Clinical trials: Venous Leg Ulcers
Chronic Leg Ulcers, Wound Healing
Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers
Some leg ulcers do not seem to respond that well to the standard treatments that we currently use. One reason for this may be that there are high levels of bacteria in the ulcer which may be slowing down the rate of healing.
- Trial name
- NCT00825760
- Testing
- Topical PPA904 gel and light
- Where
- 4 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- Photopharmica
Venous Ulcers, Bedsores
HealiAid in the Treatment of Different Wounds
The goal of this open-label, post-market clinical follow-up study is to demonstrate the safety and effectiveness of HealiAid Collagen Wound Dressing in patients classified into different types of wounds: venous ulcers, bedsores…
- Conditions
- Venous Ulcers, Bedsores, Diabetic Foot Wound, Burn Wound
- Trial name
- NCT06280053
- Testing
- HealiAid Collagen Wound Dressing
- Volunteers
- 18 people
- Sponsor
- Maxigen Biotech Inc.
Diabetic Foot Ulcer, Venous Leg Ulcer
Modified Multi-Platform Trial Assessing Multiple CAMPs and SOC vs SOC Alone in the Treatment of DFU and VLUs
This is a multicenter, prospective, randomized controlled modified multi-platform (matriarch) trial evaluating several cellular, acellular, and matrix-like products (CAMPs) and standard of care versus standard of care alone in…
- Conditions
- Diabetic Foot Ulcer, Venous Leg Ulcer, Ulcer Foot, Leg Ulcer
- Trial name
- NCT06560502
- Testing
- Standard of Care-DFU, AmnioCore - DFU, Amnio Quad-Core - DFU
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Stability Biologics
Wounds and Injuries, Venous Leg Ulcer
DURAFIBER Ag Post-Market Clinical Follow-Up
The aim of the study is to evaluate the performance of DURAFIBER Ag and to assess how many bacteria are present in infected wounds over an 8 week period.
- Conditions
- Wounds and Injuries, Venous Leg Ulcer, Infection
- Trial name
- NCT03277131
- Testing
- DURAFIBER Ag
- Where
- 7 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Smith & Nephew, Inc.
Venous Leg Ulcer, Venous Insufficiency of Leg
Preliminary Investigation of a Smart Compression Therapy Prototype
Compression wraps treat venous leg ulcers when applied correctly. Often, clinicians apply the wraps at the wrong compression, or the wrap loosens, stopping clinical benefits.
- Trial name
- PRESUF-VLU (NCT05610241)
- Testing
- Compression Therapy System Prototype, Standard Compression
- Where
- Ireland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- DeRoyal Industries, Inc.
Venous Leg Ulcer
Impact of Venotrain UlcerteC Venous Compression Device in the Treatment of Venous Ulcers in Daily Practice
The cornerstone of the management of venous leg or predominantly venous leg ulcers with IPS> 0.8 is venous compression as recommended by the HAS in June 2006.
- Trial name
- INVICTUS (NCT03736941)
- Testing
- Patients with venous leg
- Where
- 2 sites in France
- Volunteers
- 129 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Foot Ulcer, Varicose Ulcer
Skin Ulcers Treatment With an Handicraft Topical Device
The aim of this study was to evaluate the efficacy of a handicraft topical device of negative pressure versus traditional healing treatment for skin ulcers in lower limbs; in patients with diabetes mellitus, venous stasis and…
- Trial name
- NCT02512159
- Testing
- drenovac handcrafted, Healing
- Volunteers
- 144 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Pathologic Processes, Diabetes Mellitus
Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs
The purpose of the study is to evaluate the efficacy of multiple human placental membrane products and Standard of Care (SOC) versus SOC alone in the management of nonhealing diabetic foot ulcers (DFUs) and venous leg ulcers…
- Conditions
- Pathologic Processes, Diabetes Mellitus, Glucose Metabolism Disorders, Metabolic Diseases
- Trial name
- C5CAMP (NCT06674980)
- Testing
- Standard of Care - DFU, AM/Single - DFU, AM/Double - DFU
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- C5 Biomedical
Venous Leg Ulcer
Low Dose Aspirin for Venous Leg Ulcers
Venous leg ulcers (VLU) are the most common leg ulcer, can be painful, and limit work, lifestyles and activity, especially in older patients.
- Trial name
- Aspirin4VLU (NCT02158806)
- Testing
- Aspirin
- Volunteers
- 251 people
- Sponsor
- University of Auckland, New Zealand
Ulcers
A Clinical Study of the Safety and Efficacy of MEBO Wound Ointment in Subjects With Venous Leg Ulcers
This is a Phase II, randomized, controlled, two-center pilot study designed to assess the safety and efficacy of MEBO in the treatment of 14 subjects with VLUs.
- Trial name
- NCT01138436
- Testing
- MEBO Wound Ointment (MEBO), Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Skingenix, Inc.
Venous Leg Ulcer (VLU), Diabetic Foot Ulcer (DFU)
A Real World Data Collection of Human Amniotic Membrane(s) on Diabetic Foot Ulcers, Venous Leg Ulcers, Pressure Ulcers and Post Operative Wounds
This study is designed to evaluate the effectiveness of Tri-Membrane Wrap™, Membrane Wrap™ and Membrane Wrap-Hydro™ compared to the effectiveness of Standard of Care alone though a retrospective data collection.
- Conditions
- Venous Leg Ulcer (VLU), Diabetic Foot Ulcer (DFU), Pressure Ulcer (PU)
- Trial name
- NCT07078968
- Testing
- Tri-Membrane Wrap™, Membrane Wrap™, Membrane Wrap-Hydro™
- Where
- 4 sites in United States
- Volunteers
- 500 people
- Sponsor
- BioLab Holdings
Venous Thromboses, Venous Disease
The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study
This study is a prospective, non-randomized, multicenter, single-arm, clinical study to evaluate the performance, safety and efficacy of the GORE® VIABAHN® FORTEGRA Venous Stent (formerly known as GORE® VIAFORT Vascular Stent)…
- Conditions
- Venous Thromboses, Venous Disease, Venous Leg Ulcer, Venous Stasis
- Trial name
- NCT05489588
- Testing
- GORE® VIAFORT Vascular Stent
- Where
- 24 sites in United States
- Volunteers
- 165 people
- Sponsor
- W.L.Gore & Associates
Diabetic Ulcers, Arterial Ulcers
Multicenter, Randomized, Non-inferiority Study to Compare the Performance and Safety of Debrisoft® Duo With Debrisoft® Pad in the Debridement of Wounds
The aim of this post market clinical follow up (PMCF) study is to confirm the performance of Debrisoft® Duo, to collect safety data regarding expected adverse events and to detect potential unexpected adverse events associated…
- Conditions
- Diabetic Ulcers, Arterial Ulcers, Venous Ulcers, Pressure Ulcers
- Trial name
- NCT07312513
- Testing
- two sided debridement pad, one sided debridment pad
- Where
- 5 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Lohmann & Rauscher
Venous Leg Ulcer
Helium Neon Laser Versus Gallium Arsenide Laser
There will be different effects for different laser wavelengths in treatment of venous ulcer.
- Trial name
- NCT04689620
- Testing
- laser
- Volunteers
- 60 people
- Sponsor
- Mahmoud Awad Ramadan Elkholy
Chronic Venous Leg Ulcers
Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers
The primary objective is to evaluate the clinical benefit of CureXcell® as adjunct to Standard of Care in the treatment of Chronic Venous Leg Ulcers.
- Trial name
- NCT02130310
- Testing
- CureXcell®
- Where
- 28 sites in United States
- Volunteers
- 252 people
- Sponsor
- Macrocure Ltd.
Venous Leg Ulcer
Treatment Outcome of Autologous PRP Versus Conventional Therapy Among Patients With Chronic Venous Leg Ulcers
The use of PRP has dramatically increased in the fields of orthopedics, spine surgery, reconstructive plastic surgery, oral and maxillofacial surgery, and dermatological indications.
- Trial name
- NCT05974982
- Testing
- PRP, Conventional therapy
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Venous Leg Ulcers
A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Chronic Non-Healing Venous Leg Ulcers
To assess the efficacy of the PRP Concepts Fibrin Bio-Matrix and compare its performance with usual and customary practice for the treatment of chronic non-healing venous leg ulcers (VLU).
- Trial name
- NCT02312518
- Testing
- PRP Concepts Fibrin Bio-Matrix, Usual and Customary Practice
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- PRP Concepts, LLC
Varicose Ulcer
Wool-derived Keratin Dressings for Venous Leg Ulcers
Venous leg ulcers (VLU) are the most common leg ulcer, can be painful, and limit work, lifestyles and activity, especially in older patients.
- Trial name
- Keratin4VLU (NCT02896725)
- Testing
- Keratin dressings, Usual care dressings
- Where
- New Zealand
- Volunteers
- 143 people
- Sponsor
- University of Auckland, New Zealand
Venous Ulcers
Effectiveness of Double-layer Compression Therapy in the Healing of Chronic Venous Ulcers in Primary Health Care
The purpose of this study is to evaluate the effectiveness of a multilayer compression bandage (two layers), compared with the crepe bandage, on healing of venous leg ulcers, in patients attended in nursing Primary Care Health…
- Trial name
- NCT02364921
- Testing
- Two multilayer compression bandage, Crepe bandage
- Where
- Spain
- Volunteers
- 93 people
- Sponsor
- Gerencia de Atención Primaria, Madrid
Skin Ulcer Venous Stasis Chronic, Mixed Arteriovenous Leg Ulcer
Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers
The purpose of this study is to determine the effectiveness of the NatroxTM Topical Oxygen device versus a placebo in patients with non-healing leg ulceration in conjunction with standard best practice.
- Trial name
- NCT01913704
- Testing
- NatroxTM Device
- Where
- 2 sites in Czechia
- Sponsor
- Inotec AMD Limited