Clinical trials: Vasoplegic Syndrome
Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction
RaGuS Trial by Postoperative Patients
Vasoplegic syndrome is characterized clinically by reduced systemic vascular resistance and normal or increased cardiac output. It is principally observed in cardiovascular and orthopedic interventions and is characterized by a…
- Conditions
- Vasoplegic Syndrome, Sirs Due to Noninfectious Process Without Organ Dysfunction, Orthostatic Hypotension
- Trial name
- RaGuS (NCT04440085)
- Testing
- Midodrine Hydrochloride
- Volunteers
- 50 people
- Sponsor
- Bürgerspital Solothurn
Cytokine Hemadsorption Therapy in Critically Ill Patients Who Have no Microbiological Findings and Develop Vasoplegic Shock
EFFECTS OF EXTRACORPOREAL CYTOKINE ELIMINATION ON HEMODYNAMIA AND MORTALITY IN CRITICAL PATIENTS
Observation of the effects of cytokine adsorbent hemadsorption therapy on hemodynamics and mortality in critically ill patients who developed vasoplegic shock due to hyperinflammation without microbiological findings in the…
- Trial name
- NCT05984407
- Testing
- cytokine hemadsorption therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hakan Küçükkepeci
Vasoplegic Syndrome, Liver Transplant; Complications
Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients
This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.
- Trial name
- NCT04054999
- Testing
- Hydroxocobalamin, Methylene Blue
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Vasoplegic Syndrome
Vitamin B12a Vasoplegic Syndrome
The study team will evaluate the medication Hydroxocobalamin (B12a) for treatment of low blood pressure after cardiac surgery.
- Trial name
- NCT03735316
- Testing
- Hydroxocobalamin, Cardiopulmonary Bypass
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Post Operative Vasoplegic Syndrome, Acute Kidney Injury
POLECAT: Perioperative Delta Renin Concentration
We want to measure the amount of a hormone called renin in people's bodies before and after they have major abdominal surgery. We want to see if changes in renin levels are connected to problems with blood flow, unstable blood…
- Trial name
- POLECAT (NCT05942846)
- Volunteers
- 405 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Vasoplegic Syndrome
Weaning of Norepinephrine Guided by the Dynamic Arterial Compliance in Cardiac Surgery Post Operative.
After cardiac surgery, vasoplegic syndrome is a hemodynamic state characterized by profound hypotension associated with a decrease in systemic vascular resistance.
- Trial name
- SNEAD (NCT02479529)
- Testing
- Norepinephrine
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hemodynamic Instability, Vasoplegic Syndrome
Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal Circulation
This single-institution randomized controlled trial prospective will enrolled 48 patients scheduled for an aortic valve replacement.
- Trial name
- HIPPIE (NCT02675374)
- Testing
- dexchlorpheniramine (Polaramine®) injection
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux
Vasoplegic Syndrome of Cardiac Surgery
Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery
This is a randomized, double-blind clinical trial designed to compare the inotropic effects of vasopressin versus norepinephrine in patients who develop vasoplegic syndrome in the immediate postoperative period following cardiac…
- Trial name
- INVASC (NCT06934798)
- Testing
- Vasopressin intravenous infusion, Norepinephrine intravenous infusion
- Where
- Brazil
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Vasoplegic Syndrome, Vasoplegia
Analysis of miRNAs Expression in Vasoplegic Syndrome After On-pump Coronary Artery Bypass Surgery
This study looks for a correlation between microRNAs (miRNAs) and vasoplegic syndrome after on-pump coronary artery bypass surgery.
- Conditions
- Vasoplegic Syndrome, Vasoplegia, Surgery-Complications, Surgery
- Trial name
- PREVENT (NCT05354193)
- Testing
- vasoplegic syndrome
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- University of Sao Paulo General Hospital
Postoperative Vasoplegic Syndrome
Small Doses of Pituitrin Versus Norepinephrine for the Management of Vasoplegic Syndrome in Patients After Cardiac Surgery
Vasoplegic syndrome is a common complication after cardiac surgery. Low dose vasopressin can up-regulate blood pressure and improve clinical outcomes compared with norepinephrine (mainly acute kidney injury Anesthesiology 2017…
- Trial name
- NCT03106831
- Testing
- Pituitrin infusion, Norepinephrine infusion
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing Anzhen Hospital
Vasoplegic Syndrome
Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary Bypass
Several studies have described the use of alternative drugs as methylene blue (MB) (3) other than the standard limited options of the use of vasopressors and systemic corticosteroids (4) especially in the face of increasing…
- Trial name
- NCT06160219
- Testing
- Hydroxycobalamin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Shock, Septic, Critically Ill
The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial
Sepsis has been characterised as a dysregulated host response to infection. Adjunctive therapies targeting the inflammatory cascade are being increasingly explored, although to date, have failed to demonstrate consistent benefit…
- Conditions
- Shock, Septic, Critically Ill, Vasoplegic Syndrome, Sepsis
- Trial name
- VITAMINS (NCT03333278)
- Testing
- Vitamin C, Thiamine, Hydrocortisone,
- Where
- 8 sites in Australia, Brazil and 1 more
- Volunteers
- 216 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Septic Shock
A RCT to Assess the Performance of CytoSorb for Shock Reversal in Patients With Vasoplegic Septic Shock
To assess the performance of the CytoSorb® 300 mL device for shock reversal in patients with vasoplegic septic shock.
- Trial name
- PROCYSS (NCT04963920)
- Testing
- Cytosorb® 300 ml
- Where
- 18 sites in Germany
- Volunteers
- 260 people
- Sponsor
- CytoSorbents Europe GmbH
Scheduled Cardiac Surgery With Extracorporeal Circulation, Vasoplegic Syndrome
Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation
This is a randomized, double blind, multicenter study following surgery with extracorporeal circulation to compare blood pressure optimization with vasopressin versus noradrenaline.
- Trial name
- NOVACC (NCT05568160)
- Testing
- Vasopressin, Norepinephrine, Collection of clinical data
- Where
- France
- Volunteers
- 840 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Shock, Septic
Effect of a Continuous Infusion of Esmolol on Stroke Volume in Patients With Hyperdynamic Vasoplegic Septic Shock
The main objective of this study is to evaluate the effectiveness of the administration of a short acting beta-blocker in terms of effective increase in stroke volume (at least 15%) after 4 hours initiation of therapy in septic…
- Trial name
- BétaSep (NCT02609152)
- Testing
- Continuous perfusion of esmolol, Continuous perfusion of saline
- Where
- 2 sites in France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Vasoplegic Syndrome of Cardiac Surgery
Mic Mac: Micro- and Macrocirculatory Assessment During Cardiac Surgery in Patients at Risk of Vasoplegic Syndrome: A Prospective Study.
This research focuses on understanding the vasoplegic syndrome after cardiac surgery under extracorporeal circulation and in the aftermath of your surgery in the ICU.
- Trial name
- MicMac (NCT07059715)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- European Georges Pompidou Hospital
Vasoplegic Syndrome in Adult Cardiac Surgery
Evaluation of the HPA Axis in Patients With Vasoplegic Syndrome After Cardiac Surgery
Vasoplegic syndrome after cardiac surgery is common and is associated with increased morbidity and mortality. It is characterized by early and prolonged arterial hypotension, with preserved cardiac output and low systemic…
- Trial name
- VASOCORT (NCT06371976)
- Testing
- Blood sampling, Vital status
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postperfusion Syndrome
Reperfusion Syndrome and Vasoplegic Syndrome in Liver Transplant Surgery
The incidence of postreperfusion syndrome (PRS) and vasoplegic syndrome (VS) is unknown, and occasionally can be confused since these syndromes share some hemodynamic characteristics.
- Trial name
- NCT05658120
- Testing
- noradrenaline/adrenaline
- Where
- Spain
- Volunteers
- 246 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cardiogenic Shock Acute, Bypass, Cardiopulmonary
Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock
Mixed cardiogenic-vasoplegic shock (M-CS) represents a distinct and severe phenotype of cardiogenic shock characterized by concomitant myocardial dysfunction and inappropriate systemic vasodilation.
- Conditions
- Cardiogenic Shock Acute, Bypass, Cardiopulmonary, Septic Shock, Mechanical Circulatory Support
- Trial name
- PROMIX (NCT07354568)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Use of Midodrine in Post-cardiopulmonary Bypass Vasoplegic Syndrome
Midodrine as Novel Treatment of Post-Cardiopulmonary Bypass Vasoplegic Syndrome
Vasoplegic syndrome (VS) is a common and serious complication of cardiopulmonary bypass (CPB) procedures associated with a significant increase in morbidity and mortality.
- Trial name
- NCT04668859
- Testing
- Midodrine, Methylcellulose
- Volunteers
- 10 people
- Sponsor
- Medstar Health Research Institute