Clinical trials: Vertebral Compression
Denosumab Allergy
Denosumab vs Alendronate After Vertebroplasty
Osteoporotic vertebral compression fracture (OVCF) patients had a proportion of secondary fractures after percutaneous vertebroplasty (PVP).
- Trial name
- NCT05662358
- Testing
- Denosumab, Alendronate
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shenzhen People's Hospital
Osteoporotic Fractures, Vertebral Fracture
Percutaneous Vertebroplasty Vs. Sham for Osteoporotic Vertebral Compression Fractures Focusing on Pain and Economy.
The purpose of this randomized double-blind clinical trial is to determine the efficacy of percutaneous vertebroplasty (PVP) in relieving severe pain in patients with MRI-verified acute or sub-acute osteoporotic vertebral…
- Trial name
- VOPE2 (NCT06141187)
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- Spine Centre of Southern Denmark
Compression Fracture of Vertebral Body, Osteoporosis
Evaluation of Outcomes for Quality of Life and Activities of Daily Living for BKP in the Treatment of VCFs
The study objective is to collect and report 12-month outcomes pertaining to activities of daily living, quality of life, and safety parameters in a Medicare population to be treated with balloon kyphoplasty in the treatment of…
- Conditions
- Compression Fracture of Vertebral Body, Osteoporosis, Cancer
- Trial name
- EVOLVE (NCT01871519)
- Testing
- Balloon kyphoplasty
- Where
- 25 sites in United States
- Volunteers
- 354 people
- Sponsor
- Medtronic Spinal and Biologics
Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain
Determining the Prognostic Value of Continuous Intrathecal Infusion
The purpose of this study will be to determine the efficacy and the prognostic value of a continuous intrathecal prognostic infusion test in an in-hospital setting for selecting patients who would have better long term outcomes…
- Conditions
- Lumbar Post-Laminectomy Syndrome, Chronic Low Back Pain, Vertebral Compression Fracture, Failed Back Surgery Syndrome
- Trial name
- NCT03523000
- Testing
- Continuous intrathecal prognostic infusion test, Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University Hospitals Cleveland Medical Center
OVCF Database, Cohort Study
Osteoporotic Vertebral Compression Fracture Cohort Study
The study aims to construct an early warning model for Osteoporotic Vertebral Compression Fracture (OVCF) by integrating TCM syndrome patterns with modern risk factors.
- Trial name
- NCT07321795
- Where
- 4 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
Osteopenia, Osteoporosis
FREE Study - Fracture Reduction Evaluation
The primary objective of this study is to compare the effectiveness of standard medical therapy alone to kyphoplasty using the KyphX system for the treatment of acute vertebral body compression fractures.
- Conditions
- Osteopenia, Osteoporosis, Multiple Myeloma, Bone Neoplasms
- Trial name
- NCT00211211
- Testing
- Balloon Kyphoplasty
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Medtronic Spine LLC
Osteoporotic Vertebral Compression Fractures
Cost Effectiveness and Efficacy of Kyphoplasty and Vertebroplasty Trial
Randomized trial comparing cost effectiveness and efficacy of kyphoplasty vs vertebroplasty for the treatment of painful, osteoporotic vertebral compression fractures.
- Trial name
- NCT00279877
- Testing
- Kyphoplasty
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Virginia
Osteoporotic Vertebral Compression Fractures
Post-Market Study of The Tripod-Fix Vertebral Body Augmentation System in Osteoporotic Vertebral Compression Fractures
The objective of this Post-Market Clinical Follow-Up Study is to evaluate the safety and performance of the Tripod-Fix in the treatment of vertebral compression fractures (VCF) resulting from osteoporosis.
- Trial name
- NCT06270173
- Testing
- Tripod-Fix Vertebral Body Augmentation System (Tripod-Fix)
- Where
- 4 sites in Germany
- Volunteers
- 53 people
- Sponsor
- Wiltrom Co., Ltd.
Osteoporotic Vertebral Compression Fractures
SpineJack System Postmarket Registry
This postmarket registry is intended to prospectively collect real world data to support ongoing safety and performance of the SpineJack system.
- Trial name
- NCT04795765
- Testing
- SpineJack system, Balloon kyphoplasty, Vertebroplasty
- Where
- 12 sites in United States
- Volunteers
- 261 people
- Sponsor
- Stryker Instruments
Vertebral Compression Fracture
Unipedicular vs. Bipedicular Kyphoplasty for the Treatment of Osteoporotic Vertebral Fractures
Balloon kyphoplasty for the treatment of patients with osteoporotic vertebral compression fractures has been shown to be successful in providing acute pain relief, enabling improved function, and restoring of vertebral body…
- Trial name
- NCT01383616
- Testing
- Kyphon® Balloon Kyphoplasty (Kyphon Inc; Sunnydale, CA)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoporotic Vertebral Compression Fractures, Restrictive Pulmonary Disorders
Inspiratory Muscle Training After Vertebroplasty in Osteoporotic Fracture Patients
This study investigates the long-term effects of inspiratory muscle training (IMT) on pulmonary function, functional capacity, and quality of life in individuals with osteoporotic vertebral compression fractures who have…
- Conditions
- Osteoporotic Vertebral Compression Fractures, Restrictive Pulmonary Disorders, Inspiratory Muscle Weakness, Postoperative Pulmonary Function
- Trial name
- NCT07024095
- Testing
- Inspiratory Muscle Training (IMT), control group
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Istinye University
Intervertebral Disc Compression, Muscle Atrophy
50% Body Weight Reverses Stature, Lumbar Disc Expansion and Vertebral Compliance by Hyper-Buoyancy Floatation.
Study with the aim to see the effect on a space ground analogue , Hyper-Buoyancy Floatation (HBF) on lumbar column and the effect of a supplementary 50% of an axial load.
- Conditions
- Intervertebral Disc Compression, Muscle Atrophy, Spine Injury
- Trial name
- NCT05590754
- Testing
- Hyper-buoyancy Floatation (HBF), Axial Load after 4h of HBF
- Where
- 2 sites in Spain, United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Spinal Compression Fracture
Efficacy Study of Acupuncture on Spinal Compression Fracture
This study is to investigate the effectiveness of acupuncture for alleviating pain from Spinal Compression Fracture in Patients Treated with Nerve Block.
- Trial name
- NCT01913587
- Testing
- Acupuncture, Nerve block
- Where
- South Korea
- Volunteers
- 14 people
- Sponsor
- Daegu Catholic University Medical Center
Compression Fracture of Thoracic Vertebral Body, Spinal Compression Fracture
Dual-energy CT in Detecting Bone Marrow Edema of Vertebral Compression Fractures
The purpose of this study is to 1. Assess bone marrow edema within the VCF by use of a DE CT virtual noncalcium image compared with MR imaging as standard reference. 2.
- Trial name
- NCT01281826
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Cheng-Kung University Hospital
Spinal Metastases
Trial of Combined Radiotherapy and Vertebroplasty for Patients With Painful Metastatic Spinal Lesions
Since patients with spinal metastases are living longer, durable palliation with long-term tumor control are becoming increasingly important. EBRT results in durable local control of bone metastasis.
- Trial name
- NCT04242589
- Testing
- Radiotherapy, Vertebropladty
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- AHS Cancer Control Alberta
Vertebral Body Fractures
Study on the Treatment of Osteoporotic Vertebral Fractures Using Vertebral Body Stenting
This is a randomized, controlled study to document and evaluate the clinical performance of the Vertebral Body Stenting (VBS) System in osteoporotic fractures of the thoracic and lumbar spine.
- Trial name
- NCT01847898
- Testing
- Vertebral Body Stenting (VBS), Balloon Kyphoplasty
- Where
- 5 sites in Austria, Germany
- Volunteers
- 100 people
- Sponsor
- Synthes GmbH
Spine Fracture
Percutaneous Kyphoplasty Using Rotary Cutter in Osteoporotic Vertebral Fractures
Kyphoplasty(PKP) is performed under general anaesthesia in patients with osteoporotic vertebral compression fracture. The balloon is first placed into the fractured vertebra and inflated with contrast agent for height…
- Trial name
- NCT03850938
- Testing
- Conventional Kyphoplasty, Kyphoplasty with Rotary Cutter
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Li Min
Spinal Fractures
Effect and Essentiality of Vertebroplasty Surgery in Acute Vertebral Compression Fractures
Percutaneous vertebroplasty is now a common procedures of patients with acute osteoporotic vertebral compression fractures in medical units all over China, but the efficacy and essentiality of the surgery remain uncertain and is…
- Trial name
- NCT03360383
- Testing
- percutaneous vertebroplasty, conservative treatment
- Volunteers
- 400 people
- Sponsor
- Peking University People's Hospital
Vertebral Compression Fractures
Vertebroplasty In The Treatment Of Acute Fracture Trial - The VITTA Trial
The VITTA trial is a randomized, controlled, single-blinded, cross-over trial comparing percutaneous vertebroplasty with facet block in patients with acute (<1month) and painful vertebral compression fractures.
- Trial name
- VITTA (NCT02370628)
- Testing
- Percutaneous vertebroplasty, Facet block
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Osteoporotic Vertebral Compression Fracture
Denosumab and Osteoporotic Vertebral Compression Fracture
This study aimed to investigate the effect of denosumab on bone mineral density(BMD), bone turnover markers(BTMs), functional status, secondary fracture rate, and adverse effects in osteoporotic vertebral compression fracture…
- Trial name
- NCT05058443
- Testing
- Denosumab 60 mg/ml [Prolia]
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital