Clinical trials: Ventricular Remodeling
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Aortic Regurgitation
Diastolic Dysfunction in Aortic Regurgitation
Follow-up study in patients with severe aortic regurgitation after successful valve replacement. Systolic and diastolic function were assessed and persistent diastolic dysfunction was observed late (7-10 years) after operation.
- Trial name
- NCT00976625
- Testing
- Aortic Valve Replacement
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bern
Echocardiography, Pregnancy Related Conditions, Unspecified, First Trimester
Echocardiographic Assessment of Ventricular Strain During a Healthy Pregnancy in the First, Second, and Third Trimester.
Pregnancy is a physiological situation that produces transient preload and afterload changes. The heart is subjected to reversible morphological remodelings and hemodynamic and functional adaptations.
- Conditions
- Echocardiography, Pregnancy Related Conditions, Unspecified, First Trimester, Pregnancy Related Conditions, Unspecified, Second Trimester, Pregnancy Related Conditions, Unspecified, Third Trimester
- Trial name
- VStrain123P (NCT04395014)
- Testing
- 2D Echocardiography
- Where
- Mexico
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Miguel Ayala León
Aging, Cardiology
Overcoming Inactivity in Older Adults: Impact on Vascular Homeostasis
The American Heart Association (AHA) and American College of Sports Medicine (ASCM) recommend older adults (50≤ age ≤ 80) perform at least 30 minutes of moderate-intensity aerobic exercise on most days ( ≥5 days) of the week.
- Conditions
- Aging, Cardiology, Nitric Oxide
- Trial name
- NCT01212978
- Testing
- Pedometer to Increase Physical Activity
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Cardiac Remodeling, Ventricular, Right Ventricular Hypertrophy
Longitudinal Analysis of Right Ventricular Remodeling in Response to Prolonged Strength Training Using 3D-echocardiography
Right ventricular (RV) physiological remodeling in response to prolonged strength exercise remains poorly studied. This prospective, non-randomized, single-center study, proposes to follow 24 healthy sedentary volunteers who will…
- Trial name
- FORCE-VD (NCT04187170)
- Testing
- Strength physical training
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cardiac Remodeling, Ventricular
Intracardiac Flow Remodeling in Athletes
The uncertainty concerning the onset and the extent of cardiac remodeling in response to intensive training hinders medical evaluation by physician.
- Trial name
- INFINITE (NCT03076788)
- Testing
- electrocardiogram and echocardiography
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Cardiomyopathies, Pediatric ALL
Ventricular Remodelling and Metabolomics in Pediatric Cardiomyopathies (PROGRESS-OMICS)
The pathogenesis of cardiomyopathies is complex and a simple approach cannot describe the whole picture. Different etiologies are reported in pediatric age and heart failure onset can lead to poor prognosis in term of need of…
- Trial name
- PRO-OMICS (NCT04670731)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bambino Gesù Hospital and Research Institute
Stiffness, Aortic, Cardiac Remodeling, Ventricular
Study of the Aorta Adaptations to Exercise in Triathletes During Sports Season (CoATri)
Regular sustained physical activity creates a cardiac remodelling : it is athlete's heart. In our preliminary work published in 2016, the investigators demonstrated in a small population of triathletes that there is also a…
- Conditions
- Stiffness, Aortic, Cardiac Remodeling, Ventricular, Vascular Remodeling, Magnetic Resonance Imaging, Functional
- Trial name
- CoATri (NCT03356301)
- Testing
- Cardiac MRI, Applanation tonometry
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Myocardial Infarction
BELIEVE Study: Nesiritide and Post Myocardial Infarction Left Ventricular Modeling
This study is being done to determine the effects (good and bad) of intravenous infusion of a human brain natriuretic peptide (BNP), Natrecor (nesiritide), a hormone produced by the heart in persons who have just suffered a heart…
- Trial name
- NCT00252213
- Testing
- Human BNP
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension,Essential
Endothelial Function in Prehypertension
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and…
- Trial name
- NCT06316271
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Congenital Heart Disease
Study of RV Remodeling in Congenital Heart Disease
The primary aims of this study are to 1. Develop an automated method of quantitation of RV remodeling in terms of regional RV surface curvature and area strain and assess the feasibility, repeatability and accuracy in normal…
- Trial name
- RVShape (NCT02791061)
- Testing
- Cardiovascular Magnetic Resonance Imagine (MRI), Cardiopulmonary exercise testing (CPET), Echocardiography
- Where
- Singapore
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Athletes Heart
Semmelweis Sport Study
The aim of the present proposal is to investigate the development of distinct morphological, functional, biochemical and molecular aspects of short- and long-term sport-induced changes in the heart, to get a better understanding…
- Trial name
- NCT03025737
- Where
- Hungary
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Semmelweis University Heart and Vascular Center
Heart Failure, Myocardial Infarction
Diffusion MRI in Heart Failure
The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood.
- Conditions
- Heart Failure, Myocardial Infarction, Left Ventricular Hypertrophy
- Trial name
- NCT02973633
- Testing
- Diffusion Tensor MRI (DTI), Gadolinium DOTA Meglumine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
STEMI
Short and Intermediate Term Effect of Dapagliflozin on Left Ventricular Remodeling in Anterior STEMI Patients
Methodology This study will enroll (120) patients presenting with acute anterior STEMI who will undergo early reperfusion presenting at Helwan University Hospitals and Ain Shams University Hospitals.
- Trial name
- NCT05957887
- Testing
- Dapagliflozin
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mohamed Nabil Elkholy
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Hypertension, Pregnancy Induced, Preeclampsia
Blood Pressure Variability Effect on Right Ventricular Strain in Women With Hypertensive Disorders With Pregnancy
The goal of this observational study is to learn about the potential effect of blood pressure variability changes on right ventricular strain in pregnant women with gestational hypertension or pre-eclampsia
- Trial name
- NCT06100484
- Testing
- Echocardiography
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Ischemic Heart Disease, Acute Myocardial Infarction
Coronary Thromboaspiration and Infarct Size
Distal embolization can occur during coronary angioplasty performed in the acute phase of myocardial infarction and is associated with poor long-term outcome.
- Trial name
- NCT00456066
- Testing
- Export Aspiration System
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Myocardial Infarction, Diabetes Mellitus, Type 2
Evaluation of the Effect of SGLT-2 Inhibitors on Cardiac Remodeling in Post Myocardial Infarction Patients
A prospective, randomized, controlled study will be conducted at Clinical Cardioglogy department, Ain Shams University Hospitals, assessing the efficacy and tolerability of SGLT2 inhibitors (dapagliflozin) addition on the…
- Conditions
- Myocardial Infarction, Diabetes Mellitus, Type 2, Myocardial Remodeling, Ventricular
- Trial name
- NCT05335629
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Heart Failure With Preserved Ejection Fraction
Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic
The main goal of our investigation is to study the mechanisms of formation of left ventricular remodeling in patients with hypertension, working on a rotational expedition basis in the Arctic.
- Trial name
- NCT05839028
- Where
- Russia
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Obstructive Sleep Apnea
Structural and Functional Left Ventricular Remodelling in Patients With Obstructive Sleep Apnea
The purpose of this study is to determine whether patients with obstructive sleep apnea have any changes in left ventricular function and structure after 06 months of continuous positive airway pressure treatment.
- Trial name
- NCT00768807
- Testing
- CPAP (continuous positive airway pressure)
- Where
- Brazil
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa