Clinical trials: Ventilator-acquired Pneumonia
Ventilator Associated Pneumonia
Risk Factors and Common Preventive Measures for Ventilator Associated Pneumonia in Patients With Severe Traumatic Brain Injury
The primary objective of this study is to assess the incidence of VAP in patients with TBI and to identify risk factors for developing VAP in this specific patient population (types of co-injuries in patients with multiple trauma…
- Trial name
- NCT03266380
- Testing
- observational
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ventilator-Associated Pneumonia (VAP)
Efficacy and Safety of Prophylactic Antibiotics in Preventing Ventilator-associated Pneumonia: A Randomized, Double Blind, Placebo-controlled Trial
Evaluate efficacy and safety of prophylactic antibiotics in preventing early ventilator-associated pneumonia
- Trial name
- NCT07203638
- Testing
- Beta Lactam Antibiotics, Salin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Esraa Salah Mohamed Abdallah Eladl
Ventilator Associated Pneumonia, Morality
Endotracheal Tube Cuff Pressure Measurement
The effect of endotracheal cuff pressure measurement technique for preventing ventilatory associated pneumonia.
- Conditions
- Ventilator Associated Pneumonia, Morality, Trauma, Brain, Endotracheal Aspiration
- Trial name
- NCT04397952
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Ventilator Associated Pneumonia, Covid19
Presepsin Biomarker for Ventilator-associated Pneumonia Diagnosis in COVID-19 Patients
This study is observational and double blind. It evaluates the validity of presepsin (a serum biomarker of bacterial infections) as early biomarker of Ventilator Associated Pneumonia.
- Trial name
- NCT04840940
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- San Luigi Gonzaga Hospital
Gram-Negative Bacterial Infections
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Cefiderocol in Hospitalized Neonates and Infants
The primary purpose of this study is to understand the pharmacokinetics (PK) of single and multiple doses of cefiderocol in children from birth to less than 3 months of age with suspected or confirmed aerobic Gram-negative…
- Trial name
- NCT06086626
- Testing
- Cefiderocol, Standard of Care
- Where
- 4 sites in United States, South Africa and 1 more
- Volunteers
- 30 people
- Sponsor
- Shionogi
Infection Resistant to Multiple Drugs
Prospective Observational Pilot-study for the Evaluation of the Nephro- an Neurotoxicity in the Anti-infectious Therapy With Inhalative Colistin Therapy for Patients With Ventilator-associated Pneumonia (VAP)
Multi-Drug resistant pathogens (MDR) are reported worldwide with increasing incidence, especially in intensive care settings. One of the drugs which are effective against MDRs, is colistin (polymyxin E).
- Trial name
- LOKALE (NCT01894347)
- Testing
- TDM, Monitoring of Neuro-and Nephropathology
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- Charite University, Berlin, Germany
Pneumonia Ventilator Associated, Pneumonia Neonatal
Reduction of the Incidence of NAV in Neonatal Units (INBERNAV-Neo)
The aim of this project is to achieve useful, universal and standardized definitions for the diagnosis and prevention of ventilator-associated neumonia in patients in the Neonatal Intensive Care Unit (NICU).
- Conditions
- Pneumonia Ventilator Associated, Pneumonia Neonatal, Healthcare-associated Infections
- Trial name
- INBERNAV-Neo (NCT07240038)
- Testing
- Multimodal intervention to reduce the incidence of ventilator-associated pneumonia by training the health care team in specific and general evidence-based good clinical practices., Technique with a blind-protected catheter
- Where
- 39 sites in Spain
- Volunteers
- 1,500 people
- Sponsor
- Biobizkaia Health Research Institute
Pneumonia
Lung Ultrasound-Guided Positioning Strategy for the Prevention of Ventilator-Associated Pneumonia in Neonates
This study aims to determine if using lung ultrasound to guide personalized positioning for ventilated newborns is more effective than standard repositioning at preventing ventilator-associated pneumonia.
- Trial name
- LUS-POSforVAP (NCT07254507)
- Testing
- standard positioning management, Lung Ultrasound Guided Localization
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Huiyi Li
Ventilator Associated Pneumonia
Research Title: Efficacy and Safety of Point- Of-care Procalcitonin Test to Reduce Antibiotic Exposure in VAP
Several studies have shown that PCT guidance can reduce the duration of antibiotic treatment for patients with bacterial infections in the ICU, without compromising the safety outcomes.
- Trial name
- NCT03982667
- Testing
- PCT-guided group
- Where
- 2 sites in Malaysia
- Volunteers
- 100 people
- Sponsor
- Mohd Zulfakar Mazlan, MBBS
VAP - Ventilator Associated Pneumonia
Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia
Statins with their powerful anti-inflammatory, immunomodulatory, and antioxidant properties make them candidate members to be used in the management of sepsis and different types of infections including pneumonia.
- Trial name
- NCT05230472
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 161 people
- Sponsor
- Ain Shams University
Multi-drug Resistant Gram-negative Bacilli Colonization
Multidrug Resistant Gram-negative Bacilli Colonization and Infection in Burn
This is a prospective observational study to determine the role of colonization and identify the timing of development of drug resistance in multidrug resistant Gram-negative bacilli (MDR-GNB) causing infection among critically…
- Trial name
- NCT02653157
- Testing
- MDR-GNB
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of North Carolina, Chapel Hill
Ventilator-Associated Pneumonia, Severe Pneumonia
Fiberoptic Bronchoscopy in Severe Ventilator-associated Pneumonia
This randomized controlled trial evaluated the clinical effect of fiberoptic bronchoscopy in the management of adult patients with severe ventilator-associated pneumonia (VAP).
- Conditions
- Ventilator-Associated Pneumonia, Severe Pneumonia, Critical Illness
- Trial name
- NCT07149909
- Testing
- Other (Conventional Therapy), Fiberoptic Bronchoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Intubated Patient Requiring a Gastric Tube
Impact of the Choice of Gastric Tube Placement Sites on the Incidence of Ventilator Associated Pneumonia
In intensive care, many gastric tubes are inserted on a regular basis. There are different practices in terms of the location of the gastric tube.
- Trial name
- SONG (NCT05915663)
- Testing
- nasogastric tube and orogastric tube, orogastric tube and nasogastric tube
- Where
- 16 sites in France
- Volunteers
- 2,400 people
- Sponsor
- Centre Hospitalier le Mans
Endotracheal Intubation During Surgery, Hospital Acquired Infections
BIP ETT Clinical Tolerability, Safety and Performance Study
The objective of the study is to determine Bactiguard coated BIP Endotracheal tube´s tolerability, safety and performance and compare it to a standard un-coated Endotracheal tube.
- Trial name
- BIPETT (NCT01682486)
- Testing
- BIP ETT (Bactiguard), Standard ETT
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Bactiguard AB
Ventilator-acquired Pneumonia
Endotracheal Tubes for Prevention of Ventilator-associated Pneumonia
Researchers are looking at three different types of breathing tubes to see if any of them are better at preventing pneumonia than the others.
- Trial name
- PreVent (NCT01744483)
- Testing
- PVC ETT, PUC ETT, PUC-CASS ETT
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Washington
Respiratory Intensive Care Unit Patients With Ventilator Associated Pneumonia
Compined SONOPULMONARY Infection Score and APACHE Score in RICU Patients With VAP
Aim of the study : 1. Efficacy of Sono pulmonary infection score in combination with APACHE score in early diagnosis of VAP 2. Assessment of prediction role of combined SIPS SCORE and APACHE SCORE of outcome of VAP patient in…
- Trial name
- NCT06090032
- Testing
- Ultrasound
- Volunteers
- 53 people
- Sponsor
- Assiut University
Ventilator Associated Pneumonia, Staphylococcus Aureus
A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2
Clinical trial looking at safety and efficacy of suvratoxumab in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients
- Trial name
- SAATELLITE-2 (NCT05331885)
- Testing
- Suvratoxumab
- Where
- 27 sites in Belgium, France and 4 more
- Volunteers
- 24 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Ventilator-associated Pneumonia
Biomarker-based Exclusion of VAP for Improved Antibiotic Stewardship
Critically ill patients whose lungs are supported by breathing machines (ventilators) commonly develop a new lung infection, called ventilator-associated pneumonia (VAP).
- Trial name
- VAPRapid-2 (NCT01972425)
- Testing
- Biomarker-based diagnostic
- Where
- 19 sites in United Kingdom
- Volunteers
- 211 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Ventilator Associated Pneumonia
Frequency of Ventilator Associated Pneumonia (VAP) in Mechanically Ventilated Patients Using the AnapnoGuard System
Ventilator Associated Pneumonia (VAP) is a common complication experienced by mechanically ventilated patients and within the framework of Respiratory Intensive Care Units.
- Trial name
- NCT01126320
- Testing
- AnapnoGuard 100,, routine mechanical ventilator
- Where
- Israel
- Volunteers
- 161 people
- Sponsor
- Hospitech Respiration
Ventilator Associated Pneumonia, Multi-antibiotic Resistance
Ventilator Associated Pneumonia by Multi-Drug Resistant Organism
Ventilator-associated pneumonia (VAP) is an infection of the pulmonary parenchyma in patients exposed to invasive mechanical ventilation for at least 48 h and is part of ICU-acquired pneumonia.
- Trial name
- VAP-MDR (NCT05549427)
- Testing
- Ventilation
- Where
- Oman
- Volunteers
- 319 people
- Sponsor
- Sultan Qaboos University