Clinical trials: Ventilator-induced Lung Injury (VILI)
Evaluable
Effects of Continuous Anterior Chest Compression
The aim is to test the physiological effects of continuous anterior chest compression in patients with severe to moderate ARDS.
- Trial name
- StrapVent (NCT05876468)
- Testing
- Continuous anterior chest compression
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome ARDS
Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is associated with high mortality, some of which can be attributed to ventilator-induced lung injury (VILI) when artificial ventilation is not customized to the severity of lung injury.
- Trial name
- DRIVENT (NCT06322758)
- Testing
- Tidal volume customization in the acute respiratory distress syndrome
- Volunteers
- 750 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Morbid Obesity, Obesity
Bedside Lung Ultrasound to Monitor Lung Recruitment in Obese Patients
Patients with morbid obesity who require a breathing machine (mechanical ventilator) in the Intensive Care Unit (ICU) frequently experience partial lung collapse.
- Conditions
- Morbid Obesity, Obesity, Respiratory Failure, Atelectasis
- Trial name
- NCT07542093
- Volunteers
- 45 people
- Sponsor
- Assiut University
Acute Respiratory Distress Syndrome
Flow-flow ECCO2-R and 4 ml/kg Tidal Volume vs. 6 ml/kg Tidal Volume to Enhance Protection From VILI in Acute Lung Injury
The main objective of this randomized multicenter clinical trial is to test the hypothesis that further reduction of VT to 4mL/kg may enhance lung protection in patients with ARDS as compared to the conventional "ARDS-Net"…
- Trial name
- ELP (NCT01522599)
- Testing
- ARDS-Net Strategy, ECCO2-R
- Where
- Italy
- Volunteers
- 230 people
- Sponsor
- University of Turin, Italy
Ventilation, Mechanical, ARDS (Acute Respiratory Distress Syndrome)
Pleural Strain by Speckle-Tracking Ultrasound: Feasibility and Driving Pressure Associations
What is this study about? This research aims to test a new ultrasound technology called "speckle tracking" to measure how much the lining of your lungs (pleura) stretches during breathing, especially if you're on a breathing…
- Trial name
- NCT06911450
- Where
- China
- Volunteers
- 75 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Adult Respiratory Distress Syndrome
Prevention of Lung Injury Induced by Mechanical Ventilation in Acute Respiratory Distress Syndrome ARDS Patients
Given the huge volume of mechanically ventilated patients at risk of ARDS, optimizing hematosis by limiting pulmonary and systemic aggression associated with artificial ventilation techniques is a key objective if we are to…
- Trial name
- PULMODEL (NCT06835881)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome
The Effect of High Frequency Oscillation on Biological Markers of Lung Injury
Although mechanical ventilation is life saving, it is associated with a number of severe complications collectively referred to as ventilator induced lung injury (VILI).
- Trial name
- NCT00673517
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Positive End-expiratory Pressure (PEEP)
Electrical Impedance Tomography for Identification of Optimal Positive End-expiratory Pressure in Newborn Infants
Electrical impedance tomography (EIT) enables assessment of regional lung ventilation at the bedside. EIT has been safely used in newborn infants to image intrathoracic lung volume patterns as early as from the first minute of…
- Trial name
- NCT05612256
- Testing
- Electrical impedance tomography (EIT), Forced oscillation technique (FOT), Saturation oxygenation pressure index (SOPI)
- Where
- Switzerland
- Volunteers
- 86 people
- Sponsor
- University Children's Hospital Basel
Ventilation, ARDS
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability followed by 48 hours of escalation of ventilator settings within the ICU.
- Conditions
- Ventilation, ARDS, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT06737432
- Testing
- RKP Monitoring Software
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Burn Injury, Inhalational Injury
Biphasic Positive Airway Pressure Ventilation Versus Flow-Controlled Ventilation in Burn Patients
The goal of this clinical trial is to learn if the new ventilation mode flow-controlled ventilation (FCV) is a more protective mode of ventilation for adult patients after severe burn injury.
- Conditions
- Burn Injury, Inhalational Injury, Pulmonary Complications, Ventilator-induced Lung Injury (VILI)
- Trial name
- BIFLOWBURN (NCT07041957)
- Testing
- Individualized flow-controlled ventilation strategy, Pressure-controlled ventilation strategy via the application of Biphasic Positive Airway Pressure ventilation
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Bergmannsheil Bochum
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Development and Prospective Validation of the AutoEIT Foundation Model for ARDS
Acute Respiratory Distress Syndrome (ARDS) is a highly heterogeneous condition, making precision mechanical ventilation challenging.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure, Mechanical Ventilation, Ventilator-induced Lung Injury (VILI)
- Trial name
- NCT07898319
- Testing
- AutoEIT Model Training, AutoEIT Blinded Validation
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Ruijin Hospital
Acute Lung Injury, Acute Respiratory Distress Syndrome
Airway Pressure Release Ventilation in Acute Lung Injury
The purpose of this study is to compare airway pressure release ventilation (APRV) to conventional mechanical ventilation (MV) in patients with acute lung injury (ALI) to determine if APRV can reduce agitation, delirium, and…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Mechanical Ventilation
- Trial name
- NCT00750204
- Testing
- APRV, Conventional MV
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury)
Real-Time Algorithm-Driven Ventilation Feedback to Improve Lung-Protective Ventilation in Patients With ARDS (REALVENT-study)
The REALVENT trial is designed to evaluate whether a real-time, algorithm-driven ventilation feedback strategy can improve lung-protective ventilation (LPV) achievement rates in critically ill patients receiving invasive…
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), VILI (Ventilator-induced Lung Injury), Respiratory Failure, Critical Illness
- Trial name
- REALVENT (NCT07307066)
- Testing
- REal-time Algorithm-driven Ventilation feedback to improve lung-protective ventilation in critically, Standard ICU care
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Failure, Mechanical Ventilation Complication
Effect of End-inspiratory Airway Pressure Measurements on the Risk of VILI in Ventilated Patients
Mechanical ventilation may be associated with ventilator-induced lung injury (VILI). Several respiratory variables have been employed to estimate the risk of VILI, such as tidal volumes, plateau pressure, driving pressure, and…
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- P1P2Decay (NCT05991258)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Padova