Clinical trials: Ventilated Patient in Intensive Care
Intensive Care Unit, Mechanical Ventilation
Pharmacokinetic Study of Continuous Infusion of Remazolam in Mechanically Ventilated Patients in ICU
To study the pharmacokinetics of continuous infusion of remazolam in ICU mechanically ventilated critically ill patients, and the characteristics of PK in patients with liver failure; to explore whether liver failure affects the…
- Conditions
- Intensive Care Unit, Mechanical Ventilation, Anesthesia, Liver Failure
- Trial name
- NCT05480787
- Testing
- Remimazolam 0.1mg/kg/h, Remimazolam 0.3mg/kg/h, Remimazolam 0.5mg/kg/h
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Nutrition
Pilot: Feasibility of Intermittent Enteral Feeding in Ventilated MICU Patients
Specific Aims: Aim 1: Evaluate the feasibility of intermittent feeding in intensive care unit patients who are mechanically ventilated.
- Trial name
- NCT04164108
- Testing
- Intermittent Enteral Nutrition Protocol
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Intensive Care, Ventilator Lung
Respiratory Mechanics in Intensive Care Patients
This study aims at assessing the respiratory mechanics of intubated patients in intensive care unit.
- Trial name
- PREMIER (NCT03420417)
- Testing
- Esophageal pressure measurement
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Critically Ill, Subacute Adult Patients, Mechanically Ventilation
Effect of Inspiratory Muscle Training on Ventilated Patients in an Intensive Care Unit
The goal of this clinical trial is to learn if inspiratory muscle training facilite the liberation of mechanical ventilation. The main questions it aims to answer are: Does inspiratory muscle training facilitate weaning from…
- Trial name
- NCT06611683
- Testing
- Inspiratory muscle training, Routine care
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung University
Respiratory Failure
Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation
The purpose of this multi-center randomized controlled non-inferiority trial is to determine the effect of a strategy using routine nebulisation of mucolytics and bronchodilators (four times daily) as compared to a strategy using…
- Trial name
- Nebulae (NCT02159196)
- Testing
- acetylcysteine and salbutamol, acetylcysteine, salbutamol
- Where
- 7 sites in Netherlands
- Volunteers
- 950 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury
Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study.
Some ICU ventilated patients might present with large tidal volume despite very low or inexistant presser support. Patient-Self Inflicted Lung Injury (P-SILI) might appear related with large alveolar stretch an distension.
- Conditions
- Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury, Patient-Self Inflicted Lung Injury, Encephalopathy
- Trial name
- InLarge (NCT05056961)
- Testing
- Multiparametric mesurements
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Critical Illness and Mechanical Ventilation
Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients
The Use of sedative drugs in intensive care is widespread. A cohort study conducted in Australia and New Zealand in 2010 revealed a high prevalence of deep sedation within the first 48 hours of mechanical ventilation which was…
- Trial name
- SPICE III RCT (NCT01728558)
- Testing
- Early goal Directed Sedation, Standard care sedation
- Where
- 74 sites in Australia, Ireland and 6 more
- Volunteers
- 4,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critically Ill
Diaphragmatic Function in Ventilated Patients
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called…
- Trial name
- NCT00786526
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Acute Respiratory Distress Syndrome (ARDS), Ventilated Patient in Intensive Care
Comparison of Dynamic Mechanical Power Formula With Geometric Method in Pressure- and Volume-Controlled Ventilation: A Validation Study
This prospective observational study aims to validate the dynamic mechanical power (MPdyn) formula by comparing it with the gold-standard geometric method (MPgeo) in patients with acute respiratory distress syndrome (ARDS) who…
- Trial name
- NCT07099729
- Testing
- Volume-Controlled Ventilation (VCV) with inspiratory-to-expiratory (I:E) ratio of 1:2., Volume-Controlled Ventilation (VCV) with inspiratory-to-expiratory (I:E) ratio of 1:1., Pressure-Controlled Ventilation (PCV) with inspiratory-to-expiratory (I:E) ratio of 1:2.
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Intensive Care (ICU) Patients
Recovery and Aftercare in Post Intensive Care Therapy Patients - RAPIT Study
In 2010 alone were admitted 33,361 patients for treatment in Danish intensive care units. There is evidence to former intensive care patients have a significant symptom burden that affect recovery, function and activity for up to…
- Trial name
- RAPIT (NCT01721239)
- Testing
- Standardized Followup program
- Where
- Denmark
- Volunteers
- 340 people
- Sponsor
- Hillerod Hospital, Denmark
Obesity, Respiratory Insufficiency
Effects of Obesity on Care and Outcomes in Mechanically Ventilated Individuals in the Intensive Care Unit
Obesity is a significant health care issue in the United States, particularly among the critically ill. Preliminary research has shown that differences in ventilator management exist among obese and non-obese individuals.
- Trial name
- NCT00296088
- Where
- United States
- Volunteers
- 582 people
- Sponsor
- Ohio State University
Pharmacokinetics, Sedation
Pharmacokinetics of Dexmedetomidine During Prolonged Infusion in ICU
The study will examine dexmedetomidine levels in the blood of critically ill intensive care patients to understand how it is broken down by the body.
- Trial name
- DEX PK (NCT00747721)
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 13 people
- Sponsor
- Orion Corporation, Orion Pharma
Pulmonary Disease, Chronic Obstructive
Timing of Dilation Tracheostomy in Mechanically Ventilated Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is: to evaluate the optimal time-point for percutaneous dilation tracheostomy in COPD patients in terms of duration on mechanical ventilation, length of stay on ICU and mortality; to evaluate the rate of…
- Trial name
- NCT01021202
- Testing
- Percutaneous dilation tracheostomy
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ventilator Associated Pneumonia, Death
Futility of Exhaled Breath Condensate pH Measurements in Ventilated Patients in Intensive Care Unit (ICU)
Measurement of pH in Exhaled breath condensate has been mentioned as a robust variable from lung inflammation. It is non-invasive and reproducible.
- Trial name
- NCT01393431
- Where
- Argentina
- Volunteers
- 34 people
- Sponsor
- Universidad Nacional de Rosario
Mechanical Ventilation, Virtual Reality
Immersive Virtual Reality in Mechanically Ventilated Patients
New or worsening cognitive impairment occurs in up to 58% of survivors of critical illnesses and are long-lasting with significant disability and socioeconomic cost.
- Conditions
- Mechanical Ventilation, Virtual Reality, Delirium
- Trial name
- NCT03569358
- Testing
- Immersive Virtual Reality, EEG headband
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Intensive Care Unit Syndrome
High Protein Intake in Critically Ill Ventilated Patients
This prospective interventional randomized control study was conducted on forty patients with respiratory failure; all patients were intubated and mechanically ventilated for at least three days.
- Trial name
- NCT04977440
- Testing
- Whey protein
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Delayed Gastric Emptying
Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron
One big problem in mechanically ventilated ICU patients is delayed gastric emptying. Delayed gastric emptying in these patients, causes intolerance and high gastric residual volume (GRV) that can lead to abdominal distention…
- Trial name
- NCT05342818
- Testing
- Neostigmine, Ondansetron 8mg, Metoclopramide Injection
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Tanta University
Influenza A Virus Infection, Influenza B Virus Infection
Study of the Relative Oral Bioavailability of the Antiflu Medicine Oseltamivir in the Intensive Care Unit
This proposed pharmacokinetic study will test the hypothesis that in critically ill patients with respiratory failure requiring mechanical ventilation such as might be anticipated to be needed to treat patients with severe…
- Trial name
- NCT00844155
- Testing
- Oseltamivir 75 mg
- Where
- Canada
- Sponsor
- University of Manitoba
Mechanical Ventilation, Critical Illness
Acupressure for Agitation, Pain, and Sleep in Mechanically Ventilated ICU Patients
Mechanically ventilated intensive care unit (ICU) patients commonly experience agitation, pain, and sleep disturbances, which may negatively affect recovery and increase the need for sedative medications.
- Conditions
- Mechanical Ventilation, Critical Illness, Agitation, Pain
- Trial name
- CALM-ICU (NCT07619326)
- Testing
- Acupressure, Light Touch
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Yang Yun Shiuan
Mechanically Ventilated Patients
Early Directed Physical Therapy in the Management of Mechanically Ventilated Patients in a Medical Intensive Care Unit
To study all ICU patients with an independent baseline functional status, who experience a critical illness requiring intubation and mechanical ventilation, evaluating the role of protocol-directed, early physical and…
- Trial name
- NCT00322010
- Testing
- early PT OT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Chicago