Clinical trials: Vasospasm, Cerebral
Subarachnoid Hemorrhage
Effects of Prostacyclin Infusion on Cerebral Vessels and Metabolism in Patients With Subarachnoid Haemorrhage
The purpose of this study is to determine whether prostacyclin is effective in prevention of cerebral vasospasm in patients with subarachnoidal hemorrhage (SAH).
- Trial name
- NCT01447095
- Testing
- Prostacyclin 1 ng/kg/min, Prostacyclin 2 ng/kg/min
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Rune Rasmussen
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral
Brain Aneurysms: Utility of Cisternal Urokinase Irrigation
Despite the efforts made in its treatment, aneurysmal subarachnoid haemorrhage continues to induce high mortality and morbidity rates. Today there are treatment protocols in all hospitals.
- Conditions
- Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral, Hydrocephalus
- Trial name
- BA&UK (NCT04792944)
- Testing
- Urokinase, Endovascular treatment, Clipping
- Where
- Spain
- Volunteers
- 247 people
- Sponsor
- University of Valencia
Aneurysmal Subarachnoid Hemorrhage
Hypercapnia to Prevent Secondary Ischemia in SAH
Delayed cerebral vasospasm and secondary ischemic infarction are feared complications after aneurysmal subarachnoid hemorrhage (aSAH). To date, there is no effective therapy to prevent these ischemic complications.
- Trial name
- SAHCO2 (NCT01799525)
- Testing
- Hypercapnia by reduction of respiratory volume
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Wuerzburg University Hospital
Ischemia
Determinants of Vasospasm and Delayed Ischemic Deficits in Aneurysmal Subarachnoid Hemorrhage
The risk of delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is associated with large cerebral artery vasospasm, but vasospasm is not a strong predictor for DCI.
- Trial name
- NCT02829398
- Testing
- CerebroSpinal fluid and plasma samples
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Toulouse
Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral
Acetazolamide Challenge With Perfusion in the Prediction of Cerebral Vasospasm
The investigators propose a technique using cone beam CT perfusion (CBCTP) imaging with an acetazolamide challenge as a potential diagnostic tool to detect a defect in cerebral autoregulation at a time when it has not yet caused…
- Trial name
- NCT03377049
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Wisconsin, Madison
Subarachnoid Hemorrhage
Neuroinflammation and Bispectral Index After Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is associated with a high mortality and frequently leads to severe disability in survivors caused by cerebral vasospasm and infarction.
- Trial name
- NCT01516671
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cerebral Vasospasm
Stellate Ganglion Block Using Ultrasound Guidance For Treatment Of Post Clipping Cerebral Vasospasm
The present study has been designed to assess the efficacy and safety of Stellate Ganglion Block (SGB) in relieving symptomatic cerebral vasospasm following aneurysmal clipping.
- Trial name
- NCT02775318
- Testing
- Stellate Ganglion Block, Bupivacaine, Transcranial Doppler
- Volunteers
- 20 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Intracranial Aneurysm
Perioperative Neuroprotection of Stellate Ganglion Block
To investigate whether stellate ganglion block is helpful to brain protection during cranial aneurysm surgery
- Trial name
- NCT02275247
- Testing
- Stellate Ganglion Block
- Where
- China
- Volunteers
- 40 people
- Sponsor
- General Hospital of Ningxia Medical University
Cerebral Vasospasm, Subarachnoid Hemorrhage
Cervical Spinal Cord Stimulation in Patients With Cerebral Vasospasm After Subarachnoid Haemorrhage: VasoStim Study
Cerebral vasospasm is characterized by a vasoconstriction of cerebral arteries causing a reduction of cerebral blood flow (CBF) and leading to ischemia and infarction of the brain parenchyma.
- Trial name
- NCT05150002
- Testing
- Spinal cord stimulation
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subarachnoid Hemorrhage
Intravenous Nitrite Infusion for Reversal of Cerebral Vasospasm After Subarachnoid Hemorrhage
The hypothesis is that intravenous infusion of sodium nitrite is safe and effective for the reversal of cerebral vasospasm after subarachnoid hemorrhage in patients with a cerebral aneurysm.
- Trial name
- NCT02176837
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Hope Pharmaceuticals
Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block
Stellate Ganglion Block and Cerebral Vasospasm
At present, cerebral vasospasm (cVS) is the main cause of delayed cerebral infarction (DCI), which leads to high disability and mortality rate after aneurysmal subarachnoid hemorrhage.
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Stellate Ganglion Block, Cerebral Vasospasm
- Trial name
- BLOCK-CVS (NCT04691271)
- Testing
- Stellate ganglion block
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Beijing Tiantan Hospital
Medical Device Complication, Brain Injuries
Transcranial Doppler Using Wearable Ultrasound Patch
The main objective of this research is to measure the Doppler signal by the ultrasonic patch. Blood flow measurement is critical for vasospasm, stroke, and embolism monitoring on patients in the ICU or understanding the…
- Conditions
- Medical Device Complication, Brain Injuries, Brain Diseases, Stroke
- Trial name
- TCD (NCT06073145)
- Testing
- conventional transcranial Doppler probe and wearable ultrasound patch.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Aneurysmal Subarachnoid Hemorrhage
Prognostic Value of Circulating Endothelial Progenitor Cells in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage is a common and serious disease associated to a high rate of mortality and morbidity. Severe definitive neurological impairment can concern up to 30% of patients in relation with elevated…
- Trial name
- EVAPROPEC (NCT01773200)
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Brain Ischemia, Intracranial Vasospasm
The Tilburg Vasospasm Study
In a prospective randomized controlled trial, the investigators aim to assess whether external lumbar drainage (ELD) of CSF is safe and reduces delayed cerebral ischemia and its sequelae in patients with an aneurysmal…
- Trial name
- NCT01407614
- Testing
- external lumbar drainage (ELD) of cerebrospinal fluid
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Acute Cerebrovascular Accident, Vasospasm
Carbonic Anhydrase Antagonism in Subarachnoid Hemorrhage
Subarachnoid Hemorrhage (SAH) can occur commonly in the setting of trauma or brain aneurysm. SAH accounts for 10% of all the strokes.
- Trial name
- NCT02165644
- Testing
- Acetazolamide, Nimodipine
- Sponsor
- University of Florida
Subarachnoid Hemorrhage, Cerebral Vasospasm
Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage
Prospective evaluation of patients with subarachnoid hemorrhage (SAH) will be done by computed tomography angiography (CTA) and perfusion imaging (CTP) for any correlation between degree of vasospasm and perfusion deficit as well…
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Delayed Cerebral Ischemia
- Trial name
- NCT03214705
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Vasospasm Intracranial
Therapeutic Hypercapnia After Aneurysmal Subarachnoid Hemorrhage - Optimum Duration of Hypercapnia
Temporary hypercapnia leads to a reproducible increase of cerebral blood flow (CBF) and brain tissue oxygenation (StiO2) as shown in a previous study (Trial-Identification: NCT01799525).
- Trial name
- NCT04687605
- Testing
- Temporary hypercapnia
- Volunteers
- 12 people
- Sponsor
- University of Wuerzburg
Cerebral Vasospasm, Aneurysmal Subarachnoid Hemorrhage (aSAH)
Registry on NeVa VS for CerebraL VAsospasm ManagemenT in Post SAH PatiEnts
A multi-center, observational registry study intended to assess the HDE-approved NeVa VS cerebral artery dilation device in patients with symptomatic cerebral vasospasm caused by aneurysmal subarachnoid hemorrhage (aSAH)
- Trial name
- DILATE (NCT06893588)
- Testing
- NEVA VS
- Where
- 16 sites in United States
- Volunteers
- 200 people
- Sponsor
- Vesalio
Intracranial Aneurysm
Aneurysmal Subarachnoid Hemorrhage and Superior Mesenteric Artery Flow Study
The purpose of this research study is to determine if the diameter and flow of the superior mesenteric artery in patients with aneurysmal subarachnoid hemorrhage undergoing hypertensive therapy for cerebral artery vasospasm are…
- Trial name
- NCT02684500
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Florida
Subarachnoid Hemorrhage, Aneurysm
Lycopene Following Aneurysmal Subarachnoid Haemorrhage
In this study the investigators wish to explore the potential neuroprotective effects of acute oral supplementation of lycopene, a natural anti-oxidant derived from tomatoes, on cerebral vasospasm and autoregulation, and examine…
- Trial name
- LASH (NCT00905931)
- Testing
- Lycopene
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- University of Cambridge