Clinical trials: Ventilator-acquired Pneumonia
Pneumonia, Ventilator-Associated
Effect of Aerosolised Colistin in Ventilator Associated Pneumonia
the management of Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) gram-negative bacilli (GNB) represent a real therapeutic dilemma in intensive care unit (ICU).
- Trial name
- NCT02683603
- Testing
- AS colistin and "imipenem", IV colistin " and "imipenem" ., AS colimycin (colistin)
- Where
- Tunisia
- Volunteers
- 133 people
- Sponsor
- Tunis University
Pneumonia, Ventilator-Associated
Microbiologic Response With Linezolid And Vancomycin In Ventilator-Associated Pneumonia Due To Methicillin Resistant Staphylococcus Aureus
Ventilator-associated pneumonia (VAP) is a commonplace complication of intensive care patients ventilated for longer than 48 hours.
- Trial name
- NCT00572559
- Testing
- Vancomycin, Linezolid
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 149 people
- Sponsor
- Pfizer
Ventilator Associated Pneumonia
Impact of Imipenem With Amikacin Pharmacokinetic and Pharmacodynamic
The study is a prospective open trial conducted in 4 centers, and designed to determine if pharmacokinetic (PK) and pharmacodynamic (PD) parameters of imipenem, associated with amikacin as empirical therapy, impact…
- Trial name
- IMPACT (NCT00950222)
- Testing
- Imipenem/Amikacin
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Health Care Associated Infection, Ventilator Associated Pneumonia
Daily Chlorexidine Bath for Health Care Associated Infection Prevention
Cluster randomized controlled trial comparing two bathing strategies in critically ill patients. The intervention group will receive daily bathing with chlorhexidine. The control group will receive usual care.
- Conditions
- Health Care Associated Infection, Ventilator Associated Pneumonia, Central Line-associated Bloodstream Infection (CLABSI), Catheter-Associated Urinary Tract Infection
- Trial name
- CLEAN-IT (NCT05485051)
- Testing
- 2% chlorhexidine digluconate solution with surface-active agents, Usual Baths
- Where
- 16 sites in Brazil
- Volunteers
- 15,730 people
- Sponsor
- Hospital do Coracao
Endotracheal Extubation, Airway Obstruction
Efficacy Study of a Novel Device to Clean the Endotracheal Tube
The purpose of this study is to evaluate the in-vivo efficacy of a novel device (endOclear) for cleaning the endotracheal tube (ETT) lumen from secretions.
- Conditions
- Endotracheal Extubation, Airway Obstruction, Airway Control, Pneumonia, Ventilator-Associated
- Trial name
- NCT01765530
- Testing
- ETT cleaning maneuver
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Massachusetts General Hospital
Hospital-acquired Bacterial Pneumonia (HABP), Ventilator-associated Bacterial Pneumonia (VABP)
A Trial of HRS-8427 in the Treatment of Adults With Bacterial Pneumonia
The purpose of this study is to evaluate the efficacy and safety of HRS -8427 in patients with HABP/VABP.
- Trial name
- NCT06841731
- Testing
- HRS-8427, Meropenem
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Methicillin-Resistant Staphylococcus Aureus (MRSA), Hospital-Acquired Pneumonia
Evaluation of Patients With Methicillin-Resistant Staphylococcus Aureus Hospital-Acquired Pneumonia Treated With Linezolid or Vancomycin
The objective of this study is to review the local management of patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia treated with vancomycin or linezolid with the goal to define if any difference…
- Trial name
- NCT01561469
- Testing
- Linezolid, Vancomycin
- Volunteers
- 188 people
- Sponsor
- Pfizer
Ventilator Associated Pneumonia
Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia
The goal of this clinical trial is to learn if nebulized colistimethate sodium can prevent pneumonia in ventilated children. The main question it aims to answer is: Does nebulized colistimethate sodium lower the number of times…
- Trial name
- ColiPed (NCT06488794)
- Testing
- colistimethate sodium, 0.9% Saline
- Volunteers
- 400 people
- Sponsor
- University Hospital Fattouma Bourguiba
Ventilator-Associated Pneumonia
To Compare Endotracheal Tube (ET) With Subglottic Suction Drainage and Standard ET in the Incidence of VAP
Ventilator Associated Pneumonia (VAP) is associated with increased hospitalisation, increased health care cost and high morbidity and mortality. The incidence of VAP increases with duration of mechanical ventilation.
- Trial name
- NCT03101202
- Testing
- SSD tube
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Pneumonia, Ventilator-Associated
The Efficacy of Adjuvant Oral Care in Prevention of Ventilator Associated Pneumonia.
A Randomized Controlled Trial (RCT) at Services Hospital, Lahore, aims to reduce Ventilator-Associated Pneumonia (VAP) incidence and mortality rates while shortening ICU stays in mechanically ventilated patients by adding…
- Trial name
- NCT06039995
- Testing
- Comprehensive Oral Care, Traditional Oral Care, Mechanical Tooth Brushing using 0.2% Chlorhexidine
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore
Ventilator Associated Pneumonia
Air-impingement Manipulation to Clear Subglottic Secretion Compared With Drainage Tube in Prolonged Intubated Patients
This is a randomized controlled trial compared two methods to drainage subglottic secretion in prolonged intubated patients.After enrolled, patients are randomized assigned to intermittent subglottic secretion drainage group and…
- Trial name
- NCT02032849
- Testing
- Manual air-impingement operation, subglottic secretion drainage
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Chao Yang Hospital
Ventilator Associated Pneumonia
Open Suction Circuit Flushing With Chlorhexidine Decreases Ventilator-Associated Pneumonia: A Quasi-experimental Study
Background: Standard practice of flushing saline over the patient's secretions following suctioning is similar to pouring water over grease, leading to motivating bacterial colonization and proliferation inside the suctioning…
- Trial name
- NCT05206721
- Testing
- Open tracheal suction system flushing with chlorhexidine
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Mansoura University
Ventilator Associated Pneumonia
Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia
Ventilator Associated pneumonia (VAP) is associated with longer ICU length of stay, prolonged mechanical ventilation, and increased use of antimicrobials, health-care cost and mortality .
- Trial name
- NCT04563104
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Ain Shams University
Infection Resistant to Multiple Drugs
Prospective Observational Pilot-study for the Evaluation of the Nephro- an Neurotoxicity in the Anti-infectious Therapy With Inhalative Colistin Therapy for Patients With Ventilator-associated Pneumonia (VAP)
Multi-Drug resistant pathogens (MDR) are reported worldwide with increasing incidence, especially in intensive care settings. One of the drugs which are effective against MDRs, is colistin (polymyxin E).
- Trial name
- LOKALE (NCT01894347)
- Testing
- TDM, Monitoring of Neuro-and Nephropathology
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- Charite University, Berlin, Germany
Ventilator-associated Pneumonia
Ventilator-associated Pneumonia (VAP) and Humidification System
The purpose of this study is to determine which humidification system is more effective in preventing pneumonia in mechanically ventilated patients.
- Trial name
- NCT01546974
- Testing
- HME filter Twin Star 55, Drager Medical, Germany, Heated humidification
- Where
- Brazil
- Volunteers
- 306 people
- Sponsor
- Hospital Sao Domingos
Community Acquired Pneumonia, Hospital Acquired Pneumonia
The Impact of Simultaneous Presence of Viral and Bacterial Pathogens on Therapy and Course of Severe Pneumonia
The purpose of the study is to determine if the clinical course of pneumonia is more severe when both, bacterial and viral pathogens are find as possible causative agent and how does it affect treatment.
- Conditions
- Community Acquired Pneumonia, Hospital Acquired Pneumonia, Ventilator Associated Pneumonia
- Trial name
- SCAHAVAP (NCT02203110)
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Ventilator Associated Pneumonia
Antimicrobial Stewardship Program and Ventilator Associated Pneumonia
Antibiotic Stewardship Programs (ASPs) help clinicians improve the quality of patient care and improve patient safety through increased infection cure rates, reduced treatment failures; however, there are different techniques…
- Trial name
- NCT04097899
- Testing
- implementation of antimicrobial stewardship comprehensive care bundle program on ventilator associated pneumonia patients
- Volunteers
- 25 people
- Sponsor
- Zagazig University
Ventilator Associated Pneumonia
Probiotics to Actively Counter Ventilator Associated Pneumonia (PROACT)
PROACT study aims to resolve uncertainties to influence actual practice guidelines or public health policing regarding VAP prevention in ICU by using probiotics administration.
- Trial name
- PROACT (NCT06092554)
- Testing
- LactoLevure
- Where
- 10 sites in Belgium, Italy
- Volunteers
- 213 people
- Sponsor
- University of Bari
Ventilator Associated Pneumonia
Risk Factors and Common Preventive Measures for Ventilator Associated Pneumonia in Patients With Severe Traumatic Brain Injury
The primary objective of this study is to assess the incidence of VAP in patients with TBI and to identify risk factors for developing VAP in this specific patient population (types of co-injuries in patients with multiple trauma…
- Trial name
- NCT03266380
- Testing
- observational
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ventilator Associated Pneumonia
Biomarkers in Patients Undergoing Mechanical Ventilation
To evaluate in a cohort of patients on mechanical ventilation, for non-infectious reasons and for documented sepsis of pulmonary as well as non-pulmonary origin, the bacterial load, procalcitonine (PCT), C-Reactive Protein (CRP)…
- Trial name
- VAP (NCT02078999)
- Where
- Spain
- Volunteers
- 211 people
- Sponsor
- Corporacion Parc Tauli