Clinical trials: Vasopressor
Shock
Variation in Fluids Administered in Shock
To conduct a multicenter observational cohort study to determine the variability in fluid resuscitation in shock in a broad range of areas in hospitals and treatment areas.
- Trial name
- VOLUME (NCT03190408)
- Testing
- Fluids
- Where
- United States
- Volunteers
- 1,639 people
- Sponsor
- Montefiore Medical Center
Hypotension Drug-Induced
A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
- Trial name
- NCT06334549
- Testing
- Ephedrine-P, Phenylephrine-P, Norepinephrine-P
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Dalian Municipal Central Hospital
Epistaxis
Xylometazoline and Cocaine for Nasal Vasoconstriction
The objective of this study is to compare xylometazoline and cocaine's effect on minimizing epistaxis when administered as a local vasoconstrictor prior to nasal intubation.
- Trial name
- NCT05334017
- Testing
- Xylometazoline 0,1%, Cocaine 4%
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Diseases
Closed-loop Control Mean Arterial Pressure In Intensive Care Patients
The purpose of this case series is to evaluate the performance of a novel closed-loop (automated) vasopressor administration system that delivers norepinephrine using feedback from standard hemodynamic monitor (EV1000 Monitor)…
- Trial name
- NCT04357197
- Testing
- Closed-loop
- Sponsor
- Erasme University Hospital
Septic Shock, Refractory Shock
Terlipressin for Refractory Septic Shock
Norepinephrine was recommended as the first vasopressor for septic shock resuscitation. For the patient who did not response to high dose norepinephrine, epinephrine was recommended.
- Conditions
- Septic Shock, Refractory Shock, Norepinephrine Adverse Reaction
- Trial name
- TERESEP (NCT04339868)
- Testing
- Terlipressin
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
Percutaneous Nephrolithotomy
Effect of Ondansetron on Spinal-induced Hypotension for Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is the surgical standard for treating large or complex renal stones. The stones are removed by passing a small telescope through the side of the patient directly into the kidney, so the stone…
- Trial name
- NCT04891484
- Testing
- Ondansetron group, Saline group
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
Perioperative Care, Hemodynamics
ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management
The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries.
- Conditions
- Perioperative Care, Hemodynamics, Monitoring Blood Pressure, Arterial Lines
- Trial name
- IPAMS (NCT06982001)
- Testing
- Brachial line guided hemodynamic management, Radial line guided hemodynamic management, Radial line catheterization
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Mechanical Ventilation
Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICU
The NUTRIREA-4 trial will test the hypothesis that an individually tailored rehabilitation program combining nutritional therapy, physiotherapy, and physical activity and started early in the ICU then continued uninterruptedly…
- Trial name
- NUTRIREA-4 (NCT06581939)
- Testing
- Rehabilitation group, Control group
- Where
- 52 sites in France
- Volunteers
- 830 people
- Sponsor
- Nantes University Hospital
Shock, Septic
Multimodal Vasopressor Strategy in Septic Shock
The goal of this prospective randomized controlled trial is to compare the effects of classic stepwise vs. early balanced multimodal vasopressor strategies in septic shock.
- Trial name
- NCT06155812
- Testing
- Simultaneous administration of vasopressors, Successive administration of vasopressors
- Where
- 2 sites in Croatia, Slovenia
- Volunteers
- 79 people
- Sponsor
- University Medical Centre Maribor
Respiratory Failure, Hypotension and Shock
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events.
- Conditions
- Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication
- Trial name
- RAPID PRESS (NCT05355974)
- Testing
- Norepinephrine, Lactated Ringers, Intravenous, normal saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wright State University
Preeclampsia
Ephedrine, Phenylephrine and Metaraminol Effects on Maternal Cardiac Output, Uterine Blood Flow and Fetal Circulation
It is a prospective clinical trial with random distribution that intends to investigate maternal and fetal effects of ephedrine, phenylephrine and metaraminol during cesarean delivery in patients with pre-eclampsia.
- Trial name
- NCT02245191
- Testing
- Ephedrine, Phenylephrine, Metaraminol
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Septic Shock
Angiotensin II vs. Vasopressin in Septic Shock
This will be a randomized controlled unblinded pragmatic single-center pilot trial of the use of vasopressin vs. angiotensin II as a second-line vasopressor in patients with septic shock and persistent hypotension despite…
- Trial name
- NCT05193370
- Testing
- Angiotensin II, Vasopressin
- Where
- United States
- Sponsor
- University of New Mexico
Sepsis
Alirocumab in Patients with Sepsis
The purpose of this study is to determine whether the drug alirocumab, which may lower cholesterol, can reduce the amount of inflammation caused by an infection that has caused either low blood pressure or difficulty breathing.
- Trial name
- PALMS (NCT05469347)
- Testing
- Alirocumab
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Jonathan Sevransky
Arterial Hypertension
Measurement of Noradrenaline Concentrations Using Different Dilution Methods
Norepinephrine is the vasopressor of choice for the treatment of peri-anesthetic arterial hypotension. The use of this drug at significantly lower concentrations (dilution factor between 40 and 200) than the commercial…
- Trial name
- NCT04772599
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Endovascular Carotid Surgery, Preoperative Hypotension
Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery
The effects on brain perfusion of the two currently vasopressors used to treat accidental hypotension occurring during carotid surgery (i.e.
- Trial name
- VP-hTA-XCar (NCT01794273)
- Testing
- ephedrine and phenylephrine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypotension After Neuraxial Anesthesia, Cesarean Section
Comparing Spinal, Epidural, and Dural Puncture Epidural Anesthesia for Cesarean Delivery: Hemodynamics and Block Quality
The goal of this clinical trial is to compare three regional anesthesia techniques (spinal, epidural, and dural puncture epidural anesthesia) in healthy pregnant women undergoing planned (elective) cesarean delivery.
- Conditions
- Hypotension After Neuraxial Anesthesia, Cesarean Section, Anesthesia, Obstetrical, Post-Dural Puncture Headache
- Trial name
- NCT07883733
- Testing
- Spinal Anesthesia, Epidural Anesthesia, Dural Puncture Epidural Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Septic Shock, Sepsis
Vitamin C to Reduce Vasopressor Dose in Septic Shock
Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.
- Trial name
- ViCiS (NCT03835286)
- Testing
- Vitamin C
- Where
- Mexico
- Sponsor
- Hospital Español de Mexico
Ischemia, Vasopressor
Treatment of Vasopressor-induced Ischemia With Botulinum Toxin A
The goal of this project is to determine if performing a "chemical sympathectomy" by injecting botulinum toxin A in critically ill patients on vasopressors can treat digital ischemia.
- Trial name
- NCT01483209
- Testing
- Injection of botulinum toxin A
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Hemodynamic Instability
Hemodynamic Optimalization in Pediatric Patients
Hemodynamic unstability, defined by macrocirculation and/or microcirculation dysfunction or alteration is common in critically ill pediatric patients.
- Trial name
- HOPED (NCT04227821)
- Testing
- Vasopressor and/inotrope therapy
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital