Clinical trials: Ventricular
Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation
A Study Assessing Arrhythmia Mapping With a Globe-Shaped, High-Density, Multi-Electrode Mapping Catheter
The purpose of this study is to assess the performance and safety for the use of the investigational catheter for intracardiac mapping in the atria and ventricles.
- Conditions
- Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Ventricular Tachycardia
- Trial name
- COSMOS (NCT05373862)
- Testing
- Globe-Shaped, High-Density, Multi-Electrode Mapping Catheter
- Where
- 4 sites in Belgium, Croatia and 1 more
- Volunteers
- 40 people
- Sponsor
- Biosense Webster, Inc.
Pediatric Disorder, Pediatric Obesity
Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
Pediatric primary hypertension is increasingly common, occurring in 5-10% of normal-weight children and up to 25% of children with obesity. It is a risk factor for adult cardiovascular and renal disease.
- Conditions
- Pediatric Disorder, Pediatric Obesity, Primary Hypertension
- Trial name
- PHRAS (NCT03310684)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Left Ventricular Dysfunction, Quality of Recovery
Preoperative Maltodextrin's Effect on Cardiac Function in Cardiac Surgery
A randomized, controlled, double-blinded clinical trial evaluating the effect of the administration of a Maltodextrin solution on cardiac function in patients presenting for coronary artery bypass grafting surgery with a reduced…
- Conditions
- Left Ventricular Dysfunction, Quality of Recovery, Right Ventricular Dysfunction
- Trial name
- NCT05188222
- Testing
- Maltodextrin solution
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Jewish General Hospital
Myocardial Infarct, Remodeling, Left Ventricle
Heart Attack Blood Oxygen Therapy Trial
'Heart attack', known as acute ST-segment elevation myocardial infarction, is a leading cause of heart failure and death. A lack of blood and oxygen damages the heart muscle potentially causing heart failure and premature death.
- Trial name
- SSO2 Radial MI (NCT06662890)
- Testing
- Supersaturated oxygen
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- NHS National Waiting Times Centre Board
Heart Failure, Univentricular Heart
Registry to Assess the Safety and Feasibility of the Subpulmonary Support with the Novel Venous Cannula in Patients with Failing/Absence of the Right Heart
The purpose of the study is to monitor the clinical safety and performance of the EXCOR Venous Cannula in context of an EXCOR VAD therapy to ensure continued acceptability of identified risks, to enable detecting emerging risks…
- Conditions
- Heart Failure, Univentricular Heart, Ventricular Dysfunction, Heart Diseases
- Trial name
- RegiVe (NCT04782232)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Berlin Heart GmbH
Congenital Heart Disease
French Observatory of Congenital Ventricular Septal Defect With Pulmonary Overload
Ventricular septal defects (VSD) are the most common cardiac congenital heart defect (about 1/3 of patients with congenital heart disease).
- Trial name
- FRANCISCO (NCT03363932)
- Where
- 4 sites in France
- Volunteers
- 218 people
- Sponsor
- French Cardiology Society
Premature Ventricular Complexes, Ventricular Arythmias
WHEN DO WE HAVE to PERFORM CARDIAC MAGNETIC RESONANCE in PATIENTS REFERRED for PREMATURE VENTRICULAR COMPLEXES by THEIR CARDIOLOGISTS
Premature ventricular complexes (PVC) are a common entity affecting approximatively 20% of the general population. It can be discovered incidentally on electrocardiogram (ECG) or associated with symptoms with a wide spectrum from…
- Conditions
- Premature Ventricular Complexes, Ventricular Arythmias, Cardiac Magnetic Resonance Imaging, Focal or Diffuse Fibrosis
- Trial name
- IRMESV (NCT06801743)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Ventricular Septal Defects
Closure of Muscular Ventricular Septal Defects (VSDs) With the AMPLATZER Muscular VSD (MuVSD) Occluder - Post Approval Study
The AMPLATZER Muscular VSD Occluder was approved by the US Food and Drug Administration (FDA) in September, 2007. This study is designed to further evaluate the safety and effectiveness in subjects implanted with the AMPLATZER…
- Trial name
- VPA (NCT00647387)
- Testing
- Muscular VSD Occluder device implantation (AMPLATZER Muscular VSD Occluder)
- Where
- 51 sites in United States, Canada
- Volunteers
- 92 people
- Sponsor
- Abbott Medical Devices
Hypertrophy, Left Ventricular
Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart Failure
This study will assess the efficacy of mirabegron, a new beta3-adrenergic receptor in the prevention of heart failure. This is a two armed, prospective, randomized, placebo-controlled, multi-centric european phase IIb trial with…
- Trial name
- Beta3_LVH (NCT02599480)
- Testing
- mirabegron, Echocardiography, Cardiac MRI
- Where
- 10 sites in Belgium, France and 6 more
- Volunteers
- 296 people
- Sponsor
- Jean-Luc Balligand
Ventricular Dysfunction, Cardiotoxicity
Optimising Screening for the Cardiotoxic Effects of Cancer Therapy
Cancer is a major worldwide health problem, with around 330.000 new annual cases only in the UK. Improved survival rates due to better treatments have lead to an increase in the prevalence of chemotherapy related cardiac disease…
- Conditions
- Ventricular Dysfunction, Cardiotoxicity, Chemotherapeutic Toxicity
- Trial name
- NCT06817044
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Barts & The London NHS Trust
Arrhythmogenic Right Ventricular Cardiomyopathy
Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC
This first-in-human study is designed to evaluate the safety, and preliminary efficacy (PD) of TN-401 gene therapy in adult patients with symptomatic PKP2 mutation-associated ARVC.
- Trial name
- RIDGE-1 (NCT06228924)
- Testing
- TN-401
- Where
- 7 sites in United States
- Volunteers
- 15 people
- Sponsor
- Tenaya Therapeutics
Ventricular Tachycardia
Catheter Evaluation for Endocardial Ablation in Patients With Ventricular Tachycardia
The primary objective is to provide additional corroborative safety and efficacy data for the Navistar ThermoCool catheter for the treatment of subjects with ischemic Ventricular Tachycardia.
- Trial name
- VT-CoA (NCT00412607)
- Testing
- NAVISTAR® THERMOCOOL® Catheter
- Volunteers
- 249 people
- Sponsor
- Biosense Webster, Inc.
Right Ventricular Dysfunction
Hemodynamic Assessment of the Right Ventricle Using Pressure-volume Loop Catheter and Pulmonary Artery Catheter in Patients Undergoing Left Ventricular Assist Device Placement
This study will include the placement of a pressure volume (PV) loop catheter in the right atrium of patients undergoing left ventricular assist device (LVAD) placement and measure relevant PV loop data.
- Trial name
- NCT04478890
- Testing
- Hemodynamic assessment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Cardiac Arrest, Ventricular Fibrillation
The OSIRIS ECPR Trial
The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal…
- Conditions
- Cardiac Arrest, Ventricular Fibrillation, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Arrest
- Trial name
- OSIRIS (NCT06805344)
- Testing
- Extracorporeal cardiopulmonary resuscitation based approach, Conventional cardiopulmonary resuscitation
- Volunteers
- 686 people
- Sponsor
- General University Hospital, Prague
Ventricular Arrythmia, Ventricular Tachycardia
VIVO European Observational Registry
A multi-center, observational registry conducted in Europe and the UK to prospectively review VIVO in a clinical setting in 125 patients.
- Conditions
- Ventricular Arrythmia, Ventricular Tachycardia, Premature Ventricular Contraction
- Trial name
- NCT04990089
- Testing
- VIVO
- Where
- 8 sites in Ireland, Italy and 3 more
- Volunteers
- 125 people
- Sponsor
- Catheter Precision. Inc.
ICP Regulation Using a New Device for Automated Zero-calibration for a Ventricular Drainage System
A Prospective Clinical Trial to Evaluate an Automated Cerebral Ventricular Drainage System in Patients in the Neurointensive Care
This is a prospective, randomised trial to evaluate a new medical device for automated zero calibration of ventricular drainage systems in neurointensive care patients.
- Trial name
- NCT05177692
- Testing
- Vguard
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Skane University Hospital
Premature Ventricular Contractions
Concealed Myocardial Abnormalities by Cardiac Magnetic Resonance Imaging in Idiopathic VT
Idiopathic Ventricular arrhythmia (VAs) refers to VAs that occur in the absence of clinically apparent structural heart disease.
- Trial name
- NCT06146556
- Testing
- catheter based ablation
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Left Ventricular Systolic Function
Predictors of Left Ventricular Systolic Function Recovery After Transcatheter Aortic Valve Replacement
Investigate the preprocedural predictors of left ventricular systolic function Recovery after TAVR
- Trial name
- NCT05069168
- Testing
- Echocardiography before and after TAVR
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Assiut University
PreTerm Neonate, Pulmonary Hypertension of Newborn
Identification of the Risk of Remote Pulmonary Hypertension in Preterm Births.
This study aims to learn about the prevalence of pulmonary hypertension and right ventricular dysfunction in patients born prematurely, at birth and at a distance, and the association with the development of pulmonary…
- Conditions
- PreTerm Neonate, Pulmonary Hypertension of Newborn, Right Ventricular Dysfunction
- Trial name
- Iper-NeoRisk (NCT06800300)
- Where
- 2 sites in Italy
- Volunteers
- 51 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Left Ventricular Systolic Dysfunction, Myocardial Infarction
Adherence to Cied Implantation Guidelines and Cardiac Rehabilitation
There are limited data on how the guideline indications for ICD implantation are applied in clinical practice across Europe. Moreover, the impact of "time-dependence" of some indications to implantation on the guidelines…
- Trial name
- ANGELICA (NCT05764109)
- Where
- Italy
- Volunteers
- 488 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA