Clinical trials: Ventilator Acquired Pneumonia
Ventilator Associated Pneumonia
Strategies to Prevent Pneumonia (SToP Pneumonia)
This study tests whether special oral care provided by nurses to critically ill patients who are on a breathing machine (mechanical ventilator) can help to reduce the build-up of dental plaque on the teeth and reduce the risk of…
- Trial name
- NCT00234598
- Testing
- Toothbrushing only, Chlorhexidine only, Toothbrushing and Chlorhexidine
- Where
- United States
- Volunteers
- 547 people
- Sponsor
- Virginia Commonwealth University
Biofilm Formation, Structural and Microbiological Characterization of Endotracheal Tube Biofilm
Structural and Microbiological Characterization of Endotracheal Tube Biofilm in Patients at Increased Risk for the Development of Ventilator-associated Pneumonia in the Intensive Care Unit
Ventilator-associated pneumonia (VAP) remains the most frequent healthcare-associated infection (HAI) in the intensive care unit (ICU) and one of the most critical risk factors associated with both significant morbidity as well…
- Conditions
- Biofilm Formation, Structural and Microbiological Characterization of Endotracheal Tube Biofilm, Ventilator-associated Pneumonia (VAP)
- Trial name
- BIOPAVIR (NCT04926493)
- Testing
- microbiological characterization
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Mechanical Ventilation, Infection Prevention
Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units
The goal of the ORACLE study is to evaluate the impact of implementing a standardized oral hygiene bundle on outcomes in critically ill, mechanically ventilated patients.
- Conditions
- Mechanical Ventilation, Infection Prevention, Oral Care, Oral Hygiene, Oral Health
- Trial name
- ORACLE (NCT07129733)
- Testing
- Oral hygiene bundle
- Where
- 6 sites in Brazil
- Volunteers
- 4,800 people
- Sponsor
- Hospital do Coracao
Oral Infection, Ventilator-associated Pneumonia
Evaluating the Effectiveness of the Tongue Cleaner in Critical Patients
The concern with oral infection and its systemic repercussions is old, many studies have been undertaken to establish this relationship more precisely.
- Trial name
- NCT01294943
- Testing
- Tongue cleaner
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Pneumonia
Nebulized Amikacin Versus Intravenous Amikacin in the Treatment of Nosocomial Pneumonia
The investigator's goal in this study is to evaluate the efficacy and safety of nebulized amikacin versus intravenous amikacin in patients with hospital and ventilator acquired pneumonia in surgical patients admitted to the…
- Trial name
- NCT02728518
- Testing
- Nebulized Amikacin, Intravenous Amikacin
- Volunteers
- 133 people
- Sponsor
- National Heart Institute, Egypt
Ventilator-associated Pneumonia
Ventilator-associated Pneumonia (VAP) and Humidification System
The purpose of this study is to determine which humidification system is more effective in preventing pneumonia in mechanically ventilated patients.
- Trial name
- NCT01546974
- Testing
- HME filter Twin Star 55, Drager Medical, Germany, Heated humidification
- Where
- Brazil
- Volunteers
- 306 people
- Sponsor
- Hospital Sao Domingos
Ventilator Associated Pneumonia
Inhibition Effects of Probiotics on Pathogens Associated With VAP
This study evaluates that P. aeruginosa, A. baumannii, K. pneumonia and Staph aureus which are obtained from patients' tracheal aspiration culture who treated with mechanical ventilation will be compared with Lactobacillus (LAB)…
- Trial name
- NCT02928042
- Testing
- Lactobacillus bacteria
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Pneumonia, Ventilator-Associated, Pseudomonas Infections
Azithromycin as a Quorum-Sensing Inhibitor for the Prevention of Pseudomonas Aeruginosa Ventilator-Associated Pneumonia
The purpose of this study is to assess the clinical efficacy of azithromycin, used as a quorum-sensing blocker, when compared to placebo for preventing or delaying the occurrence of pneumonia in ventilated patients colonized with…
- Trial name
- NCT00610623
- Testing
- azithromycin
- Where
- 20 sites in Belgium, France and 4 more
- Volunteers
- 92 people
- Sponsor
- Anbics Management-Services Ag
Bacterial Respiratory Infections
Microdosing of BAC ONE to the Distal Lung
Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which…
- Trial name
- BAC ONE (NCT02558062)
- Testing
- BAC ONE administration
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Edinburgh
Ventilator-Associated Pneumonia, Healthcare-Associated Pneumonia
Application of Ventilator-Associated Events (VAE) in Ventilator-Associated Pneumonia (VAP) Notified in Brazil
Multicentric observational prospective cohort study in 12 (twelve) hospitals representing all Brazilian regions. The main objective of this project is to evaluate the incidence of Ventilator-Associated Pneumonia (VAP) when using…
- Conditions
- Ventilator-Associated Pneumonia, Healthcare-Associated Pneumonia, Healthcare Associated Infection
- Trial name
- NCT05589727
- Where
- 12 sites in Brazil
- Volunteers
- 987 people
- Sponsor
- Giovanna Marssola Nascimento
Ventilator-associated Pneumonia (VAP)
Use of Reticulocyte Ratio and Neutrophil / Lymphocyte Ratio in the Diagnosis of Ventilator-associated Pneumonia
In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.
- Trial name
- NCT04620941
- Testing
- reticulocyte/hemoglobin (Ret-He) ratio
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Muğla Sıtkı Koçman University
Aspiration, Aspiration Pneumonia
Early Antibiotics After Aspiration in ICU Patients
The purpose of this study is to evaluate the use of early antibiotics in ICU patients who appear to have aspirated, to help determine whether this improves outcomes by reducing the later incidence of pneumonia and other negative…
- Trial name
- NCT05079620
- Testing
- Ceftriaxone, Amoxicillin clavulanic acid, Cefepime
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UConn Health
Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC)
A Study to Assess Sulbactam-durlobactam in Pediatric Patients With Acinetobacter Baumannii-calcoaceticus Complex Infection
The goal of this clinical trial is to investigate the use of Sulbactam-Durlobactam (SUL-DUR) in pediatric patients and is being conducted to collect pharmacokinetic (PK) and safety data to enable the identification of appropriate…
- Trial name
- NCT06801223
- Testing
- Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Sulbactam 20mg/kg-Durlobactam 20mg/kg (Every 8 hours), Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 8 hours)
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Innoviva Specialty Therapeutics
Ventilator Associated Pneumonia ( VAP), Sepsis
High Dose of Vitamin C on Mechanically Ventilated Septic Patients in Intensive Care Unit
Prospective, Randomized clinical trial study will be carried out in intensive care unit in Ain Shams University Hospitals on 40 forty septic patients admitted to ICU and mechanically ventilated.
- Trial name
- NCT04029675
- Testing
- Vitamin C
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Pneumonia, Ventilator-Associated
Biomarkers for Ventilator-associated Pneumonia
The purpose of this study is to evaluate different peptide biomarkers, variations in the microbiome and patterns in the bacterial transcriptome as prognostic or diagnostic biomarkers of VAP.
- Trial name
- VAPmarkers (NCT05117125)
- Testing
- Heparin-binding protein, Interleukin-26, Microbiome
- Where
- 5 sites in Norway, Portugal and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Region Skane
SARS-CoV2 Infection, Ventilator Associated Pneumonia
FilmArray® and Management of Ventilator Associated Pneumonia in COVID-19 ARDS
Ventilator Associated Pneumonia (VAPs) are a very common side effect in intensive care units. They are the leading causes of nosocomial infections and excess mortality in intensive care units: associated with a controversial…
- Conditions
- SARS-CoV2 Infection, Ventilator Associated Pneumonia, Ards, COVID-19
- Trial name
- COVIDARRAY (NCT05076240)
- Testing
- FilmArray® analysis
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ventilator Acquired Pneumonia
Assessment of the Role of Probiotics in Prevention of Ventilator-Associated Pneumonia in Neonates
Evaluate the preventive value of probiotics on VAP among ventilated neonates.
- Trial name
- NCT07001163
- Testing
- Probiotic
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Lamiaa Khaled Zidan
Hospital Acquired Bacterial Pneumonia (HABP), Ventilator Associated Bacterial Pneumonia (VABP)
Efficacy and Safety of BV100 Plus Low Dose Polymyxin B Versus Colistin Plus High-dose Ampicillin/Sulbactam in Patients With Hospital-acquired or Ventilator-associated Bacterial Pneumonia Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex
This is a two-part study, with Part A being the randomized, controlled portion of the study in patients with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP) suspected or confirmed…
- Conditions
- Hospital Acquired Bacterial Pneumonia (HABP), Ventilator Associated Bacterial Pneumonia (VABP), Colistin Resistanrt ABC, Acinetobacter Baumannii-calcoaceticus Complex
- Trial name
- RIV-TARGET (NCT07326540)
- Testing
- BV100 (300 mg), Polymyxin B, Colistin
- Where
- Georgia
- Volunteers
- 248 people
- Sponsor
- BioVersys SAS
Ventilator Associated Pneumonia, Pneumonia, Bacterial
Defining Antibiotic Treatment Duration for Ventilator - Associated Lung Infection
Intensive care units (ICUs), with high antibiotic consumption, are epicentres of antimicrobial resistance (AMR). Ventilator associated pneumonia (VAP) is the commonest hospital-acquired infection (HAI) in ICUs and is associated…
- Trial name
- REGARD_VAP (NCT03382548)
- Testing
- Reducing Antibiotics treatment duration, Standard Antibiotics treatment duration
- Where
- 7 sites in Nepal, Singapore and 1 more
- Volunteers
- 460 people
- Sponsor
- University of Oxford
Pneumonia, Ventilator-Associated
Can we Better Understand the Development of VAP and Eventually Predict and Prevent it?
Pathogens of ventilator-associated pneumonia (VAP) come from colonizers of the trachea. The hypothesis of the investigators is that during the first days of intubation, independently of the use of antibiotics, there is a change…
- Trial name
- NCT01875692
- Where
- Switzerland
- Volunteers
- 286 people
- Sponsor
- University Hospital, Geneva