Clinical trials: Ventilator-free Days
Pneumonia
Reduced Ventilator-Free Days and Bacterial Colonization of Sub-Glottic Secretions
Ventilator associated pneumonia (VAP) is common problem among ICU patients and major source of infection among patients receiving mechanical ventilation.
- Trial name
- NCT02311296
- Where
- United States
- Sponsor
- University of Tennessee, Chattanooga
Acute Respiratory Distress Syndrome (ARDS)
Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment
This is a multicentre, double-blind, placebo-controlled Phase III randomized clinical trial designed to evaluate the efficacy and safety of inhaled aprotinin in adult patients with moderate or severe acute respiratory distress…
- Trial name
- NCT07317050
- Testing
- Aprotinin (inhaled)
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion
Mechanical Ventilation, Fluid Overload
Lung Ultrasound-Guided Fluid Deresuscitation in ICU Patients
Timely recognition and treatment of fluid overload can expedite liberation from invasive mechanical ventilation in intensive care unit (ICU) patients.
- Conditions
- Mechanical Ventilation, Fluid Overload, Deresuscitation, Ventilator-free Days
- Trial name
- CONFIDENCE (NCT05188092)
- Testing
- Lung ultrasound guided deresuscitation
- Where
- 3 sites in Netherlands
- Volunteers
- 998 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Distress Syndrome
Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome
A randomized, concurrent controlled trial to assess if adding sigh breaths to usual invasive mechanical ventilation of victims of trauma who are at risk of developing ARDS will decrease the number of days they require invasive…
- Trial name
- SiVent (NCT02582957)
- Testing
- Sigh breaths
- Where
- 15 sites in United States
- Volunteers
- 524 people
- Sponsor
- University of Minnesota
Prolonged Mechanical Ventilation, Respiratory Failure
EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)
Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Respiratory Failure, Critical Illness
- Trial name
- PMV (NCT07372794)
- Testing
- EIT-Guided Respiratory Physiotherapy, Conventional Respiratory Physiotherapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum
Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS)
This Phase 2 study tests whether adding two immune therapies - nogapendekin alfa-inbakicept (NAI) and off-the-shelf iNKT cell infusions - to standard care can safely help critically ill adults with severe community-acquired…
- Conditions
- Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum, Sepsis, Lymphopenia / Immunoparalysis in Critically Ill Adults
- Trial name
- NCT07492888
- Testing
- Nogapendekin Alfa-Inbakicept (NAI), Allogeneic invariant Natural Killer T (iNKT) Cells (AgenT-797)
- Sponsor
- ImmunityBio, Inc.
Viral Pneumonia
PTH - Preemptive Treatment for Herpesviridae
The aim of this study is to show that a preemptive treatment by ganciclovir (for positive CMV viremia) or aciclovir (for positive HSV oro-pharyngeal PCR) is able to increase the number of ventilator-free days at Day 60.
- Trial name
- PTH (NCT02152358)
- Testing
- Aciclovir, Ganciclovir
- Where
- France
- Volunteers
- 317 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Intra-Abdominal Hypertension, Respiratory Mechanics
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
This prospective observational cohort study aims to investigate the relationship between intra-abdominal pressure (IAP), respiratory system mechanics, and successful liberation from invasive mechanical ventilation in adult…
- Conditions
- Intra-Abdominal Hypertension, Respiratory Mechanics, Mechanical Ventilation
- Trial name
- IAP-VENT (NCT07889609)
- Testing
- Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Ventilator-free Days
PRotective VENTilation in Patients Without ARDS
The purpose of this national multicentre randomized controlled trial is to compare a ventilation strategy using lower tidal volumes and higher respiratory rates with a ventilation strategy using higher tidal volumes and a lower…
- Trial name
- PReVENT-NL (NCT02153294)
- Testing
- low tidal volume, high tidal volume
- Where
- Netherlands
- Volunteers
- 952 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
ICU Acquired Weakness
Impact of Early Mobilization on Mechanical Ventilation Duration in Intubated Critically Ill Patients
The purpose of the present study is to compare usual care in terms of mobilization performed to intubated ICU patients to a standardized program designed to deliver early mobilization at least 5 days a week.
- Trial name
- EarlyMob (NCT02520193)
- Testing
- Protocolized early mobilization in ICU
- Where
- 23 sites in Belgium, France and 1 more
- Volunteers
- 772 people
- Sponsor
- University Hospital, Angers
Mechanical Ventilation Weaning, Chronic Disease
Phenotype-Guided Weaning in Mechanically Ventilated Patients With Chronic Comorbidities
The goal of this clinical trial is to learn whether a phenotype-guided weaning strategy can help adults with chronic comorbidities be liberated from invasive mechanical ventilation earlier.
- Trial name
- NCT07594418
- Testing
- Phenotype-Guided Weaning Strategy, Standard Care
- Volunteers
- 1,380 people
- Sponsor
- Southeast University, China
Obstructive Lung Diseases
Can NAVA Mode Reduce Mechanical Ventilation Day in Patients With COPD ?
Background： Neurally Adjusted Ventilatory Assist (NAVA) mode is a new mode of ventilator, using electronic potential of diaphragm to adjust tidal volume.
- Trial name
- NCT05595733
- Testing
- Ventilator mode
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Fu Jen Catholic University Hospital
Ventilator-free Days, Quality of Breathing
Effect of Automated Closed-Loop Ventilation Versus Conventional Ventilation on Duration and Quality of Ventilation
INTELLiVENT-Adaptive Support Ventilation (ASV) is a fully automated closed-loop mode of mechanical ventilation available on commercial ventilators.
- Trial name
- ACTiVE (NCT04593810)
- Testing
- INTELLiVENT-ASV, CONVENTIONAL VENTILATION
- Where
- 10 sites in Italy, Netherlands
- Volunteers
- 1,201 people
- Sponsor
- Prof. Dr. Marcus J. Schultz
Acute Respiratory Distress Syndrome, ARDS
Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure
This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a proven standardized lung protective ventilation protocol in the new electronic medical record system iCentra…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS, Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
- Trial name
- IMPROVENT (NCT03225807)
- Where
- United States
- Volunteers
- 8,692 people
- Sponsor
- Intermountain Health Care, Inc.
The Number of Ventilator-free Days in the 28 Days Following LT
Veno-arterial ExtraCorporeal Membrane Oxygenation to Reduce Morbidity and Mortality Following Lung TransPlant
In patients undergoing lung transplantation (LT), the investigators hypothesize that a "systematic" intraoperative ECMO strategy would reduce the need for invasive mechanical ventilation in the first 28 days without increasing…
- Trial name
- ECMOToP (NCT05664204)
- Testing
- Veno-arterial extracorporeal membrane oxygenation
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Mechanical Ventilation Complication
Volume Support/Assist Control Mode Ventilation and Diaphragmatic Atrophy
The objective of the study is to determine how controlled mode ventilation and support mode ventilation impact ventilator-free days and diaphragmatic atrophy.
- Trial name
- NCT03901924
- Testing
- Volume Support Mode Mechanical Ventilation, Assist Control Mode Mechanical Ventilation
- Where
- 2 sites in United States
- Volunteers
- 468 people
- Sponsor
- University of Chicago
Ventilator-free Days
REstricted Versus Liberal Positive End-Expiratory Pressure in Patients Without ARDS
The 'REstricted versus Liberal positive end-expiratory pressure in patients without Acute respiratory distress syndrome' (RELAx) trial is a national multicenter, open randomized controlled trial in ICU patients without ARDS at…
- Trial name
- RELAx (NCT03167580)
- Testing
- restricted PEEP, liberal PEEP
- Where
- 13 sites in Netherlands
- Volunteers
- 980 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Oxidative Stress, Inflammation
Effect of Alpha-lipoic Acid on Biochemical Markers and Important Outcomes in Patients Admitted to Intensive Care Units
Increasing Reactive oxygen and nitrogen production occurred simultaneously with decreasing serum and intracellular level of antioxidants and enzymes in critical ill patients, which result in increasing ventilator dependency and…
- Conditions
- Oxidative Stress, Inflammation, Malnutrition
- Trial name
- NCT01888861
- Testing
- alpha-lipoic acid
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- najmeh hejazi
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute