Clinical trials: Venous Thrombosis (Disorder)
Deep Vein Thrombosis, Atrial Fibrillation
Evaluation of Precision and Accuracy of INR Measurements in a Point of Care Device
Comparison of capillary whole blood INR determined by LumiraDx Instrument to venous plasma INR determined by laboratory reference method (IL ACL ELITE PRO) for method comparison and assessment of accuracy and bias by regression…
- Conditions
- Deep Vein Thrombosis, Atrial Fibrillation, Post-Myocardial Infarction Syndrome, Pulmonary Embolism
- Trial name
- OPTIMAL (NCT03682419)
- Testing
- VKA Patients, Non-VKA Patients
- Where
- 3 sites in United Kingdom
- Volunteers
- 420 people
- Sponsor
- LumiraDx UK Limited
Venous Thrombosis
Peripherally Inserted Central Catheter (PICC) Thrombosis: Reverse Taper Versus Non-tapered Catheters
The purpose of this study is to compare two different marketed PICC (peripherally inserted central catheter) designs. Clotting rates, procedural bleeding and ease of catheter insertion will be compared.
- Trial name
- NCT00728819
- Testing
- Tapered PICC, Non-tapered PICC
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- University of Pennsylvania
Central Retinal Vein Occlusion
Spontaneous Retinal Artery Pulses (SPARs) as a Prognostic Determinant of Central Retinal Vein Occlusions (CRVO) in Patients With or Without Intravitreal Aflibercept Injections
Central retinal vein occlusion (CRVO) is the second most common retinal vascular disease after diabetic retinopathy. It induces circulatory slowdown and blood stasis, which can appear as retinal hemorrhages.
- Trial name
- PULSOV (NCT04793100)
- Testing
- Ophthalmologic exam at inclusion and 12 months after CRVO, Treatment standardization with aflibercept
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Venous Thromboembolic Disease
Cost Effectiveness Analysis of an Ancillary Study of the REMOTEV Study
The implications of the medico-economic impact are essential in the choice of first-line therapists. The economic impact is an important criterion to recommend the privileged use of Direct Oral Anticoagulants (AOD) in first…
- Trial name
- NCT03887806
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Macular Edema, Central Retinal Vein Occlusion
Conbercept Ophthalmic Injection for Patients of Central Retinal Vein Occlusion
This study evaluates the efficacy and safety of Conbercept ophthalmic injection. This is a multi-center, randomized, double-masked, placebo-controlled phase III clinical study.
- Trial name
- CRAVE (NCT03223714)
- Testing
- Conbercept Ophthalmic Injection
- Where
- 27 sites in China
- Volunteers
- 242 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Venous Thromboembolism
The Use of Fondaparinux in Preventing Thromboembolism in High Risk Trauma Patients
Trauma patients are at high risk of developing deep vein thrombosis (DVT) and pulmonary embolism (PE). The incidence of DVT varies greatly from 5-63% among studies depending on patient's individual risk factors, modality of…
- Trial name
- NCT00531843
- Testing
- fondaparinux sodium, sequential compression devices
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Mary Knudson, M.D.
Cerebral Stroke, Cerebral Venous Thrombosis
Intracranial Hypertension and Optic Nerve Sheath Diameter
Intracranial hypertension (ICH) is a mortality risk factor in severe traumatic brain injury (TBI), in purulent meningitis, in hepatic encephalopathy and in Reye's syndrome.
- Trial name
- DENO (NCT01796015)
- Testing
- ONSD ultrasound
- Where
- 2 sites in France
- Volunteers
- 230 people
- Sponsor
- Hospices Civils de Lyon
Cardiovascular Diseases, Venous Thromboembolism
Mutations, Hormone Therapy (HRT) and Venous Thromboembolism
To assess the interaction between hormone replacement therapy and the prothrombotic mutations, Factor V Leiden and the recently described prothrombin mutation (20210A) on the incidence of venous thromboembolism (VTE) in a…
- Conditions
- Cardiovascular Diseases, Venous Thromboembolism, Postmenopause
- Trial name
- NCT00005515
- Sponsor
- University of Washington
Cardiovascular Diseases, Heart Diseases
Prevention of Recurrent Venous Thromboembolism (PREVENT)
A multicenter randomized, double blind placebo controlled trial to determine the efficacy of long-term, low dose warfarin in the secondary prevention of venous thromboembolism.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Peripheral Vascular Diseases, Thromboembolism
- Trial name
- NCT00000614
- Testing
- warfarin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Deep Venous Thrombosis
Study to Assess Safety, Tolerability, and Efficacy of GMI-1271 in Patients With Calf-level Deep Venous Thrombosis (DVT)
This study will evaluate the safety profile of GMI-1271 and its effect on thrombus resolution in patients with distal calf vein Deep Venous Thrombosis (DVT).
- Trial name
- NCT02744833
- Testing
- GMI-1271, Enoxaparin Sodium (Lovenox®)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- GlycoMimetics Incorporated
Venous Thromboembolism
Rivaroxaban and Vitamin K Antagonists for the Anticoagulation for the Implantation of Vena Cava Filters
The purpose of this study is to evaluate the efficacy and safety of new oral anticoagulants and vitamin K antagonists for the anticoagulation for the implantation of vena cava filters in patients with deep venous thrombosis.
- Trial name
- EPICT (NCT04066764)
- Testing
- Rivaroxaban, Warfarin, Nadroparin
- Where
- 7 sites in China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepatocellular Carcinoma, Radiotherapy
Phase II Study of Concurrent Lenvatinib and Radiotherapy for Advanced HCC
This is a single-arm, open-label study performed at our hospital, patients with progression hepatocellular carcinoma (HCC) met inclusion criteria will be enrolled.
- Conditions
- Hepatocellular Carcinoma, Radiotherapy, Lenvatinib
- Trial name
- NCT04791176
- Testing
- concurrent lenvatinib and Radiotherapy, followed lenvatinib maintenance
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer
Incidence of Venous Thromboembolism and Cardiovascular Events in Breast Cancer Patients Undergoing Cyclin-dependent Kinase 4/6 Inhibitors: The Breast Cancer Associated Vascular Events During Cyclin-dependent Kinase 4/6 Inhibitors Therapy (BRAVE-Cyclin) Study
"Incidence of Venous Thromboembolism and Cardiovascular Events in Patients with Breast Cancer Treated with Cyclin-Dependent Kinase Inhibitors 4/6, the BRAVE-Cyclin Study" is national, single-center, observational, prospective…
- Trial name
- BRAVE-Cyclin (NCT07008508)
- Testing
- Cyclin-dependent Kinase 4/6 Inhibitor
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Macular Edema, Retinal Vein Occlusion
A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion
This study will evaluate the safety and efficacy of an intravitreal implant of dexamethasone for the treatment of macular edema associated with retinal vein occlusion.
- Trial name
- NCT00168324
- Testing
- 700 µg Dexamethasone, 350 µg Dexamethasone
- Where
- 13 sites in United States, Australia and 11 more
- Volunteers
- 599 people
- Sponsor
- Allergan
Venous Thrombosis, Pulmonary Embolism
Deep Venous Thrombosis After Hepatobiliopancreatic Surgery
To investigate the incidence of pre- and early postoperative deep venous thrombosis in patients undergoing hepatobiliopancreatic surgery, as well as potential corresponding risk factors with special attention to circulating tumor…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Hepatectomy, Pancreatectomy
- Trial name
- POPLITEA (NCT02649023)
- Where
- Germany
- Volunteers
- 76 people
- Sponsor
- Technische Universität Dresden
Cerebral Vein Thrombosis
Rivaroxaban vs. Warfarin in CVT Treatment
Cerebral venous thrombosis (CVT) is an uncommon venous-type of stroke tends to affect younger patients with somewhat different risk factors and much better outcome compared to arterial strokes.
- Trial name
- RWCVT (NCT04569279)
- Testing
- Rivaroxaban, Warfarin
- Where
- Syria
- Volunteers
- 71 people
- Sponsor
- Damascus University
Deep Vein Thrombosis
Whole-leg Ultrasound in Pregnant Patients
This study seeks to determine the rate of thromboembolic complications (blood clots), including death attributed to thromboembolic disease, when anticoagulation (blood thinner) therapy is withheld from pregnant patients suspected…
- Trial name
- CLOT-3 (NCT01319474)
- Testing
- Whole-leg compression ultrasound
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- Intermountain Health Care, Inc.
Macular Degeneration, Diabetic Retinopathy
Iopidine to Decrease Intraocular Pressure Rise After Injections
This is a prospective, randomized, controlled, open-label, single-site investigator-initiated clinical trial. A total of 120 participants will be randomized in a 1:1 ratio either to receive one drop of apraclonidine 1% ophthalmic…
- Conditions
- Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion, Glaucoma
- Trial name
- NCT07891910
- Testing
- Apraclonidine 1.0% ophthalmic solution
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Retina Consultants of Delmarva
Bariatric Surgery
Rivaroxaban as Thrombosis Prophylaxis in Bariatric Surgery
The aim of this study is to investigate the efficacy and safety of rivaroxaban in obese patients undergoing bariatric surgery. The objectives are to assess the safety and feasibility of venous thromboembolism (VTE) prophylaxis…
- Trial name
- BARIVA (NCT03522259)
- Testing
- Rivaroxaban 10 MG Oral Tablet [Xarelto]
- Where
- 3 sites in Switzerland
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Carcinoma, Renal Cell, Thrombus
Prognostic Factor for Renal Cell Carcinoma (RCC) With Venous Tumor Thrombus
Renal cell carcinoma (RCC) has its propensity to invade the venous system, with extension into the renal vein and the inferior vena cava (IVC) in 23% and 7%, respectively.
- Trial name
- NCT01328691
- Where
- South Korea
- Volunteers
- 118 people
- Sponsor
- Seoul National University Hospital
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