Clinical trials: Ventricular Dysfunction
Hypertension,Essential
Endothelial Function in Prehypertension
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and…
- Trial name
- NCT06316271
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Psoriatic Arthritis (PsA), Subclinical Right Ventricular Systolic Dysfunction
Right Ventricular Strain in Detecting Subclinical Right Ventricular Systolic Dysfunction in Psoriatic Arthritis Patients: Relation to Serum Endostatin Level
The aim is to assess early right ventricular systolic dysfunction in psoriatic arthritis patients using RV strain echocardiography
- Trial name
- NCT07046312
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Heart Failure
Identification Of Blood Markers For Asymptomatic Ventricular Dysfunction
The diagnosis of asymptomatic left ventricular dysfunction is difficult in general practice since it requires transthoracic cardiac echocardiography that is generally performed in specialized services.
- Trial name
- IBLOMAVED (NCT01024049)
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Exercise-induced Myocardial Damage, Right Ventricular Diastolic Dysfunction
Effects of Exogenous Ketones on Acute Changes and Recovery of the Heart Muscle After Intense Exercise.
It is well known that scar tissue on the heart muscle can cause (life-threatening) arrhythmias. However, the exact cause of this scar tissue is not entirely clear.
- Trial name
- NCT06715748
- Testing
- Ketone Monoester (KE)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
STEMI - ST Elevation Myocardial Infarction, Left Ventricular Systolic Dysfunction
The Effect of Early Administration of Dapagliflozin in STEMI Patients With LV Systolic Dysfunction
300 STIMI patients with LV systolic dysfunction will be divided into two equal groups (Group I (Study arm, n=150); will receive dapagliflozin plus conventional therapy and group (II) Control arm (n=150); will receive conventional…
- Trial name
- NCT05045274
- Testing
- Dapagliflozin 10Mg Tab
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Hypertrophic Cardiomyopathy, Endothelial Dysfunction
Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies
Left ventricular obstruction is an invalidating complication of hypertrophic cardiomyopathies (HCM), and endothelial dysfunction has also been observed in these pathologies.
- Trial name
- HCM-Vein (NCT04129905)
- Testing
- BNP blood sample test, Electrocardiogram, Holter ECG
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Acute Kidney Injury (Nontraumatic)
Comparison Between Right and Left Ventricular Systolic Dysfunction as a Risk Factors for Aki in Critical Care Patients
The cardio renal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently.
- Trial name
- NCT03369561
- Testing
- Serum urea and creatinine and the calculated e GFR
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Left Ventricular Diastoic Dysfunction Cohort Study
Epidemic Profile of Left Ventricular Diastoic Dysfunction in the Community Elderly and Establishing Prediction Model: the Northern Shanghai Study
This study is one of the largest ongoing prospective population studies to evaluate target organ damages (TODs) and Left Ventricular Diastoic Dysfunction in the community-dwelling elderly Chinese, which is authorised and funded…
- Trial name
- ELITISM (NCT03735251)
- Testing
- Diuretic，Betaloc，antiplatelet drugs
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- Ya-Wei Xu
Myocardial Ischemia, Left Ventricular Systolic Dysfunction
The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging
Using blood testing and cardiac magnetic resonance imaging (MRI), the investigators aim to determine if there are necrotic areas of myocardium in participants who complete a marathon.
- Conditions
- Myocardial Ischemia, Left Ventricular Systolic Dysfunction, Elevated Cardiac Enzymes
- Trial name
- MARATHON-MRI (NCT00752752)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Heart Diseases, Left Ventricular Dysfunction
Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction
To test the specific research questions, healthy men and age-matched healthy premenopausal females will be enrolled. Subjects will undergo cardiac magnetic resonance imaging and spectroscopy (MRI/MRS) to evaluate cardiac…
- Trial name
- NCT04671966
- Testing
- Estradiol patch, Cetrotide, Fasting
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Peripartum Cardiomyopathy
Peripartum Cardiomyopathy in Nigeria Registry
Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world.
- Trial name
- PEACE (NCT03081949)
- Testing
- Oral Sodium Selenite 200 µg/day for 3 months
- Where
- 2 sites in Nigeria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aminu Kano Teaching Hospital
Myocardial Infarction, Ventricular Dysfunction
Cologne Register of Wearable Defibrillator (CRWD)
The wearable cardiac defibrillator (WCD) is an alternative to the implantation of cardioverter defibrillator (ICD) for patients at high risk for sudden cardiac death (mostly bridging therapy).
- Conditions
- Myocardial Infarction, Ventricular Dysfunction, Myocarditis
- Trial name
- NCT02073942
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Coronary Endothelial Dysfunction, Apical Ballooning Syndrome
The Relationship Between the Response to Mental Stress and Vascular Endothelial Function
The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects.
- Conditions
- Coronary Endothelial Dysfunction, Apical Ballooning Syndrome, Myocardial Infarction
- Trial name
- NCT00975559
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Takotsubo Cardiomyopathy
Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy
The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome.
- Trial name
- TAKO MEMRI (NCT07491718)
- Testing
- Bisoprolol, Valsartan, sacubitril/ valsartan
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Sleep Apnea, Obstructive
Right Ventricular Function in Obstructive Sleep Apnea
The purpose of this study is to determine the structural and functional cardiac alterations in obstructive sleep apne (OSA) independent from systemic and pulmonary arterial hypertension and their correlation to the severity of…
- Trial name
- NCT00640536
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Florence Nightingale Hospital, Istanbul
OSA, Left Ventricular Dysfunction
Evaluation of Left Ventricular Function and Therapeutic Effect of CPAP in Patients With OSAS by 3D STE
The changes of left ventricular function in patients with sleep apnea were studied by three-dimensional speckle-tracking echocardiography to evaluate the changes of left ventricular function after CPAP treatment
- Trial name
- NCT04957004
- Testing
- CPAP
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Sleep Apnea, Ventricular Arrythmias
Sleep Apnea-hypopnea Syndrome (SAHS) and Ventricular Arrhythmias
Hypothesis: The CPAP treatment diminishes the effect of ventricular arrhythmias in patients with ischemic heart disease or dilated myocardiopathy, systolic ventricular disfunction and sleep apnea-hypopnea syndrome…
- Conditions
- Sleep Apnea, Ventricular Arrythmias, Systolic Left Ventricle Dysfunction
- Trial name
- SAHS-ICD (NCT00765713)
- Testing
- Nasal continuous positive airway pressure
- Where
- 3 sites in Spain
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
Healthy
Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart.
- Trial name
- NCT00001528
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aortic Stenosis
Microvascular Dysfunction in Aortic Stenosis
Aortic stenosis (AS), or narrowing of the aortic valve, is the commonest condition requiring valve surgery in the developed world. It is currently not known what determines who will go on to develop symptoms.
- Trial name
- PRIMID-AS (NCT01658345)
- Where
- 3 sites in United Kingdom
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester