Clinical trials: Vasovagal Syncope
Syncope, Vasovagal
The Effect of CPC on Aborting Tilt Induced Syncope in Patients With a History of Vasovagal Syncope or Near Syncope
Syncope is defined as transient loss of consciousness associated with inability to maintain postural tone with rapid and spontaneous recovery.
- Trial name
- NCT04972123
- Testing
- CPC - Capsaicin, Phenylephrine, Caffeine, Tilt Table Test
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- University of Wisconsin, Madison
Syncope, Vasovagal
Heart Rate Variation in Females Predicts Tilt Test Results
Head-up tilt test (HUTT) is widely used to evaluate patients with unexplained syncope, but data on clinical predictors of HUTT results are limited.
- Trial name
- NCT06496074
- Testing
- Head-up Tilt Test
- Where
- Brazil
- Volunteers
- 149 people
- Sponsor
- Federal University of Piaui
Neurally Mediated Syncope
The Iliac Arterio-venous Fistula for Treatment of Neurally Mediated Syncope Study
The purpose of the study is to investigate the efficacy of the ROX coupler in treating patients with tilt test proven Neurally mediated syncope.
- Trial name
- SHAM-ROX NMS (NCT02388087)
- Testing
- ROX COUPLER, Right heart catheterisation and routine care
- Volunteers
- 20 people
- Sponsor
- East Sussex Healthcare NHS Trust
Cardiac Pacemaker, Arrythmia
Aveir DR Real-World Evidence Post-Approval Study
The purpose of this post-approval study is to evaluate the long-term safety of the dual-chamber Aveir DR leadless pacemaker using real-world evidence methods.
- Conditions
- Cardiac Pacemaker, Arrythmia, Bradycardia
- Trial name
- NCT05935007
- Testing
- Aveir DR Leadless Pacemaker System
- Where
- United States
- Volunteers
- 1,805 people
- Sponsor
- Abbott Medical Devices
Vasovagal Syncope
Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates
The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments.
- Trial name
- Pacing_SV (NCT03446326)
- Testing
- Pacing
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Syncope, Vasovagal
Different Catheter Ablation Strategy in Vasovagal Syncope
This study is a prospective, single-center randomized controlled clinical trial. patients with refractory vasovagal syncope were randomly divided into two groups according to the proportion of 1:1.
- Trial name
- NCT05573178
- Testing
- cardiac ganglion plexus ablation(cardioneuroablation)
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- China National Center for Cardiovascular Diseases
Syncope, Syncope, Vasovagal
Assessment of the Mechanism of Non-cardiac Syncope
Identifying the mechanism of non-cardiac syncope is the essential prerequisite for an effective personalized therapy. Aim of this multicentre, prospective, cross-sectional, observational study is to assess effectiveness and…
- Conditions
- Syncope, Syncope, Vasovagal, Orthostatic Hypotension, Syncope, Carotid Sinus
- Trial name
- 2STEPS (NCT05728255)
- Testing
- ABPM plys SCAFB
- Where
- 8 sites in France, Italy and 3 more
- Volunteers
- 330 people
- Sponsor
- Istituto Auxologico Italiano
Dysautonomia
MRI to Assess the Effects of Dysautonomia and Chronic Nausea on Brain Transmitters
The purpose of this research study is to better understand what causes dysautonomia and how this affects blood pressure and pulse. Dysautonomia is a condition of the autonomic nervous system.
- Trial name
- NCT01692561
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Postural Orthostatic Tachycardia Syndrome, Syncope, Vasovagal
Tilt Table With Suspected Postural Orthostatic Tachycardia Syndrome (POTS) Subjects
Dysautonomia, primarily defined as postural orthostatic tachycardia syndrome (POTS) can seriously disrupt a child's daily activities. It is most commonly associated with nausea or abdominal pain.
- Conditions
- Postural Orthostatic Tachycardia Syndrome, Syncope, Vasovagal, Neurocardiogenic Syncope
- Trial name
- POTS (NCT01617616)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Wake Forest University Health Sciences
Syncope
Evaluation of Chronic Orthostatic Intolerance
This study will conduct tests with patients with primary chronic orthostatic intolerance (COI) to learn more about this disorder of the autonomic nervous system.
- Trial name
- NCT00069693
- Where
- 3 sites in United States, Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University
Syncope
Effect of Psychotherapy on Quality of Life and Recurrence of Events in Patients With Recurrent Vasovagal Syncope: A Randomized Pilot Study
Recurrent vasovagal syncope although presenting a benign prognosis in terms of survival, is associated with significant impairment of quality of life.
- Trial name
- NCT04252729
- Testing
- Psychotherapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Mauricio Ibrahim Scanavacca
Hypotensive Syncope
Stop Vasodepressor Drugs in Reflex Syncope
Investigate clinical effects (reduction of number of syncope and associate symptoms) of suspension of vasoactive drugs in patients affected by vasodepressor reflex syncope.
- Trial name
- STOP-VD (NCT02137278)
- Testing
- Vasoactive drug therapies, Stop/reduce vasoactive drugs
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Gruppo Italiano Multidisciplinare per lo Studio della Sincope
Syncope
ISSUE3: International Study on Syncope of Uncertain Etiology 3
ISSUE 3 is a multi-center, prospective, randomised controlled double-blind study aimed to assess the effectiveness of pacemaker therapy for prevention of asystolic neurally-mediated syncope.
- Trial name
- NCT00359203
- Testing
- Dual chamber pacemeker
- Where
- Italy
- Volunteers
- 511 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Syncope, Vasovagal
Preventing Post-Vaccination Presyncope and Syncope in Adolescents Using Simple, Clinic-based Interventions: A Pilot Study
This is a randomized controlled open-label trial. During the study, adolescents scheduled to receive at least one intramuscular (IM) vaccine will receive either Buzzy®, Music, or Buzzy® and Music intervention(s) in addition to…
- Trial name
- NCT03533829
- Testing
- Buzzy®, Music
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Syncope, Vasovagal, Pain Intensity
Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
This randomized controlled trial will examine the impact of local anesthetic on the frequency of vasovagal reactions and the patients perception of pain during femoral arterial sheath removal after percutaneous coronary…
- Trial name
- NCT00465439
- Testing
- Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Vasovagal Syncope
Study of Atomoxetine in the Prevention of Vasovagal Syncope
Project rationale: Vasovagal syncope (VVS) affects up to 50% of people, and recurrent syncope markedly reduces quality of life. We recently reported that it is frequently associated with injury and not surprisingly with clinical…
- Trial name
- POST7 (NCT05159687)
- Testing
- Atomoxetine Hydrochloride
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of Calgary
Syncope, Vasovagal
Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed Tomography
Cardioneuroablation (CNA) is a new method for the treatment of asystolic reflex syncope, however, optimal methods for identification of presumed sites of ganglionated plexi (GP), which are the target for CNA and are located in…
- Trial name
- Roman5 (NCT06472102)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Vasovagal Syncope (VVS), Syncope
A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of Syncope Trial (POST11)
About 20% of adults faint recurrently. These patients are often highly symptomatic, have problems with employment and driving, can be injured, and have poor quality of life.
- Trial name
- POST 11 (NCT05755737)
- Testing
- Ondansetron
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Calgary
Syncope
Benefit of Dual-chamber Pacing With Closed Loop Stimulation (CLS) in Tilt-induced Cardioinhibitory Reflex Syncope
The purpose of this study is to assess whether the Closed Loop Stimulation (CLS) in addition to the DDD pacing is effective in reducing syncopal recurrences.
- Trial name
- BIOSync CLS (NCT02324920)
- Testing
- DDD-CLS, ODO
- Where
- 24 sites in Canada, France and 4 more
- Volunteers
- 128 people
- Sponsor
- Biotronik SE & Co. KG