Clinical trials: Venous Thrombosis (Disorder)
Venous Thrombosis, Venous Insufficiency
Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome
Venous thrombosis is the development of a blood clot in a vein. Post-thrombotic syndrome (PTS) is a painful condition that can develop following a venous thrombosis in one of the deep veins of the leg.
- Trial name
- NCT00395265
- Where
- United States
- Volunteers
- 2,211 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Wet Macular Degeneration, Age-related Macular Degeneration
Dorzolamide-timolol Drops With Injections to Treat AMD, RVO or DME.
This study seeks to evaluate the effect of topical aqueous suppression on the anatomic and functional response to intravitreal anti-vascular endothelial growth factor (VEGF) injections in non-responders with wet age-related…
- Conditions
- Wet Macular Degeneration, Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT02571972
- Testing
- Dorzolamide-timolol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Wills Eye
Trauma Injury, Thromboembolism
Antithrombin to Improve Thromboprophylaxis and Reduce the Incidence of Trauma-Related Venous Thromboembolism
The purpose of this study is to determine if additional interventions will assist with decreasing the risk and/or severity of thromboembolism (clotting complications) in patients who have experienced a major traumatic event.
- Conditions
- Trauma Injury, Thromboembolism, Venous Thromboembolism
- Trial name
- TRAIT (NCT05794165)
- Testing
- Thrombate infusion
- Where
- 5 sites in United States
- Volunteers
- 314 people
- Sponsor
- Bryan Cotton
Macular Edema, Diabetic Macular Edema
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of IVT MHU650 in Macular Edema Patients
This was an open-label, multi-center, FIH study with a single ascending dose (SAD) design that assessed the safety, tolerability and pharmacokinetics (PK) of a single IVT dose of MHU650 in up to 24 participants with macular edema.
- Conditions
- Macular Edema, Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusion
- Trial name
- NCT04635800
- Testing
- MHU650
- Where
- 6 sites in United States, Puerto Rico
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension, Portal, Interventional Radiology
Percutaneous Portal Vein Recanalization for Refractory Portal Hypertension in Children With Non-Cirrhotic Extrahepatic Portal Vein Obstruction
This monocentric, prospective, observational study aims to evaluate the clinical efficacy, safety, and technical success of percutaneous portal vein recanalization (PVR) performed via interventional radiology.
- Conditions
- Hypertension, Portal, Interventional Radiology, Percutaneous Portal Vein Recanalization (PVR), Extrahepatic Portal Vein Obstruction (EHPVO)
- Trial name
- PRIMO-01 (NCT07873021)
- Testing
- Percutaneous Portal Vein Recanalization (PVR)
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Papa Giovanni XXIII Hospital
Retinal Vein Occlusion, Posterior Vitreous Detachment
Posterior Vitreous Detachment (PVD) Assessment During Dual Retinal Vein Occlusion (RVO) Lucentis Evaluations
This is a study of subjects with retinal vein occlusion (RVO) specifically looking at the difference in outcomes between patients with posterior vitreous detachment (PVD) and those without PVD.
- Trial name
- PADDLE (NCT00831350)
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Barnes Retina Institute
Venous Thromboembolism
Dose Ranging Study in Elective Total Hip Replacement Surgery
The primary objective is to: demonstrate the efficacy of SR123781A in the prevention of venous thromboembolism (VTE) by the demonstration of a dose-response in patients undergoing total hip replacement surgery.
- Trial name
- DRIVE (NCT00338897)
- Testing
- SR123781A
- Where
- 14 sites in Argentina, Bulgaria and 12 more
- Volunteers
- 1,090 people
- Sponsor
- Sanofi
Retinal Vein Occlusion
Extension Study to Compare Long-term Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With RVO
The study is intended to characterize the clinical benefit regarding safety and efficacy of a long term treatment with Lucentis in comparison with Ozurdex over an additional 6 months and a 3-month follow-up period, following the…
- Trial name
- NCT01580020
- Testing
- RFB002, Dexamethasone
- Where
- 37 sites in Germany
- Volunteers
- 175 people
- Sponsor
- Novartis Pharmaceuticals
Venous Thromboembolism, Pulmonary Embolism
Venous Thromboembolism in DM1
The risk for venous thromboembolism (VTE) in DM1 and in other inherited myopathies, which can lead to chronic immobilization, are unknown.
- Conditions
- Venous Thromboembolism, Pulmonary Embolism, Deep Vein Thrombosis, Myopathy
- Trial name
- DM1-VTE (NCT03141749)
- Volunteers
- 2,810 people
- Sponsor
- Institut de Myologie, France
Liver Cancer, Surgery
Pre- Vs Postoperative Thromboprophylaxis for Liver Resection
Thromboprophylaxis for liver surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in liver surgery patients, there is no international consensus when…
- Conditions
- Liver Cancer, Surgery, Thrombosis, Deep Vein, Embolism, Pulmonary
- Trial name
- PREPOSTEROUS (NCT04731558)
- Testing
- enoxaparin or tinzaparin or dalteparin, No intervention
- Where
- 7 sites in Finland, Norway
- Volunteers
- 1,012 people
- Sponsor
- Helsinki University Central Hospital
Post Thrombotic Syndrome, Deep Vein Thrombosis
Post Thrombotic Syndrome Prevention Study
This is a two arm, prospective, single center, randomized clinical trial. Subjects will be randomly assigned into one of two groups using block randomization technique in a 1:1 ratio.
- Trial name
- NCT03039517
- Testing
- ACTitouch, Compression garments (stockings)
- Where
- United States
- Sponsor
- NYU Langone Health
Graves' Disease, Graves Ophthalmopathy
Coagulation After Intravenous Methylprednisolone Administration
The alterations of coagulation and fibrinolysis parameters have been described in patients with endogenous Cushing's syndrome (CS) and those treated with glucocorticosteroids (GCs).
- Conditions
- Graves' Disease, Graves Ophthalmopathy, Blood Coagulation, Venous Thromboembolism
- Trial name
- NCT03535090
- Testing
- Methylprednisolone
- Volunteers
- 26 people
- Sponsor
- Piotr Miskiewicz
May-Thurner Syndrome, Deep Vein Thrombosis
Venous Stent for the Iliofemoral Vein Investigational Clinical Trial Using the DUO Venous Stent System
This is a prospective, multi-center, single-arm, non-blinded clinical trial designed to investigate the safety and efficacy of the Vesper DUO Venous Stent System as compared to a pre-defined performance goal (PG) established from…
- Conditions
- May-Thurner Syndrome, Deep Vein Thrombosis, Chronic Venous Insufficiency
- Trial name
- VIVID (NCT04580160)
- Testing
- Duo Venous Stent System
- Where
- 30 sites in United States, Poland
- Volunteers
- 162 people
- Sponsor
- Vesper Medical, Inc.
Retinal Artery Occlusion, Retinal Vein Occlusion
Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Trial name
- NCT02898480
- Testing
- Remote ischemic conditioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Retinal Vein Occlusion
NIR Fluorescence Molecular Imaging of ANXV-800CW in RVO Patients
The primary objective is safety, tolerability and feasibility of systemic intravenous injection of ANXV-800CW in patients with RVO in three dosing-cohorts in a phase I safety study.
- Trial name
- SIGHT (NCT05133791)
- Testing
- Annexin A5
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- University Medical Center Groningen
COVID-19, Hemostasis
Thrombo Embolic Events in Hospitalized Patients With Covid-19 Serious Acute Pneumopathy
The understanding of haemostasis and inflammation cross-talk has gained considerable knowledge during the past decade in the field of arterial and venous thrombosis.
- Conditions
- COVID-19, Hemostasis, Coagulation
- Trial name
- THROMBCOVID2 (NCT04377490)
- Testing
- venous ultrasound, blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Cardiac Surgery, Central Venous Catheter Thrombosis
Continuous Heparin Infusion to Prevent Catheter-related Thrombosis
Catheter-related thrombosis could impair blood flow in the vein, block the central venous catheter, induce catheter-related infection or venous thromboembolism in the deep veins or pulmonary vessels, which furthermore progress…
- Conditions
- Cardiac Surgery, Central Venous Catheter Thrombosis, Heparin
- Trial name
- NCT04767113
- Testing
- Heparin sodium, Normal saline
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Guangdong Provincial People's Hospital
Venous Thrombosis, Pulmonary Embolism
Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis
The purpose of this study is to determine whether a limited duration of treatment (two weeks of low molecular weight treatment) is a safe and effective treatment for distal deep vein thrombosis of the lower limb.
- Trial name
- TWISTER (NCT01252420)
- Testing
- Enoxaparin
- Where
- 4 sites in Australia, New Zealand
- Volunteers
- 330 people
- Sponsor
- Monash Medical Centre
Macular Edema, Cystoid
Dexamethasone Intravitreal Implant in Retinal Vein Occlusion
Purpose: To evaluate retinal functional improvement by means of visual acuity and retinal sensibility examination after intravitreal dexamethasone implant in patients affected by cystoid macular edema secondary to retinal vein…
- Trial name
- NCT03559491
- Testing
- Intravitreal injection
- Volunteers
- 30 people
- Sponsor
- Università degli Studi dell'Insubria
Venous Thrombosis
Oral Rivaroxaban in Children With Venous Thrombosis
The purpose of this study is to find out whether rivaroxaban is safe to use in children and how long it stays in the body. There will also be a check for bleeding and worsening of blood clots.
- Trial name
- EINSTEINJunior (NCT01684423)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Active comparator, Rivaroxaban (BAY59-7939) suspension
- Where
- 59 sites in United States, Australia and 8 more
- Volunteers
- 64 people
- Sponsor
- Bayer
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