Clinical trials: Ventilator-associated Conditions
Ventilator-Associated Pneumonia, Acute Respiratory Distress Syndrome
Clinical and Biological Markers in Acute Respiratory Failure
In a recent experimental study, the investigators showed that the growth factor Activin A is expressed in the lungs of rats with the acute respiratory distress syndrome (ARDS) at levels that are comparable with those determined…
- Trial name
- NCT02019095
- Testing
- Bronchoscopy for the sampling of bronchoalveolar lavage (BAL) fluid
- Where
- 2 sites in Greece
- Volunteers
- 55 people
- Sponsor
- University of Athens
Ventilator Associated Pneumonia
Implementing Oral Care Bundle on Critical Care Nurses' Practice and Mechanically Ventilated Patients' Outcomes
Oral care is a fundamental aspect of nursing that impact the health and comfort of patients over both the short and long term. Caring for very sick patients in a busy stressful environment may result in oral care having a lower…
- Trial name
- NCT05351619
- Testing
- oral care bundle implementation
- Where
- Egypt
- Volunteers
- 82 people
- Sponsor
- Mansoura University
Ventilator-Associated Pneumonia
Mobile-Based Microlearning for Improving ICU Nurses' Adherence to Ventilator-Associated Pneumonia Prevention Protocols
Ventilator-associated pneumonia (VAP) is one of the most common healthcare-associated infections among mechanically ventilated patients and is associated with increased morbidity, mortality, length of intensive care unit stay…
- Trial name
- VAP-ML (NCT07866027)
- Testing
- Mobile-Based Microlearning Program, Routine Education
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Pneumonia, Pneumonia, Ventilator-Associated
Advanced Understanding of Staphylococcus Aureus and Pseudomonas Aeruginosa Infections in EuRopE - ICU
Intensive Care Unit (ICU) acquired pneumonia, including ventilator-associated pneumonia, is a frequently occurring health-care associated infection, which causes considerable morbidity, mortality and health care costs.
- Conditions
- Pneumonia, Pneumonia, Ventilator-Associated, Nosocomial Pneumonia
- Trial name
- ASPIRE-ICU (NCT02413242)
- Testing
- Various observed exposure(s) of interest
- Where
- Netherlands
- Volunteers
- 2,031 people
- Sponsor
- Jan Kluytmans
Multi Drug Resistant Infections, Pneumnia
Systemic Traditional Chinese Medicine in Multidrug-Resistant Bacterial Pneumonia
This is a multicenter prospective observational cohort study of hospitalized patients with multidrug-resistant bacterial pneumonia.
- Trial name
- MDRBP-TCM (NCT07726095)
- Where
- China
- Volunteers
- 528 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Pneumonia, Ventilator-Associated
Can we Better Understand the Development of VAP and Eventually Predict and Prevent it?
Pathogens of ventilator-associated pneumonia (VAP) come from colonizers of the trachea. The hypothesis of the investigators is that during the first days of intubation, independently of the use of antibiotics, there is a change…
- Trial name
- NCT01875692
- Where
- Switzerland
- Volunteers
- 286 people
- Sponsor
- University Hospital, Geneva
Pneumonia, Ventilator-Associated, Pneumonia, Bacterial
A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia
The purpose of this study is to assess the safety and tolerability of doripenem compared to imipenem in Ventilator-assisted pneumonia and complicated Intra-abdominal Infection.
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Bacterial, Pneumonia, Abdominal Abscess
- Trial name
- NCT00515034
- Testing
- Imipenem/cilastatin, Doripenem
- Volunteers
- 146 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
Macrophage Programing in Acute Lung Injury: MiniBAL
The goal of this observational clinical trial is to learn about the role white blood cells (macrophages) play in lung inflammation in people with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- NCT05767671
- Testing
- Non-Bronchoscopic Mini Bronchoalveolar Lavage
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- William Janssen, MD
Ventilation, ARDS
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability followed by 48 hours of escalation of ventilator settings within the ICU.
- Conditions
- Ventilation, ARDS, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT06737432
- Testing
- RKP Monitoring Software
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Ventilator Associated Pneumonia
Lung Ultrasound in Procalcitonin- Guided Antibiotic Discontinuation in Ventilator Associated Pneumonia
Ventilator Associated pneumonia (VAP) is associated with longer ICU length of stay, prolonged mechanical ventilation, and increased use of antimicrobials, health-care cost and mortality .
- Trial name
- NCT04563104
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Ain Shams University
Ventilator Associated Pneumonia
Gastrointestinal Complications in Association With Oropharyngeal and Respiratory Infections in Mechanical Ventilation
Detection of gastrointestinal complications in mechanically ventilated critically ill patients and its relation to oropharyngeal and respiratory infections in relation to oropharyngeal and gastric PH.
- Trial name
- NCT03267693
- Testing
- Gastric and oropharyngeal PH
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pneumonia, Ventilator-Associated
Study Assessing Immunogenicity and Safety of IC43 In Intensive Care Patients
Randomized, placebo-controlled, partially blinded phase 2 pilot study. Multicenter study (approximately 50 centers) in approximately 9 countries. Proposed start date is December 2008.
- Trial name
- NCT00876252
- Testing
- IC43
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Valneva Austria GmbH
Pneumonia, Bacterial
Study Evaluating Safety and Efficacy of Tigecycline Versus Imipenem/Cilastatin Subjects With Hospital-Acquired Pneumonia
This study will compare the safety and efficacy of a tigecycline regimen versus an imipenem/cilastatin regimen for the treatment of subjects who are hospitalized with hospital-acquired pneumonia (HAP).
- Trial name
- NCT00707239
- Testing
- tigecycline, imipenem/cilastatin
- Where
- 40 sites in United States, Argentina and 12 more
- Volunteers
- 108 people
- Sponsor
- Pfizer
Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia
Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex
This is a 2-part study, with Part A being the randomized, controlled portion of the study in patients with ABC hospital-acquired bacterial pneumonia (HABP), ventilator-associated bacterial pneumonia (VABP), or bacteremia.
- Conditions
- Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia, Bacteremia
- Trial name
- ATTACK (NCT03894046)
- Testing
- Sulbactam, Durlobactam, Colistin
- Where
- 90 sites in United States, Belarus and 15 more
- Volunteers
- 207 people
- Sponsor
- Entasis Therapeutics
Critical Illness, Enteral Nutrition
Optimizing Enteral Nutrition Regimen for Critically Ill Patients
Clinical Trial The goal of this clinical trial is to learn whether different enteral feeding cycles (18-hour, 20-hour, or standard 24-hour continuous feeding) improve outcomes for critically ill ICU patients who need tube…
- Conditions
- Critical Illness, Enteral Nutrition, Ventilator Associated Pneumonia, Hyperglycemia
- Trial name
- NCT07270939
- Testing
- 20-Hour Cycled Enteral Nutrition with a 4-Hour Fasting Window, 18-Hour Cycled Enteral Nutrition with a 6-Hour Fasting Window
- Volunteers
- 150 people
- Sponsor
- Hamad Medical Corporation
Ventilator-associated Pneumonia
Subglottic Secretions Surveillance to Predict Bacterial Pathogens Involved in Ventilator-associated Pneumonia
Many studies provide evidence for the benefit of lower respiratory tract surveillance, mostly by culture of endotracheal secretions, to predict bacterial pathogens (especially multi-drugs resistant pathogens) involved in VAP.
- Trial name
- NCT02585180
- Testing
- Endotracheal tubes not allowing SSD, Endotracheal tubes allowing SSD
- Where
- 15 sites in Belgium, France
- Volunteers
- 420 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Traumatic Brain Injury, Ventilator Associated Pneumonia
Effect of E-BAL on Severity of VAP Assessed Through CPIS on the Patients of Traumatic Brain Injury in Neurocritical Care, Also Effect on Days of Ventilation and ICU Stay.
Severe traumatic brain injury (STBI) is a leading cause of disability, mortality, and economic burden worldwide. The impact of severe traumatic brain injury (STBI) on the economy of developing countries like Pakistan is…
- Trial name
- NCT04977843
- Testing
- EARLY BRONCHOALVEOLAR LAVAGE
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jinnah Hospital
Ventilator-Associated Pneumonia
Epidemiology of Risk Factors for Hospital-acquired Pneumonia (HAP) in Intensive Care Unit (ICU) Patients
A retrospective, observational study compiled data from all consecutively admitted patients older than 18 years at ICU University Hospital in Olomouc in the period from 1 January 2011 to 31 December 2015 who fulfilled the…
- Trial name
- NCT02779933
- Testing
- Epidemiology od HAP
- Volunteers
- 310 people
- Sponsor
- University Hospital Olomouc
Ventilator Associated Pneumonia
Antimicrobial Stewardship For Ventilator Associated Pneumonia in Intensive Care
Increasing emergence of multidrug resistant (MDR) bacteria worldwide is now considered one of the most urgent threats to global health.
- Trial name
- ASPIC (NCT05124977)
- Testing
- Antimicrobial Stewardship, Standard management
- Where
- France
- Volunteers
- 590 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris