Clinical trials: Ventriculitis, Infectious
Ventriculitis, Infectious
Effect of Probiotic and Zinc Supplementations on the Clinical Outcome in Pediatric Patients with Ventriculitis
The aim of the study is to evaluate the effect of non-antibiotic-based supplemental interventions in the management of ventriculitis among pediatric patients.
- Trial name
- NCT06151392
- Testing
- Probiotic Formula, Zinc
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Ventriculitis, Infectious
Evaluation of a TDM Program for Intensive Care Patients in the Cerebrospinal Fluid
Therapeutic drug monitoring of antibiotics in critically ill patients is a present research topic of the last ten years. Research results have shown subtherapeutic blood concentrations in those patients.
- Trial name
- EMIL (NCT04426383)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Intraventricular Hemorrhage, Subarachnoid Hemorrhage
AFFECT Study for Patients With Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, and Ventriculitis
The goal of this clinical trial is to evaluate efficacy and safety of evacuation of cerebrospinal fluid, blood, and harmful bacteria from the intraventricular, subdural and subarachnoid spaces by Active Controlled Irrigation and…
- Conditions
- Intraventricular Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, Ventriculitis
- Trial name
- AFFECT (NCT05649904)
- Testing
- IRRAflow with Active Fluid Exchange System, External Ventricular Drain
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Ohio State University
Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP)
Safety, Pharmacokinetics and Efficacy of BV100 Plus Low Dose Polymyxin B Plus Ceftazidime/Avibactam, or Plus Cefiderocol in Patients With Pulmonary and Extrapulmonary Infections Due to Carbapenem-resistant Acinetobacter Baumannii-calcoaceticus Complex
This Phase IIb study aims to evaluate the safety and efficacy of BV100 in combination with low dose polymyxin B plus ceftazidime/avibactam or cefiderocol in patients with suspected or confirmed CRABC infections.
- Conditions
- Ventilator Associated Bacterial Pneumonia (VABP), Hospital Acquired Bacterial Pneumonia (HABP), Blood Stream Infection, Meningitis, Bacterial
- Trial name
- RIV- CARE (NCT07431307)
- Testing
- BV100 with 50 mg polymyxin B plus ceftazidime/avibactam, BV100 with 50 mg polymyxin B plus cefiderocol, Best Available Therapy (BAT)
- Volunteers
- 120 people
- Sponsor
- BioVersys AG
Hydrocephalus, Intracranial Hypertension
Impact of Ventricular Catheter Used With Antimicrobial Agents on Patients With a Ventricular Catheter
External ventricular catheters are used for intracranial pressure monitoring and temporary cerebrospinal fluid (CSF) drainage in neurosurgery.
- Trial name
- NCT00286104
- Testing
- Antibiotics-impregnated ventricular catheter (Bactiseal®), Plain ventricular catheter (Codman EDS II/III)
- Where
- China
- Volunteers
- 184 people
- Sponsor
- Chinese University of Hong Kong
Ventriculitis, Cerebral
Diagnostics of External Ventricular Drain Infections in Neurosurgical Patients
External ventricular drains (EVD) are small tubes used in neuro-critical care inserted to measure pressure and treat acute build-up of fluid in the brain by draining the cerebrospinal fluid (CSF) in the ventricles, often…
- Trial name
- EVD-Infect (NCT04736407)
- Testing
- Observational sampling of CSF timed around routine clinical repositioning, or not
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Karolinska University Hospital
Intracranial Infections, Ventriculitis
The Clinical Character，Risk and Prognosis of Post-neurosurgical Intracranial Infection With Different Pathogens.
Intracranial infection is one of the common clinical complications after neurosurgery, especially after external cerebrospinal fluid drainage.
- Conditions
- Intracranial Infections, Ventriculitis, Meningitis, Gram-Positive Bacterial Infections
- Trial name
- NCT04917380
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ventricular Drain Related Infection, Nosocomial Infection
Novel Diagnostic Methods to Identify External Ventricular Drain Associated Infections
External ventricular drain infections are difficult to identify with current diagnostic methods. Initiation of antibiotic treatment is usually supported by indirect methods of bacterial infection, such as clinical signs or…
- Conditions
- Ventricular Drain Related Infection, Nosocomial Infection, Infection, Bacterial, Ventriculitis, Infectious
- Trial name
- EVD Infect II (NCT05904535)
- Testing
- Cerbrospinal fluid sampling.
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Cerebrospinal Fluid Shunts, Ventriculoperitoneal Shunt
Ceftaroline Diffusion Into Cerebrospinal Fluid of Children
Ceftaroline fosamil is an intravenous (IV) drug that belongs to a group of antibiotics called cephalosporins . Antibiotics are drugs used to treat infections.
- Trial name
- NCT02600793
- Testing
- Ceftaroline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Basim Asmar