Clinical trials: Ventilator Weaning
Respiratory Insufficiency in Children, Noninvasive Ventilation
Validation of Indirect Calorimetry in Children Undergoing Non-invasive Ventilation
Nutritional status in critically ill pediatric patients is considered a fundamental prognostic factor in terms of mortality, morbidity, complications and outcome.
- Conditions
- Respiratory Insufficiency in Children, Noninvasive Ventilation, Nutrition Assessment
- Trial name
- CALO-NIV (NCT03824249)
- Testing
- Indirect Calorimetry
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Critically Ill
Microcirculation in Spontaneous Breathing Trial
Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients.
- Trial name
- NCT04711590
- Testing
- Microcirculation examination
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- National Taiwan University Hospital
Respiratory Failure
Negative Pressure Ventilation Imapcts Weaning Ventilator In Medical Intensive Care Units (ICUs)
This is a Quasi-experimental research design. The subjects are limited in intensive care unit within north medical center hospital. All subjects depend on ventilator and receive weaning plans.
- Trial name
- NCT01155596
- Testing
- negative pressure ventilator use
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Weaning Failure, Central Respiratory Depression
Exploration of Mechanisms for Weaning Failure
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline…
- Conditions
- Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder
- Trial name
- NCT06424314
- Testing
- Monitoring of respiratory mechanics parameters
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Pediatric Liver Transplantation, Weaning From Mechanical Ventilation
NAVA vs PSV Ventilation During Weaning From Mechanical Ventilation in Children After Liver Transplantation
Liver transplantation is the treatment of choice for acute and chronic end-stage liver disease. Neurally Adjusted Ventilator Assist (NAVA) may be a feasible solution to guide the liberation from mechanical ventilation reducing…
- Trial name
- NAVIGATE (NCT04792788)
- Testing
- Weaning from mechanical ventilation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Post-cardiac Surgery, Ventilator Weaning
Correlation Analysis Between Mostcare Parameters and Spontaneous Breathing Trial in Patients After Cardiac Surgery
Cardiac output (CO) monitoring is of primary importance in high-risk surgery and critically ill patients. Intermittent thermodilution (ThD) by means of a pulmonary artery catheter (PAC) was invasiveness, the occurrence of…
- Trial name
- NCT06230497
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Ventilator Induced Diaphragm Dysfunction
Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing
A randomized clinical trial to investigate the use of the temporary Diaphragm Pacing Therapy System (DPTS) to rehabilitate the diaphragm in mechanically ventilated patients who have failed at least two weaning attempts.
- Trial name
- RESCUE2 (NCT03096639)
- Testing
- Diaphragmatic Pacing Therapy DPTS
- Where
- 21 sites in France, Germany
- Volunteers
- 110 people
- Sponsor
- Lungpacer Medical Inc.
Heart Failure Acute, Ventilator Lung
SGLT2 Inhibitors in Patients With ADHF During Ventilator Weaning
This study will explore the potential benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in preventing cardiac ischemia and cardiopulmonary edema in patients with acute decompensated heart failure during weaning from…
- Trial name
- NCT06142474
- Testing
- SGLT2 inhibitor
- Where
- Taiwan
- Volunteers
- 450 people
- Sponsor
- National Taiwan University Hospital
Pediatric Respiratory Diseases, Ventilator Weaning
WOB and Paediatric Mechanical Ventilation
Rationale: The most common approach to weaning infants and children is gradual reduction of ventilatory support ("traditional approach").
- Conditions
- Pediatric Respiratory Diseases, Ventilator Weaning, Respiration, Artificial, Respiratory Failure
- Trial name
- PedWOB (NCT05254691)
- Testing
- Sprinting
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Mechanical Ventilation, Single-lung Ventilation
Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time
The results of this study will help to define the capability and reliability of PulmoVista 500 to detect changes in both global and regional ventilation.
- Conditions
- Mechanical Ventilation, Single-lung Ventilation, ARDS, ALI - Acute Lung Injury
- Trial name
- NCT03076983
- Testing
- Lung Monitoring with EIT device (PulmoVista 500)
- Where
- 3 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Drägerwerk AG & Co. KGaA
Ventilators, Mechanical, Work of Breathing
Effort of Breathing Guided Ventilator Protocol
This pilot study tests the feasibility of using a computerized ventilator management protocol seeking to encourage lung protective ventilation during the acute phase of ventilation, and esophageal manometry based titration of…
- Trial name
- EOBvent (NCT02989246)
- Testing
- Ventilator protocol, Esophageal Catheter
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Hospital Los Angeles
Ventilators, Mechanical, Intensive Care Units
Postoperative INTELLiVENT-ASV Ventilation
The aim of this study is to investigate whether postoperative ventilation with INTELLiVENT-ASV(adaptive support ventilation) in high risk patients, after cardiothoracic surgery, is as effective, more user-friendly and as safe as…
- Conditions
- Ventilators, Mechanical, Intensive Care Units, Postoperative Care
- Trial name
- POSITiVE (NCT03180203)
- Testing
- INTELLiVENT-ASV, Conventional modes
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Mechanical Ventilation Complication
Mechanical Ventilator Weaning in Chronically Ventilated Patients
Mechanical ventilation is a commonly used life-saving hospital procedure for patients with severe breathing difficulty. Some patients have difficulty separating from the ventilator and need to be removed gradually.
- Trial name
- NCT06976554
- Testing
- weaning
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prematurity; Extreme
High Flow Nasal Cannula in Preterm Infants
The HIFLO study evaluates the impact of HFNC oxygen therapy on duration of nCPAP therapy, oxygen therapy and hospitalization. The cost of use of CPAP and two HFNC devices are also evaluated.
- Trial name
- HIFLO (NCT03007056)
- Testing
- High flow nasal cannula
- Where
- France
- Volunteers
- 207 people
- Sponsor
- Hôpital de la Croix-Rousse
Ventilator Weaning
Echocardiographic Detection of Extravascular Lung Water Increase During Weaning From Mechanical Ventilation
Switching from positive airway pressure ventilation to spontaneous ventilation during weaning from mechanical ventilation, pulmonary edema may occur and in this case, doppler echocardiographic (U/S) indices of cardiac dysfunction…
- Trial name
- ECHOBAG (NCT02412202)
- Testing
- Monitoring of pulmonary oedema induced by weaning from mechanical ventilation
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Thessaly
Ventilator Weaning, Sarcopenia
Comparison of Sarcopenia Index, Diaphragm Ultrasonography, and Traditional Weaning Parameters in Predicting Successful Weaning From Mechanical Ventilation
This study investigates whether the Sarcopenia Index (SI = serum creatinine/cystatin C × 100), a simple biomarker derived from routine blood tests, can predict weaning success in critically ill patients undergoing invasive…
- Conditions
- Ventilator Weaning, Sarcopenia, Diaphragm Ultrasonography
- Trial name
- NCT07844421
- Testing
- sarcopenia index, diaphragma ultrasound, parameters of mechanical ventilation (MV)
- Volunteers
- 80 people
- Sponsor
- Kocaeli City Hospital
Weaning Failure
Predictive Analysis Software for Successful Weaning From Ventilator of Patients
Making a weaning decision for a patient on a mechanical ventilator is an important clinical issue. The most common index to predict successful weaning is the rapid shallow breathing index (RSBI), however, the accuracy of RSBI to…
- Trial name
- NCT02915458
- Where
- Taiwan
- Volunteers
- 188 people
- Sponsor
- Chang Gung Memorial Hospital
Intra-Abdominal Hypertension, Respiratory Mechanics
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
This prospective observational cohort study aims to investigate the relationship between intra-abdominal pressure (IAP), respiratory system mechanics, and successful liberation from invasive mechanical ventilation in adult…
- Conditions
- Intra-Abdominal Hypertension, Respiratory Mechanics, Mechanical Ventilation
- Trial name
- IAP-VENT (NCT07889609)
- Testing
- Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Respiration, Artificial, COVID-19
Characteristics of Weaning From Mechanical Ventilation in COVID-19
This report is a multicenter, observational, analytical and prospective study. The objective was to describe the weaning of mechanical ventilation in patients with SARS-CoV-2 and the clinical results according to the different…
- Trial name
- CovWean (NCT05049200)
- Where
- 2 sites in Argentina
- Volunteers
- 326 people
- Sponsor
- Sanatorio Anchorena San Martin