Clinical trials: Ventilated Patient in Intensive Care
Ventilator Weaning, Mechanical Ventilation
Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients
The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in…
- Conditions
- Ventilator Weaning, Mechanical Ventilation, Respiratory Insufficiency Requiring Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07120438
- Volunteers
- 55 people
- Sponsor
- Gadjah Mada University
Ventilation Therapy; Complications
Diaphragmatic Mobility In Ventilated Assisted Patients
The study was a randomized controlled trial. A total of 24 patients who met the inclusion criteria were included in this study and randomly divided by sealed envelope method into Experimental and Control groups with 12 patients…
- Trial name
- NCT04733261
- Testing
- Diaphragmatic mobility, Chest Physiotherapy
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aqua Medical Services (Pvt) Ltd
Conscious Sedation
Dexmedetomidine for Continuous Sedation
The study aims to demonstrate that dexmedetomidine is non-inferior to current best practice sedation with propofol/midazolam and daily sedation stops, in maintaining a target depth of sedation in long-stay intensive care unit…
- Trial name
- NCT00226785
- Testing
- Dexmedetomidine
- Where
- 4 sites in Finland, Switzerland
- Volunteers
- 900 people
- Sponsor
- Orion Corporation, Orion Pharma
Ventilator Weaning, Intensive Care Unit
Use of Transient Elastogaphy to Assess Diaphragm Function in Mechanically Ventilated Patients
Mechanical ventilation is a life-saving treatment that can be associated with diaphragm dysfunction, a potentially deleterious acquired disability.
- Trial name
- Elasto-ICU (NCT03832231)
- Testing
- Shear Wave Elastography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diaphragm Dysfunction
Respiratory Physiotherapy and Diaphragm Thickness in Ventilated ICU Patients
This study aims to evaluate the effect of respiratory physiotherapy on diaphragm thickness in patients receiving mechanical ventilation support in the intensive care unit.
- Trial name
- NCT07538102
- Testing
- Standard ICU Physiotherapy, Neuromuscular Electrical Stimulation (NMES)
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Hitit University
Adult ICU Patients
Metabolic Trajectories and Protein Intake in Long-Stay Ventilated Intensive Care Unit (ICU) Patients
Survival of critically ill patients has improved, resulting in a growing population of chronically critically ill (CCI) individuals with prolonged organ dysfunction, mechanical ventilation, and high morbidity.
- Trial name
- MetaChronic (NCT07268274)
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Universidade do Algarve
Disorder; Mental, Sedative, Depressed Level of Consciousness
Use of Bispectral Index Monitoring to Detect Deep Sedation in Mechanically Ventilated Patients: Validity Study
In the previous study, the investigators obtained the cutoff value of Bispectral Index to detect early deep sedation in patients with mechanical ventilation.
- Conditions
- Disorder; Mental, Sedative, Depressed Level of Consciousness, Mechanical Ventilation Complication, Psychosis Associated With Intensive Care
- Trial name
- NCT02439840
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Capital Medical University
Nociceptive Pain
Guiding Sufentanil Administration With Skin Conductance in Mechanically Ventilated Intensive Care Patients
Opioid administration in mechanically ventilated patients in the intensive care unit (ICU) is essential to maintaining patient respiratory and hemodynamic stability.
- Trial name
- NCT04696016
- Testing
- Skin conductance guided antinociception, Standard care antinociception
- Volunteers
- 30 people
- Sponsor
- Erasme University Hospital
To Assess the Tissular and Plasma Kinetics of Ertapenem
Prospective, Open-label Study of Pharmacokinetics of Ertapenem in the Muscle Using Microdialysis in Mechanically Ventilated Intensive Care Unit Patients, Treated or Not by Norepinephrine
Goal of study: To assess the tissular and plasma kinetics of ertapenem; To determine the optimal dosages in the patients according to norepinephrine administration: to assess muscular diffusion of free form of ertapenem after…
- Trial name
- NCT00489138
- Testing
- Ertapenem
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hyperoxia, Complication
The Effectiveness of the Use of Oxygen Reserve Index in Preventing Hyperoxia in the Intensive Care Unit.
Oxygen therapy is the most common treatment modality for patients with hypoxemia in intensive care units, but target values for normoxemia are not clearly defined. Therefore, iatrogenic hyperoxemia is a very common situation.
- Conditions
- Hyperoxia, Complication, Mechanical Ventilation Complication
- Trial name
- NCT05807815
- Testing
- Titration of fraction of inspired oxygen (FiO2) guided by ORI and oxygen saturation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Tepecik Training and Research Hospital
Ventilated Patient in Intensive Care, Management of the Expiratory End-expiratory Pressure (PEEP) and Body Position
Effect of PEEP and Trendelenburg on Ultrasound Size of Internal Jugular and Subclavian Veins
There is no recommendation for the management of the positive end-expiratory pressure (PEEP) during setting of a central venous catheter (CVC) in a ventilated patient.
- Trial name
- PEEPUS (NCT02569424)
- Testing
- Patient's position
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Clermont-Ferrand
Methicillin-resistant Staphylococcus Aureus, Methicillin-Sensitive Staphylococcus Aureus Infection
A Systematic Oral Care Program in Post-Mechanically Ventilated, Post-Intensive Care Patients
The purpose of this study is to see if a 4 day oral care program in patients who have been on a breathing machine results in better oral health, reduces the amount of certain bacteria in the mouth and reduces infection while in…
- Trial name
- NCT03886623
- Testing
- 4-day systematic oral hygiene, Standard of Care oral care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Ohio State University
COVID-19, Bacterial Infections
Incidence of Colonization by Multidrug-resistant Organisms in Mechanically Ventilated Patients With Severe COVID-19
Retrospective single-center cohort study to evaluate the incidence of colonization by multidrug-resistant organisms (MDRO) in mechanically ventilated patients admitted to a large intensive care unit (ICU) for severe acute…
- Conditions
- COVID-19, Bacterial Infections, Colonization, Asymptomatic
- Trial name
- MDR_in_Fiera (NCT05293418)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 435 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Weaning Mechanical Ventilation, Ultrasonography
The Relationship Between Diaphragm Function Assessed by Ultrasound and Weaning Success in Mechanically Ventilated Patients in the ICU
The diaphragm is the most important muscle involved in the respiratory system and is solely responsible for approximately 65-80% of vital capacity.
- Conditions
- Weaning Mechanical Ventilation, Ultrasonography, Intensive Care (ICU), Assesment of Diaphragmatic Function by Ultrasound to Predict Weaning Success in Mechanical Ventilated Intensive Care Unit Patients
- Trial name
- ICU (NCT07332403)
- Testing
- Diaphragm ultrasound before weaning procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
ICU-acquired Weakness, Mechanical Ventilation
eCASH and Early Goal-Directed Mobilization to Prevent ICU-Acquired Weakness
This single-center, prospective, randomized controlled trial aims to evaluate whether an eCASH concept-based analgesia and sedation strategy combined with early goal-directed mobilization can reduce the incidence of intensive…
- Conditions
- ICU-acquired Weakness, Mechanical Ventilation, Critical Illness
- Trial name
- eCASH-EGDM (NCT07677488)
- Testing
- eCASH-Based Analgesia and Sedation Strategy Combined With Early Goal-Directed Mobilization, Routine ICU Nursing Care
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Ventilated Patient in Intensive Care
Effectiveness of Diaphragmatic Function and Parasternal Intercostal Muscles Functions as Predictors for Successful Weaning From Mechanical Ventilation
Critically ill patients frequently develop respiratory muscle dysfunction that may contribute to difficult and prolonged weaning from mechanical ventilation.
- Trial name
- NCT07630662
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- Ain Shams University
Ventilator Associated Pneumonia ( VAP), Sepsis
High Dose of Vitamin C on Mechanically Ventilated Septic Patients in Intensive Care Unit
Prospective, Randomized clinical trial study will be carried out in intensive care unit in Ain Shams University Hospitals on 40 forty septic patients admitted to ICU and mechanically ventilated.
- Trial name
- NCT04029675
- Testing
- Vitamin C
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
COPD, COPD Exacerbation
Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.
Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube. In ICU, a prolonged duration of invasive mechanical ventilation may be responsible for…
- Conditions
- COPD, COPD Exacerbation, Ventilated Patients, Ventilator-Associated Pneumonia (VAP)
- Trial name
- SLEECOP (NCT06653933)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Weaning Failure, Sepsis
Ultrasound-Assessed Diaphragmatic Dysfunction as a Predictor of Weaning Outcome
This study aims to assess whether the degree of diaphragm excursion and diaphragm thickening measured by ultrasound during a weaning trial may be used to predict successful weaning from mechanical ventilation in patients with…
- Trial name
- NCT04825509
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Mechanical Ventilation Complication
Automated Secretion Removal in ICU Patients
SUMMARY Rationale In intubated and mechanically ventilated critically ill patients, removal of airway secretions is typically performed by tracheal suctioning, an intervention that is labor-intensive and very unpleasant for the…
- Trial name
- TrachFlush (NCT05056103)
- Testing
- TrachFlush
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)