Clinical trials: Veno-occlusive Disease
Macular Edema Caused by Retinal Vein Occlusion
Dexamethasone-implant for the Treatment of RVO
To evaluate the efficacy and safety of a dexamethasone-implant alone or in combination with bevacizumab. 64 eyes are prospectively investigated.
- Trial name
- NCT01767545
- Testing
- Dexamethasone implant, Bevacizumab
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Branch Retinal Vein Occlusion
Long-term Treatment Effect of Intravitreal Ant-VEGF in Branch Retinal Vein Occlusion
Retinal vein occlusion (RVO) is the second leading cause of retinal vascular disease in patients older than 50 years.The prevalence varies from 0.7% to 1.6% in the literature.
- Trial name
- NCT02033031
- Testing
- Lucentis intravitreal injection, Avastin intravitreal injection
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Medical University of Vienna
Retinal Vein Occlusion, Macular Edema
A Long-Term Safety Study of OZURDEX® in Clinical Practice
This study is a multicenter, prospective, observational study to evaluate the long-term safety of OZURDEX® in patients with macular oedema following central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) or…
- Conditions
- Retinal Vein Occlusion, Macular Edema, Uveitis, Posterior
- Trial name
- NCT01539577
- Testing
- dexamethasone 700 μg intravitreal implant
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 875 people
- Sponsor
- Allergan
Retinal Vein Occlusions
Anatomic Outcomes Following Ozurdex Injections
Ozurdex(TM) has recently been FDA approved for use in macular edema secondary to retinal vein occlusion. It remains unclear how quickly the drug works and for how long as the initial studies did not have frequent anatomic…
- Trial name
- NCT01282411
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Barnes Retina Institute
Central Retinal Vein Occlusion
Surgical Stabilizer Assisted RVC With rtPA for CRVO
This phase Ib study investigates the safety and efficacy of performing a retinal vein cannulation with recombinant tissue Plasminogen Activator infusion into a retinal vein with the help of an updated dedicated surgical…
- Trial name
- NCT03417401
- Testing
- Vitrectomy with retinal vein cannulation and intravenous rtPA (Actilyse) infusion up to 1mg., Intravenous Infusion
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Macular Edema
Major and Macular Branched Retinal Venous Occlusion
Although it is important in the clinical management to classify BRVO into subtypes based on the location of the occlusion (major or macular), few studies have provided such information[8,9].
- Trial name
- NCT01219205
- Testing
- intravitreal bevacizumab
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Hallym University Medical Center
Visual Impairment, Macular Edema
Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Branch Retinal Vein Occlusion (BRVO)
This clinical trial is designed to compare ranibizumab in comparison with Dexamethasone implant after 6 months of treatment. In the study arm Ranibizumab will be given monthly in a pro re nata scheme whereas the comparator…
- Conditions
- Visual Impairment, Macular Edema, Branch Retinal Vein Occlusion
- Trial name
- COMRADE-B (NCT01396057)
- Testing
- Ranibizumab, Dexamethasone Implant
- Where
- 66 sites in Czechia, Germany and 3 more
- Volunteers
- 244 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Macular Edema (DME), Neovascular Age-related Macular Degeneration (NVAMD)
A 2-part Study Consisting of a Multiple Ascending Dose Safety Study in Participants With Macular Edema Following Branch Retinal Vein Occlusion and a Dose-finding Safety and Preliminary Efficacy Study in Participants With Either Diabetic Macular Edema or Neovascular Age-related Macular Degeneration
EYE-TIE-201 is a 2-part study to investigate the safety and effectiveness of a new drug being developed called EYE201. All participants in the study will receive a total of 3 injections of EYE201 into the study eye, spaced at 4…
- Conditions
- Diabetic Macular Edema (DME), Neovascular Age-related Macular Degeneration (NVAMD), BRVO - Branch Retinal Vein Occlusion
- Trial name
- NCT06664502
- Testing
- EYE201
- Where
- 27 sites in United States, Puerto Rico
- Volunteers
- 38 people
- Sponsor
- EyeBiotech Ltd.
Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome
Ultrasound Elastography to Predict Development of SOS
The long-term goal of our research is to accurately identify SOS patients who would benefit from defibrotide treatment using US SWE. The overall objective of this study is to validate SWE as an early diagnostic marker for SOS.
- Conditions
- Bone Marrow Transplant Complications, Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Stem Cell Transplant Complications
- Trial name
- NCT03858530
- Testing
- Ultrasound Examination
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetic Macular Edema, Vogt Koyanagi Harada Disease
Custom Needle Preparation for Suprachoroidal Steroid Injection (One Year Results)
Suprachoroidal drug delivery is a recent route for managing various ocular conditions. Safety and long term results are still under investigations.
- Conditions
- Diabetic Macular Edema, Vogt Koyanagi Harada Disease, Retinal Vein Occlusion
- Trial name
- NCT05496530
- Testing
- Suprachoroidal triamcinolone acetonide injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Retinal Vein Occlusion
Ultra-wide-field Fluorescein Angiography in Patients With Retinal Vein Occlusion
The changes of ischemic index and vascular leakage index, and the effect on macular edema and neovascularization in retinal vein occlusion by ultra-wide field fluorescence angiography (UWFA)
- Trial name
- UWFARVO (NCT04075695)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Renmin Hospital of Wuhan University
Hypertensive Patients With Retinal Vein Occlusion
Diameters and Wall-to-lumen Ratio of Retinal Arterioles in Patients With Retinal Vein Occlusion.
to evaluate the wall-to-lumen ratio (WLR) of retinal arterioles in hypertensive patients with retinal vein occlusion (RVO) before and after dexamethasone intravitreal implant 0.7 mg (DEX) compared to a matched control group of…
- Trial name
- NCT01789437
- Testing
- Dexamethasone Intravitreal Implant (Ozuredex)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Brescia
Veno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome
Liver Stiffness Measurement Predicts VOD/SOS Development (ELASTOVOD ITALIAN MULTICENTRIC STUDY)
ELASTOVOD is a prospective multicenter study, involving several centers of Onco-haematology in Italy. Investigators perform hepatic elastographic measurements (with Transient Elastography, ARFI or 2D-SWE) on patients undergoing…
- Conditions
- Veno Occlusive Disease, Hepatic, Sinusoidal Obstruction Syndrome, Stem Cell Transplant Complications
- Trial name
- ELASTOVOD (NCT03426358)
- Testing
- LSM assessed by Elastographic Techniques
- Where
- 37 sites in Italy
- Volunteers
- 1,101 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Retinal Vein Occlusion
Ozurdex for Retinal Vein Occlusion Study (ORVO Study)
To measure the pro-permeability factors in the aqueous humor of patients with persistent/recurrent macular edema after an injection of Ozurdex.
- Trial name
- ORVO (NCT01790685)
- Testing
- dexamethasone implant
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Hepatic Veno-Occlusive Disease
Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study
Single arm, open-label study to provide Defibrotide to patients diagnosed with VOD. Defibrotide is no longer available though the Emergency Use IND mechanism (also known as compassionate use, or single patient named use).
- Trial name
- Treatment IND (NCT00628498)
- Testing
- Defibrotide
- Where
- 125 sites in United States
- Volunteers
- 1,206 people
- Sponsor
- Jazz Pharmaceuticals
Muscle Tightness, Hypertrophy
Comparison of Occlusive and Classical Hypertrophy Training in Terms of Thickness and Stiffness of The Muscle
Occlusive or ischemic training is a type of strength training which is becoming more and more popular every day. The safety, efficacy and detailed description about the use of occlusive training is well documented in the…
- Conditions
- Muscle Tightness, Hypertrophy, Occlusion Vein
- Trial name
- NCT03149133
- Testing
- Heavy hypertrophy training, Light hypertrophy training
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Macular Edema, Central Retinal Vein Occlusion
Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
The present study provided additional efficacy and safety data for 0.5-mg ranibizumab using as needed (PRN) dosing over 24 months in patients with visual impairment due to macular edema secondary to Central Retinal Vein Occlusion…
- Trial name
- CRYSTAL (NCT01535261)
- Testing
- Ranibizumab 0.5 mg/0.05 ml
- Where
- 78 sites in Australia, Austria and 16 more
- Volunteers
- 357 people
- Sponsor
- Novartis Pharmaceuticals
Macular Edema, Retinal Vein Occlusion
Retrospective Data Collection Study in Patients With Macular Oedema Receiving OZURDEX®
This study will use retrospective data to evaluate the safety and efficacy of OZURDEX® (dexamethasone intravitreal implant 0.7 mg) in the treatment of macular oedema due to retinal vein occlusion (RVO) in clinical practice.
- Trial name
- NCT02181530
- Testing
- No Intervention
- Where
- Poland
- Volunteers
- 43 people
- Sponsor
- Allergan
Branch Retinal Vein Occlusion
Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion
The purpose of this study is to evaluate the effect of intravitreal injections of Macugen every 6 weeks for the treatment of macular edema secondary to branch retinal vein occlusion (BRVO).
- Trial name
- NCT00406107
- Testing
- pegaptanib sodium (Macugen)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Palmetto Retina Center, LLC
Macular Edema, Retinal Vein Occlusion
Suprachoroidal Injection of Triamcinolone Acetonide With IVT Aflibercept in Subjects With Macular Edema Following RVO
A phase 2, multicenter, randomized, active-controlled, masked, parallel arm study designed to evaluate the safety and efficacy of a single suprachoroidal injection of CLS-TA, triamcinolone acetonide injectable suspension, given…
- Trial name
- TANZANITE (NCT02303184)
- Testing
- 4 mg CLS-TA, IVT aflibercept
- Where
- 14 sites in United States
- Volunteers
- 46 people
- Sponsor
- Clearside Biomedical, Inc.