Clinical trials: Ventilation and Oxygenation
Lung Cancer
Effect of Preoperative Budesonide Inhalation on Arterial Blood Oxygenation and Intrapulmonary Shunt During OLV
The purpose of this study is to conduct a randomized controlled trial to evaluate the effect of preoperative budesonide inhalation on arterial blood oxygenation and intrapulmonary shunt in patients received one-lung ventilation
- Trial name
- NCT03394222
- Testing
- preoperative budesonide inhalation, preoperative normal saline inhalation
- Volunteers
- 50 people
- Sponsor
- Fujian Medical University Union Hospital
Apnea, Ventilation Therapy; Complications
THRIVE in Children at Different Flow Rates
This study investigates under controlled circumstances the concept of THRIVE to improve the ventilation and the carbon dioxide elimination, to prolong the apnoea time without deoxygenation and to improve safety of airway…
- Trial name
- NCT03812354
- Testing
- THRIVE 4L/kg/min, THRIVE 2L/kg/min
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Respiratory Distress Syndrome, Adult, Extracorporeal Membrane Oxygenation
PGE1 as Additive Anticoagulant in ECMO-Therapy
Bleeding complications and thromboembolic complications are frequent during extracorporeal membrane oxygenation (ECMO). Retrospective data suggest that platelet inhibition using prostaglandins, in this case PGE1, may reduce…
- Trial name
- ECMO_PGE1 (NCT02895373)
- Testing
- Alprostadil, 0.9% sodium chloride solution
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Thomas Staudinger
Apnea, Postanesthetic, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial (Optilaryngo)
Suspension laryngoscopy is realised during apnea. In effect, surgeons are in the mouth of the patient and we can't have access at the aiways.
- Conditions
- Apnea, Postanesthetic, Desaturation of Blood, Apnea, Anesthesia
- Trial name
- optilaryngo (NCT03843580)
- Testing
- optiflow
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Chronic Obstructive Pulmonary Disease
Innovation in NOn Invasive Ventilation in COPD Patients Treated by Long Term Oxygen Therapy
The aim of this study is to investigate the efficacy of non-invasive ventilation (NIV) on nocturnal hypoventilation in patients with chronic obstructive pulmonary disease (COPD) who are on long term oxygen therapy (LTOT) at home.
- Trial name
- INOV-LTOT (NCT03584269)
- Testing
- NIV Device + LTOT, LTOT
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Grenoble
Hypoxia, Pars Plana Vitrectomy
Influence of HFNO on Spontaneous Breathing Support in Patients of Different ASA Risk During Moderate Multimodal Analgo-sedation for Pars Plana Vitrectomy
Pars plana vitrectomy is minimally invasive endoscopic procedure which is usually performed in moderate analgo-sedation given by anesthesiologist combined with topical anesthesia and regional eye anesthesia (retrobulbar or…
- Conditions
- Hypoxia, Pars Plana Vitrectomy, Respiratory Complications
- Trial name
- NCT04055077
- Testing
- Low-flow nasal oxygenation (LFNO) ASA I, Low-flow nasal oxygenation (LFNO) ASA II, Low-flow nasal oxygenation (LFNO) ASA III
- Where
- Croatia
- Volunteers
- 176 people
- Sponsor
- University of Split, School of Medicine
Infratentorial Neoplasms, Hyperventilation
The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery
The aim of this study is to evaluate the changes of cerebral oxygen saturation during hyperventilation and normo-ventilation (using near-infrared spectroscopy) in pediatrics undergoing posterior fossa tumor resection.
- Conditions
- Infratentorial Neoplasms, Hyperventilation, Craniotomy
- Trial name
- NCT04232059
- Testing
- cerebral oximetry
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Kasr El Aini Hospital
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Lung Cancer
The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery
During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation.
- Trial name
- NCT03936140
- Testing
- Inhaled iloprost, Distilled water
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul St. Mary's Hospital
Acute Respiratory Distress Syndrome
Inflammation During ECMO Therapy and ECMO Weaning
The goal of this interventional clinical trial is to compare patients who undergo ECMO therapy for treatment of acute respiratory distress syndrome (ARDS) and a randomized into one of two possible weaning strategy groups.
- Trial name
- ECMOWean (NCT05640635)
- Testing
- Ventilator weaning first, ECMO weaning first
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Tuebingen
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS
Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery.
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Electrical Impedance Tomography, Trauma and Postoperative Pulmonary Insufficiency
- Trial name
- EIT-PEEP-SURG (NCT07313644)
- Testing
- EIT-giuded PEEP, Control
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Nguyen Dang Thu
Acute Respiratory Failure, Intratracheal Intubation
Comparison of Pre-oxygenation of NIV and HFNC Therapy for Intubation of ICU Patients With Acute Respiratory Failure
The aim of the study is to evaluate the incidence of severe hypoxemia episodes during the intubation procedure with two methods of pre-oxygenation: 1. NIV (Non Invasive Ventilation) 2. HFNC (High-flow nasal canula oxygen therapy)
- Trial name
- FLORALI2 (NCT02668458)
- Testing
- High Flow nasal canula oxygen therapy, Noninvasive ventilation
- Where
- 27 sites in France
- Volunteers
- 320 people
- Sponsor
- Poitiers University Hospital
Apnea
Different Flow Rates on Gas Exchange in Children During Apnea
Background: Children desaturate rapidly during apnea following anesthetic induction. The optimal apneic oxygenation flow rate and its effect on CO2 accumulation remain unclear.
- Trial name
- NCT06659887
- Testing
- nasal cannula
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Yasser S Mostafa, MD
Acute Respiratory Distress Syndrome, Acute Respiratory Failure
Pronation During Veno-venous Extra Corporeal Membrane Oxygenation
The Acute Respiratory Distress Syndrome (ARDS) is defined by a recent (within 1 week) respiratory failure, not fully explained by cardiac failure or fluid overload.
- Trial name
- NCT05198986
- Testing
- Prone Position during Extra Corporeal Membrane Oxygenation (ECMO)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University Magna Graecia
Smoking, Tobacco
Respiratory Function and Oxygenation in Smokers and Non-smokers
This study aimed to compare respiratory function, exercise capacity, and intercostal muscle oxygenation in healthy smokers and non-smokers.
- Trial name
- NCT07027956
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Acute Respiratory Distress Syndrome, Septic Shock
Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
The implementation of this project will improve the effectiveness of surgical treatment and reduce the level of complications and mortality among patients with heart failure and heart failure in the terminal stage.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Sepsis
- Trial name
- OST (NCT05042622)
- Testing
- Cytokine adsorber filter, Extracorporeal hemoperfusion cartridge
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Acute Respiratory Distress Syndrome (ARDS), Hypoxemia
Early Prone Positioning and Clinical Outcomes in Non-Intubated Acute Respiratory Distress Syndrome (ARDS) Patients
This study aimed to evaluate the effectiveness of early prone positioning in improving clinical outcomes among non-intubated patients with Acute Respiratory Distress Syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Hypoxemia, Respiratory Failure, Non-Intubated Patients
- Trial name
- EPP-ARDS (NCT07133022)
- Testing
- Early Prone Positioning Protocol, Standard ICU Care
- Where
- Palestinian Territories
- Volunteers
- 100 people
- Sponsor
- Loai Muawiah Zabin
Hypertension
Effect of Vasopressin vs Norepinephrine on Pulmonary Oxygenation and Lung Mechanics in Patients With Hypertension Therapy During One-lung Ventilation : Preliminary Study
Hypotension during anesthesia often occurs because reduced systemic vascular resistance and blocked sympathetic nervous system by anesthetic drugs.
- Trial name
- NCT04170751
- Testing
- 16 mcg / cc of norepinephrine(group N), 0.4 unit / cc of vasopressin(group V)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in patients with pulmonary arterial hypertension PAH, who live permanently >2600m.
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, Polygraphy, Sleep
- Trial name
- NCT07801963
- Testing
- Descent to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Acute Respiratory Distress Syndrome
Assessment of Cardiac Output in Patients With ARDS Implanted With Venous-venous ECMO.
In patients with severe acute respiratory distress syndrome, extracorporeal membrane oxygenation (ECMO), which also as known as extracorporeal life support, may be used.
- Trial name
- PiCCMO (NCT05164484)
- Testing
- Transpulmonary thermodilution
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris