filtered Air, Terazosin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Washington
Vasoconstriction, Healthy
Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction
The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.
- Conditions
- Vasoconstriction, Healthy, Insulin Resistance
- Trial name
- NCT05244694
- Testing
- Insulin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Cold Exposure
The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold
Individuals who operate in cold weather are at risk of developing cold injuries, for example, frostbite. They also often experience a loss of hand function and joint mobility due to a decrease in skin temperature and blood flow.
- Trial name
- NCT06784531
- Testing
- Mitoquinone mesylate (MitoQ), Cold Water Hand Immersion, Cold Air Exposure
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine