Clinical trials: Venous Congestion
Venous Congestion, Postoperative Care
Portal and Splenic Venous Pulsatility in Postoperative Critically Ill Patients
Venous congestion is common in critically ill postoperative patients and may be associated with adverse outcomes. Doppler ultrasound assessment of venous flow patterns, including portal venous pulsatility, is increasingly used to…
- Trial name
- PULSE-ICU (NCT07826481)
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Cardiac Surgical Procedures, Hemodynamics
Structured Hemodynamic Assessment to Guide Care After Cardiac Surgery
This multicenter pilot randomized controlled trial will evaluate whether providing treating physicians with a structured hemodynamic assessment influences care after cardiac surgery.
- Conditions
- Cardiac Surgical Procedures, Hemodynamics, Fluid Therapy, Acute Kidney Injury
- Trial name
- UTF-in-CVICU (NCT07792707)
- Testing
- Expert Report of a Structured Hemodynamic Assessment, Standard Care (in control arm)
- Where
- 2 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pulmonary Hypertension, Thromboembolism, Pulmonary
Perioperative Portal Vein Pulsatility as a Postoperative Prognostic Indicator in Pulmonary Endarterectomy
The investigators aim to evaluate the utility of portal vein pulsatility as a predictor of the composite outcome of persistent organ dysfunction plus death in patients undergoing elective or urgent pulmonary endarterectomy for…
- Conditions
- Pulmonary Hypertension, Thromboembolism, Pulmonary, Perioperative/Postoperative Complications, Venous Hypertension
- Trial name
- PVP-ETO-CPC (NCT03197792)
- Testing
- All patients
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Venous Congestion, Heart Failure Acute
Vexus Assessment and Natriuresis-guided Diuretic Therapy in Acute Heart Failure
This study evaluates whether natriuresis-guided diuretic therapy improves outcomes in patients with acute heart failure (AHF) and severe congestion.
- Conditions
- Venous Congestion, Heart Failure Acute, VExUS, Diuretics
- Trial name
- VANTAGE-HF (NCT07558798)
- Testing
- Natriuresis-guided escalation of loop diuretics
- Where
- 2 sites in Norway
- Volunteers
- 270 people
- Sponsor
- University Hospital, Akershus
Pelvic Pain, Varicose Veins
Embolization of Pelvic Varicosities in Patients With Pelvic Congestion Syndrome
Results of recent systematic reviews suggest favorable results of embolization for the treatment of Pelvic Congestion Syndrome (PCS) compared with pre-procedure symptoms for several outcomes, including pain reduction, overall…
- Trial name
- NCT03057067
- Testing
- Embolization of pelvic vein varicosities
- Where
- Norway
- Volunteers
- 3 people
- Sponsor
- St. Olavs Hospital
Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after surgery and anesthesia. Its primary clinical manifestations include a significant decline in cognitive abilities after surgery and…
- Trial name
- NCT07483151
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POCD assessments
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhuan Zhang
Hemodynamic, Fluid Responsiveness
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes.
- Conditions
- Hemodynamic, Fluid Responsiveness, Venous Congestion, Fluid Challenge
- Trial name
- FREVO (NCT06772038)
- Where
- 3 sites in China, France
- Volunteers
- 64 people
- Sponsor
- Bicetre Hospital
Fluid Overload, Congestion
Determinants of Portal Vein Pulsatility Index
The pulsatile pattern of the portal vein is considered a marker of right ventricular dysfunction, but volemia may also contribute to this phenomenon.
- Trial name
- NCT06582368
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Pelvic Congestive Syndrome, Pelvic Varices
Endovascular Versus Medical Treatment for the Pelvic Congestion Syndrome
Compare the efficacy and safety of endovascular treatment with sandwich technique (controlled release coils and 2% polidocanol foam) associated with diosmin-hisperidine and ibuprofen medical treatment and only the best chronic…
- Conditions
- Pelvic Congestive Syndrome, Pelvic Varices, Venous Disease
- Trial name
- ENDPCS (NCT04358497)
- Testing
- Medtronic® Concerto® detachable coil system, sclerosis, Diosmin / Hesperidin
- Volunteers
- 120 people
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Pelvic Congestion Syndrome
Embolization of Ovarian Vein and Pelvic Venous Reservoir for Treatment of Secondary Pelvic Congestion Syndrome
Transcatheter Embolization of Ovarian Vein and Pelvic Venous Reservoir for Treatment of Pelvic Congestion Syndrome Secondary to May-Thurner Syndrome.
- Trial name
- NCT07472504
- Testing
- embolization therapy
- Volunteers
- 100 people
- Sponsor
- Mark Magdy Zekry
Acute Kidney Injury, Cardiac Surgery
Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery
Acute kidney injury affects more than 30% of patients after cardiac surgery, and is associated with an excess in mortality. There is a clinical continuum between acute kidney injury (transient if <48h, persistent if >48h), the…
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Venous Congestion, Hemodynamic Stability
- Trial name
- VeXUS (NCT06251713)
- Testing
- VeXUS score guided fluid management strategy, Usual care
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Pancreas Cancer, Pancreatectomy
Gastric Venous Reconstruction After Total Pancreatectomy
Total pancreatoduodenectomy (TP) is the standard surgical approach for treatment of extended pancreas tumors. If the gastric coronary vein has to be sacrificed for oncologic or for technical reasons in total pancreatectomy with…
- Trial name
- GENDER (NCT04850430)
- Testing
- Gastric venous reconstruction
- Where
- 2 sites in Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
Congestion, Heart Failure
Portal Vein Flow Variability to Quantify Right-Sided Hemodynamic Congestion (PORTAL)
This study evaluates the accuracy of a comprehensive venous Doppler echography including the portal vein pulsatility index (PVPI) to quantify invasively measured right-sided venous pressures.
- Conditions
- Congestion, Heart Failure, Right Heart Catheterisation, Central Venous Pressure
- Trial name
- PORTAL (NCT05411263)
- Testing
- Comprehensive transthoracic echocardiography, Doppler echography & Kino-cardiograph (Kino)
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Vrije Universiteit Brussel
Malignant Liver Tumor
Deportalization, Venous Deprivation, Venous Congestion
Patients with multiple primary or secondary liver tumors have a low survival rate unless they can benefit from curative extended hepatic resections with R0 or R1 marge resection.
- Trial name
- NCT03995459
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
ARDS, Acute Kidney Injury
Mechanical Ventilation-induced Acute Kidney Injury [AKI]
Positive end-expiratory pressure (PEEP) is a fundamental tool in the management of patients with acute respiratory distress syndrome (ARDS). However, there is currently no common criterion for deciding which level of PEEP to use.
- Trial name
- AKI (NCT06638255)
- Testing
- Sequence A involves administering Low PEEP for 12 hours, followed by High PEEP for 12 hours., Sequence B involves setting High PEEP for 12 hours, followed by Low PEEP for 12 hours.
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Heart Failure (AHF), Fluid Over-load
Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.
This randomized controlled trial evaluates the effectiveness of two training approaches (in-person versus remote) for teaching medical residents to apply the Venous Excess Ultrasound (VExUS) score for bedside volume assessment in…
- Conditions
- Acute Heart Failure (AHF), Fluid Over-load, Congestion, Congestion, Venous
- Trial name
- NCT07541768
- Testing
- In-person VExUS Training Program, Remote VExUS Training Program, No intervention
- Where
- Switzerland
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Patency, Hepatic Venous Congestion
Usability of Ringed Polytetrafluoroethylene Graft for Venous Vascular Reconstruction of Living Donor Liver Transplantation
Middle hepatic vein (MHV) reconstruction with an interposition vessel graft has been settled as a standard procedure for living donor liver transplantation (LDLT) using a right lobe graft.
- Trial name
- MHVLDLT (NCT01205802)
- Testing
- MHV reconstruction
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
Cardiorenal Syndrome, Heart Failure
Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure
The purpose of this study is to assess the feasibility, safety and effectiveness of VExUS guided organ decongestion compared to standard of care in patients hospitalized with acute decompensated heart failue (ADHF).
- Conditions
- Cardiorenal Syndrome, Heart Failure, Acute Kidney Injury, Acute Decompensated Heart Failure
- Trial name
- VExOUS-ADHF (NCT06714409)
- Testing
- VExUS guided decongestion
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Acute Renal Failure (ARF)
Venous Congestion and Acute Renal Failure in Cardiac Surgery Postoperative
Acute renal failure (ARF) is a frequent complication in the postoperative cardiac surgery, and is a major risk factor for mortality in this context.
- Trial name
- COVD (NCT03013621)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Venous Hemodynamics
Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score
The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting.
- Trial name
- VeNIVPro (NCT07273617)
- Testing
- application of PEEP: starting PEEP = 15 mbar, application of PEEP: starting PEEP = 0 mbar
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland