Clinical trials: Ventilation Therapy; Complications
Respiratory Distress Syndrome, Preterm Birth
nHFOV vs nCPAP: Effects on Gas Exchange for the Treatment of Neonates Recovering From RDS
The purpose of this study is to compare the effects of two different techniques of non-invasive ventilation (nCPAP and nHFOV) on gas exchange in preterm infants recovering from respiratory distress syndrome.
- Trial name
- NCT02772835
- Testing
- Medin-cno
- Where
- 8 sites in Italy, Lithuania
- Volunteers
- 30 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Ventilation Therapy; Complications, Technical Skills
Educational Strategies for Maintaining Technical Skills in Neonatal Resuscitation for the Nursing Team
Despite efforts for initial training in neonatal resuscitation, health professionals show a decline in post-training skills, requiring continuing training.
- Conditions
- Ventilation Therapy; Complications, Technical Skills, Nurse's Role
- Trial name
- Neo-VPP (NCT06882018)
- Testing
- Repeated practice guided by peers, Instructor-guided deliberate practice
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ahmed Moussa
Overactive Bladder, Obstructive Sleep Apnea
Tolterodine Relieves Overactive Bladder Symptoms in Women With Moderate-to-severe Obstructive Sleep Apnea Syndrome
In this study, we aim to determine whether combined tolterodine and CPAP therapy is a more effective treatment for patients with OSAS than CPAP treatment only.
- Conditions
- Overactive Bladder, Obstructive Sleep Apnea, Overactive Bladder Syndrome
- Trial name
- NCT05250245
- Testing
- Tolterodine Tartrate 4 MG, Continuous positive airway pressure therapy (CPAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Mechanical Ventilation Complication
The Effects of Early Mobilization and Endurance Training for Patients With Prolonged Mechanical Ventilator
The primary hypothesis is that prolonged mechanically ventilated adults who participate in an early mobilization and endurance exercise training protocol, have an improved pulmonary outcome and functional capacity and more…
- Trial name
- NCT05154786
- Testing
- Early Mobilization and endurance training, Usual Care
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taichung Tzu Chi Hospital
Ventilation Therapy; Complications
Comparison of iLTS and LMA Fastrach in a Simulated Airway.
Comparison of time to ventilation based on the chest rising of the Airway Simulator between the iLTS-D and LMA Fastrach
- Trial name
- NCT03542747
- Testing
- Time to ventilation with the iLTS, Time to ventilation with the Fastrach
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- Johannes Gutenberg University Mainz
Spinal Cord Injuries, Respiratory Complication
Effectiveness of Jamboxx Respiratory Therapy Device: Study 1
The Effectiveness of the Jamboxx Respiratory Therapy Device in Treatment of Patients with Decreased Respiratory Function is a proposal for investigation of the application of gaming to improving respiratory health.
- Trial name
- NCT03533400
- Testing
- Jamboxx Respiratory Therapy Device, Jamboxx Musical Device
- Where
- United States
- Sponsor
- My Music Machines Inc.
Respiratory Distress Syndrome in Premature Infant
Surfactant Therapy Via Supraglottic Airway to Preterm Neonates With RDS in Vietnam
Preterm babies often have trouble breathing because their lungs are not fully developed. This condition is called respiratory distress syndrome (RDS). A medicine called surfactant helps their lungs open up and work better.
- Trial name
- NEOSURF (NCT07098910)
- Testing
- Surfactant Administration Through Laryngeal or Supraglottic Airways (SALSA), Intubation - Surfactant administration - Extubation (INSURE)
- Where
- Vietnam
- Volunteers
- 440 people
- Sponsor
- Karolinska Institutet
Pleural Effusion
Positive Airway Pressure on Pleural Effusion After Drainage
The purpose of this study is to determine if the addition of intermittent positive airway pressure breathing (specific lung expansion technique) to conventional chest physiotherapy chest drainage is effective to accelerate the…
- Trial name
- NCT02246946
- Testing
- Positive Airway Pressure, Conventional Chest Physiotherapy, Control group
- Where
- Brazil
- Volunteers
- 156 people
- Sponsor
- Universidade Cidade de Sao Paulo
Respiratory Distress Syndrome (RDS), Newborn
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation for Respiratory Distress Syndrome in Preterm Neonates
The goal of this clinical trial is to learn if nasal high frequency oscillatory ventilation (nHFOV) works no worse than nasal intermittent mandatory ventilation (NIMV) as early breathing support.
- Conditions
- Respiratory Distress Syndrome (RDS), Newborn, Premature Birth
- Trial name
- NOV-RDS (NCT07837141)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 158 people
- Sponsor
- Aga Khan University
Spinal Cord Injury, Tetraplegia
Effect of Air-stacking on Peak Cough Flow in Patients With Acute Cervical or High Thoracic Spinal Cord Injury
Respiratory complications continue to be one of the leading causes of morbidity and mortality in people with spinal cord injury, especially among cervical and higher thoracic injuries.
- Trial name
- NCT01046175
- Testing
- Air-stacking with a manual resuscitator, Air-stacking with ventilator
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Ullevaal University Hospital
Rib Fractures, Blunt Chest Trauma
Effectiveness of an Innovative Chest Stabilizer in Rib Fracture Treatment: Impact on Respiratory Function, Complications, and Clinical Outcomes
This study aims to evaluate the effectiveness of an innovative, non-invasive chest stabilizer in patients with multiple rib fractures caused by blunt chest trauma.
- Conditions
- Rib Fractures, Blunt Chest Trauma, Thoracic Injuries, Pulmonary Complications
- Trial name
- NCT07238582
- Testing
- Standard Analgesic Therapy, Innovative Chest Stabilizer
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Caner İşevi, MD
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- SAVE (NCT00005777)
- Testing
- Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 220 people
- Sponsor
- NICHD Neonatal Research Network
Ventilation Therapy; Complications
Correlation Between Muscle Thickness and Inflammation With Ventilator Use in Critically Ill Patients
Decrease thickness of diaphragm muscle, cross-sectional area of rectus femoris and biceps brachii muscle, and increase in CRP would affect ventilator length of use in critically ill patients in ICU
- Trial name
- NCT03933332
- Testing
- Diaphragm thickness, Cross-sectional area of rectus femoris muscle, Cross-sectional area of biceps brachii
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Universitas Indonesia
Ventilation Therapy; Complications, Ventilator-Induced Lung Injury
Clinical Decision Support Tool in PARDS Pilot Study
Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation.
- Conditions
- Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
- Trial name
- NCT04068012
- Testing
- Ventilator protocol
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Children's Hospital Los Angeles
Sleep Apnea, Cardiovascular Diseases
Oxidative Stress and Cardiovascular Morbidity in Sleep Apnea-Hypopnea Syndrome (SAHS)
The purpose of this study is to compare the levels of 8-isoprostane and other oxidative stress biomarkers in plasma and condensed exhaled air between patients with SAHS and cardiovascular complications, patients with SAHS without…
- Trial name
- OSCAMSA (NCT00487929)
- Testing
- nasal CPAP
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
Ventilation Therapy; Complications
Comparison of Effectiveness of Mask Ventilation and Endotracheal Tube in Pharynx (TTIP) in Patients With Potential Difficult Airway
The purpose of this study is to determine the efficacy of TTIP-first ventilation and to compare the efficacy of TTIP first ventilation with the current practice of mask-first ventilation
- Trial name
- NCT05005390
- Testing
- TTIP ventilation, Mask Ventilation
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- The University of Texas Health Science Center, Houston
COVID-19, Mechanical Ventilation
Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome
This multicentric prospective clinical practice study aims at evaluating clinical factors associated with a prolonged invasive mechanical ventilation and other outcomes such as mortality and ICU length of stay in patients…
- Conditions
- COVID-19, Mechanical Ventilation, Quality of Life, Radiologic Increased Density of Lung
- Trial name
- NCT04411459
- Testing
- Invasive mechanical ventilation
- Where
- 20 sites in Italy
- Volunteers
- 470 people
- Sponsor
- Azienda Usl di Bologna
Ventilation Therapy; Complications
Amflow-device Can Help Proper Ambu-bag Ventilation
This is a simulation study with a prospective randomized cross-over design. The aim of this study is to evaluate whether Amflow-assisted ambu-bag can delivery the accurate tidal volume compare to ordinary ambu-bag
- Trial name
- NCT03119935
- Testing
- Amflow, Ambu bag
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Complication of Ventilation Therapy, Observation of Neuromuscular Block
Influence of the Neuromuscular Blockade on Mask Ventilation
Mask ventilation during induction of anesthesia can be improved by administration of neuromuscular blocking agents (NMBAs). NMBAs are usually administered after testing mask ventilation; however, muscle relaxants may improve mask…
- Trial name
- NCT02318810
- Testing
- Rocuronium 0.3 mg/kg, Rocuronium 0.6 mg/kg, Rocuronium 0.9 mg/kg
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University of Rostock
Apnea
Prophylactic Versus Therapeutic Caffeine for Apnea of Prematurity
Investigators hypothesized that the timing of caffeine administration in either prophylaxis or treatment of apnea of prematurity will affect the apnea response to caffeine
- Trial name
- NCT02677584
- Testing
- Prophylactic caffeine citrate, Therapeutic caffeine citrate
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Mansoura University Children Hospital