Clinical trials: Very Low Calorie Diet
Diabetes Mellitus Type 2 in Obese
Implementation of a Very Low Calorie Diet for Remission of Type 2 Diabetes in the Community
The complications associated with uncontrolled type-2 diabetes mellitus (T2DM) are numerous; reducing the quality of life for the patient and consuming a considerable portion of healthcare finances.
- Trial name
- NCT03536377
- Testing
- very low calorie liquid diet
- Where
- 4 sites in Barbados
- Volunteers
- 100 people
- Sponsor
- The University of The West Indies
Obesity
Effect of a Very Low-Calorie Ketogenic Diet on Gut Microbiota and Fat Distribution
Short-term interventions that use very low-calorie ketogenic diets and meal replacements may be prescribed for selected overweight or obese patients with type 2 diabetes or prediabetes.
- Trial name
- NCT04019431
- Testing
- Whey protein, vegetable protein or animal protein
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
Obesity
Very Low Calorie Ketogenic Low-fat Diet (VLCKLFD)
This study aimed to assess the efficacy and safety of the Zélé program, a controlled ketogenic diet, for weight loss and maintenance.
- Trial name
- Zelé2021 (NCT06275347)
- Testing
- Low-fat normoprotein Controlled Ketogenic Diet., Hypocaloric Balanced Diet
- Where
- Mexico
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Universidad Veracruzana
Type2 Diabetes, NAFLD
Effects of VLCD and Bariatric Surgery in Patients With Type 2 Diabetes
The investigators are therefore interested to explore the effects of VLCD and different bariatric surgery procedures to changes in the physical deposition of fat in organs which regulate glucose metabolism (i.e.
- Conditions
- Type2 Diabetes, NAFLD, Obesity
- Trial name
- BARIATRICMRI (NCT05092399)
- Testing
- Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Nottingham
Diabetes Mellitus Type 2 in Obese
VLCD & Adjuvant Exercise Effect in Overweight Diabetic Men
Sarcopenia is defined as the incremental age-related loss of skeletal muscle in humans which generally begins from forty years old.
- Trial name
- VLCDeXDM (NCT04957589)
- Testing
- Very Low Calorie Diet, High Intensity Interval Training
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Nottingham
Severe Obesity
VLCD by Enteral Route for Weight Loss
Body weight excess, from overweight to overt obesity, is associated with adverse health outcomes. In view of the time-trends of the obesity epidemic and the related cost burden, the search for effective strategies for weight…
- Trial name
- NEP (NCT01965990)
- Testing
- NEP
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- San Giuseppe Moscati Hospital
Obesity
Combined Effects of GLP-1 Analogue and Exercise on Maintenance of Weight Loss and Health After Very-low Calorie Diet
Introduction: The success rate of weight loss maintenance is limited. Therefore, the purpose of this study is to investigate the maintenance of weight loss and immunometabolic health outcomes after diet-induced weight loss…
- Trial name
- S-LITE (NCT04122716)
- Testing
- Liraglutide, Exercise
- Where
- Denmark
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Signe Torekov
Obesity, Very Low Calorie Diet
Very Low Calorie Diet Weight Loss
Understanding how foods and nutrients are digested, absorbed and metabolized when weight is stable and during weight loss induced by very low calorie diet procedure using the technologies of genomics, transcriptomics, proteomics…
- Trial name
- NCT02780206
- Testing
- Stable isotope amino acid infusion
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Texas A&M University
Obese
Pre-operative Diet: Effect of Wound Healing After Bariatric Surgery
This study is a randomised control trial comparing the effects of a pre-operative very low calorie diet (VLCD) on wound healing in the morbidly obese patients undergoing bariatric surgery.
- Trial name
- NCT01950052
- Testing
- Diet group 800 Kcal diet
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- King's College Hospital NHS Trust
Rectal Cancer, Obesity
Preoperative Very Low Energy Diet for Obese Rectal Cancer Patients
This pilot study will aim to determine the feasibility, safety, and cost associated with a preoperative VLED for obese rectal cancer patients.
- Trial name
- NCT04379830
- Testing
- Very Low Energy Diet
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Kidney Diseases, Obesity
Intermittent Low Energy Diet in CKD: MIX UP Feasibility Study
This study proposes to investigate the acceptability and efficacy of intermittent VLED (5:2 diet) plus exercise, compared with the investigator's established Weight Management Programme (WMP), in obese patients with CKD, using…
- Trial name
- MIX-UP (NCT03736551)
- Testing
- 5:2 diet, Renal Weight Management Programme
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- King's College Hospital NHS Trust
Morbid Obesity
Utilization of Very Low Calorie Diet in Obese General Surgery Patients
The investigators are studying the use of a two-week very low calorie diet (VLCD) in obese general surgery patients in a randomized single-blinded trial.
- Trial name
- NCT03553849
- Testing
- Very low calorie diet
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Morbid Obesity, Type 2 Diabetes Mellitus
Caloric Restriction and Insulin Secretion
Caloric restriction in obese diabetic patients quickly improves glucose control, independently from weight loss. However, the early effects of a very-low calorie diet (VLCD) on insulin sensitivity and insulin secretion in…
- Trial name
- NCT01447524
- Testing
- Very Low Calorie Diet
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Rome Tor Vergata
Obesity
Effects of Leptin Treatment on Weight Loss
This is a double blind placebo controlled clinical study designed to determine the effects of leptin on the changes that occur in the body during weight loss achieved by a very low calorie diet.
- Trial name
- NCT00050791
- Testing
- Leptin, Very Low Calorie Diet
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
PCOS, Obesity
Ketogenic Diet in PCOS With Obesity and Insulin Resistance
The purpose of the VLCKD randomized clinical trial is to demonstrate the superiority of very low calorie ketogenic diet with respect to the standard low calorie diet in reducing body weight and insulin resistance in obese and…
- Conditions
- PCOS, Obesity, Insulin Resistance
- Trial name
- VLCKD (NCT04801173)
- Testing
- Very low calorie ketogenic diet, Low calorie standard diet
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Diabetes Mellitus Type 2
Effectiveness of Low-Calorie MIND-HK Diet and Very Low-Calorie Diet on Glycemic Control and Cardiovascular Outcomes in Adults With Type 2 Diabetes: A 12-Week Randomized Controlled Trial
The objective of this project is to assess the effectiveness of a low-calorie and very low-calorie Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND-HK) diet in improving glycemic control and cardiovascular…
- Trial name
- NCT07635121
- Testing
- Low-calorie MIND-HK diet, Very Low-calorie MIND-HK diet, Control group
- Volunteers
- 180 people
- Sponsor
- Hong Kong Metropolitan University
Overweight and Obesity
The Effect of Very Low Calorie Diet With and Without Exercise on Muscle Synthesis in Middle-aged Overweight Male.
The aims of this project are: to investigate the impact of VLCD on control of muscle protein synthesis, muscle structure and function, cardiac function (ejection fraction), vascular function (blood flow and capillary function)…
- Trial name
- VLCDex (NCT03116256)
- Testing
- Very low calorie diet (VLCD), High intensity interval training (HIIT), Resistance exercise training (RET)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenic Obesity
Low Calorie Diet or VLCKD Combined With Physical Training for Preserving Muscle Mass During Weight Loss in Sarcopenic Obesity
The prevalence of sarcopenic obesity (SO) is increasing worldwide, posing important challenges to public health and national health care system, especially during the COVID pandemic.
- Trial name
- NCT05287659
- Testing
- meal replacements or supplementation with leucine
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
Obesity
Effects of Re-Feeding Duration on Weight Maintenance After Weight Loss With Very-Low-Energy Diets (VLEDs)
The primary objective of the study is to test the hypothesis that prolonged re-feeding after VLED induced weight loss improves weight maintenance and eating behaviour
- Trial name
- NCT00694811
- Testing
- Re-feeding duration
- Where
- Sweden
- Volunteers
- 169 people
- Sponsor
- Göteborg University
Obesity, Glomerulopathy
Dietary Intervention in Obesity-related Glomerulopathy
Obesity-related glomerulopathy (ORG) is a silent comorbidity associated with obesity whose incidence is increasing in parallel to the obesity epidemic.
- Trial name
- ORG-VLCD-2022 (NCT05294770)
- Testing
- Optisource® Plus: Very Low Calorie Diet treatment, Hypocaloric Mediterranean Diet
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud