Clinical trials: Ventilator Associated Pneumonia ( VAP), active
Ventilator Associated Pneumonia ( VAP)
Pre-clinical Diagnosis Using Integrated Microbial and Host Response Signatures to Improve Outcomes From Ventilator-associated Pneumonia in Critically Ill Children
Ventilator-associated pneumonia (VAP), defined as pneumonia occurring 48 hours after initiation of invasive mechanical ventilation, is insidious in onset and severe in consequence.
- Trial name
- VAP-Dx (NCT07026656)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Cambridge
Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
Resistance-Optimised Antimicrobial Dosing in Critically Ill Patients, a Randomised Controlled Trial
Critically ill people who need a breathing machine often develop hospital-acquired lung infections. These infections are commonly treated with the antibiotics piperacillin/tazobactam or meropenem.
- Conditions
- Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP), Nosocomial Respiratory Infection, Critical Illness
- Trial name
- ROAD-RCT (NCT07820501)
- Testing
- Resistance-Optimised Precision Dosing, Standard Care Dosing
- Volunteers
- 610 people
- Sponsor
- The University of Queensland
Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection
Impact of Nurses' Behavior Change and Evidence-Based Practice Implementation on Quality Indicators in Intensive Care Units in Low- and Middle-Income Countries
Study title: Impact of nurses' behavior change and implementing evidence-based practice to improve quality indicators in intensive care units in low-and middle-income countries Background and Rationale: Quality care is crucial…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection, Pressure Ulcers (Hospital-acquired Pressure Injuries), Prolonged Intensive Care Unit Length of Stay
- Trial name
- NCT07397364
- Testing
- Evidence based practices bundles of care
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Ventilator-Associated Pneumonia (VAP), Inha'le'd
Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain Injury
Ventilator associated pneumonia is the most common manifestation of hospital acquired infections in ICU. The incidence of ventilator-associated pneumonia in patients receiving mechanical ventilation is as high as 20% -71%, which…
- Trial name
- NCT06819462
- Testing
- Inhaled colistin, Inhaled 0.9% sodium chloride
- Where
- China
- Volunteers
- 444 people
- Sponsor
- Southeast University, China
Ventilator-Associated Pneumonia (VAP)
Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Placebo-Controlled Trial
Previous studies have identified Acinetobacter baumannii (AB), Pseudomonas aeruginosa (PA), and Klebsiella pneumoniae (KP) as the predominant pathogens responsible for ventilator-associated pneumonia (VAP).
- Trial name
- CIVAP (NCT06834971)
- Testing
- Colistimethate sodium (CMS)
- Where
- China
- Volunteers
- 508 people
- Sponsor
- Qilu Hospital of Shandong University
Ventilator Acquired Pneumonia, Mechanical Ventilation Complication
ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units.
- Trial name
- ClusterVAP (NCT07245888)
- Where
- 4 sites in France, Portugal and 1 more
- Volunteers
- 400 people
- Sponsor
- Region Skane
COPD, COPD Exacerbation
Study of Sleep Quality in the Intensive Care Unit and Association with Weaning from Invasive Ventilation in Patients with Chronic Obstructive Bronchopneumopathy.
Patients admitted in ICU may require invasive mechanical ventilation, using a mechanical ventilator and an endotracheal tube. In ICU, a prolonged duration of invasive mechanical ventilation may be responsible for…
- Conditions
- COPD, COPD Exacerbation, Ventilated Patients, Ventilator-Associated Pneumonia (VAP)
- Trial name
- SLEECOP (NCT06653933)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Ventilator Associated Pneumonia (VAP)
Heparin Binding Protein Versus Platelet Count and Mean Platelet Volume Kinetics in the Diagnosis and Prognosis of VAP
mechanically ventilated for 48 hours or more and subsequently develop ventilator-associated pneumonia (VAP). After obtaining approval from the local ethical committee at the Faculty of Medicine, El-Minia University, and informed…
- Trial name
- NCT06993623
- Testing
- heparin binding protien
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Esraa Hamdy Thabit Riad
Ventilator Associated Pneumonia ( VAP)
Effect of Two Oral Care Methods on Oral Flora and VAP in Mechanically Ventilated Patients
This randomized controlled trial aims to evaluate the effect of two oral care methods on oral bacterial colonization and ventilator-associated pneumonia (VAP) in mechanically ventilated intensive care unit (ICU) patients.
- Trial name
- ORAVAP-RCT (NCT07283380)
- Testing
- Pediatric toothbrush, Sponge stick
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Marmara University
Mechanical Ventilation, Infection Prevention
Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units
The goal of the ORACLE study is to evaluate the impact of implementing a standardized oral hygiene bundle on outcomes in critically ill, mechanically ventilated patients.
- Conditions
- Mechanical Ventilation, Infection Prevention, Oral Care, Oral Hygiene, Oral Health
- Trial name
- ORACLE (NCT07129733)
- Testing
- Oral hygiene bundle
- Where
- 6 sites in Brazil
- Volunteers
- 4,800 people
- Sponsor
- Hospital do Coracao
Critical Illness, Mechanical Ventilation
Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Controlled Trial
Ventilator-associated pneumonia (VAP) remains the most common hospital-acquired infection worldwide, affecting up to 40% of mechanically ventilated patients and contributing to increased morbidity, prolonged hospital stays, and…
- Trial name
- MICRO-VAP (NCT07463339)
- Testing
- Microbiome-guided inhaled antibiotic prophylaxis
- Volunteers
- 70 people
- Sponsor
- University of Calgary
Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP)
Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients
Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients.
- Conditions
- Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP), Respiratory Depression Neonatal
- Trial name
- NCT07375667
- Testing
- The dynamics of airway resistance, conventional suctioning
- Where
- 3 sites in China
- Volunteers
- 258 people
- Sponsor
- Affiliated Hospital of Nantong University
Ventilator-associated Pneumonia
B Lymphocyte Populations in the Pulmonary Microenvironment of Patients Under Mechanical Ventilation With or Without VAP (Ventilator-Associated Pneumonia)
Diagnosis of VAP relies on a set of non-specific clinical, biological, and imaging criteria. Understanding host-pathogen interactions and the mechanisms of deregulations leading to infection of pulmonary tissue appears essential.
- Trial name
- OLYMPE (NCT07436780)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Limoges
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Ventilator Associated Pneumonia (VAP), Evidence Based Practice
Effect of Implementing Evidence-based Practice and Nurse's Behavior Change on Quality of Care in Intensive Care Unit: Focus on Ventilator Associated Pneumonia in a Tertiary Hospital in Bangladesh
Quality of care is crucial for preventing adverse events such as infection in the intensive care units (ICUs). The most common ICU-acquired infections include pneumonia such as ventilator-associated pneumonia (VAP), Central Line…
- Trial name
- EBP in Nursing (NCT06624540)
- Testing
- This is a pre- and post- quasi-experimental study., Education with EBP
- Where
- 2 sites in Bangladesh, Japan
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Ventilator Associated Pneumonia
Perpetual Observational Study - Ventilator Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation.
- Trial name
- POS-VAP (NCT05719259)
- Where
- 35 sites in Albania, Belgium and 11 more
- Volunteers
- 20,000 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
Ventilator Associated Bacterial Pneumonia (VABP), Critical Illness
Effect of Ventilator Hyperinflation Combined With Body Positioning on ABG in VAP
This study aims to evaluate the effect of ventilator hyperinflation combined with body positioning on arterial blood gases in patients with ventilator-associated pneumonia.
- Trial name
- NCT07854730
- Testing
- Ventilator hyperinflation, Manual hyperinflation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Zaytoonah University of Jordan
VAP - Ventilator Associated Pneumonia
Bacteriophage Cocktail Therapy for Multidrug-Resistant Gram-Negative Ventilator-Associated Pneumonia
The purpose of this study is to systematically evaluate the efficacy and safety of bacteriophage cocktail therapy in patients with ventilator-associated pneumonia caused by Gram-negative bacterial infections.
- Trial name
- NCT07202234
- Testing
- Phage cocktail administered via nebulization, Nebulized normal saline inhalation therapy
- Volunteers
- 248 people
- Sponsor
- Chinese PLA General Hospital
Ventilator-Associated Pneumonia (VAP)
Efficacy and Safety of Prophylactic Antibiotics in Preventing Ventilator-associated Pneumonia: A Randomized, Double Blind, Placebo-controlled Trial
Evaluate efficacy and safety of prophylactic antibiotics in preventing early ventilator-associated pneumonia
- Trial name
- NCT07203638
- Testing
- Beta Lactam Antibiotics, Salin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Esraa Salah Mohamed Abdallah Eladl
Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)
National Surveillance and Prevention of Neonatal VAP
The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD), Antibiotic-Resistant Organisms (AROs), Health-Care Associated Infection (HAI)
- Trial name
- NCT07109791
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta