Clinical trials: Ventilator Associated Pneumonia (VAP)
Ventilator-associated Pneumonia
Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates
The goal of this pilot study is to test the hypothesis that mechanically ventilated infants receiving Biotene OralBalance® gel for oral care would have a reduced intubation time compared to infants receiving oral care placebo.
- Trial name
- NCT01314742
- Testing
- Biotene OralBalance® gel, Sterile Water moisten cotton tipped applicator
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Ventilator Associated Pneumonia
Perpetual Observational Study - Ventilator Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation.
- Trial name
- POS-VAP (NCT05719259)
- Where
- 35 sites in Albania, Belgium and 11 more
- Volunteers
- 20,000 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
Ventilator-associated Pneumonia, Hospital-acquired Pneumonia
Identifying Risk Factors for Gram-negative Resistance for HAP/VAP in the Intensive Care Unit
Single center, retrospective chart review. Patients admitted to MDMC ICU from 4/1/2017 to 6/30/2020 will be identified through the electronic medical record utilizing ICD codes for HAP and VAP.
- Trial name
- NCT04700202
- Testing
- Observational
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Methodist Health System
VAP - Ventilator Associated Pneumonia, Care
Effect of the Aspiration Care Bundle on Preventing VAP
Many pharmacological and non-pharmacological interventions are used to prevent ventilator-associated pneumonia (VAP). Nurses are directly responsible for implementing non-pharmacological interventions and therefore have an…
- Conditions
- VAP - Ventilator Associated Pneumonia, Care, Bundle Care, Aspiration
- Trial name
- NCT07138651
- Testing
- Aspiration care bundle
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Ventilator Associated Pneumonia
Study of Different Etiologic Diagnostic Methods in Ventilator Associated Pneumonia (VAP)
The study is designed to evaluate sensitivity, specificity and accuracy of non-bronchoscopic bronchoalveolar lavage and endotracheal aspirate in comparison with bronchoscopic bronchoalveolar lavage (gold standard), as methods for…
- Trial name
- NCT02363023
- Testing
- Collect tracheal and pulmonary secretions
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Uberlandia
Complicated Intra-Abdominal Infections, cIAIs, Hospital-acquired Pneumonia (HAP)
Real-World Effectiveness of Aztreonam-Avibactam Against MBL-Producing CRE
Why This Study is Needed Some bacterial infections have become resistant to common antibiotics, making them very difficult to treat. This is a growing and serious health problem.
- Conditions
- Complicated Intra-Abdominal Infections, cIAIs, Hospital-acquired Pneumonia (HAP), Ventilator-Associated Pneumonia (VAP)
- Trial name
- AWARE (NCT07268560)
- Testing
- Aztreonam-Avibactam
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Sir Run Run Shaw Hospital
Enterobacteriaceae Infections
Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers.
Antimicrobial resistance is a major threat worldwide and now concerns last-ressource antibiotics such as carbapenems. As the resistance to carbapenems is directly due to their use, their spare has become a public health…
- Trial name
- PROBATAZO (NCT04276480)
- Testing
- Piperacillin-tazobactam
- Where
- 2 sites in France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Bordeaux
Ventilator Associated Pneumonia ( VAP), Sepsis
High Dose of Vitamin C on Mechanically Ventilated Septic Patients in Intensive Care Unit
Prospective, Randomized clinical trial study will be carried out in intensive care unit in Ain Shams University Hospitals on 40 forty septic patients admitted to ICU and mechanically ventilated.
- Trial name
- NCT04029675
- Testing
- Vitamin C
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Endotracheal Extubation, Airway Obstruction
Efficacy Study of a Novel Device to Clean the Endotracheal Tube
The purpose of this study is to evaluate the in-vivo efficacy of a novel device (endOclear) for cleaning the endotracheal tube (ETT) lumen from secretions.
- Conditions
- Endotracheal Extubation, Airway Obstruction, Airway Control, Pneumonia, Ventilator-Associated
- Trial name
- NCT01765530
- Testing
- ETT cleaning maneuver
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Massachusetts General Hospital
Ventilator-Associated Pneumonia (VAP)
Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia
Ventilator-associated pneumonia is the leading nosocomial infection in the intensive care units, and is associated with prolonged mechanical ventilation and overuse of antibiotics.
- Trial name
- POSTPONE (NCT06743529)
- Testing
- control group, Conservative strategy
- Where
- 42 sites in France, Guadeloupe
- Volunteers
- 686 people
- Sponsor
- Nantes University Hospital
Mechanical Ventilation
Lung Microbiota and VAP Development (PULMIVAP)
Ventilator-associated pneumonia (VAP) refers to a lower respiratory tract nosocomial infection acquired >48h after being intubated in Intensive Care Units.
- Trial name
- PULMIVAP (NCT04849039)
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilator Associated Pneumonia, Covid19
Incidence of VAP in Patients With Severe COVID-19
Combined retrospective and prospective cohort study to evaluate the incidence of microbiologically confirmed VAP in mechanically ventilated patients with COVID-19.
- Trial name
- CoV-AP (NCT04766983)
- Testing
- bronchoalveolar lavage
- Where
- Italy
- Volunteers
- 323 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilator-Associated Pneumonia (VAP), Inha'le'd
Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain Injury
Ventilator associated pneumonia is the most common manifestation of hospital acquired infections in ICU. The incidence of ventilator-associated pneumonia in patients receiving mechanical ventilation is as high as 20% -71%, which…
- Trial name
- NCT06819462
- Testing
- Inhaled colistin, Inhaled 0.9% sodium chloride
- Where
- China
- Volunteers
- 444 people
- Sponsor
- Southeast University, China
Ventilator Associated Pneumonia ( VAP)
Clinical Outcomes of Inhaled Amikacin in Ventilator Associated Pneumonia
Article: Clinical Outcomes of Inhaled Amikacin in Ventilator-Associated Pneumonia: A group randomized controlled,add-on trial English:Patients in intensive care units often need ventilators to breathe.
- Trial name
- RCT (NCT07369336)
- Testing
- Amikacin (Inhalation), Standard-of-Care Intravenous Antibiotics
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Ventilator Associated Pneumonia ( VAP)
VAP Identification by AI
Ventilator-associated pneumonia (VAP) is the most frequent infection in the intensive care setting. For VAP there is currently no reliable diagnostic criteria.
- Trial name
- AI-VAP (NCT06917521)
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Ventilator Associated Pneumonia, Aspiration
Ventilator Aspiration With PneuX (PneuX vs Standard Care Feasibility RCT)
This is a single centre, open-label, feasibility randomised controlled trial. The study aims to assess the feasibility of conducting an RCT to compare the PneuX ETT with standard care in hospitalised patients requiring mechanical…
- Conditions
- Ventilator Associated Pneumonia, Aspiration, Infections, Ventilator Lung
- Trial name
- VAP-X (NCT05410106)
- Testing
- PneuX Endotracheal Tube, Standard care (Taperguard, Covidien)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cardiff and Vale University Health Board
VAP - Ventilator Associated Pneumonia, Antibiotic
EARLY Antibiotics aDAptation in Severe Pneumonia(The EARLY ADAPT Study)
The objective of the study is to determine whether rapid multiplex PCR testing of respiratory samples can reduce exposure to broad-spectrum antibiotics in intensive care unit patients with suspected or confirmed…
- Conditions
- VAP - Ventilator Associated Pneumonia, Antibiotic, Antibiotic Stewardship, Antibiotic Prescribing for Acute Respiratory-tract Infections
- Trial name
- EARLY ADAPT (NCT07267624)
- Testing
- PCR multiplex BioFire Pneumonia plus
- Where
- 5 sites in Switzerland
- Volunteers
- 170 people
- Sponsor
- University Hospital, Geneva
Microbial Colonization, COVID-19 Respiratory Infection
Impact of Teeth Brushing in Ventilated COVID-19 Patients.
The aims of this study were: 1. Observation of dynamics in oral microbiota and its association with the incidence of HAIs and VAP in mechanically ventilated COVID-19 patients in an ICU setting 2.
- Conditions
- Microbial Colonization, COVID-19 Respiratory Infection, Dysbiosis, VAP - Ventilator Associated Pneumonia
- Trial name
- NCT05575050
- Testing
- Oral Procedure
- Where
- Poland
- Volunteers
- 56 people
- Sponsor
- University Hospital in Krakow
Ventilator-Associated Pneumonia (VAP)
Efficacy and Safety of Prophylactic Antibiotics in Preventing Ventilator-associated Pneumonia: A Randomized, Double Blind, Placebo-controlled Trial
Evaluate efficacy and safety of prophylactic antibiotics in preventing early ventilator-associated pneumonia
- Trial name
- NCT07203638
- Testing
- Beta Lactam Antibiotics, Salin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Esraa Salah Mohamed Abdallah Eladl
VAP - Ventilator Associated Pneumonia
Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation
HyPerMICROBE is a single-centre, controlled, randomised, prospective, superiority clinical trial to compare the efficacy of daily oral care with 3% hydrogen peroxide (Oroxid®) versus standard of care (0.2% chlorhexidine…
- Trial name
- HyperMICROBE (NCT06045429)
- Testing
- Oroxid®, Chlorhexidine mouthwash
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- Charles University, Czech Republic