Clinical trials: Ventilator Acquired Pneumonia
Evidence-based Practices, Nursing Education
Effect of Selected Evidence-based Practices and Related Nurses' Education on the Incidence and Severity of Ventilator-associated Pneumonia
Background: Invasive mechanical ventilation (MV) is used as a cornerstone in the treatment plan of intensive care units (ICUs) patients to provide adequate tissue oxygenation to support the body during the treatment course.
- Conditions
- Evidence-based Practices, Nursing Education, Incidence, Ventilator-associated Pneumonia
- Trial name
- NCT05877105
- Testing
- Ventilator-associated pneumonia prevention Evidence-based practices (VAPPEBP) which consists of ten items bundle
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Cairo University
Ventilator-Associated Pneumonia
Impact of the Duration of Antibiotics on Clinical Events in Patients With Pseudomonas Aeruginosa Ventilator-associated Pneumonia (iDIAPASON)
Ventilator-associated pneumonia (VAP) accounts for 25% of infections in intensive care units (Réseau RAISIN 2012). A short duration (8 days; SD) vs.
- Trial name
- iDIAPASON (NCT02634411)
- Testing
- 8 days of effective antibiotic treatment, 15 days of effective antibiotic treatment
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure
Silver-Coated Endotracheal Tube to Reduce Ventilator Associated Pneumonia (VAP)
The purpose of this study is to determine if the use of a silver-coated endotracheal tube (ETT) can reduce the incidence and/or delay the time of onset of VAP when compared to a non silver-coated ETT in patients who have been…
- Trial name
- NASCENT (NCT00148642)
- Testing
- silver salts coated endotracheal tube, uncoated endotracheal tube
- Where
- 5 sites in United States
- Volunteers
- 2,003 people
- Sponsor
- C. R. Bard
Ventilator-Associated Pneumonia
To Compare Endotracheal Tube (ET) With Subglottic Suction Drainage and Standard ET in the Incidence of VAP
Ventilator Associated Pneumonia (VAP) is associated with increased hospitalisation, increased health care cost and high morbidity and mortality. The incidence of VAP increases with duration of mechanical ventilation.
- Trial name
- NCT03101202
- Testing
- SSD tube
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
VAP - Ventilator Associated Pneumonia
Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial
This is a prospective pilot/feasibility trial of a bundled diagnostic stewardship intervention at the level of the microbiologic testing pathway in ventilator-associated pneumonia (VAP).
- Trial name
- NCT05176353
- Testing
- VAP diagnostic stewardship bundle
- Where
- United States
- Volunteers
- 4,892 people
- Sponsor
- University of Michigan
Bloodstream Infection, Ventilator Associated Bacterial Pneumonia
Optimising TREATment for Severe Gram-Negative Bacterial Infections
TREAT-GNB is an innovative trial to expedite the evaluation of various antibiotic choices and treatment strategies for severe multidrug-resistant Gram-negative bacterial infections, specifically bloodstream and lower respiratory…
- Conditions
- Bloodstream Infection, Ventilator Associated Bacterial Pneumonia, Hospital Acquired Bacterial Pneumonia, Carbapenem Resistant Bacterial Infection
- Trial name
- TREAT-GNB (NCT07004049)
- Testing
- Colistin/Polymyxin B + Sulbactam, Colistin/Polymyxin B + Tigecycline/Eravacycline, Colistin/Polymyxin B + Meropenem
- Where
- 41 sites in Australia, China and 10 more
- Volunteers
- 600 people
- Sponsor
- National University of Singapore
Ventilators, Mechanical
Bacterial Lysates on Respiratory Tract Microecology and Evaluation of the Efficacy of Prevention and Treatment of VAP
The purpose of this study is to assess the effect of bacterial lysates on respiratory tract microecology in patients with mechanical ventilation and the efficacy of prevention and treatment of ventilator associated pneumonia.
- Trial name
- NCT05270018
- Testing
- Bacterial Lysates, normal saline
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sheng Wang MD PhD
Ventilator-associated Pneumonia
Ventilator-associated Pneumonia (VAP) and Humidification System
The purpose of this study is to determine which humidification system is more effective in preventing pneumonia in mechanically ventilated patients.
- Trial name
- NCT01546974
- Testing
- HME filter Twin Star 55, Drager Medical, Germany, Heated humidification
- Where
- Brazil
- Volunteers
- 306 people
- Sponsor
- Hospital Sao Domingos
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille
Sepsis, ARDS
Early Severe Illness TrAnslational BioLogy InformaticS in Humans
Advanced stages of the response to life-threatening infection, severe trauma, or other physiological insults often lead to exhaustion of the homeostatic mechanisms that sustain normal blood pressure and oxygenation.
- Conditions
- Sepsis, ARDS, Critical Illness, Neurocognitive Dysfunction
- Trial name
- ESTABLISH (NCT05591924)
- Testing
- Phelebotomy, Broncheoalveolar Lavage, Tracheal Aspirate
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Ventilator Associated Pneumonia, Nosocomial Pneumonia
Oral Hygiene With Chlorhexidine and Incidence of Ventilator-Associated Pneumonia in Children Submitted to Heart Surgery
Hospital infections play an important role in the increase of patients' morbimortality and hospitalization costs, especially in the case of individuals admitted to intensive care units (ICU) during postoperative heart surgery.
- Conditions
- Ventilator Associated Pneumonia, Nosocomial Pneumonia, Heart Surgery
- Trial name
- NCT00829842
- Testing
- oral hygiene
- Volunteers
- 160 people
- Sponsor
- University of Sao Paulo
Urinary Tract Infection Complicated, Acute Pyelonephritis
Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults
Vabomere™, (meropenem-vaborbactam) is being compared to the Best Available Therapy in the treatment of adults with selected serious infections due to Carbapenem Resistant Enterobacteriaceae
- Conditions
- Urinary Tract Infection Complicated, Acute Pyelonephritis, Hospital Acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia
- Trial name
- NCT02168946
- Testing
- Vabomere, Best Available Therapy
- Where
- 50 sites in United States, Argentina and 6 more
- Volunteers
- 77 people
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Gram-Negative Bacterial Infections
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants
The primary purpose of this study is to understand the pharmacokinetics (PK) of single and multiple doses of cefiderocol in children from birth to less than 3 months of age with suspected or confirmed aerobic Gram-negative…
- Trial name
- NCT06086626
- Testing
- Cefiderocol, Standard of Care
- Where
- 4 sites in United States, South Africa and 1 more
- Volunteers
- 30 people
- Sponsor
- Shionogi
Ventilator-Associated Pneumonia
The Pharmacodynamics of Doripenem Between 4-hour and 1-hour Infusion in Patients With Ventilator-associated Pneumonia
This is prospective and randomized study to assess the pharmacodynamics (t>MIC) of 0.5 g every 8 h of doripenem in patients with VAP following administration by a 4 h infusion or 1 h infusion.
- Trial name
- NCT01467648
- Testing
- Doripenem
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Sutep Jaruratanasirikul
Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia
A Study to Evaluate the Efficacy and Safety of Meropenem and Pralurbactam in HABP/VABP
This study is to evaluate the efficacy and safety of Meropenem and Pralurbactam for Injection in Subjects with HABP/VABP. The primary objective is to demonstrate non-inferiority of Meropenem and Pralurbactam to Ceftazidime and…
- Trial name
- NCT07327619
- Testing
- Meropenem and Pralurbactam, Ceftazidime-avibactam
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Ventilator Associated Pneumonia ( VAP)
Impact of Antibio Prophylaxis on Occurence of Ventilator Associated Pneumonia in Trauma Patients
The relevance of a short course of antibiotic prophylaxis for the prevention of ventilator assocaited pneumonia (VAP) in trauma patients, and its impact on bacterial ecology, remains to be clarified.
- Trial name
- antiVAP (NCT07059039)
- Where
- France
- Volunteers
- 2,143 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infections, Respiratory, Ventilator Associated Pneumonia
Comparison Between Different Ventilator Hyperinflation Maneuvers
The hyperinflation ventilator was performed in different modalities and ventilatory adjustments, with total pressure of 40cmH2O.
- Trial name
- NCT03631342
- Testing
- VCV20, VCV40, PCV
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Brazilian Institute of Higher Education of Censa
Respiratory Insufficiency
Efficacy of Early Tracheostomy to Reduce Incidence of Ventilator Acquired Pneumonia (VAP)
The study aims to assess early (one to three days after intubation) tracheostomy effectiveness in terms of reduction in ventilator associated pneumonia (VAP) incidence.
- Trial name
- NCT00262431
- Testing
- Tracheostomy on day 3-5 in early group and 10-12 in late group
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- University of Turin, Italy
Pneumonia, Ventilator-Associated, Pneumonia, Bacterial
A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia
The purpose of this study is to assess the safety and tolerability of doripenem compared to imipenem in Ventilator-assisted pneumonia and complicated Intra-abdominal Infection.
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Bacterial, Pneumonia, Abdominal Abscess
- Trial name
- NCT00515034
- Testing
- Imipenem/cilastatin, Doripenem
- Volunteers
- 146 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Ventilator Associated Pneumonia, Critical Care
Delayed Antibiotic Therapy in Non-severe Ventilator Acquired Pneumonia (VAP)
This retro-prospective monocentric observational study compare the impact of the implementation of a restrictive (delayed) versus aggressive (immediate) antibiotic strategy for Ventilator Acquired Pneumonia suspicion without…
- Conditions
- Ventilator Associated Pneumonia, Critical Care, Antibiotic Therapy
- Trial name
- DELAVAP (NCT05205525)
- Testing
- Restrictive antibiotic strategy, Aggressive antibiotic strategy
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Nantes University Hospital