Clinical trials: Vertebral Metastasis
Spinal Metastasis
Clinical Trial Comparing Dose-intensified SBRT With Conventional Radiation Therapy for Spinal Metastases
This study will compare pain (primary end-point) and local metastatic tumor control (secondary end-point) after dose-intensified image-guided fractionated stereotactic body radiation therapy (SBRT) for painful mass-type spinal…
- Trial name
- DOSIS RCT (NCT02800551)
- Testing
- dose-intensified image-guided SBRT using simultaneous integrated boost, External 3-dimensional conformal radiotherapy (3D-CRT)
- Where
- Switzerland
- Volunteers
- 219 people
- Sponsor
- University of Zurich
Degenerative Disc Disease, Spondylolisthesis
The European Robotic Spinal Instrumentation (EUROSPIN) Study
In a multinational prospective study, preoperative, intraoperative, perioperative and follow-up data on patients receiving thoracolumbar pedicle screw placement for degenerative disease or infections or tumors will be collected.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Recurrent Disc Herniation
- Trial name
- EUROSPIN (NCT03398915)
- Testing
- Transpedicular Instrumentation
- Where
- 12 sites in Austria, France and 5 more
- Volunteers
- 932 people
- Sponsor
- Marc Schröder
Cancer, Metastasis
Effect of Samarium on the Relief of Pain Due to Vertebral Metastases
Cancer cells may spread from the primary site to the vertebrae resulting in their deformity. The standard treatment for this case is removal of the cancer deposits in the vertebra and filling the induced cavity with a cement like…
- Conditions
- Cancer, Metastasis, Pain
- Trial name
- NCT00374751
- Testing
- Samarium (153SM)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Metastases to Bone
Pilot Randomized Study for Treatment Volume De-Escalation for Spinal Metastases With Stereotactic Body Radiation Therapy
A single centre, non-profit, randomised, unblinded pilot study on volume definition for spinal stereotactic body radiation therapy treatment. Randomization will be 1:1 between two types of SBRT treatment for spinal metastases.
- Trial name
- REVOL-SPINE (NCT07538024)
- Testing
- Stereotactic Body Radiation Therapy (SBRT) in control arm, Stereotactic Body Radiation Therapy (SBRT) in experimental arm
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Spinal Metastases
Randomized Trial on Same-day SBRT and Surgical Stabilization for Symptomatic Spinal Metastases
The BLEND RCT aims to evaluate the (cost-)effectiveness of same-day SBRT and surgical stabilization with or without decompression for the treatment of symptomatic, unstable spinal metastases on physical functioning four weeks…
- Trial name
- BLEND (NCT05575323)
- Testing
- Same-day SBRT and spinal surgery, Standard of care
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Spinal Neoplasms
Standard Dose Versus High Dose Stereotactic Spine Radiosurgery for Metastatic Spinal Neoplasms
The goal of this clinical trial is to learn if a higher dose of Stereotactic Spine Radiosurgery (SSRS), an advanced radiation technique, is better for treating cancer that has spread to the spine (spinal metastases).
- Trial name
- NCT07039968
- Testing
- Spine Stereotactic Radiosurgery (SSRS)
- Where
- 2 sites in Taiwan
- Volunteers
- 196 people
- Sponsor
- National Taiwan University Hospital
Spinal Metastases, Solid Tumor Cancer
Preoperative Stereotactic Radiotherapy for Treatment of Spinal Metastases
The goal of this interventional clinical trial is to evaluate the efficacy and safety of preoperative hypofractionated Stereotactic Body Radiotherapy (SBRT) in the treatment of patients undergoing surgery for spinal metastases.
- Trial name
- PRESTRASM (NCT07135817)
- Testing
- Preoperative Stereotactic Body Radiotherapy (SBRT), Spinal Surgery for Decompression and/or Stabilization
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Medical Center Goettingen
Spinal Cord Compression Due to Metastasis to Spine
High-precision Radiotherapy of Motor Deficits Due to Metastatic Spinal Cord Compression
The major goal of this clinical study is to investigate to which extent high-precision radiotherapy (RT) with modern techniques can prevent progression or recurrence of motor deficits (weakness) of the legs following RT.
- Trial name
- PRE-MODE (NCT03070431)
- Testing
- High-precision RT 5x5 Gy in 1 week
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Schleswig-Holstein
Vertebral Metastasis
Conformal High Dose Intensity Modulated Radiation Therapy for Disease to Thoracic and Lumbar Spine
The purpose of this study is to determine if Conformal High Dose Intensity Modulated Radiation Therapy is an appropriate option for treating cancer that has spread to the spinal column.
- Trial name
- NCT01654068
- Testing
- Conformal High Dose Intensity Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Ronald McGarry
Vertebral Metastases
Photodynamic Therapy for the Treatment of Vertebral Metastases
An estimated 10 percent of primary breast, prostate, lung, thyroid and renal cell tumors metastasize to the spine. The majority of these tumors are detected before surgical intervention is required and most patients receive…
- Trial name
- NCT02464761
- Testing
- Visudyne
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Spine Metastases
Minimally Invasive Surgery (MIS) for Spine Metastases
The purpose of this study is to collect information on the effect of minimally invasive spine tumor decompression on treated patients.
- Trial name
- NCT02367378
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Metastases
A Prospective Study of Performing MRI Simulation in Treatment Position in Spinal Stereotactic Body Radiation Therapy
To learn the usefulness of performing MRI scans in different positions and learn the best practice for spinal stereotactic body radiation therapy (spinal SBRT) planning and dose delivery.
- Trial name
- NCT05155423
- Testing
- mask for immobilization, Elekta BodyFix
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Lesions in Vertebral Bodies
Evaluation of t-RFA and RF-TVA Prior to/Following Radiation Therapy to Treat Painful Metastatic Vertebral Body Tumor(s)
The purpose of this study is to evaluate treating painful metastatic lesions in vertebral bodies with pathologic fractures with targeted radiofrequency ablation (t-RFA) and vertebral augmentation (VA) prior to or following…
- Trial name
- STARRT (NCT02225223)
- Testing
- STAR™ Tumor Ablation System, StabiliT® Vertebral Augmentation System
- Where
- 14 sites in United States
- Volunteers
- 35 people
- Sponsor
- Merit Medical Systems, Inc.
Metastatic Neoplasm to the Spine, Metastatic Neoplasm
Spine Radiosurgery for Symptomatic Metastatic Neoplasms
The purpose of this study is to compare three types of radiation therapy for cancer that has spread to the spine. The two types of radiation therapy used in this trial are External Beam Radiation Therapy (EBRT) and Stereotactic…
- Trial name
- SPORTSMEN (NCT05617716)
- Testing
- Conventional external beam radiation therapy dose (EBRT), Spine radiosurgery/stereotactic body radiation therapy standard dose, Spine radiosurgery/stereotactic body radiation therapy high dose
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Oklahoma
Cancer, Spine Metastasis
A Pilot Study to Explore Serum and Imaging Biomarkers in Patients With Spinal Cord Compression
One of the complications of having cancer in the spinal vertebrae is that it can spread and lead to compression of the spinal cord.
- Trial name
- NCT00928382
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Spinal Metastases
Conventional With Stereotactic Radiotherapy for Pain Reduction and Quality of Life in Spinal Metastases
A randomized, multicentre, phase III study comparing conventional radiotherapy (1x8Gy) with stereotactic radiotherapy (1x20Gy) for pain reduction and quality of life in spinal metastases.
- Trial name
- RACOST (NCT02407795)
- Testing
- conventional radiotherapy, stereotactic radiotherapy
- Where
- 6 sites in Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Vertebral Compression Fracture, Myeloma
The Value of Systematic Biopsies During Vertebroplasty for the Treatment of Osteoporotic Vertebral Fractures
Background : Vertebral fracture is the most common complication of osteoporosis. Vertebroplasty is a widespread treatment modality for osteoporotic vertebral fractures, providing consolidation, rapid pain relief and preventing…
- Conditions
- Vertebral Compression Fracture, Myeloma, Bone Metastases, Malignant Bone Tumour
- Trial name
- NCT06153576
- Where
- France
- Volunteers
- 1,120 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Spinal Metastases
Study Comparing Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy (CRT) for Spinal Metastases
The purpose of this study is to find out if SBRT is better than CRT at controlling pain in the spine 3 months after receiving treatment.
- Trial name
- NCT02512965
- Testing
- 20 Gy in 5 fractions, Conventional SBRT: 24 Gy in 2 fractions
- Where
- 22 sites in Australia, Canada
- Volunteers
- 229 people
- Sponsor
- Canadian Cancer Trials Group
Spinal Fracture, Osteoporosis
Quality of Life After Vertebroplasty Versus Conservative Treatment in Patients With Painful Osteoporotic Vertebral Fractures
The purpose of this study is to determine whether percutaneous vertebroplasty is able to improve long-term quality of life in patients with pain secondary to osteoporotic vertebral fractures, compared to conventional medical…
- Conditions
- Spinal Fracture, Osteoporosis, Back Pain
- Trial name
- NCT00994032
- Testing
- percutaneous injection of cement into the vertebral body, Medical treatment
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Clinic of Barcelona
Spinal Metastases, Blood Transfusion Complication
The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis
The goal of this single-center prospective randomized controlled trial is to test and compare the safety and effectiveness of autologous blood transfusion in spinal surgery for lung cancer spinal metastases.
- Conditions
- Spinal Metastases, Blood Transfusion Complication, Lung Cancer, Surgery
- Trial name
- NCT06244264
- Testing
- Autoblood transfusion
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Guangdong Provincial People's Hospital