Clinical trials: Very Low Calorie Diet
Obesity, Morbid, Obesity
Effects of Very Low Calorie Diet vs Metabolic Surgery on Weight Loss and Obesity Comorbidities
It is a prospective randomized trial on 218 subjects, 109 for each arms. The purpose of this trial is to compare very low calorie diet and metabolic surgery induced weight loss and its maintenance.
- Conditions
- Obesity, Morbid, Obesity, Diet, Healthy, Bariatric Surgery Candidate
- Trial name
- ARGOS (NCT04583683)
- Testing
- Very low calorie diet with Fortimel (Nutricia) supplementation, Metabolic Surgery
- Where
- Italy
- Volunteers
- 218 people
- Sponsor
- Catholic University of the Sacred Heart
Obesity
Improving Maintenance Following Very Low Calorie Diet: The Sustain Lost Weight (SLW) Intervention
Obtain a preliminary assessment of the feasibility and acceptability of delivering the sustained lost weight (SLW) intervention in a real-world clinical setting for patients who have completed a 21-week very low calorie diet…
- Trial name
- NCT01222988
- Testing
- Optifast Products
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Type 2 Diabetes Mellitus in Obese
Glucagon-like Peptide-1 Agonism With Very Low Calorie Diets
The very-low calorie diet (VLCD) is a highly effective and safe way to rapidly lose significant amounts of weight and dramatically improve blood sugar control in a short period of time (typically 8-12 weeks).
- Trial name
- SemVLCD (NCT05606471)
- Testing
- Semaglutide Pen Injector [Ozempic], Very-low Calorie Diet
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
NAFLD
Effect of VLCD on the Reduction of Liver Steatosis and Fibrosis in Subjects With Obesity and NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a common complication of obesity which can progress to deadly complications like end-stage liver disease and hepatocellular carcinoma.
- Trial name
- NCT04861571
- Testing
- Dietary intervention with very low calorie diet (VLCD), Control Arm
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Obesity
Effects of Very Low-calorie Diet Versus Bariatric Surgery on Body Composition and Gut Microbiota Pattern
Obesity is a chronic disease characterized by the excessive accumulation of fat in body and it continues to be a major public health problem worldwide.
- Trial name
- NCT05459675
- Testing
- Very low-calorie diet, Bariatric surgery
- Where
- Thailand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Obesity, Morbid, Bariatric Surgery
Study to Evaluate Effectiveness of a Weight Loss Program in Obese Patients During 3 Months Prior to Bariatric Surgery
Prospective multicenter observational clinical study on a dietary regimen in obese patients scheduled for bariatric surgery.
- Conditions
- Obesity, Morbid, Bariatric Surgery, Comorbidity
- Trial name
- NCT03530566
- Testing
- PnK® Method, standard diet
- Volunteers
- 25 people
- Sponsor
- Protein Supplies SL
Bariatric Surgery Candidate, Ketogenic Dieting
Ketogenic Diet Prior to Bariatric Surgery
Standard dietary regiments for bariatric are advised prior to surgery. The most used diet is a very low calorie diet (VLCD). These diets potentially have multiple pittfalls.
- Trial name
- NCT06850493
- Testing
- VLCKD (ketogenic diet), VLCD (Very-low-calorie-diet)
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Obesity Adult Onset
Gut Microbiota, Mitochondrial Function and Metabolic Health in Obesity
It has been suggested that individuals with the condition known as metabolically healthy obesity (MHO) may not have the same increased risk of developing metabolic abnormalities as their non-metabolically healthy counterparts.
- Trial name
- NCT06279780
- Testing
- very low-calorie diet
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Celia Bañuls
Obesity, Insulin Resistance
Effects of a Calorie Restricted, Very Low Fat Plant-based Diet and Multi-component Exercise Program on Metabolic Health
The purpose of this study is to understand how weight loss by a very low fat plant-based diet with an exercise program affects metabolic and cardiovascular health in overweight adults at high risk for disease.
- Trial name
- PE (NCT02706288)
- Testing
- Weight loss with very low fat plant-based diet and regular exercise
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity, Weight Loss
Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD
Obesity leads to physiological imbalance resulting in hyperglycemia, dyslipidaemia and inflammation and can generate systematic oxidative stress through multiple biochemical mechanisms.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05055154
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 26 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa
Weight Loss, Inflammation
Effect of Very-low Calorie Diet and Synbiotic Supplementation in Gut Microbiota (Pronokal Method)
The present study aimed to investigate the changes produced in gut microbiota by a very-low-calorie-ketogenic diet followed by a low calorie diet, whether the use of synbiotics is able to modulate gut microbiota diversity and…
- Trial name
- Pronokal (NCT03530501)
- Testing
- Diet, Synbiotic1, Synbiotic2
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Obesity, Weight Loss
Obesity Treatment With a Very Low Energy Diet in Mexican Adults
Clinical practice guidelines recommend behavioral change protocols for obesity treatment, such as the Diabetes Prevention Program, which involves a low-energy diet, physical activity recommendations, behavioral therapy, and…
- Trial name
- NCT05631535
- Testing
- Intensive lifestyle change program with a very-low-energy diet, Intensive lifestyle change program with a low-energy diet
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Universidad de Sonora
Obesity, Morbid Obesity
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART)
The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the…
- Trial name
- KETOHEART (NCT05781269)
- Testing
- VLCKD, r-MedDiet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obesity, Weight Loss
KU Alternate Meal Energy Level Study
Compare intermittent versus continuous calorie restriction to learn more about these eating plans and determine whether they are useful and effective to lose weight and keep it off.
- Trial name
- KAMEL (NCT03696966)
- Testing
- Portion-Controlled Meals, Low-Calorie Diet, Intermittent Very-Low Calorie Diet
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Kansas Medical Center
Obesity, Weight Loss
The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels
High levels of mannose-binding lectin (MBL), an activator of a part of the immune system called the complement system, have been associated with increased mortality and risk of early signs of kidney damage in patients with type 2…
- Trial name
- WLMBL (NCT00854412)
- Testing
- Weight loss
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Obstructive Sleep Apnea
Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults
The purpose of this study is to test the effectiveness of two different weight loss diets on obstructive sleep apnea (OSA) severity.
- Trial name
- NCT02251574
- Testing
- Low Calorie Diet, Very Low Calorie Diet, Standard Care
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Fibromyalgia, Knee Osteoarthritis
Efficacy of a Very Low Calories Ketogenic Diet in Obese Patients With Fibromyalgia or Symptomatic Knee Osteoarthritis
Adult patients with fibromyalgia or symptomatic knee osteoarthritis and comorbid obesity eligible to a very low calories ketogenic diet will be enrolled in the pilot study
- Trial name
- KD-FM-OA (NCT05848544)
- Testing
- Very low-calorie ketogenic diet for patients with symptomatic knee osteoarthritis, Very low-calorie ketogenic diet for patients with fibromyalgia
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli
Obesity, Morbid, Obesity
Omega-3 vs Very Low Calorie Diet for Liver Size Reduction
A recent review demonstrated that Non-alcoholic fatty liver disease (NAFLD) affects 10-35% of the adult population worldwide, with the prevalence approaching 85-100% in obese populations.
- Conditions
- Obesity, Morbid, Obesity, NAFLD, NASH - Nonalcoholic Steatohepatitis
- Trial name
- NCT03132662
- Testing
- Omega-3, Very Low Calorie Diet
- Volunteers
- 60 people
- Sponsor
- McMaster University
NASH, NAFLD
Role of the Very Low Calorie Ketogenic Diet (VLCKD) in Patients With Non-Alcoholic Steatohepatitis (NASH) With Fibrosis
The purpose of the KETONASH study is to evaluate, in patients with metabolic-associated fatty liver disease (MAFLD) with non-alcoholic steatohepatitis (NASH) and significant liver fibrosis, the effect of a very low-calorie…
- Conditions
- NASH, NAFLD, Obesity, Liver Fibrosis
- Trial name
- KETONASH (NCT06308757)
- Testing
- Very-low-calorie ketogenic diet (VLCKD) with meal replacements, Mediterranean low-calorie diet (LCD)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- University of Bologna
Bariatric Surgery Candidate
Compliance With Standard Care vs Ready to Eat Meals Prior to Bariatric Surgery
Currently, a ketosis-inducing programme, usually a liquid meal replacement, is the standard of care for pre-operative dietary management.
- Trial name
- NCT06461247
- Testing
- Very Low Calorie Diet Ready-to-eat (VLCD RTE) meals, Standard Care Group
- Where
- 2 sites in Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore