Clinical trials: Ventilated Patient in Intensive Care
Delirium in the Intensive Care Unit
Methadone vs. Transdermal Fentanyl for Opioid Withdrawal Syndrome
Many patients in the general intensive care unit experience pain, as a result of an injury or underlying disease, surgery or an invasive procedure.
- Trial name
- NCT05697783
- Testing
- Administration of methadone instead of fentanyl patch
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Meir Medical Center
Critically Ill, Subacute Adult Patients, Mechanically Ventilation
Effect of Inspiratory Muscle Training on Ventilated Patients in an Intensive Care Unit
The goal of this clinical trial is to learn if inspiratory muscle training facilite the liberation of mechanical ventilation. The main questions it aims to answer are: Does inspiratory muscle training facilitate weaning from…
- Trial name
- NCT06611683
- Testing
- Inspiratory muscle training, Routine care
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung University
All-cause Mortality, Quality of Life
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when…
- Conditions
- All-cause Mortality, Quality of Life, Disability, Intellectual, Neurological Disorder
- Trial name
- PREVENT-NEURO (NCT06819592)
- Testing
- Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- Where
- 29 sites in Australia, Canada and 1 more
- Volunteers
- 3,300 people
- Sponsor
- The George Institute
Nociceptive Pain
Guiding Sufentanil Administration With Skin Conductance in Mechanically Ventilated Intensive Care Patients
Opioid administration in mechanically ventilated patients in the intensive care unit (ICU) is essential to maintaining patient respiratory and hemodynamic stability.
- Trial name
- NCT04696016
- Testing
- Skin conductance guided antinociception, Standard care antinociception
- Volunteers
- 30 people
- Sponsor
- Erasme University Hospital
Obesity, Respiratory Insufficiency
Effects of Obesity on Care and Outcomes in Mechanically Ventilated Individuals in the Intensive Care Unit
Obesity is a significant health care issue in the United States, particularly among the critically ill. Preliminary research has shown that differences in ventilator management exist among obese and non-obese individuals.
- Trial name
- NCT00296088
- Where
- United States
- Volunteers
- 582 people
- Sponsor
- Ohio State University
ARDS (Moderate or Severe), Prone Position
The PRE-VAIL Study
During the prone position, there may be an increase in intragastric pressure. The investigators focus on a scientific question: Whether reducing enteral nutrition before the prone position will benefit patients with severe…
- Conditions
- ARDS (Moderate or Severe), Prone Position, Enteral Nutrition Feeding, Intensive Care Unit (ICU) Admission
- Trial name
- NCT07176624
- Testing
- Enteral nutrition is reduced before the prone position
- Where
- China
- Volunteers
- 259 people
- Sponsor
- The First Hospital of Jilin University
Intensive Care Patients Invasively Ventilated
S4 :Trial Of Fully Closed-Loop Ventilation In ICU.
Preliminary study to compare IntelliVent-ASV to conventional modes used from intubation to extubation or death in ICU patients requiring mechanical ventilation measuring duration of mechanical ventilation in order to design a…
- Trial name
- S4 (NCT01781091)
- Testing
- INTELLIVENT ASV FULLY CLOSED-LOOP VENTILATION, Conventionals Modes
- Where
- 2 sites in France, Italy
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Long-term Sedation for Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Remimazolam vs Propofol for Long-Term Sedation in Mechanically Ventilated ICU Patients
This multicenter, randomized, controlled, non-inferiority trial is designed to determine whether remimazolam is non-inferior to propofol for prolonged sedation in adult ICU patients requiring mechanical ventilation for ≥48 hours.
- Trial name
- RePro-ICU (NCT07880548)
- Testing
- Remimazolam group, Propofol group
- Where
- 21 sites in China
- Volunteers
- 274 people
- Sponsor
- Sun Yat-sen University
Ventilator Weaning
Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients
Difficult ventilatory weaning is associated with a 20% mortality rate. 40% of these patients will develop intensive care unit (ICU)-acquired neuromyopathy, associated with reduced cough strength and a 4-fold increase in the risk…
- Trial name
- PHYSIO WEAN (NCT06499389)
- Testing
- Systematic and early intensive instrumental respiratory physiotherapy for patients undergoing difficult ventilatory weaning, Protocolized standard-of-care respiratory physiotherapy
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Critically Ill
Diaphragmatic Function in Ventilated Patients
Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called…
- Trial name
- NCT00786526
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Invasive Ventilation
Prediction of PaO2 Values Using the PRoPERLy II Database
Four prospective observational studies of ventilation in critically ill patients were harmonized and pooled.
- Trial name
- PRoPERLy-II (NCT06589427)
- Testing
- Invasive ventilation.
- Where
- Netherlands
- Volunteers
- 8,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mechanical Ventilation, Nonverbal Communication
Brain Computer Interface for Communication in Ventilated Patients
Objectives: Specific Aim 1: To demonstrate the feasibility of using a Steady State Visual Evoked Potential (SSVEP) based Brain Computer Interface (BCI) device to facilitate communication of common patient needs in alert…
- Conditions
- Mechanical Ventilation, Nonverbal Communication, Intratracheal Intubation, Critical Illness
- Trial name
- NCT02791425
- Testing
- Brain Computer Interface (BCI) device, Communication picture board
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Michigan
Trauma, Traumatic Injury
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in…
- Conditions
- Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
- Trial name
- EPO-TRAUMA (NCT04588311)
- Testing
- Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9%
- Where
- 41 sites in Australia, Belgium and 7 more
- Volunteers
- 2,500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Physiological Dead Space, Ventilation-Perfusion Mismatch
Correlation of EtCO₂- and P(A-a)O₂-Based Dead Space Calculations in Mechanically Ventilated ICU Patients
This study aims to evaluate two different methods for calculating physiological dead space in adult patients undergoing invasive mechanical ventilation in the intensive care unit (ICU).
- Conditions
- Physiological Dead Space, Ventilation-Perfusion Mismatch, Mechanical Ventilation, Enghoff Correction
- Trial name
- CODE-EtA (NCT06947486)
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Karadeniz Technical University
Intubation, Mechanical Ventilation
Validation of the Relationship Between Oxygenation Parameters and ORI™, in Mechanically Ventilated ICU Patients
The ORI™ or Oxygen Reserve Index (Masimo, Irvine, CA, USA) is a non-invasive monitoring system for measuring oxygen reserve. It is a digital sensor (almost identical to the SpO2 sensor) which allows an analysis of the absorption…
- Conditions
- Intubation, Mechanical Ventilation, Intensive Care Unit
- Trial name
- FiO2RI (NCT05085119)
- Testing
- Stepwise modifications of FiO2
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiration Disorders
Effectiveness of Sedation Management in an Australian Intensive Care Unit
Sedation is an important treatment when caring for the critically ill patient on a respirator. Adequate sedation has been found to reduce stress, promote relaxation, induce amnesia, improve the tolerance of the respirator, and…
- Trial name
- NCT00202319
- Testing
- Sedation management protocol
- Where
- Australia
- Volunteers
- 316 people
- Sponsor
- Melbourne Health
Mechanically Ventilated Patients
Prevention of Delirium in Intensive Care by Melatonin
This is a double-blind, randomized, placebo-controlled, Phase 2b/3 two-part adaptive clinical trial. The trial is designed to investigate the pharmacokinetics and the efficacy of multiple dosing regimens of melatonin and to…
- Trial name
- DEMEL (NCT03524937)
- Testing
- MELATONIN (HIGH DOSE), MELATONIN (LOW DOSE)
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilated Patient in Intensive Care
Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning
Patients in the ICU who are being taken off of a breathing machine (ventilator weaning) commonly experience anxiety, agitation, sleep disruption, and physiologic stress.
- Trial name
- NCT07710469
- Testing
- Weighted blanket, Standard hospital linens
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Nutrition
Pilot: Feasibility of Intermittent Enteral Feeding in Ventilated MICU Patients
Specific Aims: Aim 1: Evaluate the feasibility of intermittent feeding in intensive care unit patients who are mechanically ventilated.
- Trial name
- NCT04164108
- Testing
- Intermittent Enteral Nutrition Protocol
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Ventilated Patient in Intensive Care, Failure of Extubation
The Rapid Shallow Breathing Index (RSBI) is a Widely Used Predictor for Weaning Patients From Mechanical Ventilation This Study Aims to Determine the Predictive Value of RSBI Measurements for Extubation Success in Mechanically Ventilated ICU Patients
Early extubation in ICU patients is crucial for reducing complications of prolonged ventilation, including morbidity and mortality.
- Trial name
- NCT07467265
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University