Clinical trials: Very Premature Baby
Tissue Oxygenation
The Correlation Between Tissue Oxygenations Using NIRS and Clinical Outcomes in Very Preterm Infants.
With the development of neonatal critical medicine, the survival rate of premature infants has gradually increased, and the incidence of late complications has significantly decreased, but preterm delivery is still the main cause…
- Trial name
- TCBTOUNACOIVPI (NCT06483867)
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Neurodevelopmental Outcomes
Single Patient Room Versus Open Bay in NICU
The NICU at the IWK Health Center in Halifax, Nova Scotia is embarking on a redevelopment project that will see its current open bay design converted to a single room care environment.
- Trial name
- NCT03867669
- Testing
- Open Bay Unit, Single patient room
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- IWK Health Centre
Preterm Birth, Very Preterm Infant
NICU-to-Home Dyadic Support for Very Preterm Infants and Families
This feasibility study will evaluate delivery of the Supporting Play Exploration and Early Development Intervention after neonatal intensive care unit discharge for very preterm infants and their families.
- Conditions
- Preterm Birth, Very Preterm Infant, Infant Development, Neonatal Intensive Care Unit
- Trial name
- MN-SPEEDI (NCT07820462)
- Testing
- Homebased SPEEDI, Telehealth SPEEDI
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Necrotizing Enterocolitis
Probiotics to Prevent NEC - a Historical Control Study
Probiotics is given routinely to infants admitted to the department of neonatology during the first 3 days of life with gestational age less than 30 weeks since March 2010.
- Trial name
- NCT01670916
- Testing
- probiotics
- Where
- Denmark
- Volunteers
- 714 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infant, Very Low Birth Weight, Growth Failure
Preterm Infants on Early Solid Foods
Introduction: Preterm infants with a birth weight less than 1500 grams have special nutritional needs in comparison to full-term neonates.
- Trial name
- PIES-Project (NCT01809548)
- Testing
- Early intervention group, Late intervention group
- Where
- Austria
- Volunteers
- 177 people
- Sponsor
- Medical University of Vienna
Infant, Premature, Diseases, Infant, Small for Gestational Age
Optimizing Individual Nutrition in Preterm Very Low Birth Weight Infants
In preterm infants fed human milk, milk needs to be fortified to meet nutrient recommendations. Fortification can be 1) standard, 2) individualized (adjusted based on daily human milk nutrient analysis and milk volume), or 3)…
- Trial name
- NCT02372136
- Testing
- Individualized Nutrition, Optimized nutrition
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center
Nephrocalcinosis, Preterm Infant
The Incidence and the Risk Factors of Nephrocalcinosis in Very Preterm Infants
The study aims to assess the incidence and the risk factors of nephrocalcinosis in very preterm infants using patient data collected during hospitalisation at the Neonatology Centre.
- Trial name
- NCT04382976
- Where
- Lithuania
- Volunteers
- 171 people
- Sponsor
- Vilnius University
Prematurity, Neurodevelopmental Disorder
Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
Preterm infants are vulnerable to brain injury, nutritional deficiencies and poor early growth which places them at increased risk for developmental problems later in life.
- Conditions
- Prematurity, Neurodevelopmental Disorder, Carnitine Deficiency
- Trial name
- NCT01783041
- Testing
- L-carnitine, 5% Dextrose
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- Montefiore Medical Center
Breast Milk Production, Human Milk Feeding
Efficacy of Herbal Galactagogue Silitidil After Preterm Birth
After preterm birth mothers often suffer from hypogalactia. Herbal galactogogues can be used in order to increase milk production.
- Conditions
- Breast Milk Production, Human Milk Feeding, Hypogalactia, Preterm Infant Nutrition
- Trial name
- NCT03577587
- Testing
- Silitidil for 21 days
- Where
- Germany
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Waldkrankenhaus Protestant Hospital, Spandau
Procedural Pain, Pre-Term
Multimodal Approach to the Ontogenesis of Nociception in Very Preterm and Term Infants
The management of pain related to venipuncture remains insufficient in very preterm infants (VPI. The separation between the mother (father) and her(his) child can aggravate the short-term painful experience of the newborn.
- Conditions
- Procedural Pain, Pre-Term, Venipuncture
- Trial name
- NOCI-Prem (NCT05404594)
- Testing
- Maternal vocal contact
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Prematurity Complications
Gut Permeability and Microbiome in Preterm Infants
NEC, a life-threatening, GI emergency characterized by increased IP, affects approximately 7 to 10% of preterm neonates, and typically occurs within 7 to 14 days of birth with mortality as high as 30-50%.
- Trial name
- NCT07667049
- Testing
- measurement of intestinal permeability
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Maryland, Baltimore
Intestinal Blood Flow
Packed Red Blood Cell Transfusion and Intestinal Blood Flow in Preterm Neonates
The purpose of the study is to determine whether packed red blood cell (PRBC) transfusion affects intestinal blood flow of premature infants during feedings and if so, whether return of normal intestinal blood flow pattern occurs…
- Trial name
- NCT01628133
- Testing
- ultrasound
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- St. Louis University
Enterocolitis, Necrotizing
Probiotics Reduce Incidence of Necrotizing Enterocolitis for Very Low Birth Weight Infants
We investigate the efficacy of probiotics in reducing the incidence and severity of necrotizing enterocolitis (NEC) for very low birth weight (VLBW) infants.A prospective, masked, multi-center randomized control trial will be…
- Trial name
- NCT00540033
- Testing
- infloran
- Where
- Taiwan
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Infant, Premature, Diseases
Novel Human Milk Based Human Milk Fortifier
The primary objective is to assess weight gain of VLBW infants fed human milk supplemented with a novel human milk-based fortifier, in comparison to use of other fortifiers (historic controls).
- Trial name
- MHMHMF (NCT04478487)
- Testing
- Medolac human milk based human milk fortifier (MHMHMF)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwest Health
Prematurity, Very Low Birth Weight
Impact of Sex and Own Mother's Milk Pasteurization on Morbidity and Mortality of Very Low Birth Weight Infants
In very low birth weight (<1500g) preterm infants, nutrition with mother's own milk, as opposed to formula, is associated with reduced morbidity and mortality.
- Trial name
- G-PAMINEO (NCT07411872)
- Where
- Germany
- Volunteers
- 900 people
- Sponsor
- Charite University, Berlin, Germany
Intracranial Hemorrhage, Periventricular Leukomalacia
Does Erythropoietin Improve Outcome in Very Preterm Infants?
The main goal of this trial is to investigate whether early administration of human erythropoietin (EPO) in very preterm infants improves neurodevelopmental outcome at 24 months corrected age.
- Conditions
- Intracranial Hemorrhage, Periventricular Leukomalacia, Cerebral Palsy, Developmental Psychomotor Disorders
- Trial name
- NCT00413946
- Testing
- Recombinant human Erythropoietin, saline
- Where
- 5 sites in Switzerland
- Volunteers
- 420 people
- Sponsor
- Swiss Neonatal Network
Prematurity
Early Intervention Based on Neonatal Crawling in Very Premature Infants Without Major Brain Damage
Extreme prematurity is constantly increasing according to the World Health Organization. However, methods to train premature infants at risk of disability is sorely lacking. The goal of this project is to overcome this problem.
- Trial name
- Premalocom1 (NCT05278286)
- Testing
- Crawling stimulation with the crawliskate, Tummy time without the crawliskate
- Where
- 2 sites in France
- Volunteers
- 48 people
- Sponsor
- Marianne Barbu-Roth
Very Low Birth Weight Infant, Ureaplasma/Mycoplasma Positive
Pharmacokinetic Study of Clarithromycin in Very Low Birth Weight (VLBW)
The purpose of this study is to investigate the pharmacokinetics of clarithromycin which is used for premature infants with ureaplasma.
- Trial name
- NCT01851954
- Testing
- Clarithromycin
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Seoul National University Hospital
Premature Birth
Continuity of Leg Movements in VLBW Premature Infants: From Spontaneous Kicking and Supported Stepping to Independent Walking
The purposes of this one-year follow-up study are twofold: (1) to prospectively examine the spontaneous kicking and the supported stepping movement in VLBW premature infants until attainment of independent walking; and (2) to…
- Trial name
- NCT00354783
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital
Respiratory Distress Syndrome in Premature Infants, Very Low Birth Weight Baby
Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation
This study hopes to determine whether nitric oxide along with oxygen during the first 20 minutes of life in infants needing help with breathing will reduce the percentage and total exposure to oxygen during that time frame.
- Trial name
- iNO (NCT01220687)
- Testing
- iNO, Nitrogen
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Oklahoma