Clinical trials: Ventriculoperitoneal Shunt
Hydrocephalus
Noninvasive Intracranial Pressure and Hydrocephalus Patients
Using a pulse oximeter, we have developed an algorithm that estimates intracranial pressure (ICP) based on patients who have had traumatic brain injuries.
- Trial name
- NCT02404740
- Testing
- Pulse oximetry
- Volunteers
- 163 people
- Sponsor
- University of Colorado, Denver
Ventriculoperitoneal Shunt, Infection
Retrospective Analysis of Clinical Features in Ventriculoperitoneal Shunt Infectionsin Adults
The objectives of this study are: To describe the incidence of clinical features in adults with internal ventriculoperitoneal (VP) shunt infections, To determine the validity of laboratory parameters in adults with internal…
- Trial name
- NCT00524108
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Pittsburgh
Hydrocephalus, Ventriculoperitoneal Shunt Malfunction
Comparison of Programmable and Non-programmable CSF Shunts Among Adult Hydrocephalus Patients With Different Etiologies
Programmable valve (PV) has been shown as a solution to the high revision rate in pediatric hydrocephalus patients, but it remains controversial among adults.
- Trial name
- NCT05534659
- Testing
- Programmable valve, Non-programmable valve
- Volunteers
- 325 people
- Sponsor
- Chang Gung Memorial Hospital
Idiopathic Normal Pressure Hydrocephalus (INPH)
Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)
The aim of this single-center, two-arm, open-labeled, randomized controlled clinical study is to compare two surgical interventions, endoscopic third ventriculostomy and ventriculoperitoneal shunt, in treating idiopathic normal…
- Trial name
- NCT06488248
- Testing
- Endoscopic third ventriculostomy (ETV), Ventriculoperitoneal shunt (VPS)
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University Hospital, Basel, Switzerland
Communicating Hydrocephalus
Third Ventriculostomy Versus Shunt for Children With Hydrocephalus
Ventriculoperitoneal shunts are the standard of care for patients with communicating hydrocephalus, but they have a high failure rate - up to 40% fail within 1 year and 50% fail within 2 years.
- Trial name
- NCT01801267
- Testing
- Endoscopic third ventriculostomy (ETV), Ventricular shunt
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Cerebrospinal Fluid Shunts, Ventriculoperitoneal Shunt
Ceftaroline Diffusion Into Cerebrospinal Fluid of Children
Ceftaroline fosamil is an intravenous (IV) drug that belongs to a group of antibiotics called cephalosporins . Antibiotics are drugs used to treat infections.
- Trial name
- NCT02600793
- Testing
- Ceftaroline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Basim Asmar
Hydrocephalus, Normal Pressure
MRI-Volumetry in the Evaluation of Shunt Treatment for Hydrocephalus
This randomized, double-blinded, cross-over study aim to evaluate the effects of shunt treatment in idiopathic normal pressure hydrocephalus (iNPH) by measuring cerebral ventricular volume and clinical symptoms at different shunt…
- Trial name
- NCT04599153
- Testing
- Ventriculoperitoneal shunt opening pressure setting
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Uppsala University
Hydrocephalus in Children
Precision Surgery for Pediatric Hydrocephalus: VPS vs. ETV With ML-Guided Prediction
Study type: Multicenter retrospective cohort study with prospective validation Primary purpose: To determine whether an individualized, imaging-guided treatment algorithm Ventriculoperitoneal shunt (VPS) vs endoscopic third…
- Trial name
- VPS ETV ML (NCT07330206)
- Testing
- MRI-Guided Precision Shunt or ETV Strategy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- West China Hospital
Hydrocephalus, Ventriculoperitoneal Shunt Infection
Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies
Objectives Primary: To measure the reduction in VP shunt infection rates using topical vancomycin powder. Secondary: To compare efficacy across different Etiological Strata (Congenital, Post-hemorrhagic, post-inflammatory).
- Conditions
- Hydrocephalus, Ventriculoperitoneal Shunt Infection, Surgical Site Infection (SSI), Cerebrospinal Fluid Shunt Infection
- Trial name
- NCT07547826
- Testing
- Topical Vancomycin Powder, Standard Perioperative Care
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Assiut University
Hydrocephalus
Improvement of Peritoneal Catheter Placement in VPS With a Splitable Trocar
This study is a phase I/IIa, single-center, open-labeled, randomized, controlled clinical trial. The aim of this study is to evaluate the safety and efficacy of a modified ventriculoperitoneal catheter placement using a splitable…
- Trial name
- NCT05476874
- Testing
- Open Mini-Laparotomy, Abdominal Puncture
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southern Medical University, China
Hydrocephalus
Comparison of Optic Nerve Sheath Diameter Measured by Ultrasonography Before and After Ventriculoperitoneal Shunt Surgery in Adult Patients With Hydrocephalus
Hydrocephalus is a disturbance of cerebrospinal fluid production, flow and absorption leading to intracranial hypertension. Assessment of the change in intracranial pressure after ventriculoperitoneal shunt surgery is important…
- Trial name
- NCT02663947
- Testing
- ultrasonographic measurement of optic nerve sheath diameter
- Where
- South Korea
- Sponsor
- Yonsei University
The iNPH Patients Scheduled for VP or LP Shunt Procedures
Factors Associated With Post-induction Hypotension in iNPH Patient Undergoing VP and LP Shunt
This study is a retrospective work involving the review of patients who were scheduled for VP or LP shunt in Siriraj Hospital, Mahidol University, Thailand.
- Trial name
- NCT05183061
- Testing
- Ehedrine Norepineprine
- Where
- Thailand
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hydrocephalus, Shunt Malfunction
Role of Endoscopic Third Ventriculostomy in Management of Malfunctioning Ventriculoperitoneal Shunt
The aim of this study is to analyze our experience in management of malfunctioning ventriculoperitoneal shunt by using endoscopic third ventriculostomy (ETV).
- Trial name
- NCT06341946
- Testing
- Endoscopic third ventriculostomy
- Volunteers
- 30 people
- Sponsor
- Sohag University
Idiopathic Normal Pressure Hydrocephalus, Normal Pressure Hydrocephalus
Prediction of Response to Shunt Surgery in Normal Pressure Hydrocephalus Using Radscale and Lumbar Puncture
Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder in older adults characterized by walking difficulties, cognitive decline, and urinary dysfunction.
- Trial name
- NCT07832877
- Volunteers
- 40 people
- Sponsor
- Assiut University
Intraventricular Hemorrhage, Premature Infants
Intraventricular Hemorrhage and Post Hemorrhagic Ventricular Dilation: Natural Course, Treatment, and Outcome
Intraventricular hemorrhage and its resultant post-hemorrhagic hydrocephalus are significant risk factors for the development of neurodevelopmental delays in preterm infants.
- Trial name
- NCT00957840
- Testing
- NIRS, aEEG, and CSF concentration of biomarkers
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Utah
Hydrocephalus in Children
The Effect of Education Given to Parents of Children With Ventriculoperitoneal Shunt on Their Anxiety and Self-efficacy
This study aims to evaluate the effect of tele-education given to parents of children with ventriculoperitoneal shunt on their anxiety and self-efficacy.
- Trial name
- NCT06313879
- Testing
- Tele-education and Counseling Program
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Pamukkale University
Aneurysm, Ruptured, Hyperglycemia
Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood
The goal of this study is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and ventriculo-peritoneal-shunt (VPS)-dependency also evaluating the influence of blood glucose on VPS…
- Conditions
- Aneurysm, Ruptured, Hyperglycemia, Hydrocephalus
- Trial name
- HCP-Glc (NCT06486909)
- Testing
- Cerebrospinal Fluid (CSF) Sample, Blood Serum Sample
- Where
- 3 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Isabel Hostettler
Hydrocephalus
A Prospective Study Comparing CSF Shunt Flow Between "Virtual Off" and "Flow Permissive" Shunt Valve Settings Using a Wireless, Noninvasive Shunt Flow Sensor
Hydrocephalus is commonly treated with a cerebrospinal fluid (CSF) shunt, a device that drains excess fluid from the brain. However, shunts can stop working over time, and determining whether fluid is flowing through a shunt can…
- Trial name
- NCT07815314
- Testing
- Rhaeos Shunt Monitoring System (RSMS), ShuntCheck III
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Rhaeos, Inc.
Normal Pressure Hydrocephalus, Sleep Apnea
Normal Pressure Hydrocephalus and Sleep Apnea
Normal-pressure hydrocephalus is associated with increases in the intracranial pressure during the night sleep. Sleep apnea also increases the intracranial pressure during the apneic spells.
- Conditions
- Normal Pressure Hydrocephalus, Sleep Apnea, Cerebrospinal Fluid Shunt Occlusion
- Trial name
- NPH/OSA (NCT04471740)
- Testing
- CSF shunt diversion
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Valencia
Hydrocephalus
HCRN Endoscopic Versus Shunt Treatment of Hydrocephalus in Infants
Hydrocephalus is a potentially debilitating neurological condition that primarily affects babies under a year of age and has traditionally been treated by inserting a shunt between the brain and the abdomen.
- Trial name
- ESTHI (NCT04177914)
- Testing
- Endoscopic Third Ventriculostomy with Choroid Plexus Cauterization (ETV+CPC), Ventriculoperitoneal Shunt
- Where
- 21 sites in United States, Canada
- Volunteers
- 165 people
- Sponsor
- University of Utah