Clinical trials: Vertebral Metastasis
Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System
Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases
The goal of this clinical research study is to learn whether delivering spine radiosurgery in a single large dose is better than delivering spine radiosurgery over 3 smaller doses.
- Trial name
- NCT03028337
- Testing
- Spine Radiosurgery, Questionnaires
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Spine Metastasis, Early Goal Directed Therapy
Efficacy of Angiographic Embolization vs Non-embolization of Moderate/Poor Vascularized Vertebral Metastases on Intraoperative Bleeding During Surgery Decompression and Vertebral Stabilization.
Although angiographic embolization has been introduced for preoperative management of spine metastases in 1975 and is suggested today by many authors in the management of such pathologies, it needs to be confirmed by RCT.
- Conditions
- Spine Metastasis, Early Goal Directed Therapy, Embolization, Therapeutic, Blood Loss
- Trial name
- Embart (NCT03853434)
- Testing
- Embolization
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Istituto Ortopedico Rizzoli
Metastatic Cancers, Multiple Myeloma
Vertebral Augmentation and Radiotherapy of Collapse Spinal Metastatic Cancer
Vertebral augmentation with radiotherapy to increase the functional status and quality of life for patients with vertebral body metastatic cancers.
- Conditions
- Metastatic Cancers, Multiple Myeloma, Vertebral Fracture
- Trial name
- NCT02376933
- Testing
- Vertebroplasty, Radiotherapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Arizona
Spine Metastasis
A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
- Trial name
- NCT03072979
- Testing
- Stereotactic body radiotherapy
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National University Hospital, Singapore
Hepatocellular Carcinoma, Spine Metastasis
Diffusion-Weighted Magnetic Resonance Imaging
Recently, diffusion-weighted (DW) MR imaging has widened its application on various oncologic applications. Especially, it is expected the DW MRI could provide valuable information about early response evaluation after treatment…
- Trial name
- NCT02242786
- Testing
- External beam radiation therapy
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Samsung Medical Center
Spinal Diseases, Spinal Metastases
Intra-arterial Chemotherapy for Spinal Metastases
Metastatic malignant tumors comprise the vast majority of spinal tumors in adults. The most devastating complication of spinal metastatic disease (SMD) is invasion of the spinal canal and compression of the spinal cord or the…
- Conditions
- Spinal Diseases, Spinal Metastases, Spinal Tumors
- Trial name
- SIAC (NCT01637766)
- Testing
- Melphalan (intra-arterial infusion)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Neoplasm Metastasis
Stereotactic Body Radiotherapy Followed by Surgical Stabilization for Patients With Unstable Spinal Metastases
The aim of this study is to assess the feasibility and safety of combining stereotactic body radiotherapy (SBRT) and pedicle screw fixation in a 48-hour window for the treatment of painful unstable metastases of the thoracic…
- Trial name
- BLEND (NCT02622841)
- Testing
- BLEND
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- UMC Utrecht
Osteoporotic Fractures, Hip Fractures
Prediction and Secondary Prevention of Fractures
The purpose of this study is to investigate patient related factors that contribute to increased risk of recurrent fractures and to investigate patient adherence to prescribed anti-osteoporotic drugs.
- Conditions
- Osteoporotic Fractures, Hip Fractures, Wrist Fractures, Ankle Fractures
- Trial name
- NOFRACTsub (NCT02608801)
- Where
- 6 sites in Norway
- Volunteers
- 840 people
- Sponsor
- Oslo University Hospital
Vertebral Metastases
Study of Image-Guided SBRT for Vertebral Metastases
Based on the known efficacy of ablative single dose SBRT and VMAT technique in various solid tumors, investigators have designed this study to assess feasibility of SBRT in selected patients with spine metastases.
- Trial name
- NCT02616887
- Testing
- Single dose SBRT and VMAT technique
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Istituto Clinico Humanitas
Spinal Metastases
Trial of Combined Radiotherapy and Vertebroplasty for Patients With Painful Metastatic Spinal Lesions
Since patients with spinal metastases are living longer, durable palliation with long-term tumor control are becoming increasingly important. EBRT results in durable local control of bone metastasis.
- Trial name
- NCT04242589
- Testing
- Radiotherapy, Vertebropladty
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- AHS Cancer Control Alberta
Spine Metastases, Radiation Therapy
Increased Early Pain Relief by Adding Vertebroplasty to SBRT
The goal of treating metastases is to preserve stability and neurological function while reducing pain. The actual standard of care is stereotaxic body radiation therapy (SBRT) alone in non-surgical patients.
- Conditions
- Spine Metastases, Radiation Therapy, Pain
- Trial name
- NCT05317026
- Testing
- Vertebroplasty, Stereotactic Body Radiation Therapy only
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Spinal Metastases
Preoperative Embolization in Surgical Treatment of Spinal Metastases.
The main purpose of this study is to assess the efficacy of preoperative embolization in decreasing operative blood loss, decreasing the need for intraoperative transfusion and facilitate surgical resection in metastatic spine…
- Trial name
- NCT01365715
- Testing
- Arteriography and preoperative embolization, Arteriography
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Vertebral Metastases, Vertebral Fracture
A Multicenter Prospective Observational Study on Vertebral Fracture Risk Stratification in Patients With Vertebral Metastases
Vertebral fracture is a common clinically significant skeletal related event in cancer patients. Stratification of patients diagnosed with one or more vertebral metastases according to the risk of pathological fracture is an…
- Trial name
- Valid-METASTRA (NCT06910618)
- Where
- 4 sites in Germany, Hungary and 2 more
- Volunteers
- 300 people
- Sponsor
- Buda Health Center
Osteoporotic Vertebral Fracture, Prediction Model
Construction and Validation of a Risk Prediction Model for Secondary Vertebral Fracture in Patients With Osteoporotic Vertebral Compression Fractures After Percutaneous Vertebroplasty
"Retrospectively collecting clinical data from post-PVA (Percutaneous Vertebroplasty) patients, recording incidences of secondary vertebral fractures, and conducting statistical analysis to create a risk prediction model for…
- Trial name
- NCT06172179
- Testing
- No interventions
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Metastatic Lesions in Vertebral Bodies
The STAR™ Tumor Ablation Registry
Registry collecting data on use of The STAR™ Tumor Ablation System.
- Trial name
- NCT02419703
- Testing
- STAR™ Tumor Ablation System
- Where
- 15 sites in United States
- Volunteers
- 65 people
- Sponsor
- Merit Medical Systems, Inc.
Metastases to Bone, Metastatic Breast Cancer
Tumoral Bone Strength Assessment by Numerical Simulation Using Quantitative CT : the MEKANOS Study
Osteolytic bone metastases and myeloma bone lesions are responsible of long bone and vertebral fractures leading to restricted mobility, surgery and medullar compression that severely alter quality of life and that have a huge…
- Conditions
- Metastases to Bone, Metastatic Breast Cancer, Metastatic NSCLC
- Trial name
- MEKANOS (NCT04170634)
- Testing
- Evaluation of the fracture risk using data from routine qCT (quantitative Computed Tomography) scan and numerical simulation
- Where
- 12 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Pain
Whole Versus Partial Vertebral Body IMRT for Spinal Metastases
To compare the treatment effect and toxicity between Intensity-Modulated Radiation therapy for whole metastatic vertebral body and simple metastatic lesions of vertebra in metastatic spinal tumors
- Trial name
- NCT02972229
- Testing
- 10x(3-5) Gy IMRT, 10x3 Gy IMRT
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
To Evaluate Performance of the DLS
Validation of a Multitask Deep Learning System at Spine Metastasis CT
15 resident oncologists were conducted to evaluate the clinical efficacy of DLS in multicenter. They were 1:1 randomly asked to independently read the test images without the assistance of DLS software or with the assistance.
- Trial name
- NCT05156567
- Testing
- Deep Learning System
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai 6th People's Hospital
Tumors
Kypho-IORT: Intraoperative Radiotherapy During Kyphoplasty for Spinal Metastases
Vertebral column is the most prevalent location of bone metastases. Besides axial pain, vertebral metastases cause pathological fracture and neurological dysfunction by spinal cord compression.
- Trial name
- Kypho-IORT (NCT01280032)
- Testing
- intraoperative radiotherapy
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Universitätsmedizin Mannheim
Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT)
Extended Prophylactic Anticoagulation Following Spinal Surgery for Metastatic Disease
People who have surgery on their spine to treat cancer that has spread (metastatic disease) have a high chance of developing dangerous blood clots in the legs or lungs.
- Conditions
- Venous Thromboembolism (VTE), Deep Vein Thrombosis (DVT), Pulmonary Embolism (PE), Spine Metastasis
- Trial name
- NCT07713875
- Testing
- Apixaban
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- James Bayley