Clinical trials: Vasoconstriction
Hypoxic Pulmonary Vasoconstriction
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction at Altitude
The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxygenation at rest and during…
- Trial name
- NCT00724321
- Testing
- iloprost
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Vasoconstriction, Oral Soft Tissue Conditions
Evidence of Spreading Vasoconstriction in Human Gingiva
The aim of this study is to observe the mechanism of spreading vasoconstriction in human healthy gingiva. Epinephrine solution is applied on the attached gingiva in group "A" and on the surface of the tooth next to the ginvial…
- Conditions
- Vasoconstriction, Oral Soft Tissue Conditions, Dental and Gingival Conditions
- Trial name
- NCT04131283
- Testing
- Epinephrine
- Where
- Hungary
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Altitude Sickness, Hypertension, Pulmonary
AZ, MZ, and the Pulmonary System Response to Hypoxia
The purpose of this proposal is to compare the physiological effects of acetazolamide (AZ) and methazolamide (MZ) on the control of breathing and hypoxic pulmonary vasoconstriction.
- Trial name
- NCT02760121
- Testing
- Acetazolamide, Methazolamide
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy
The Dose-response Study of Topically Delivered Halobetasol Propionate Ointment in Normal Skin in Healthy Adult Subjects
The purpose of this study is to determine the duration of application of halobetasol propionate 0.05% ointment to be used in a definitive study of bioequivalence of to formulations of this ointment.
- Trial name
- NCT00865267
- Testing
- Ultravate® 0.05% ointment, single exposure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Raynaud Phenomenon, Systemic Sclerosis
Cold Challenge With C21 in RP
This is a randomised, double-blind, placebo-controlled, cross-over phase 2 trial investigating the effect of C21 on cold-induced vasoconstriction in subjects with Raynaud's phenomenon secondary to systemic sclerosis.
- Trial name
- NCT04388176
- Testing
- C21
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Vicore Pharma AB
Epistaxis
Xylometazoline and Cocaine for Nasal Vasoconstriction
The objective of this study is to compare xylometazoline and cocaine's effect on minimizing epistaxis when administered as a local vasoconstrictor prior to nasal intubation.
- Trial name
- NCT05334017
- Testing
- Xylometazoline 0,1%, Cocaine 4%
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Oxidative Stress, Inflammation
Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution
This study aims to evaluate whether dietary supplementation with fish oil can protect against the cardiopulmonary alterations linked to air pollution
- Conditions
- Oxidative Stress, Inflammation, Blood Pressure, Vasoconstriction
- Trial name
- NCT03255187
- Testing
- Fish oil supplementation, Sunflower seed oil supplementation
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fudan University
Cardiovascular Diseases, Cardiovascular Risk Factor
Local Antioxidant Therapy Vasoconstriction Effects in Different Races
Cardiovascular disease (CVD) afflicts nearly one-third of the adult population with all races and ethnicities represented in CVD prevalence.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
- Trial name
- NCT03684213
- Testing
- Control (Norepinephrine), Norepinephrine + Ascorbic Acid, Norepinephrine + L-NAME
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Vasoconstriction
Evaluation of the Vasoconstriction Properties of MC2-01 Cream
The objective of this trial is to compare the vasoconstriction potential
- Trial name
- NCT03758365
- Testing
- MC2-01 Cream, Clobetasol Propionate 0.05% Lotion, Betamethasone Dipropionate 0.05% Cream
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- MC2 Therapeutics
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05001048
- Testing
- Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Intracranial Hypotension
HES Patch Versus Blood Patch
The injection of autologous blood Blood Patch (BP) into the epidural space is the standard treatment for headache associated with intracranial hypotension. It provokes cerebral vasoconstriction.
- Trial name
- NCT02570724
- Testing
- injection of HES " Voluven® ", blood patch
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Right Ventricular Function, Prone Position
Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine
Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay.
- Conditions
- Right Ventricular Function, Prone Position, Atelectasis, Atelectases, Postoperative Pulmonary
- Trial name
- BAROLO (NCT07632027)
- Testing
- Prone position
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Cardiovascular Diseases, Cardiovascular Risk Factor
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
The goal of this study is to examine possible mechanisms of heightened vasoconstriction in Black/African American men and women as possible links to the elevated prevalence of cardiovascular dysfunction and disease.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
- Trial name
- NCT03680404
- Testing
- Control (Phenylephrine), Phenylephrine + Apocynin, Phenylephrine + Allopurinol
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Cardiovascular Diseases, Cardiovascular Risk Factor
The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction
The goal of the study is to examine the possible mechanisms of impaired cutaneous microvascular function through local heating along with administration of vasoconstrictors.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
- Trial name
- NCT03679780
- Testing
- BQ-788, BQ-123, L-Arginine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Chronic Kidney Diseases, Blood Pressure
Curcumin and Exercise in Chronic Kidney Disease
Chronic kidney disease (CKD) is associated with a pro-oxidative and pro-inflammatory state, and this is thought to contribute to a decrease in vascular function leading to greater cardiovascular disease (CVD) risk.
- Conditions
- Chronic Kidney Diseases, Blood Pressure, Hyperemia, Vasoconstriction
- Trial name
- NCT04132648
- Testing
- Curcumin
- Sponsor
- University of Iowa
Septic Shock, Hemodynamic Instability
Hemodynamic Measurements of Macrocirculatory and Perfusion Parameters in ICU
In septic shock there is growing evidence of a state of hemodynamic "disconnection" with seemingly adequate macrocirculatory values despite actual microcirculation failing to meet cellular demand.
- Conditions
- Septic Shock, Hemodynamic Instability, Vasoconstriction
- Trial name
- NCT05225402
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Vasodilation, Vasoconstriction
Sex Differences in Sympathetic Vascular Reactivity at High Altitude
This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.
- Trial name
- NCT05525416
- Testing
- Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine
- Where
- 2 sites in Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cocaine Induced Sympathoexciation and Vasoconstriction
Study to Improve Scientific Understanding of the Cardiovascular Actions of Cocaine
The purpose of this study is to improve the scientific understanding of the cardiovascular actions of cocaine, in particular the ability of cocaine to increase blood pressure.
- Trial name
- NCT00338546
- Testing
- Cocaine hydrochloride, Dexmedetomidine, Microneurography
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hypotension, Hypoxia
Increasing Dose Safety Study of Hemospan in Orthopedic Surgery Patients
The purpose of this study is to evaluate the safety and possible effectiveness of Hemospan solution in patients undergoing elective orthopedic surgery who receive spinal anesthesia.
- Trial name
- NCT00494949
- Testing
- Hemospan (MP4OX), Ringer's lactate
- Where
- 2 sites in Sweden
- Volunteers
- 30 people
- Sponsor
- Sangart