Clinical trials: Vestibular Disorders
Neurofibromatosis 2, Vestibular Schwannoma
Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors
In this research study the researchers want to learn more about the effects (both good and bad) the study drug selumetinib has on participants with neurofibromatosis type II (NF2) related tumor.
- Conditions
- Neurofibromatosis 2, Vestibular Schwannoma, Meningioma, Ependymoma
- Trial name
- SEL-TH-1601 (NCT03095248)
- Testing
- Selumetinib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Siderosis, Neurological Disorder
Audiovestibular Function in Infratentorial Superficial Siderosis
One in six people in the United Kingdom and over 400 million people worldwide have disabling hearing loss. This figure will double by 2050 as predicted by the World Health Organisation.
- Conditions
- Siderosis, Neurological Disorder, Rare Diseases, Age Related Hearing Loss
- Trial name
- AViSS (NCT04200664)
- Testing
- Hearing assessment, Vestibular/balance assessment, Quality of life assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University College, London
HC-BPPV
Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo
The purpose of this study was to compare the immediate efficacies of each treatment maneuvers in treatment of apogeotropic horizontal canal benign paroxysmal positional vertigo (HC-BPPV).
- Trial name
- BPPV-HC (NCT00810641)
- Testing
- Gufoni maneuver, Head-shaking maneuver
- Where
- 2 sites in South Korea
- Volunteers
- 157 people
- Sponsor
- Chonbuk National University
Migraine Disorders
Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine
The investigators' study plans to randomize treatment naive patients with vestibular migraine to an 8 week trial of an escalating dose of either nortriptyline or topiramate followed by an 8 week crossover to the other drug if…
- Trial name
- NCT02169830
- Testing
- nortriptyline, Topiramate, Diet Modification
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- St. Louis University
Vestibular Diseases
Computerized Vestibular Rehabilitation
Disorders of vestibular function and balance are an important component of many conditions that commonly affect veterans, such as inner ear diseases, diabetes, and traumatic brain injury.
- Trial name
- NCT03589859
- Testing
- VOR Test, Computer Game, Nausea Scale
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Vestibular Neuronitis, Vestibular Neuronitis, Bilateral
Recovery of Visual Acuity in People With Vestibular Deficits
The purpose of this study is to determine whether exercises relieve the symptoms of dizziness and imbalance in people with vestibular deficits and improves the ability to see clearly during head movements.
- Conditions
- Vestibular Neuronitis, Vestibular Neuronitis, Bilateral, Vestibular Schwannoma
- Trial name
- NCT00411216
- Testing
- Control exercises, gaze stabilization exercises
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Emory University
Optokinetic Nystagmus
Production of a Device to Obtain Continuous Ambulatory Vestibular Assessment (CAVA) - Healthy Volunteer Trial
Clinical investigation of a medical device (CAVA) for recording eye movements. Healthy volunteers will wear the device for 23 hours a day, for 30 days.
- Trial name
- CAVA (NCT03661762)
- Testing
- CAVA
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Julie Dawson
Dizziness, Vertigo
Trental for the Treatment of Vertigo/Dizziness/Imbalance
Imbalance, dizziness and vertigo as a result of problems in the inner ear (vestibular dysfunction) are becoming increasingly more prevalent in Americans 40 years of age and older.
- Trial name
- NCT02592863
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Missouri-Columbia
Parkinson's Disease
Vestibular Stimulation in Parkinson's Disease
The purpose of this study is to determine whether caloric vestibular stimulation improves symptoms of Parkinson's Disease.
- Trial name
- NCT02703844
- Testing
- Caloric Vestibular Stimulation
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Kent
Meniere's Disease
SPI-1005 for the Treatment of Patients With Meniere's Disease
This study will evaluate the safety, efficacy, and Pharmacokinetics (PK) of two dose levels of SPI-1005 administered for 28 days compared to placebo in patients with Meniere's disease.
- Trial name
- NCT03325790
- Testing
- 200mg SPI-1005 BID, 400mg SPI-1005 BID
- Where
- 13 sites in United States
- Volunteers
- 149 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Dizziness
Head-Mounted Vibrotactile Prosthesis for Patients With Chronic Postural Instability
The goal of this project is to provide individuals that have a balance deficit with a device that will give them signals that they can feel (vibrations) in order to help them maintain a correct sense of balance and perception of…
- Trial name
- NCT00889824
- Testing
- balance prosthesis
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Washington University School of Medicine
Obesity, Metabolic Syndrome
Effect of Vestibular Stimulation on Fat Consumption and Energy Expenditure as Assessed Using Indirect Calorimetry
There is an ongoing and worsening problem with obesity in the developed, and much of the developing world. Although it has long been realized that Western diets that are rich in sugar and fat play an important role in this, it…
- Trial name
- NCT03138382
- Testing
- Vestibular Nerve Stimulator
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Meniere's Disease
Study of OTO-104 in Subjects With Unilateral Meniere's Disease
The purpose of this study is to evaluate the effectiveness of OTO-104 for the treatment of Meniere's disease.
- Trial name
- AVERTS-2 (NCT02717442)
- Testing
- OTO-104
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Otonomy, Inc.
Dizziness
Vestibular Rehabilitation and Dizziness in Geriatric Patients
The purpose of this study is to develop effective exercise intervention to reduce dizziness and fall risk in older adults with non-specific dizziness.
- Trial name
- NCT00275392
- Testing
- Vestibular rehabilitation
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- US Department of Veterans Affairs
Temporomandibular Joint Disorders
Neurostimulation in Temporomandibular Disorders (TMD) Patients
The investigators propose to conduct a randomized blinded placebo-controlled clinical trial in patients with chronic TMD (N=20).
- Trial name
- CVS (NCT01502709)
- Testing
- Caloric Vestibular Neurostimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Vestibular Disorder
Dose of Vestibular Rehabilitation for Vestibular Hypofunction
The purposes of this research are to 1) utilize virtual reality (VR) to evaluate the exercise dose required to improve symptoms in those with vestibular (dizziness) disorders, 2) compare VR vestibular exercises to standard…
- Trial name
- VRVR (NCT04851184)
- Testing
- Gaze stabilization Exercises using Virtual Reality Device, Gaze stabilization non-instrumented
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- George Washington University
Ototoxicity
SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity
The primary objective of this study is to determine the safety and efficacy of SPI-1005 treatment in CF patients with active pulmonary exacerbation that are receiving an IV course of tobramycin, determined by comparing hearing…
- Trial name
- NCT02819856
- Testing
- SPI-1005 Ebselen 200mg Capsule x1, SPI-1005 Ebselen 200mg Capsule x2, SPI-1005 Ebselen 200mg Capsule x3
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Vestibular Schwannoma, Meningioma
Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma
This will be a multi-center, proof of concept phase 0 study to assess the suppression of p-AKT in Vestibular Schwannoma (VS) and meningiomas by AR-42 in adult patients undergoing tumor resection.
- Conditions
- Vestibular Schwannoma, Meningioma, Acoustic Neuroma, Neurofibromatosis Type 2
- Trial name
- NCT02282917
- Testing
- AR-42
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Vertigo, Dizziness
Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT)
AVERT is a randomized controlled trial comparing video-oculography (VOG)-guided care to standard care to assess accuracy of diagnoses and initial management decisions for emergency department (ED) patients with a chief symptom of…
- Trial name
- AVERT (NCT02483429)
- Testing
- VRT Care
- Where
- 5 sites in United States
- Volunteers
- 130 people
- Sponsor
- Johns Hopkins University
Neurofibromatosis Type 2, Progressive Vestibular Schwannomas
Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas
To determine the hearing response rate at 24 weeks after treatment with bevacizumab for symptomatic vestibular schwannomas (VS) in children and young adults with Neurofibromatosis Type 2 (NF 2).
- Trial name
- NCT01767792
- Testing
- Bevacizumab
- Where
- 12 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Alabama at Birmingham