Clinical trials: Ventilators
Ventilator Associated Pneumonia, Corona Virus Infection
Epidemiology and Outcome of Ventilator-associated Pneumonia Among Critically Ill COVID-19 Patients
The aim of this study is to determine the risk factors for development of ventilator-associated pneumonia (VAP) and to identify the prognostic factors of VAP among Coronavirus Disease 2019 (CoViD-19) patients.
- Trial name
- NCT04372576
- Testing
- Assessment of ventilator-associated pneumonia criteria
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
Respiration, Artificial, Reverse Triggering
Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study
Background: Reverse triggering (RT) is a frequent phenomenon observed in sedated patients under a mechanical ventilation mode called assist-control ventilation.
- Trial name
- SEVERE (NCT06293976)
- Testing
- Changes in the ventilator respiratory rate and tidal volume
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Inflammation
Study of the Influence of Various Tidal Volumes on Exhaled Breath Condensate (EBC) in Mechanically Ventilated Patients
The aim of the present study is to evaluate the effect of low (6 ml/kg) and high (12 ml/kg) tidal volume ventilation on inflammatory and oxidative stress biomarkers in the exhaled breath condensate (EBC) of ICU patients without…
- Trial name
- TDEBC (NCT00910026)
- Testing
- low tidal volume ventilation, high tidal volume ventilation
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Larissa University Hospital
PreTerm Neonate, Extubation Readiness
Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.
The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective…
- Conditions
- PreTerm Neonate, Extubation Readiness, Extubation Failure, Respiratory Morbidity
- Trial name
- CERAINE (NCT06808997)
- Where
- 31 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Post-cardiac Surgery, Ventilator Weaning
Correlation Analysis Between Mostcare Parameters and Spontaneous Breathing Trial in Patients After Cardiac Surgery
Cardiac output (CO) monitoring is of primary importance in high-risk surgery and critically ill patients. Intermittent thermodilution (ThD) by means of a pulmonary artery catheter (PAC) was invasiveness, the occurrence of…
- Trial name
- NCT06230497
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Ventilator-Associated Pneumonia
The Effect of Solutions Used in Oral Care on Preventing Ventilator-Associated Pneumonia.
The goal of this clinical trial is to learn about effects of chlorhexidine gluconate, sodium bicarbonate, ozonated water and hypochlorous acid solutions used in oral care of patients on mechanical ventilation support on…
- Trial name
- NCT06118242
- Testing
- Use of oral care solutions
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Aydin Adnan Menderes University
ICU's Patients Under Mechanical Ventilation
Effect of Drainage of Subglottic Secretions on Pneumonia Acquired Under Mechanical Ventilation
The purpose of this study is to determine whether drainage of subglottic secretions is effective to reduce the incidence of pneumonia acquired under mechanical ventilation in ICU's patients.
- Trial name
- NCT00219661
- Testing
- drainage of subglottic secretions (HiLo Evac tube)
- Where
- 4 sites in France
- Volunteers
- 440 people
- Sponsor
- Poissy-Saint Germain Hospital
Ventilator Induced Lung Injury
Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing, a First in Human Trial
Study conducted to confirm phrenic nerve stimulation using the Lungpacer LIVE Catheter, confirm capture of the diaphragm and confirm that the diaphragm can be paced in synchrony with mechanical ventilator breaths.
- Trial name
- NCT02670460
- Testing
- LIVE Catheter
- Where
- Paraguay
- Volunteers
- 24 people
- Sponsor
- Lungpacer Medical Inc.
Wounds and Injuries, Respiratory Failure
FiO2 Closed Loop Control Ventilation
A randomized, multi-center trial involving critically-ill patients comparing conventional, manual control of inspired oxygen (FiO2) within a target range, with a computer-controlled, closed-loop FiO2 delivery using a continuous…
- Trial name
- CLC (NCT02810080)
- Testing
- Closed Loop Control Ventilation, Manual Control Ventilation
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Zoll Medical Corporation
Ventilator Associated Pneumonia
Effect of Educational Program About Preventive Care Bundle for Prevention of Ventilator Associated Pneumonia Among Newborns
This study is designed to investigate the effect of educational program for nurses about preventive care bundle for prevention of ventilator associated pneumonia among newborns.
- Trial name
- NCT06066489
- Testing
- educational program about VAP
- Volunteers
- 137 people
- Sponsor
- Damanhour University
Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
Reversibility of Bronchial Obstruction in Children Born Preterm
This observational study aims to compare responses to different, commonly used inhaled bronchodilators in children born preterm with bronchial obstruction at spirometry.
- Conditions
- Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Chronic Lung Disease of Newborn, Preterm Birth Complication
- Trial name
- NCT06110481
- Where
- Czechia
- Volunteers
- 73 people
- Sponsor
- Charles University, Czech Republic
Premature, Premature Lungs
Baby ABS (Abdominal Binder Study)
The primary outcome of this study is to determine if the use of the FDA-approved DandleLion NeoBellyBand increases the thickness of the rectus abdominis muscle in premature babies receiving continuous positive pressure…
- Conditions
- Premature, Premature Lungs, Ventilator Lung; Newborn, Rectus Abdominis
- Trial name
- NCT07049900
- Testing
- NeoBelly Band
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Apnea of Newborn, Preterm Labor
Analyze Changes in Respiratory Rate When Using the Scare Respirator
Pilot study of 10 preterm, who are going to be randomly placed to 3 phases : 2 hour of basal observation of respiratory rate, heart rate, saturation, NIPS and aEEG recording, 2 hours with a 20cycles/minute with "scare…
- Trial name
- RESPSUS (NCT04584814)
- Testing
- without any device, scare ventilator at 20, scare ventilator at 40
- Where
- Chile
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Ventilator Associated Pneumonia
Research Title: Efficacy and Safety of Point- Of-care Procalcitonin Test to Reduce Antibiotic Exposure in VAP
Several studies have shown that PCT guidance can reduce the duration of antibiotic treatment for patients with bacterial infections in the ICU, without compromising the safety outcomes.
- Trial name
- NCT03982667
- Testing
- PCT-guided group
- Where
- 2 sites in Malaysia
- Volunteers
- 100 people
- Sponsor
- Mohd Zulfakar Mazlan, MBBS
Ventilator-induced Lung Injury
The Effect of Two Different Intra-abdominal Pressure Applications on "Mechanical Power" in Laparoscopic Cholecystectomy
In laparoscopic surgeries; a trocar is inserted through a small incision and an intervention is made into the peritoneal cavity.
- Trial name
- NCT05859906
- Testing
- mechanical power measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Ayse Ulgey
Ventilator Weaning, Ultrasonography
Role of Lung Ultrasound in Predicting Weaning Outcomes
We aimed to verify the potencial role of bedside lung ultrasound findings of critically ill patients candidates to liberation from mechanical ventilation in predicting weaning outcomes.
- Trial name
- NCT02022839
- Where
- Brazil
- Volunteers
- 250 people
- Sponsor
- Hospital Moinhos de Vento
Pneumonia, Ventilator-Associated
The Efficacy of Adjuvant Oral Care in Prevention of Ventilator Associated Pneumonia.
A Randomized Controlled Trial (RCT) at Services Hospital, Lahore, aims to reduce Ventilator-Associated Pneumonia (VAP) incidence and mortality rates while shortening ICU stays in mechanically ventilated patients by adding…
- Trial name
- NCT06039995
- Testing
- Comprehensive Oral Care, Traditional Oral Care, Mechanical Tooth Brushing using 0.2% Chlorhexidine
- Where
- 2 sites in Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Health Sciences Lahore
Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI)
Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
This study is designed to provide evidence of efficacy of cefiderocol in the treatment of serious infections in adult patients caused by carbapenem-resistant Gram-negative pathogens.
- Conditions
- Healthcare-associated Pneumonia (HCAP), Bloodstream Infections (BSI), Hospital Acquired Pneumonia (HAP), Complicated Urinary Tract Infection (cUTI)
- Trial name
- CREDIBLE - CR (NCT02714595)
- Testing
- Cefiderocol, Best Available Therapy
- Where
- 85 sites in United States, Brazil and 14 more
- Volunteers
- 152 people
- Sponsor
- Shionogi
Infant, Premature, Bronchopulmonary Dysplasia (BPD)
Dexamethasone Regimens for BPD Prevention in Preterm Infants
The goal of this clinical trial is to compare the effectiveness of two different dexamethasone treatment regimens (the DART regimen and the medium-dose tapering regimen) in reducing the incidence of Bronchopulmonary Dysplasia…
- Trial name
- NCT07052201
- Testing
- Dexamethasone. Dart, Dexametasone. Medium
- Where
- 24 sites in China
- Volunteers
- 970 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Bronchopulmonary Dysplasia
Implementation of a Consensus-Based Discharge Protocol for Preterm Infants With Lung Disease
The researchers have worked to create consensus recommendations among national efforts to help with the transition and coordination of care for preterm infants with lung disease around discharge from the neonatal intensive care…
- Trial name
- NCT05285345
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital