Clinical trials: Ventilator Associated Pneumonia ( VAP)
Ventilator Associated Pneumonia
Effectiveness of a VAP Prevention Bundle in the PICU
This observational monocentric prospective study aims to evaluate the efficacy of new measures for ventilator associated pneumonia (VAP) management in the pediatric population in the pediatric intensive care unit (PICU) of…
- Trial name
- NCT03763695
- Testing
- Measures for the VAP prevention in the PICU, Evaluation of VAP incidence before the protocol introduction
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bacterial Infections
Diagnostic Breath Analysis for Detection of Ventilator Acquired Pneumonia (VAP)
Breath samples from patients with Ventilator Acquired Pneumonia (VAP) will be analyzed to identify Volatile Organic Compounds (VOC) that have been specifically associated with VAP in previous animal models.
- Trial name
- VAP-VOC (NCT03053258)
- Testing
- Collection of exhaled breath sample
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Landon Pediatric Foundation
VAP - Ventilator Associated Pneumonia
Microbiological Profile of VAP Patients in Respiratory ICU
Identification of the microbial profile of Ventilator associated pneumonia causing microorganisms among Respiratory ICU patients .
- Trial name
- VAP (NCT05738928)
- Testing
- blood and sputum culture
- Volunteers
- 86 people
- Sponsor
- Assiut University
Ventilator Associated Pneumonia
Probiotics to Actively Counter Ventilator Associated Pneumonia (PROACT)
PROACT study aims to resolve uncertainties to influence actual practice guidelines or public health policing regarding VAP prevention in ICU by using probiotics administration.
- Trial name
- PROACT (NCT06092554)
- Testing
- LactoLevure
- Where
- 10 sites in Belgium, Italy
- Volunteers
- 213 people
- Sponsor
- University of Bari
Antibiotic Side Effect
Usage of Procalcitonin to Reduce Antibiotics Duration in VAP in Neurosurgical ICU
Using Procalcitonin Tests to reduce antibiotics duration in Neurosurgical patients with Ventilated Associated Pneumonia
- Trial name
- NCT06395454
- Testing
- Shorten antibiotics duration based on procalcitonin test levels
- Volunteers
- 48 people
- Sponsor
- Universiti Sains Malaysia
VAP - Ventilator Associated Pneumonia
Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial
This is a prospective pilot/feasibility trial of a bundled diagnostic stewardship intervention at the level of the microbiologic testing pathway in ventilator-associated pneumonia (VAP).
- Trial name
- NCT05176353
- Testing
- VAP diagnostic stewardship bundle
- Where
- United States
- Volunteers
- 4,892 people
- Sponsor
- University of Michigan
Pneumonia, Ventilator-Associated, Colistin Adverse Reaction
Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonates
This study is planned to compare the clinical efficacy and safety of aerosolized plus intravenous colistin vs. intravenous colistin as adjunctive therapy for the treatment of ventilator-associated pneumonia (VAP) due to…
- Conditions
- Pneumonia, Ventilator-Associated, Colistin Adverse Reaction, Infection Due to Multidrug Resistant Acinetobacter, Infection Resistant to Multiple Drugs
- Trial name
- NCT02806141
- Testing
- Aerosolized plus intravenous colistin, Intravenous colistin
- Where
- Thailand
- Volunteers
- 204 people
- Sponsor
- Hat Yai Medical Education Center
VAP - Ventilator Associated Pneumonia
Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia
Statins with their powerful anti-inflammatory, immunomodulatory, and antioxidant properties make them candidate members to be used in the management of sepsis and different types of infections including pneumonia.
- Trial name
- NCT05230472
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 161 people
- Sponsor
- Ain Shams University
Ventilator Associated Pneumonia
Role of Lactoferrin in Prevention of Ventilator Associated Pneumonia in Neonates.
The aim of the study is to 1. Evaluate the preventive value of Lactoferrin on VAP among ventilated neonates. 2. Evaluate the Primary outcome of Lactoferrin on: Sepsis, Feeding intolerance, Vomiting, Constipation or diarrhea 3.
- Trial name
- NCT07255742
- Testing
- Lactoferrin in prevention of VAP, Control
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Dalia Mohamed Salah
Early Ventilator Associated Pneumonia
Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Hypothesis: 4 days of antibiotic therapy, as compared to 8 days, is equally effective and results in decreased antibiotic exposure among surgical ICU patients with early VAP.
- Trial name
- DATE (NCT01994980)
- Testing
- Default 4 days antibiotic therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Denver Health and Hospital Authority
Ventilator Associated Pneumonia (VAP), Evidence Based Practice
Effect of Implementing Evidence-based Practice and Nurse's Behavior Change on Quality of Care in Intensive Care Unit: Focus on Ventilator Associated Pneumonia in a Tertiary Hospital in Bangladesh
Quality of care is crucial for preventing adverse events such as infection in the intensive care units (ICUs). The most common ICU-acquired infections include pneumonia such as ventilator-associated pneumonia (VAP), Central Line…
- Trial name
- EBP in Nursing (NCT06624540)
- Testing
- This is a pre- and post- quasi-experimental study., Education with EBP
- Where
- 2 sites in Bangladesh, Japan
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Nosocomial Infections
Multi-center Observational Study to Evaluate Epidemiology and Resistance Patterns of Common ICU-Infections (MOSER)
Most literature on ICU infections and the resistant patterns comes from the western literature. This data may not truly reflect the incidence, epidemiology and resistance patterns in developing countries such as India.
- Trial name
- MOSER (NCT01346735)
- Testing
- No intervention
- Where
- India
- Volunteers
- 381 people
- Sponsor
- Indian Society of Critical Care Medicine
Ventilator Associated Pneumonia
Air-impingement Manipulation to Clear Subglottic Secretion to Prevent VAP in Prolonged Intubated Patients
Ventilator-associated pneumonia (VAP) is the most frequent infection occurring in patients who are admitted to the ICU. The accumulation of respiratory secretions in the subglottic space is a well-proven cause of VAP.
- Trial name
- NCT02632539
- Testing
- Manual air-impingement operation, subglottic secretion drainage
- Volunteers
- 220 people
- Sponsor
- Beijing Chao Yang Hospital
Ventilator-associated Pneumonia
Impact of Direct Antimicrobial Susceptibility Testing on Respiratory Sample of Intensive Care Patient With Suspected VAP
Inappropriate antibiotic therapy in ventilator-associated pneumonia (VAP) is associated with increased mortality. The international guidelines recommend using broad spectrum antimicrobials especially in patients who received…
- Trial name
- AB-DIRECT2 (NCT02897466)
- Testing
- Direct Antimicrobial Susceptibility Testing
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Associated Pneumonia
A Multi-Center Observational Surveillance Study of VAP Causing Bacteria
Detect the clinical causitive pathogen of Ventilator Associated Pneumonia (VAP) patients by the bronchoalveolar lavage (BAL) method.
- Trial name
- NCT00484588
- Volunteers
- 500 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Cross Infection, Pneumonia, Bacterial
Intravenous Colistin Versus Intravenous Colistin Plus Nebulized Colistin in VAP Due MDR Acinetobacter Baumannii
Compare the clinical efficiency evaluated by the treatment of the intravenous colistin plus inhaled colistin opposite to the treatment with colistin intravenous plus inhaled saline solution in patients with VAP due to baumannii…
- Trial name
- NCT00645723
- Testing
- Colistin, Colistin and saline solution
- Where
- Spain
- Volunteers
- 67 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Pneumonia
STATIN-VAP STATIN-VAP - STATINs and Ventilator-Associated Pneumonia
The objective is to assess the efficacy and safety of oral simvastatin in patients with a suspicion of ventilator-associated pneumonia (VAP).
- Trial name
- NCT01057758
- Testing
- SIMVASTATIN
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pneumonia
A Peri-intubation Oral Intervention to Reduce Oral Flora and VAP
The purpose of this study is determine if a single, early dose of chlorhexidine applied within 12 hours after endotracheal tube insertion will reduce the bacteria in the oral cavity and the incidence of pneumonia in trauma…
- Trial name
- NCT00248300
- Testing
- Chlorhexidine
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Virginia Commonwealth University
Ventilator Associated Pneumonia
Inhibition Effects of Probiotics on Pathogens Associated With VAP
This study evaluates that P. aeruginosa, A. baumannii, K. pneumonia and Staph aureus which are obtained from patients' tracheal aspiration culture who treated with mechanical ventilation will be compared with Lactobacillus (LAB)…
- Trial name
- NCT02928042
- Testing
- Lactobacillus bacteria
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Ventilator Associated Pneumonia
Oral Care as a Preventive Measure of VAP; Miswak Versus Chlorhexidine and Toothbrush.
Dental plaque score calculation and swabs of Oropharynx and teeth were collected on admission. For group I, Miswak stick was used 4 hourly for oral care. For group II, 0.12% Chlorhexidine/ toothbrush were used 4 hourly
- Trial name
- NCT02288390
- Testing
- Oral care in mechanically ventilated patients
- Volunteers
- 40 people
- Sponsor
- University of Alexandria