Clinical trials: Vasopressor Agents
Septic Shock, Norepinephrine Adverse Reaction
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
This is a single-center study retrospectively evaluating a local clinical routine to administer norepinephrine in midline catheters, with regard to complications and patient outcomes
- Conditions
- Septic Shock, Norepinephrine Adverse Reaction, Hypotension and Shock
- Trial name
- NCT06121115
- Testing
- Norepinephrine
- Where
- Sweden
- Volunteers
- 473 people
- Sponsor
- Region Skane
Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Vasopressor Agents in Pulmonary Hypertension Crisis
Comparison of the efficacy and safety of three vasoactive agents-dopamine, norepinephrine, and epinephrine-in the treatment of patients with pulmonary hypertension crisis: prospective, randomised controlled trial monitored by…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Hypertension, Pulmonary
- Trial name
- NCT07667829
- Testing
- Norepinephrine, Dopamine, Epinephrine
- Where
- 3 sites in China
- Volunteers
- 75 people
- Sponsor
- China National Center for Cardiovascular Diseases
Enteral Nutrition, Vasopressor Agents
Enteral Nutrition and Vasoactive Drugs
Enteral nutrition in critically ill patients undergoing vasoactive support due to hemodynamic instability is controversial. Hypothesis: enteral nutrition delivered in such patients can be feasible and safe.
- Conditions
- Enteral Nutrition, Vasopressor Agents, Hemodynamics Instability, Critical Care
- Trial name
- NUTRIVAD (NCT03401632)
- Testing
- Enteral nutrition
- Where
- 23 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Severo Ochoa
Hypotension, Neonatal Hypotension
Appropriate Dosage of Vasopressor in Neonates and Infants
In this study, the investigators will evaluate cerebral blood flow before and after drug infusion using ultrasound to suggest blood pressure criteria and dosage of ephedrine, a vasopressor, to maintain adequate cerebral blood…
- Conditions
- Hypotension, Neonatal Hypotension, Intraoperative Complications
- Trial name
- NCT06257316
- Testing
- EPHEDrine Hydrochloride 5 mg/ml
- Volunteers
- 132 people
- Sponsor
- Seoul National University Hospital
Vasopressor Adverse Reaction, Pressure Injury
The Effect of Vasopressor on Pressure Injury Development
Background: Vasopressors are life-saving agents that increase mean arterial pressure. The pharmacodynamic features of these agents and previous studies suggest that vasopressors may be an essential risk factor in developing…
- Conditions
- Vasopressor Adverse Reaction, Pressure Injury, Pressure Ulcer
- Trial name
- NCT06163352
- Testing
- Norepinephrine
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Koç University
Acute Allergic Reaction, Anaphylaxis
Phase 1 Crossover Study Evaluating the Safety, Tolerability, and Pharmacokinetics of KP001 in Healthy Adult Volunteers
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of several KP001 dose regimens to identify a treatment regimen with a PK profile that safely meets or exceeds the PK profile of…
- Trial name
- NCT06963411
- Testing
- KP001
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kokua Pharma Inc.
Critical Illness, Enteral Feeding Intolerance
Evaluation of Enteral Nutrition in Critically Ill Children
The aim of this study was to evaluate the effect of calorie and enteral feeding timing on survival in critically ill children receiving inotropic, vasopressor and inodilatory supplements.
- Trial name
- NCT04013893
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Cukurova University
Hemodynamic Instability, Shock
VOLume and Vasopressor Therapy in Patients With Hemodynamic instAbility
This prospective observational study will include critically ill patients with hemodynamic compromise. It will compare passive leg raising and a mini volume challenge (MVC) carried out on every patient sequentially.
- Conditions
- Hemodynamic Instability, Shock, Septic Shock
- Trial name
- VOLTA (NCT04089098)
- Testing
- passive leg raising versus mini volume challenge
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- University of Leipzig
Cesarean Section Complications
Vasopressor Prophylaxis After Spinal Anesthesia
Norepinephrine has been recently introduced as a prophylactic vasopressor during Cesarean delivery with promising results ; However, the optimum dose for efficient prophylaxis with the least side effects is not known.
- Trial name
- NCT03234816
- Testing
- Norepinephrine 0.05 mcg /Kg/min, Norepinephrine 0.1 mcg /Kg/min, Norepinephrine 0.15 mcg /Kg/min
- Where
- Egypt
- Volunteers
- 270 people
- Sponsor
- Cairo University
Hypotension During Surgery
Pneumatic Leg Compression and Norepinephrine Requirements in Patients Having Non-cardiac Surgery
The PLANE trial is a randomized, single-center trial investigating whether pneumatic leg compression reduces the amount of norepinephrine needed to keep MAP above 65mmHg compared to routine care without PLC in patients having…
- Trial name
- PLANE (NCT06950606)
- Testing
- Pneumatic leg compression
- Where
- Germany
- Volunteers
- 238 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cesarean Section Complications, Spinal Anesthesia
Vasopressor Infusion in Cesarean Delivery
Comparison will be conducted between continuous variable infusions of both drugs (Phenylephrine and Norepinephrine) with starting doses of 0.75 mcg/Kg/min and 0.1 mcg/Kg/min respectively for prophylaxis against Post-spinal…
- Trial name
- NCT03248791
- Testing
- Phenylephrine, Norepinephrine, Bupivacaine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Peri-intubation Hypotension
Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency Department
Rapid sequence intubation is commonly performed in the emergency department to secure the airway of critically ill patients. However, blood pressure may decrease during or shortly after intubation because of the patient's…
- Trial name
- NCT07620327
- Testing
- Adrenaline, 0.9 % sodium chloride
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Severe Sepsis, Emergency
Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery
This study wants to compared the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in septic patients requiring emergency surgery.
- Conditions
- Severe Sepsis, Emergency, Surgery
- Trial name
- NCT01654003
- Testing
- CONTROL, OPTIMIZED
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Septic Shock, Sepsis
Vitamin C to Reduce Vasopressor Dose in Septic Shock
Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.
- Trial name
- ViCiS (NCT03835286)
- Testing
- Vitamin C
- Where
- Mexico
- Sponsor
- Hospital Español de Mexico
Closed-Loop Communication
Computer Assisted Vasopressor Titration in Critically Ill Patients
The purpose of this pilot study is to evaluate the performance of a novel closed-loop (automated) vasopressor administration system that delivers norepinephrine using feedback from standard operating room hemodynamic monitor…
- Trial name
- NCT04106791
- Testing
- closed-loop system for vasopressor administration
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Erasme University Hospital
Hypotension
Up-Down Determination of the ED90 of Metaraminol to Treat Hypotension During Cesarean Section
The purpose of this study is to find the best dose of metaraminol to be used in patients during elective cesarean sections.
- Trial name
- NCT01108874
- Testing
- Metaraminol
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Closed-Loop Communication
COntrolled MAp Trauma Brain Injury (COMAT Study)
The goal of this randomized controlled trial will be to show that the use of a novel automated system to guide vasopressor administration in head trauma injury patients will results in more time spent with a mean arterial…
- Trial name
- COMAT (NCT03792581)
- Testing
- EV1000 and closed-loop system
- Where
- France
- Sponsor
- Erasme University Hospital
Sepsis
Perfusion Efficiency-Guided MAP De-escalation in Elderly Septic Shock
This is a single-center, prospective, randomized crossover physiological trial conducted in elderly patients (≥65 years) with septic shock in the intensive care unit (ICU).
- Trial name
- NCT07887854
- Testing
- Ascending MAP titration sequence, Descending MAP titration sequence
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing, Immunotherapy or Oral Challenges
The goal of this exploratory study is to evaluate the effects of inhaled epinephrine in subjects, who may not be eligible for the GHL-101 trial, and who are experiencing systemic allergic reaction (SAR) that occur following…
- Trial name
- NCT07038746
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Dr. George Luciuk
Hypersensitivity, Anaphylaxis
Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral Challenges
The purpose of this exploratory study is to evaluate the effects of inhaled epinephrine in patients with known or suspected metabisulfite sensitivity who experience a systemic allergic reaction (SAR) while undergoing allergy…
- Trial name
- NCT06445374
- Testing
- Inhaled Epinephrine
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Dr. George Luciuk