Clinical trials: Ventilated Patient in Intensive Care
Viral Pneumonia
Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection
The goal of this Phase 2 study is to assess the safety, antiviral biomarker responses and efficacy of SNG001 when given to patients requiring invasive mechanical ventilation due to a respiratory virus infection.
- Trial name
- INVENT (NCT06999603)
- Testing
- SNG001
- Where
- 10 sites in United States, United Kingdom
- Volunteers
- 11 people
- Sponsor
- Synairgen Research Ltd.
Intensive Care (ICU) Patients
Recovery and Aftercare in Post Intensive Care Therapy Patients - RAPIT Study
In 2010 alone were admitted 33,361 patients for treatment in Danish intensive care units. There is evidence to former intensive care patients have a significant symptom burden that affect recovery, function and activity for up to…
- Trial name
- RAPIT (NCT01721239)
- Testing
- Standardized Followup program
- Where
- Denmark
- Volunteers
- 340 people
- Sponsor
- Hillerod Hospital, Denmark
Intensive Care Unit Acquired Weakness
Muscle Effects Of Neuromuscular Electrostimulation In Mechanically Ventilated Patients In An Icu
To prevent the development of ICUAW, both early mobilization and neuromuscular electrical stimulation (NMES) have been shown to prevent muscle atrophy in critically ill patients by preserving muscle mass.
- Trial name
- NCT06409611
- Testing
- neuromuscular electrical stimulation
- Where
- 3 sites in Brazil
- Volunteers
- 22 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Oxygen Therapy
Comparative Study Between Liberal and Conservative Oxygen Therapy in Mechanically Ventilated Intensive Care Patients
To assess the benefits and drawbacks of high versus low oxygen therapy on mortality and myocardial function in mechanically ventilated patients
- Trial name
- NCT04824703
- Testing
- Oxygen
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Aswan University Hospital
Reverse Triggering, Patient Ventilator Dyssynchrony
Intrinsic Respiratory Rate Assessment During Mechanical Ventilation to Accelerate Spontaneous Breathing and Extubation
The goal of this study is to identify patients with reverse triggering who's the potential to breath spontaneously is hidden because of the ventilator management strategy by performing a simple 30sec-test with includes reducing…
- Trial name
- INTRINSIC (NCT06445049)
- Testing
- brief test
- Volunteers
- 70 people
- Sponsor
- Unity Health Toronto
Analgesia
Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in ICU
Remifentanil has been approved by the FDA for continuation as an analgesic into the immediate postoperative period in adult patients under the direct supervision of an anesthesia practitioner in a postoperative anesthesia care…
- Trial name
- NCT05003570
- Testing
- Remifentanil, Fentanyl
- Where
- 17 sites in China
- Volunteers
- 138 people
- Sponsor
- Southeast University, China
Ventilated Patient in Intensive Care
Effectiveness of Diaphragmatic Function and Parasternal Intercostal Muscles Functions as Predictors for Successful Weaning From Mechanical Ventilation
Critically ill patients frequently develop respiratory muscle dysfunction that may contribute to difficult and prolonged weaning from mechanical ventilation.
- Trial name
- NCT07630662
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- Ain Shams University
Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU
The primary objective of the study is to create a small dataset of regional pulmonary strain values in patients suffering from pulmonary diseases under mechanical ventilation in an intensive care setting.
- Trial name
- NCT03405779
- Testing
- Lung ultrasonography
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Defecation Disorder, Gastrointestinal Motility Disorder
"The Effect of Abdominal Massage on Gastrointestinal Functions in Mechanically Ventilated Patients Receiving Enteral Nutrition in Intensive Care"
This study aims to evaluate the effects of abdominal massage on gastrointestinal functions in mechanically ventilated patients receiving enteral nutrition in intensive care units.
- Conditions
- Defecation Disorder, Gastrointestinal Motility Disorder, Gastrointestinal Motility and Defecation Conditions
- Trial name
- AMGF-ICU (NCT06631001)
- Testing
- Abdominal Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Mersin University
Indirect Calorimetry, Mechanical Ventilation
Effect of PEEP on Indirect Calorimetry in Critically Ill Patients
Indirect calorimetry is used in intensive care to measure how much oxygen a patient consumes and how much carbon dioxide is produced.
- Conditions
- Indirect Calorimetry, Mechanical Ventilation, Positive End-Expiratory Pressure
- Trial name
- IC-PEEP (NCT07796698)
- Testing
- Protocolized PEEP Adjustment
- Volunteers
- 20 people
- Sponsor
- Vastra Gotaland Region
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury
Effects of Large Tidal Volumes Despite Minimal Inspiratory Support in Spontaneously Ventilated Intubated Resuscitation Patients. Pathophysiological Exploratory Study.
Some ICU ventilated patients might present with large tidal volume despite very low or inexistant presser support. Patient-Self Inflicted Lung Injury (P-SILI) might appear related with large alveolar stretch an distension.
- Conditions
- Invasive Mechanical Ventilation, Ventilator-Induced Lung Injury, Patient-Self Inflicted Lung Injury, Encephalopathy
- Trial name
- InLarge (NCT05056961)
- Testing
- Multiparametric mesurements
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Position Sense Disorders, Hemodynamic Instability
The Effect of Lying Position on Hemodynamic Parameters in Patients With Mechanical Ventilated and Spontaneously Breathing.
Aim: The study was carried out to examine the effect of lying positions on hemodynamic parameters in patients with mechanical ventilation (MV) and spontaneous breathing.
- Trial name
- NCT06538051
- Testing
- lying positions
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Aydin Adnan Menderes University
COPD, COPD Exacerbation
Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.
Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube. In ICU, a prolonged duration of invasive mechanical ventilation may be responsible for…
- Conditions
- COPD, COPD Exacerbation, Ventilated Patients, Ventilator-Associated Pneumonia (VAP)
- Trial name
- SLEECOP (NCT06653933)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Respiratory Insufficiency
Early Sedation With Dexmedetomidine vs. Placebo in Older Ventilated Critically Ill Patients
Sedation remains a ubiquitous and crucial component of intensive care treatments in critically ill mechanically ventilated patients.
- Trial name
- SPICEIV (NCT06251375)
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Mechanical Ventilation, Intensive Care (ICU)
Effects of PERMISSive Lung-protective Ventilation on Outcome in Critically Ill Invasively Ventilated Patients
RATIONALE Lung-protective ventilation using a lower respiratory rate (RR) is an appealing strategy to reduce ventilation intensity, which may require permissive hypercapnia.
- Trial name
- PERMISS pilot (NCT07077174)
- Testing
- Permissive lung-protective ventilation, Conventional lung-protective ventilation
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Critically Ill, Mechanically Ventilated
Treatment of Invasively Ventilated Adults With Early Activity and Mobilisation
The aim of this study is to evaluate the effect of early activity and mobilisation during prolonged IMV on the composite outcome "days alive and out of hospital to day 180".
- Trial name
- TEAM(III) (NCT03133377)
- Testing
- Early activity and mobilisation
- Where
- 49 sites in Australia, Germany and 3 more
- Volunteers
- 750 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Critical Illness, Mechanical Ventilation
Metabolic Response to Supine Physiotherapy in Mechanically Ventilated ICU Patients
Critically ill patients who require mechanical ventilation frequently experience rapid loss of muscle mass and physical function during their stay in the intensive care unit (ICU).
- Conditions
- Critical Illness, Mechanical Ventilation, Intensive Care Unit-Acquired Weakness, Physical Rehabilitation in the Intensive Care Unit
- Trial name
- NCT07361419
- Testing
- Supine Physiotherapy Session
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Extremadura
Aged, Postoperative Period
Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients
Sleep disturbances frequently occur in intensive care unit (ICU) patients undergoing mechanical ventilation. In a previous study, sedative dose dexmedetomidine (median 0.6 microgram/kg/h) improved sleep quality in mechanically…
- Conditions
- Aged, Postoperative Period, Intensive Care Units, Mechanical Ventilation Complication
- Trial name
- NCT03335527
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University First Hospital
Weaning Failure, Sepsis
Ultrasound-Assessed Diaphragmatic Dysfunction as a Predictor of Weaning Outcome
This study aims to assess whether the degree of diaphragm excursion and diaphragm thickening measured by ultrasound during a weaning trial may be used to predict successful weaning from mechanical ventilation in patients with…
- Trial name
- NCT04825509
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University