Clinical trials: Vertebra; Degeneration
Lumbar Disc Disease, Lumbar Spine Degeneration
The Six-Minute Walking Test (6WT) and Timed-Up-and-Go (TUG) Test as Measures of Objective Functional Impairment in Patients Undergoing Interlaminar or Transforaminal Epidural Steroid Injection for Lumbar Degenerative Disc Disease (DDD)
The primary objective is to determine the validity of the Six-Minute-Walking Test (6WT) and Timed-Up and Go (TUG) test to measure objective functional impairment (OFI) in patients undergoing either interlaminar epidural steroid…
- Conditions
- Lumbar Disc Disease, Lumbar Spine Degeneration, Lumbar Spinal Stenosis
- Trial name
- NCT04062942
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
Scoliosis, Back Pain
InterFuse® S and T for the Treatment of Scoliosis, Spondylolisthesis and Degenerative Disc Disease (DDD)
The primary objective of this prospective, post-market study is to collect data to assess the long term outcome of a broad contact modular interbody device in the form of the InterFuse S™ or InterFuse T™ device in patients…
- Trial name
- NCT02659722
- Testing
- InterFuse
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vertebral Technologies, Inc.
Degenerative Lumbar Spine Causing Back and/or Leg Pain, Lumbar Spine Degeneration
A Prospective, Multicenter Observational Study on MAST™ (Minimal Access Spinal Technologies) Fusion Procedures for the Treatment of the Degenerative Lumbar Spine
The aim of the study is to observe and document surgical practice and evaluate patients' outcomes following a MAST™ single or double level instrumented fusion procedure using PLIF (Posterior Lumbar Interbody Fusion) or TLIF…
- Trial name
- MASTERS-D (NCT01143324)
- Testing
- MAST™ procedure
- Where
- 19 sites in Austria, Belgium and 12 more
- Volunteers
- 255 people
- Sponsor
- Medtronic Spinal and Biologics
Hyperkyphosis, Walking, Difficulty
Walking and Balance Related to Sagittal Spinal Posture Alignment
This study aims to improve understanding of the relationship between spinal alignment and walking and balance in people who have degenerative spinal conditions.
- Conditions
- Hyperkyphosis, Walking, Difficulty, Balance; Distorted, Spinal Disease
- Trial name
- WiSPA (NCT04008459)
- Testing
- Therapeutic exercise class
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- University of Oxford
Lumbar Degenerative Disease
The Effect of Osteoporotic Medications on Vertebral Bone Quality Score
The goal of this clinical trial is to determine the change in VBQ score, T score, TBS, and Hounsfield Units (HU) after 3-6 months of treatment with abaloparatide in osteoporotic patients who will undergo spinal fusion and…
- Trial name
- NCT07587775
- Testing
- Abaloparatide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- State University of New York at Buffalo
Degenerative Spine Diseases
Vertebral Bone Marrow Clot for Spinal Surgery
Spinal fusion (SF) is a common orthopedic procedure to treat spinal diseases. Apart from fixation systems, the procedure requires bone grafting to further improve SF.
- Trial name
- NCT05947175
- Testing
- Vertebral bone marrow (vBMA) clot, Bone allograft chips
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- Istituto Ortopedico Rizzoli
Cervical Spine Degenerative Disease
AO CSH Mainstream Study on Cervical Spine Degeneration
Adult patients with cervical degenerative diseases undergoing primary anterior and/or posterior cervical fusion will be prospectively enrolled from participating sites.
- Trial name
- CASDEM (NCT06845293)
- Volunteers
- 300 people
- Sponsor
- AO Innovation Translation Center
Degenerative Disc Disease, Lumbar Disc Disease
LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)
The objective of this study is to evaluate the safety and effectiveness of LDGraft (investigational device) compared to 100% human tissue product allograft bone (control) when applied in an ALIF procedure in the treatment of…
- Conditions
- Degenerative Disc Disease, Lumbar Disc Disease, Spine Disease, Lumbar Spine Degeneration
- Trial name
- RESTORE (NCT06462729)
- Testing
- LDGraft, Allograft Bone
- Where
- 4 sites in United States, Australia
- Volunteers
- 40 people
- Sponsor
- Locate Bio Pty Ltd
Degenerative Osteoarthritis, Degenerative Lumbar Vertebra
Efficacy and Safety Study of Lumbar Interbody Fusion With MatriTMBONE Associated With Autologous Bone Marrow
The main objective of this clinical study is the estimation of the rate of intersomatic fusion observed 12 months after lumbar interbody fusion by posterior approach with PEEK interbody cage of fusion in PEEK performed with…
- Trial name
- MatriBone (NCT01335243)
- Testing
- The Transforaminal Lumbar Interbody Fusion (TLIF) surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Bordeaux
Lumbar Spine Instability, Lumbar Spinal Stenosis
Modified-Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block Following Lumbar Instrumentation Surgery
Ultrasound (US)-guided peripheral nerve blocks have been used increasily due to the advantages of ultrasound in anesthesia practice. TLIP block is one of these nerve blocks performed under US guidance.
- Conditions
- Lumbar Spine Instability, Lumbar Spinal Stenosis, Lumbar Disc Disease, Lumbar Spine Degeneration
- Trial name
- NCT04189341
- Testing
- Erector spinae plane block (Group E), Modified-thoracolumbar interfascial plane block
- Where
- Turkey (Türkiye)
- Sponsor
- Medipol University
Disc Degeneration, Spinal Deformity
MDT-0123 Japan Study
The purpose of this clinical trial is to compare the efficacy and safety of this investigational device with autologous iliac bone graft (ICBG) in patients who are deemed to require bone fusion through spinal fixation at two…
- Trial name
- NCT07414745
- Testing
- MDT-0123, ICBG
- Where
- 14 sites in Japan
- Volunteers
- 140 people
- Sponsor
- Medtronic Spinal and Biologics
Vertebra; Degeneration, Spinal Trauma
SpineTRACK Registry - Spinal Outcomes Registry
The Spine TRACK Spinal Surgery Registry is a prospective multi-center observational data collection initiative, to capture clinical and radiographic outcomes in candidates for spine surgery with degenerative, deformity, and…
- Conditions
- Vertebra; Degeneration, Spinal Trauma, Spinal Deformity
- Trial name
- NCT01372592
- Testing
- Surgery
- Where
- 28 sites in United States, Brazil
- Volunteers
- 8,079 people
- Sponsor
- NuVasive
Other Disorders of the Autonomic Nervous System, Vertebra; Degeneration
Autonomic Effects of T4 Mobilization in Asymptomatic Subjects
The purpose of this study is to determine whether passive accessory intervertebral mobilization applied to the fourth thoracic vertebra produces autonomic effects.
- Trial name
- NCT02164123
- Testing
- Spinal mobilization, Spinal Mobilization II
- Where
- Brazil
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Lumbar Spondylolisthesis, Lumbar Spine Degeneration
Comparison of Complication Rates Between Initial and Re-operative Anterior Lumbar Interbody Fusion Surgery: Is There a Difference?
To identify the current mortality rate for initial Anterior Lumbar Interbody Fusion(ALIF)procedures. Establish/prove mortality rates for this operation have dropped in the past decade.
- Trial name
- NCT05945550
- Where
- United States
- Volunteers
- 3,500 people
- Sponsor
- Methodist Health System
Lumbar Spine Degeneration, Arthrosis; Spine
Postoperative Bracing Patterns After Lumbar Surgery
A variety of postoperative bracing are routinely applied after spinal procedures but there are limited data regarding their efficacy, especially with the increasing use of internal fixation.Currently, no data are available…
- Conditions
- Lumbar Spine Degeneration, Arthrosis; Spine, Surgery
- Trial name
- NCT03427281
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spine Degeneration
Unscheduled Hospital Readmission After Crenel Lateral Interbody Fusion
The goal of this observational study is to learn about the readmission related to Crenel Lateral Interbody Fusion (CLIF). The main question it aims to answer is: What are the risk factors for readmission after CLIF surgery?
- Trial name
- NCT06614296
- Testing
- Crenel Lateral Interbody Fusion, Crenel lateral interbody fusion plus second stage surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lumbar Spine Degeneration
A Randomized Trial of Exparel vs Saline in Opioid Reduction of Pain Management Following Lumbar Spine Surgeries.
The purpose of this study is to establish a relationship between liposomal bupivacaine surgical site injection and postop opioid utilization.
- Trial name
- Exparel (NCT04644796)
- Testing
- saline 0.9%, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Missouri-Columbia
Cervical Spine Degeneration, Movement, Abnormal
Cervical Spine Motion in the Elderly
Rationale: Physiological motion of the cervical spine is a subject of interest for medical specialists. Segmental range of motion (sROM) has been most commonly used to define motion but inter- and intra-variability is large.
- Conditions
- Cervical Spine Degeneration, Movement, Abnormal, Aging
- Trial name
- NCT04222777
- Testing
- Cinematographic Recording
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Degeneration Spine, Cervical Radiculopathy
Salt Water Gargling on Swallowing Following ACDF
The goal of this randomized control trial is to collect sufficient preliminary data on the efficacy of sodium chloride, hereafter referred to as "saltwater" or "saline" in reducing the difficulty of swallowing following…
- Conditions
- Degeneration Spine, Cervical Radiculopathy, Cervical Stenosis, Cervical Spondylosis
- Trial name
- NCT06475365
- Testing
- Sodium chloride gargle
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Degenerative Disc Disease, Chronic Lower Back Pain
Intervertebral DXM Gel Injection in Adults With Painful Lumbar Degenerative Disc Disease
The purpose of this study is to assess the safety and the efficacy of an hydrogel (double cross-link microgel - DXM) injection into the intervertebral disc (IVD) space in patients with painful lumbar degenerative disc disease…
- Conditions
- Degenerative Disc Disease, Chronic Lower Back Pain, Discogenic Pain, Intervertebral Disc Degeneration
- Trial name
- DXM gel (NCT04727385)
- Testing
- Double Crosslink Microgel
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Gelmetix