Clinical trials: Vasopressor
Maternal Haemodynamic Stability
Maternal Haemodynamic Changes After Crystalloid Co-loading and Phenylephrine Versus Phenylephrine Alone During Spinal Anaesthesia for Elective Caesarean Delivery
Spinal anaesthesia is the anaesthetic technique of choice for elective caesarean delivery. Hypotension, a result of the decrease in systemic vascular resistance caused by spinal anaesthesia, is a frequent complication occurring…
- Trial name
- NICOM-USB (NCT04026685)
- Testing
- Phenylephrine infusion, Phenylephrine infusion and Ringer-Acetate bolus
- Where
- Switzerland
- Volunteers
- 66 people
- Sponsor
- University Hospital, Basel, Switzerland
Septic Shock
External Cooling in Septic Shock Patients
The rapidity of the resolution of cardiovascular failure has a strong impact on septic shock patients' outcome. The aim of this multicenter randomized controlled trial is to determine whether external cooling might accelerate…
- Trial name
- sepsis-cool (NCT00527007)
- Testing
- External cooling
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypotension
Vasopressor Outcomes in Spine Surgery
This is a prospective, randomized control trial comparing norepinephrine versus phenylephrine for vasopressor support in patients undergoing elective spinal fusion surgery.
- Trial name
- V-SPINE (NCT06053398)
- Testing
- Phenylephrine, Norepinephrine
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Texas Southwestern Medical Center
Cesarean Section Complications, Spinal Anesthetic Toxicity
Comparison of Vasopressor Boluses for Management of Hypotension After Spinal Anesthesia
In this study the investigators will compare the efficacy and side effects of two doses of norepinephrine bolus (6 mcg and 10 mcg) in management of maternal hypotensive episode after subarachnoid block during Cesarean delivery.
- Trial name
- NCT03712111
- Testing
- Norepinephrine 6 mcg, Norepinephrine 10 mcg, Bupivacaine Hydrochloride
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Cairo University
Coronary Artery Bypass Graft
High Frequency Ventilation During Off Pump Coronary Artery Bypass Graft (CABG)
This study is to test the safety of high frequency-low volume ventilation during off pump coronary artery bypass as reflected in the near infrared spectroscopy values for cerebral oxygenation.
- Trial name
- VHF (NCT00863044)
- Testing
- Apnea, High frequency ventilation
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Montreal Heart Institute
Septic Shock, Norepinephrine Adverse Reaction
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
This is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes
- Conditions
- Septic Shock, Norepinephrine Adverse Reaction, Hypotension and Shock
- Trial name
- NCT06121115
- Testing
- Norepinephrine
- Where
- Sweden
- Volunteers
- 473 people
- Sponsor
- Region Skane
Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Vasopressor Agents in Pulmonary Hypertension Crisis
Comparison of the efficacy and safety of three vasoactive agents-dopamine, norepinephrine, and epinephrine-in the treatment of patients with pulmonary hypertension crisis: prospective, randomised controlled trial monitored by…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Hypertension, Pulmonary
- Trial name
- NCT07667829
- Testing
- Norepinephrine, Dopamine, Epinephrine
- Where
- 3 sites in China
- Volunteers
- 75 people
- Sponsor
- China National Center for Cardiovascular Diseases
Enteral Nutrition, Vasopressor Agents
Enteral Nutrition and Vasoactive Drugs
Enteral nutrition in critically ill patients undergoing vasoactive support due to hemodynamic instability is controversial. Hypothesis: enteral nutrition delivered in such patients can be feasible and safe.
- Conditions
- Enteral Nutrition, Vasopressor Agents, Hemodynamics Instability, Critical Care
- Trial name
- NUTRIVAD (NCT03401632)
- Testing
- Enteral nutrition
- Where
- 23 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Severo Ochoa
Liver Transplant Recipients
Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.
Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea…
- Trial name
- NCT06418893
- Testing
- Target control infusion propofol, Inhalational isoflurane
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hypotension, Neonatal Hypotension
Appropriate Dosage of Vasopressor in Neonates and Infants
In this study, the investigators will evaluate cerebral blood flow before and after drug infusion using ultrasound to suggest blood pressure criteria and dosage of ephedrine, a vasopressor, to maintain adequate cerebral blood…
- Conditions
- Hypotension, Neonatal Hypotension, Intraoperative Complications
- Trial name
- NCT06257316
- Testing
- EPHEDrine Hydrochloride 5 mg/ml
- Volunteers
- 132 people
- Sponsor
- Seoul National University Hospital
Vasopressor Adverse Reaction, Pressure Injury
The Effect of Vasopressor on Pressure Injury Development
Background: Vasopressors are life-saving agents that increase mean arterial pressure. The pharmacodynamic features of these agents and previous studies suggest that vasopressors may be an essential risk factor in developing…
- Conditions
- Vasopressor Adverse Reaction, Pressure Injury, Pressure Ulcer
- Trial name
- NCT06163352
- Testing
- Norepinephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Koç University
Acute Allergic Reaction, Anaphylaxis
Phase 1 Crossover Study Evaluating the Safety, Tolerability, and Pharmacokinetics of KP001 in Healthy Adult Volunteers
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of several KP001 dose regimens to identify a treatment regimen with a PK profile that safely meets or exceeds the PK profile of…
- Trial name
- NCT06963411
- Testing
- KP001
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kokua Pharma Inc.
Critical Illness, Enteral Feeding Intolerance
Evaluation of Enteral Nutrition in Critically Ill Children
The aim of this study was to evaluate the effect of calorie and enteral feeding timing on survival in critically ill children receiving inotropic, vasopressor and inodilatory supplements.
- Trial name
- NCT04013893
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Cukurova University
Sepsis
Early Vasopressors in Sepsis
Sepsis is a life-threatening reaction to an infection. It happens when the immune system overreacts to an infection and starts to damage the body's tissues and organs.
- Trial name
- EVIS (NCT05179499)
- Testing
- Norepinephrine, Balanced Crystalloid
- Where
- 25 sites in United Kingdom
- Volunteers
- 1,006 people
- Sponsor
- NHS Greater Glasgow and Clyde
Hemodynamic Instability, Shock
VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
This prospective observational study will include critically ill patients with hemodynamic compromise. It will compare passive leg raising and a mini volume challenge (MVC) carried out on every patient sequentially.
- Conditions
- Hemodynamic Instability, Shock, Septic Shock
- Trial name
- VOLTA (NCT04089098)
- Testing
- passive leg raising versus mini volume challenge
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- University of Leipzig
Esophageal Varices, Bleeding
EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding
Previous studies showed that combination of endoscopic therapy with vasoconstrictor is better than either vasoconstrictor or endoscopic therapy alone in achieving the successful hemostatsis of acute variceal bleeding.
- Trial name
- EVL (NCT01112852)
- Testing
- pantoloc 40 mg, somatostatin or terlipressin
- Volunteers
- 118 people
- Sponsor
- National Science and Technology Council, Taiwan
Cesarean Section Complications
Vasopressor Prophylaxis After Spinal Anesthesia
Norepinephrine has been recently introduced as a prophylactic vasopressor during Cesarean delivery with promising results ; However, the optimum dose for efficient prophylaxis with the least side effects is not known.
- Trial name
- NCT03234816
- Testing
- Norepinephrine 0.05 mcg /Kg/min, Norepinephrine 0.1 mcg /Kg/min, Norepinephrine 0.15 mcg /Kg/min
- Where
- Egypt
- Volunteers
- 270 people
- Sponsor
- Cairo University
Hypotension During Surgery
Pneumatic Leg Compression and Norepinephrine Requirements in Patients Having Non-cardiac Surgery
The PLANE trial is a randomized, single-center trial investigating whether pneumatic leg compression reduces the amount of norepinephrine needed to keep MAP above 65mmHg compared to routine care without PLC in patients having…
- Trial name
- PLANE (NCT06950606)
- Testing
- Pneumatic leg compression
- Where
- Germany
- Volunteers
- 238 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Healthy
Comparison of Intranasal Oxytocin Effects Using Co-administration With a Vasoconstrictor
This study aims to dissociate direct from indirectly mediated effects of intranasal oxytocin administration by using treatment with or without prior intranasal administration of a vasoconstrictor to reduce peripheral increases in…
- Trial name
- NCT04134663
- Testing
- vasoconstrictor and oxytocin treatment
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Sepsis
Alirocumab in Patients with Sepsis
The purpose of this study is to determine whether the drug alirocumab, which may lower cholesterol, can reduce the amount of inflammation caused by an infection that has caused either low blood pressure or difficulty breathing.
- Trial name
- PALMS (NCT05469347)
- Testing
- Alirocumab
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Jonathan Sevransky