Clinical trials: Ventriculoperitoneal Shunt
Pseudotumor Cerebri
ShuntCheck Performance Characteristics in Asymptomatic Pseudotumor Cerebri Patients
The purpose of the study is to determine if the ShuntCheck test can correctly identify flow or no flow in a ventriculoperitoneal shunt in patients with pseudotumor cerebri.
- Trial name
- NCT04309383
- Testing
- ShuntCheck
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of South Florida
Ventriculo-Peritoneal Shunt Infection
Pilot Testing for Midline Measuring Device
Identifying the exact middling on the patient's head during the planning phase of surgery is crucial yet can be challenged by patient's head position and hair.
- Trial name
- MMD (NCT04883060)
- Testing
- midline localizer
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Iowa
Hydrocephalus
Thermal Camera Detection of Ventriculoperitoneal Shunt Flow
There have been reports in the past of using thermal cameras to demonstrate flow in the tubing as a surrogate of proper shunt function.
- Trial name
- Infrared Shunt (NCT03451669)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
Idiopathic Intracranial Hypertension
Surgical Idiopathic Intracranial Hypertension Treatment Trial
Randomized trial of adults (≥18 years old) with idiopathic intracranial hypertension and moderate to severe visual loss without substantial recent treatment who are randomly assigned to (1) medical therapy, (2) medical therapy…
- Trial name
- SIGHT (NCT03501966)
- Testing
- Acetazolamide, Optic Nerve Sheath Fenestration, Ventriculoperitoneal CSF Shunting
- Where
- 36 sites in United States, Canada and 1 more
- Volunteers
- 7 people
- Sponsor
- Jaeb Center for Health Research
Hydrocephalus, Normal Pressure
Assessment of ShuntCheck Performance Characteristics in Asymptomatic Patients With Normal Pressure Hydrocephalus
The purpose of the study is to determine if the ShuntCheck test can correctly identify flow or no flow in a ventriculoperitoneal shunt in patients with asymptomatic normal pressure hydrocephalus.
- Trial name
- NCT04011566
- Testing
- ShuntCheck
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of South Florida
Subarachnoid Hemorrhage, Ventriculo-Peritoneal Shunt Infection
Early Ventriculo-peritoneal Shunt in Subarachnoid Patients With External Ventricular Drainage
Acute hydrocephalus is a common complication following subarachnoid hemorrhage (SAH). Early and emergency insertion of external ventricular drain (EVD) is standard treatment of acute post-SAH hydrocephalus.
- Conditions
- Subarachnoid Hemorrhage, Ventriculo-Peritoneal Shunt Infection, Hydrocephalus
- Trial name
- EarlyVPS (NCT04567277)
- Testing
- External ventricular drainage (EVD) conversion into ventriculo-peritoneal shunt (VPS)
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Mashhad University of Medical Sciences
Ventriculoperitoneal Shunt (VPS), Cranioplasty
Simultaneous Vs Staged VPS and CP :A Multi-cnter RCT.
The purpose of this prospective, multi-center randomized controlled trail is to compare the safety and efficacy of sequential surgery or staged surgery in patients with skull defect and hydrocephalus.
- Trial name
- NCT07462676
- Testing
- Time of choosing VPS and VP
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Anhui Provincial Hospital
Idiopathic Normal Pressure Hydrocephalus
Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)
The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research
- Trial name
- NCT04998175
- Testing
- ventriculo-peritoneal shunt
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hydrocephalus, Ventriculoperitoneal Shunt
Clinical Observation of V-P Shunt and Application of "Three-step Disinfection" to Reduce Post-operative Infection Rate
A randomized, single blind, parallel controlled, multicenter clinical study was performed in which patients who had undergone a cerebrospinal fluid to peritoneal shunt that met the criteria were divided into two groups (test and…
- Trial name
- NCT04785248
- Testing
- Three-step disinfection
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Baiyun Liu
Ventriculoperitoneal Shunt, Trans Fontanelle US
Insertion of Frontal Ventricular Catheter of VP Shunt in Congenital Hydrocephalus Guided by Trans Fontanelle Ultrasound
The Aim of This Study Is To Evaluate The Role Of Ultrasound In Decreasing Rate Of Proximal Obstruction In Frontal VP Shunt
- Conditions
- Ventriculoperitoneal Shunt, Trans Fontanelle US, Congenital Hydrocephalus
- Trial name
- NCT06664372
- Testing
- Trans fontanelle US Guided VP Shunt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Ventriculoperitoneal Shunt (VPS), Hydrocephalus
Intraoperative Ultrasound Guided Compared to Stereotactic Navigated Ventriculoperitoneal Shunt Placement
This study is to prospectively compare Ultrasound guided (US-G) Ventriculoperitoneal Shunt (VPS) placement to stereotactic navigation in a randomized controlled fashion with the surgical intervention time as primary outcome.
- Trial name
- NaVPS (NCT04450797)
- Testing
- US -G VPS placement, done by BK Medical 5000 US with burr hole probe (type 9063 N11C5S, 11-5 MHz)., Stereotactic navigation for VPS placement (Brainlab Dual Curve System with cranial navigation software version 3.1).
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University Hospital, Basel, Switzerland
Disorder of Consciousness
Hydrocephalus Treatment on Persistent Disorder of Consciousness
After acute brain injury or haemorrhagic stroke, hydrocephalus might participate to consciousness disorder. We plan to explore whether ventriculoperitoneal shunt insertion improves consciousness in patients with vegetative or…
- Trial name
- HYCO (NCT05219331)
- Testing
- Ventriculoperitoneal shunt
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Hydrocephalus, Normal Pressure
Diagnostic Accuracy of ShuntCheck Compared to Radionuclide Shunt: Patency in Patients With Normal Pressure Hydrocephalus
The purpose of this study is to assess the diagnostic accuracy of ShuntCheck compared with radionuclide shunt patency testing (SPS) to detect CSF shunt flow of NPH patients with suspected shunt obstruction.
- Trial name
- NCT04309487
- Testing
- ShuntCheck
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of South Florida
Idiopathic Intracranial Hypertension (IIH)
BMI in Idiopathic Intracranial Hypertension and Its Relationship With the Response to Treatment
1. To establish the correlation between the evolution of the body mass index in benign intracranial hypertension and the response to treatments. 2. To establish the BMI at which this disease occurs. 3.
- Trial name
- NCT06913712
- Testing
- Weight loss without pharmacotherapy
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- University of Valencia
Hydrocephalus
ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus
The purpose of this study is to test and compare the efficacy of Endoscopic Third Ventriculostomy with shunting of Cerebrospinal fluid (CSF)for treatment for patients of Normal pressure Hydrocephalus.
- Trial name
- NCT00946127
- Testing
- Ventriculoperitoneal Shunt Placement, Endoscopic Third Ventriculostomy(ETV)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Johns Hopkins University
Hydrocephalus, Normal Pressure, Ventriculomegaly, Cerebral
Volumetrics and Proteomics in Shunted Normal Pressure Hydrocephalus
Idiopathic normal pressure hydrocephalus (=iNPH) is a condition with disturbed circulation of cerebrospinal fluid (=CSF) causing symptoms such as balance and gait disorders, urinary incontinence and cognitive impairment in…
- Conditions
- Hydrocephalus, Normal Pressure, Ventriculomegaly, Cerebral, Shunt; Complications, Hydrocephalus Acquired
- Trial name
- LiNPH (NCT04785560)
- Testing
- Initial shunt setting post-operatively of the Certas Plus shunt valve.
- Where
- Sweden
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Idiopathic Normal Pressure Hydrocephalus
A Trial of High and Low Pressure Level Settings on a Programmable Ventriculoperitoneal Shunt Valve for Idiopathic Normal Pressure Hydrocephalus
In treating idiopathic normal pressure hydrocephalus with a shunt there is always a risk of underdrainage or overdrainage. The hypothesis is tested whether treatment of patients with an adjustable valve preset at the highest…
- Trial name
- NCT01570257
- Testing
- lowering of the performance level of an adjustable Strata valve in a ventriculoperitoneal (VP) shunt for treating idiopathic normal pressure hydrocephalus
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Erasmus Medical Center
The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation, The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change
CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with…
- Trial name
- NCT06005363
- Testing
- Dexmedetomidine, anesthesia depth monitoring
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Ventriculoperitoneal Shunt Malfunction, Radionuclide Shuntography
Qualitative Radionuclide Shuntography for Adult Patients With Suspected V-P Shunt Malfunction
The investigators retrospectively reviewed all radionuclide shuntographic tests using (99m)technetium-pertechnetate (DTPA) performed between August 2005 and December 2015 in nuclear medicine department of Far Eastern Memorial…
- Trial name
- NCT02894216
- Testing
- radionuclide shuntography
- Volunteers
- 69 people
- Sponsor
- Far Eastern Memorial Hospital
Idiopathic Normal Pressure Hydrocephalus
Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With iNPH
INPH is a chronic, progressive disease characterised by enlarged ventricles in the absence of elevated intracranial pressure. Patients often present with the Hakim triad comprising gait disturbance, dementia and urinary…
- Trial name
- iNPH (NCT02495610)
- Testing
- Gait analysis and MRI:
- Where
- Switzerland
- Volunteers
- 70 people
- Sponsor
- University of Zurich